1. Fracture healing involves inflammation, callus formation, consolidation, and remodeling. The type and location of bone formed depends on factors like fracture type, gap condition, fixation rigidity, and loading.
2. Fracture healing is divided into cortical bone healing and cancellous bone healing. Complications include malunion, delayed union, and nonunion.
3. Nonunion is established when a fracture shows no progressive healing for 3 months after at least 9 months. Treatment depends on the type of nonunion and may involve electrical stimulation, external fixation, or surgical techniques like bone grafting and internal or external fixation.
The document summarizes a seminar on fracture healing and epiphyseal injuries. It discusses the stages of fracture healing in adults, including inflammation, soft callus formation, hard callus formation, and remodeling. It also discusses differences in fracture healing between cancellous and cortical bone. Additionally, it covers anatomy of the child bone, including the epiphysis, physis, metaphysis and diaphysis. It describes factors influencing bone growth and the phases of fracture healing in children. Finally, it discusses classification systems for epiphyseal injuries including Salter Harris, Poland, Aitken, and Peterson, as well as causes, evaluation, and treatment of physeal injuries.
Fracture healing is a complex process that begins immediately after a bone is broken and continues for many years as the bone remodels. It involves the formation of a soft callus that is later replaced by hard bony callus as new bone bridges the fracture gap. The type and amount of new bone formed depends on factors like fracture type, stability, and biological environment. Fracture healing progresses through inflammatory, callus formation, consolidation, and remodeling stages. Complications can include malunion, delayed union, and nonunion, which are influenced by injury, patient, tissue, and treatment factors and require specific management approaches.
Fracture healing is a complex physiological process involving inflammation, repair, and remodeling phases. During inflammation, the fracture site fills with hematoma and swelling occurs. In repair, granulation tissue forms and a fibrocartilaginous callus develops. Remodeling involves mineralization of callus and Haversian remodeling. Many factors like nutrition, comorbidities, medications, and local/systemic inflammation can affect fracture healing. Adequate calories, protein, and other nutrients are important for providing the body with energy and materials to synthesize new proteins and tissues during healing. Both local and systemic inflammation can impair healing depending on factors like the specific inflammatory conditions and cells involved.
This document discusses fracture healing and the underlying biological processes. It is divided into three phases: inflammation, repair, and remodeling. The inflammation phase occurs within the first week as the body clears debris. The repair phase over the next 2-3 months involves callus formation through intramembranous or endochondral ossification. During the remodeling phase, which can last years, the callus is reshaped into lamellar bone through cutting cones and modeling. Key cell types and growth factors that regulate healing are also described.
1. Fracture healing involves inflammation, callus formation, consolidation, and remodeling. The type and location of bone formed depends on factors like fracture type, gap condition, fixation rigidity, and loading.
2. Fracture healing is divided into cortical bone healing and cancellous bone healing. Complications include malunion, delayed union, and nonunion.
3. Nonunion is established when a fracture shows no progressive healing for 3 months after at least 9 months. Treatment depends on the type of nonunion and may involve electrical stimulation, external fixation, or surgical techniques like bone grafting and internal or external fixation.
The document summarizes a seminar on fracture healing and epiphyseal injuries. It discusses the stages of fracture healing in adults, including inflammation, soft callus formation, hard callus formation, and remodeling. It also discusses differences in fracture healing between cancellous and cortical bone. Additionally, it covers anatomy of the child bone, including the epiphysis, physis, metaphysis and diaphysis. It describes factors influencing bone growth and the phases of fracture healing in children. Finally, it discusses classification systems for epiphyseal injuries including Salter Harris, Poland, Aitken, and Peterson, as well as causes, evaluation, and treatment of physeal injuries.
Fracture healing is a complex process that begins immediately after a bone is broken and continues for many years as the bone remodels. It involves the formation of a soft callus that is later replaced by hard bony callus as new bone bridges the fracture gap. The type and amount of new bone formed depends on factors like fracture type, stability, and biological environment. Fracture healing progresses through inflammatory, callus formation, consolidation, and remodeling stages. Complications can include malunion, delayed union, and nonunion, which are influenced by injury, patient, tissue, and treatment factors and require specific management approaches.
Fracture healing is a complex physiological process involving inflammation, repair, and remodeling phases. During inflammation, the fracture site fills with hematoma and swelling occurs. In repair, granulation tissue forms and a fibrocartilaginous callus develops. Remodeling involves mineralization of callus and Haversian remodeling. Many factors like nutrition, comorbidities, medications, and local/systemic inflammation can affect fracture healing. Adequate calories, protein, and other nutrients are important for providing the body with energy and materials to synthesize new proteins and tissues during healing. Both local and systemic inflammation can impair healing depending on factors like the specific inflammatory conditions and cells involved.
This document discusses fracture healing and the underlying biological processes. It is divided into three phases: inflammation, repair, and remodeling. The inflammation phase occurs within the first week as the body clears debris. The repair phase over the next 2-3 months involves callus formation through intramembranous or endochondral ossification. During the remodeling phase, which can last years, the callus is reshaped into lamellar bone through cutting cones and modeling. Key cell types and growth factors that regulate healing are also described.
Fracture healing is a complex physiological process involving inflammation, repair, and remodeling phases. Many factors can influence fracture healing including nutrition, comorbidities, medications, and systemic inflammation. Adequate protein, calorie, mineral, and vitamin intake is important to meet the increased nutritional demands of healing. Specifically, antioxidants, zinc, copper, calcium, phosphorus, and silicon may help accelerate fracture healing by reducing inflammation and supporting new bone formation. Both local and systemic inflammation can impair healing, though local inflammation alone does not necessarily cause impaired healing. Optimizing nutrition is one approach to enhance and speed the natural fracture healing process.
What is fixation?
Fixation in orthopedics is the process by which an injury is rendered immobile. This may be accomplished by internal fixation, or by external fixation.
What is internal fixation?
Internal fixation is an operation in orthopedics that involves the surgical implementation of implants for the purpose of repairing a bone
What is osteosynthesis?
Osteosynthesis is the reduction and internal fixation of a bone fracture with implantable devices that are usually made of metal. It is a surgical procedure with an open or per cutaneous approach to the fractured bone. Osteosynthesis aims to bring the fractured bone ends together and immobilize the fracture site while healing takes place. In a fracture that is rigidly immobilized the fracture heals by the process of intramembranous ossification
INDICATIONS for internal fixation
History of Fracture Treatment and Development Of Modern Osteosynthesis
In the Preantibiotic era, closed reduction of fractures was understandably the rule for most fractures. However, when closed reduction was insufficient, external fixation appliances served to maintain skeletal units in position, frequently without the need for MMF (Maxillo-mandibular fixation) .Following the development of antibiotics, the open treatment of fractures began to be used on a more frequent basis.
Rigid internal fixation (RIF) is “Any form of fixation applied directly to the bones which is strong enough to permit active use of the skeletal structure during the healing phase and also helps in healing”.
Bone fractures have been treated with various conservative techniques for centuries and it was not until the eighteenth century that internal fixation was first documented.
Icart, a French surgeon in Castres, performed ligature fixation with brass wire on a young man with a humeral fracture.
1886, when Hansmann of Hamburg published a technique using retrievable metal bone plates with transcutaneous screws.
Soon after, a Belgian surgeon, Albin Lambotte, improved these techniques and coined the term internal fixation.
Lambotte developed and manufactured a variety of bone plates and screws and much of his armamentarim remained in use until the 1950s.
In the twentieth century, Sherman improved on Lambotte’s designs and created parallel, threaded, finepitched, self-tapping screws. This hardware was made of corrosion-resistant vanadium steel, which was a strength improvement over silver and ivory fixation materials.
BIOLOGY OF BONE AND BONE HEALING
Bone is a complex and ever-evolving connective tissue and serves multiple purposes. Besides being the main constituent of the human skeletal system, bone is highly metabolically active and essential for the regulation of serum electrolytes—namely, calcium and phosphate.
Marrow cavities are filled with hematopoietic elements necessary to manufacture and maintain blood components and regulate the immune system. Bone is comprised
This document provides an overview of maxillofacial bone biology and healing. It discusses the embryology and development of craniofacial bones, their structure and chemical composition, and biomechanical properties. Primary mechanisms of bone fracture and healing are described, including primary healing through contact or a small gap, and secondary healing involving callus formation. Complications of bone healing like non-union and malunion are also covered. The document concludes with sections on metals and implant surfaces, and potential future uses of biodegradable fixation materials.
Stages of Bone healing and madalities to enhance bone healing Surya Vijay Singh
Bone healing, direct bone healing, indirect bone healing, primary and secondary bone healing, stages of bone healing, substitute of bone healing, autografting and allograft, fracture healing
The document discusses the process of fracture healing. It begins with an inflammatory phase where hematoma forms and inflammatory cells degrade necrotic tissue. This is followed by a reactive phase where new capillaries form granulation tissue (procallus) and osteogenic cells lay down a soft callus of collagen and fibrocartilage. Finally, there is a remodeling phase where the callus is calcified to form hard callus, then remodeled over years into the original bone shape through the action of osteoblasts and osteoclasts. Growth factors and cytokines that regulate each phase of healing are also outlined.
This document discusses bone healing and repair. It begins with an introduction and overview of bone structure and function. There are several cell types involved in bone healing including osteoblasts, osteoclasts and fibroblasts. Bone healing can occur directly through primary healing or indirectly through secondary healing which involves callus formation. Several factors can affect bone healing such as nutrition, age, infection and vascularity. Complications of bone healing include nonunion, malunion and delayed union. Bone grafts undergo revascularization from the recipient site and healing of extraction sockets occurs in stages from coagulum to bone development.
Fracture Healing,Introduction,Pathology&Stages,Factors influencing osteogenesis,differences in healing of fractured bone by conservative&operative management.
This document discusses bone healing and fracture healing. It covers two forms of bone tissue: cortical and cancellous bone. It also discusses two types of bone formation: woven bone and lamellar bone. The process of fracture healing is described in three stages: inflammation, repair, and remodeling. Key cells and growth factors involved in each stage are identified. Factors that can influence fracture healing, such as injury severity, nutrition status, and age are also outlined.
This document discusses delayed union and non-union of fractures. It defines delayed union as taking more than the usual time for a fracture to heal, and non-union as no signs of healing after 9 months. The stages of fracture healing and factors that can lead to non-union like smoking, diabetes and mechanical issues are described. Classification systems for aseptic and septic non-unions are presented. Treatment principles focus on controlling infection, stabilizing the fracture, and using bone grafts or other techniques like bone transport as needed. Recent advances in bone stimulants, stem cells and gene therapy are also mentioned.
Bone healing, or fracture healing, is the body's natural process of repairing broken bones. It involves several phases: reactive, reparative, and remodeling. In the reactive phase, a blood clot forms and granulation tissue develops at the fracture site. In the reparative phase, cartilage and bone tissue grow to bridge the fracture. Finally, in the remodeling phase, the bone is reshaped to its original form and strength over 3-5 years. Complications can include delayed healing, non-union, or a fibrous union if immobilization is improper. Modern techniques like electrical stimulation, ultrasound, and bone grafts can accelerate the natural bone healing process.
Fracture healing is a complex regenerative process involving several stages: inflammation and hematoma formation, callus formation through cartilage and bone tissue, consolidation into solid bone, and remodeling. There are two main types of healing - primary/direct healing where bone forms directly across the fracture without callus, and secondary/indirect healing which involves initial callus formation. Many factors can influence healing, including systemic factors like nutrition, age, and diseases, as well as local factors like blood supply, fracture stability, and treatment approach. Complications can arise if healing is delayed or impaired. Understanding fracture biology and influencing factors is important for orthopedic surgeons to ensure proper bone regeneration and recovery from injury.
Distraction osteogenesis of craniofacial regionKunaal Agrawal
The document provides an overview of distraction osteogenesis (DO). It discusses the historical origins and development of DO, from Hippocrates applying traction on broken bones to Ilizarov's modern principles of bone regeneration through gradual traction. The biological basis and phases of DO are explained, including fracture/osteotomy, latency period, distraction period, and consolidation period. Each phase is accompanied by the histological and cellular processes involved in regenerating new bone through gradual traction rather than acute advancement. The document serves as an introduction to DO and its application in craniofacial reconstruction.
This document discusses distraction osteogenesis of the mandible. It begins by defining distraction osteogenesis as the biological process of new bone formation between bone segments gradually separated by traction. It then discusses the history and principles of distraction osteogenesis developed by doctors like Ilizarov. It classifies different distraction osteogenesis techniques like callotasis, physeal distraction, and chondrodiatasis. It concludes by discussing the biomechanical and biological factors important for successful distraction osteogenesis applications.
This document discusses osseointegration, which refers to the direct structural and functional connection between bone and the surface of a load-bearing dental implant without intervening soft tissue. It traces the history and development of osseointegration from early experiments in the 1950s to its current understanding. The key aspects covered include definitions of osseointegration, the biological process of bone formation around implants over time, factors that influence osseointegration success, and future directions for improving integration.
Pentagon Intraarticular Osteotomy: A Novel Surgical Approach to Complex Defor...skisnfeet
The document describes a new surgical approach called the Paley-Pentagon osteotomy to correct complex deformities of the tibial plafond. Three cases are presented where the osteotomy was used to realign the ankle joint. All cases resulted in improved radiographic alignment and stability of the ankle joint as well as improved foot and ankle function and decreased pain. However, ankle range of motion was decreased. The osteotomy addresses intra-articular deformities through a single subtractive osteotomy, avoiding more destructive joint procedures.
Fracture regarding information and also useful in nursing in that types of fracture included and also include treatment regarding fracture , nursing care plan...commonly fracture is more so its very useful for study.....
This document discusses bone and fracture healing. It covers the key stages and processes of both endochondral and intramembranous ossification. Endochondral healing involves the formation of a cartilage callus that is later replaced with bone, while intramembranous healing forms bone directly without a cartilage intermediate. Both involve cells, scaffolding, blood supply, and signaling molecules. Complications like malunion, delayed union, and nonunion can occur if healing is disrupted by factors like instability, open fractures, or patient health issues.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Fracture healing is a complex physiological process involving inflammation, repair, and remodeling phases. Many factors can influence fracture healing including nutrition, comorbidities, medications, and systemic inflammation. Adequate protein, calorie, mineral, and vitamin intake is important to meet the increased nutritional demands of healing. Specifically, antioxidants, zinc, copper, calcium, phosphorus, and silicon may help accelerate fracture healing by reducing inflammation and supporting new bone formation. Both local and systemic inflammation can impair healing, though local inflammation alone does not necessarily cause impaired healing. Optimizing nutrition is one approach to enhance and speed the natural fracture healing process.
What is fixation?
Fixation in orthopedics is the process by which an injury is rendered immobile. This may be accomplished by internal fixation, or by external fixation.
What is internal fixation?
Internal fixation is an operation in orthopedics that involves the surgical implementation of implants for the purpose of repairing a bone
What is osteosynthesis?
Osteosynthesis is the reduction and internal fixation of a bone fracture with implantable devices that are usually made of metal. It is a surgical procedure with an open or per cutaneous approach to the fractured bone. Osteosynthesis aims to bring the fractured bone ends together and immobilize the fracture site while healing takes place. In a fracture that is rigidly immobilized the fracture heals by the process of intramembranous ossification
INDICATIONS for internal fixation
History of Fracture Treatment and Development Of Modern Osteosynthesis
In the Preantibiotic era, closed reduction of fractures was understandably the rule for most fractures. However, when closed reduction was insufficient, external fixation appliances served to maintain skeletal units in position, frequently without the need for MMF (Maxillo-mandibular fixation) .Following the development of antibiotics, the open treatment of fractures began to be used on a more frequent basis.
Rigid internal fixation (RIF) is “Any form of fixation applied directly to the bones which is strong enough to permit active use of the skeletal structure during the healing phase and also helps in healing”.
Bone fractures have been treated with various conservative techniques for centuries and it was not until the eighteenth century that internal fixation was first documented.
Icart, a French surgeon in Castres, performed ligature fixation with brass wire on a young man with a humeral fracture.
1886, when Hansmann of Hamburg published a technique using retrievable metal bone plates with transcutaneous screws.
Soon after, a Belgian surgeon, Albin Lambotte, improved these techniques and coined the term internal fixation.
Lambotte developed and manufactured a variety of bone plates and screws and much of his armamentarim remained in use until the 1950s.
In the twentieth century, Sherman improved on Lambotte’s designs and created parallel, threaded, finepitched, self-tapping screws. This hardware was made of corrosion-resistant vanadium steel, which was a strength improvement over silver and ivory fixation materials.
BIOLOGY OF BONE AND BONE HEALING
Bone is a complex and ever-evolving connective tissue and serves multiple purposes. Besides being the main constituent of the human skeletal system, bone is highly metabolically active and essential for the regulation of serum electrolytes—namely, calcium and phosphate.
Marrow cavities are filled with hematopoietic elements necessary to manufacture and maintain blood components and regulate the immune system. Bone is comprised
This document provides an overview of maxillofacial bone biology and healing. It discusses the embryology and development of craniofacial bones, their structure and chemical composition, and biomechanical properties. Primary mechanisms of bone fracture and healing are described, including primary healing through contact or a small gap, and secondary healing involving callus formation. Complications of bone healing like non-union and malunion are also covered. The document concludes with sections on metals and implant surfaces, and potential future uses of biodegradable fixation materials.
Stages of Bone healing and madalities to enhance bone healing Surya Vijay Singh
Bone healing, direct bone healing, indirect bone healing, primary and secondary bone healing, stages of bone healing, substitute of bone healing, autografting and allograft, fracture healing
The document discusses the process of fracture healing. It begins with an inflammatory phase where hematoma forms and inflammatory cells degrade necrotic tissue. This is followed by a reactive phase where new capillaries form granulation tissue (procallus) and osteogenic cells lay down a soft callus of collagen and fibrocartilage. Finally, there is a remodeling phase where the callus is calcified to form hard callus, then remodeled over years into the original bone shape through the action of osteoblasts and osteoclasts. Growth factors and cytokines that regulate each phase of healing are also outlined.
This document discusses bone healing and repair. It begins with an introduction and overview of bone structure and function. There are several cell types involved in bone healing including osteoblasts, osteoclasts and fibroblasts. Bone healing can occur directly through primary healing or indirectly through secondary healing which involves callus formation. Several factors can affect bone healing such as nutrition, age, infection and vascularity. Complications of bone healing include nonunion, malunion and delayed union. Bone grafts undergo revascularization from the recipient site and healing of extraction sockets occurs in stages from coagulum to bone development.
Fracture Healing,Introduction,Pathology&Stages,Factors influencing osteogenesis,differences in healing of fractured bone by conservative&operative management.
This document discusses bone healing and fracture healing. It covers two forms of bone tissue: cortical and cancellous bone. It also discusses two types of bone formation: woven bone and lamellar bone. The process of fracture healing is described in three stages: inflammation, repair, and remodeling. Key cells and growth factors involved in each stage are identified. Factors that can influence fracture healing, such as injury severity, nutrition status, and age are also outlined.
This document discusses delayed union and non-union of fractures. It defines delayed union as taking more than the usual time for a fracture to heal, and non-union as no signs of healing after 9 months. The stages of fracture healing and factors that can lead to non-union like smoking, diabetes and mechanical issues are described. Classification systems for aseptic and septic non-unions are presented. Treatment principles focus on controlling infection, stabilizing the fracture, and using bone grafts or other techniques like bone transport as needed. Recent advances in bone stimulants, stem cells and gene therapy are also mentioned.
Bone healing, or fracture healing, is the body's natural process of repairing broken bones. It involves several phases: reactive, reparative, and remodeling. In the reactive phase, a blood clot forms and granulation tissue develops at the fracture site. In the reparative phase, cartilage and bone tissue grow to bridge the fracture. Finally, in the remodeling phase, the bone is reshaped to its original form and strength over 3-5 years. Complications can include delayed healing, non-union, or a fibrous union if immobilization is improper. Modern techniques like electrical stimulation, ultrasound, and bone grafts can accelerate the natural bone healing process.
Fracture healing is a complex regenerative process involving several stages: inflammation and hematoma formation, callus formation through cartilage and bone tissue, consolidation into solid bone, and remodeling. There are two main types of healing - primary/direct healing where bone forms directly across the fracture without callus, and secondary/indirect healing which involves initial callus formation. Many factors can influence healing, including systemic factors like nutrition, age, and diseases, as well as local factors like blood supply, fracture stability, and treatment approach. Complications can arise if healing is delayed or impaired. Understanding fracture biology and influencing factors is important for orthopedic surgeons to ensure proper bone regeneration and recovery from injury.
Distraction osteogenesis of craniofacial regionKunaal Agrawal
The document provides an overview of distraction osteogenesis (DO). It discusses the historical origins and development of DO, from Hippocrates applying traction on broken bones to Ilizarov's modern principles of bone regeneration through gradual traction. The biological basis and phases of DO are explained, including fracture/osteotomy, latency period, distraction period, and consolidation period. Each phase is accompanied by the histological and cellular processes involved in regenerating new bone through gradual traction rather than acute advancement. The document serves as an introduction to DO and its application in craniofacial reconstruction.
This document discusses distraction osteogenesis of the mandible. It begins by defining distraction osteogenesis as the biological process of new bone formation between bone segments gradually separated by traction. It then discusses the history and principles of distraction osteogenesis developed by doctors like Ilizarov. It classifies different distraction osteogenesis techniques like callotasis, physeal distraction, and chondrodiatasis. It concludes by discussing the biomechanical and biological factors important for successful distraction osteogenesis applications.
This document discusses osseointegration, which refers to the direct structural and functional connection between bone and the surface of a load-bearing dental implant without intervening soft tissue. It traces the history and development of osseointegration from early experiments in the 1950s to its current understanding. The key aspects covered include definitions of osseointegration, the biological process of bone formation around implants over time, factors that influence osseointegration success, and future directions for improving integration.
Pentagon Intraarticular Osteotomy: A Novel Surgical Approach to Complex Defor...skisnfeet
The document describes a new surgical approach called the Paley-Pentagon osteotomy to correct complex deformities of the tibial plafond. Three cases are presented where the osteotomy was used to realign the ankle joint. All cases resulted in improved radiographic alignment and stability of the ankle joint as well as improved foot and ankle function and decreased pain. However, ankle range of motion was decreased. The osteotomy addresses intra-articular deformities through a single subtractive osteotomy, avoiding more destructive joint procedures.
Fracture regarding information and also useful in nursing in that types of fracture included and also include treatment regarding fracture , nursing care plan...commonly fracture is more so its very useful for study.....
This document discusses bone and fracture healing. It covers the key stages and processes of both endochondral and intramembranous ossification. Endochondral healing involves the formation of a cartilage callus that is later replaced with bone, while intramembranous healing forms bone directly without a cartilage intermediate. Both involve cells, scaffolding, blood supply, and signaling molecules. Complications like malunion, delayed union, and nonunion can occur if healing is disrupted by factors like instability, open fractures, or patient health issues.
Similar to Fracture Healing, Complications & factors promotes the fracture healing.pptx (20)
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
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Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
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2. Fracture healing
Goals of fracture healing
Encourage Healing
Restore function
Cosmetically acceptable appearance
Factors influence the fracture healing
Biologic Events
Mechanical Events
3. Blood supply of healing long bones
Blood supply to bone. A, Normal bone.
B, Immature bone. C, Fractured bone
(extraosseous blood
supply). D, Healing bone.
12. Indirect bone healing
Hematoma & granulation tissue formation
Granulation tissue replaced by fibrous tissue & fibrocartilage
Local resorption of mineralized tissue
Vascularization of resorption cavity
Formation of lamellar bone in this cavity
Remodeling
14. Indirect bone healing
Indirect bone healing A-Bone resorption B-Periosteal callus formation C-
Mineralization of fibrocartilage D-Bone remodeling
15. Direct bone healing
Fracture having small gaps (150-300µm) between fractured
ends
Gaps filled with the network of fibrous tissue
Remodeling of bone union within 7-8 weeks + longitudinal
reconstruction of fracture site
Radiographicaly slowly increasing density of fracture line
without bridging periosteal & endosteal callus
16. Direct Bone Healing
Direct bone healing
Simultaneous union and reconstruction(A, B)
Gap fills with fibrous bone (C)Haversian
remodeling(D).
18. Intra-membranous Bone Healing
Direct differentiation of mesenchymal cells in to osteoblasts
Bone bridging between comminuted bone fragments after
biologic fixation technique
Periosteal callus is smaller in comminuted fracture
Resorption of woven bone & formation of lamellar bone
Remodeling
19. Intra-membranous Bone Healing
A, Comminuted fractures fixed with
biologic techniques of indirect
reduction, major segment alignment,
and optimal stabilization appear to heal
with a combination
of direct differentiation of
mesenchymal cells to osteoblasts
and endochondral ossification. B, The
fracture site fills with endosteal and
bridging callus. C, Resorption of
woven bone and formation of lamellar
bone at the fracture sites result in
remodeling of bony callus to cortical
bone.
20. Intra-membranous Bone Healing
A, Fracture healing in comminuted nonreducible radial fracture treated
with closed reduction and external fixation. B and C,
Radiographically endosteal bone appears first, followed by bone
bridging between fragments with minimal periosteal callus formation.
D, Bone remodeling occurs after the fracture lines are bridged.
21. Trabecular Bone Healing
Increase osteoblastic activity on either side of fracture
New bone deposit on existing trabeculae
Fracture gap filled with woven bone
Radiographicaly formation of one or two dense band at
fracture site
22. Trabecular Bone Healing
Metaphyseal fracture healing after a tibial
plateau leveling osteotomy, which is well
stabilized showing trabecular bone healing.
23. COMPLICATIONS IN FRACTURE
HEALING
Delayed union (healing slower than normal)
Non-union (arrested fracture repair process)
Osteomyelitis (inflammatory condition of bone & medullary
canal)
Mal-union (anatomic bone alignment not achieved)
25. Non-union of Femur
Radiograph of dog with hypertrophic
nonunion of femur. Notice formation of large
periosteal callus that cannot bridge the fracture.
The fracture was inadequately stabilized with
an IM pin and cerclage wires.
COMPLICATIONS IN FRACTURE
HEALING
27. Osteomyelitis
Infectious periostitis. A subtle, linear periosteal
reaction (arrows) can be seen along the lateral
aspect of the third toe proximal phalanx. Note
the associated soft tissue increase in volume
and density affecting the third and fourth toes
COMPLICATIONS IN FRACTURE
HEALING
28. Factors promotes the fracture healing
The factors that promotes fracture healing are:
Growth hormones
Thyroid hormone
Calcitonin
Insulin
Vitamin K
Vitamin C
Vitamin D
Immobilization
29. Factors promotes the fracture healing
Anabolic steroids
Young age
Nutrition status
Cerament
Electric current
Physical exercise
Minerals
High protein diet
30. Suggested Reading
Griffon DJ: Fracture healing. In Johnson AL, Houlton
JEF, Vannini R, editors: AO principles of fracture
management in the dog and cat, Thieme, NY, 2005, AO
Publishing, pp. 73-97.
Johnson AL, Egger EL, Eurell JC, et al: Biomechanics
and biology of fracture healing with external skeletal
fixation, Compend Cont Educ Pract Vet 20:487, 1998.
Wilson JW: Blood supply to developing, mature and
healing bone. In Sumner-Smith G, (editor): Bone in
clinical orthopedics, ed 2, Thieme, New York NY, 2002,
AO Publishing, p. 23.
31. Suggested Reading
Budsberg SC: Osteomyelitis, In Johnson AL, Houlton
JEF, Vannini R, editors: AO principles of fracture
management in the dog and cat, Thieme NY, 2005, AO
Publishing.
Johnson AL: Corrective osteotomies, In Johnson AL,
Houlton JEF, and Vannini R, editors: AO principles of
fracture management in the dog and cat, Thieme, NY,
2005, AO Publishing.