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Gastrointestinal System
I
Nino Ekaterine Kipiani, PhD
Geomedi
11 December 2020
Syllabus
 Essence of digestion and classification of digestive processes;
 digestion in oral cavity, mastication, salivation, composition of saliva
and properties.
 Digestion in stomach; composition of gastric juice and its properties;
phases of gastric juice secretion; motor function of stomach
 Methods of study for gastrointestinal tract function. Influence of diet
regimen on gastric secretion; regulation of gastric motor function;
Ingestion of food
Is determined by the intrinsic desire for food called hunger.
The type of food the person preferentially seeks is determined by apetite.
Mastication (Chewing)
Frontal incisors – cutting
The posterior teeth -Molars - chewing
Chewing muscles are innervated by the V cranial nerve
Chewing is controlled by the nucleus in the brainstem
Stimulation of the RF taste center causes rhythmical chewing
activity.
Stimulation of hypothalamus, amygdala and cerebral cortex also cause chewing
Chewing reflex
Presence of bolus of food in mouth cause the reflex inhibition of mastication muscles.
This drop causes the stretch reflex of the jaw muscles that leads to rebound contraction.
Jaw rises to close the teeth, but it also compresses the bolus and the reflex starts again.
Swallowing – deglutition
1) Voluntary stage
Voluntary squeeze or roll of a bolus
posteriorly into the pharynx by
pressure of the tongue upward and
backward against the pallet.
2) Pharyngeal stage
Involuntary – posteriorly taken bolus
of food stimulates the epithelial
swallowing receptor areas,
impulses go to the brainstem, in
tractus solitatious via trigeminal
and glossopharyngeal nerves and it
initiates the series of automatic
pharyngeal muscle contractions.
3) Oesophageal stage
Swallowing – deglutition
Swallowing – deglutition
3) Oesophageal stage
Primary peristalsis is the
continuation of the pharyngeal
phase and the wave psses to the
stomach. Time – 8-10sec (in upright
position 5-8 sec due to gravity.)
Secondary peristlsis
Lower
oesophageal
sphincter
Composition f saliva
 Ptyalin
 Mucus
 water
Functions of the stomach
1. Storage - due to vagovagal reflex
after distention it can enlarge and
store more food up to 0.8-1.5 liter.
2. Mixing movements with the slow
rhythm generated in the walls of
stomach; The contracted pyloric
sphyncter helps mixing the food
stored in the antrum – this is called
retropulsion.
3. Hunger contractions
4. Digestion
5. Absorption
6. Protection
Motor functions of the stomach
Regulation of stomach emptying
1. Gastric factor
Increased volume of food in stomach causes stratchinf and
hence the reflexive emptying, pressure is not chaned.
2. Hormone Gastrin
3.
Goblet cells – producing mucus
Oxyntic (parietal) cells – producing HCl,
intrinsic factor,
Peptic cells – producing pepsinogene,
Crypts of Lyberkuhn
Gastric cells in Pyloric glands – secrete Gastrin
ECL – enterochromafin like cells – secrete
histamine
Gastrin
ECL – enterochromafin like cells
Composition of gastric juice
 Mucus – goblet cells
 HCl – parietal cells (oxyntic cels)
 Pepsinogen – peptic cells (chief)
 Intrinsic factor – Parietal cells
 Gastrin – Pyloric cells
Oxyntic gland
Hydrochloric acid secretion
Parietal cells
H+K+ATPase
Water hydrolysis
Na+K+ATPase -
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg
Gastrointestinal System I.pptxfxghxfhfxghghg

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Gastrointestinal System I.pptxfxghxfhfxghghg

  • 1. Gastrointestinal System I Nino Ekaterine Kipiani, PhD Geomedi 11 December 2020
  • 2. Syllabus  Essence of digestion and classification of digestive processes;  digestion in oral cavity, mastication, salivation, composition of saliva and properties.  Digestion in stomach; composition of gastric juice and its properties; phases of gastric juice secretion; motor function of stomach  Methods of study for gastrointestinal tract function. Influence of diet regimen on gastric secretion; regulation of gastric motor function;
  • 3. Ingestion of food Is determined by the intrinsic desire for food called hunger. The type of food the person preferentially seeks is determined by apetite. Mastication (Chewing) Frontal incisors – cutting The posterior teeth -Molars - chewing Chewing muscles are innervated by the V cranial nerve Chewing is controlled by the nucleus in the brainstem Stimulation of the RF taste center causes rhythmical chewing activity. Stimulation of hypothalamus, amygdala and cerebral cortex also cause chewing Chewing reflex Presence of bolus of food in mouth cause the reflex inhibition of mastication muscles. This drop causes the stretch reflex of the jaw muscles that leads to rebound contraction. Jaw rises to close the teeth, but it also compresses the bolus and the reflex starts again.
  • 4. Swallowing – deglutition 1) Voluntary stage Voluntary squeeze or roll of a bolus posteriorly into the pharynx by pressure of the tongue upward and backward against the pallet. 2) Pharyngeal stage Involuntary – posteriorly taken bolus of food stimulates the epithelial swallowing receptor areas, impulses go to the brainstem, in tractus solitatious via trigeminal and glossopharyngeal nerves and it initiates the series of automatic pharyngeal muscle contractions. 3) Oesophageal stage
  • 6.
  • 7. Swallowing – deglutition 3) Oesophageal stage Primary peristalsis is the continuation of the pharyngeal phase and the wave psses to the stomach. Time – 8-10sec (in upright position 5-8 sec due to gravity.) Secondary peristlsis
  • 8.
  • 10. Composition f saliva  Ptyalin  Mucus  water
  • 11.
  • 12.
  • 13. Functions of the stomach 1. Storage - due to vagovagal reflex after distention it can enlarge and store more food up to 0.8-1.5 liter. 2. Mixing movements with the slow rhythm generated in the walls of stomach; The contracted pyloric sphyncter helps mixing the food stored in the antrum – this is called retropulsion. 3. Hunger contractions 4. Digestion 5. Absorption 6. Protection
  • 14. Motor functions of the stomach
  • 15.
  • 16. Regulation of stomach emptying 1. Gastric factor Increased volume of food in stomach causes stratchinf and hence the reflexive emptying, pressure is not chaned. 2. Hormone Gastrin 3.
  • 17.
  • 18. Goblet cells – producing mucus Oxyntic (parietal) cells – producing HCl, intrinsic factor, Peptic cells – producing pepsinogene, Crypts of Lyberkuhn Gastric cells in Pyloric glands – secrete Gastrin ECL – enterochromafin like cells – secrete histamine
  • 20.
  • 21. Composition of gastric juice  Mucus – goblet cells  HCl – parietal cells (oxyntic cels)  Pepsinogen – peptic cells (chief)  Intrinsic factor – Parietal cells  Gastrin – Pyloric cells
  • 23. Hydrochloric acid secretion Parietal cells H+K+ATPase Water hydrolysis Na+K+ATPase -