This document discusses an herbal formula containing valerian dry extract and hypericum dry extract. It provides details on the names, parts used, active constituents, medicinal uses, mode of action, side effects, food interactions, and precautions of each herb. It also includes information on standardized extracts for both valerian and hypericum.

1. Formula 2
Valerian dry extract 160 mg
Hypericum dry extract 100 mg
Valerian dry extract Hypericum dry extract
1- Different Valeriana officinalis Hypericum perforatum
names of drug: Valeriana St. John's Wort
2- Part used: Roots Leaves and flowering tops
Iridoid glycosides
Valepotriates (80- 1- Dianthrone:
90% valtrates) Hypericin
pseudohypericin
3- Active
Volatile oil: 2- Phloroglucinol:
constituent:
1-monoterpenes Hyperforin
2-sesquiterpenes: 3- Flavonoids:
as valerenic acid Hyperoside(synergistic)
ester
1- Anxiety
4- Medicinal
2- Sedative hypnotic.(for sleep disorders)
uses:
3- Moderate depression. (Hypericum)
-increase neurotransmitters
Valerenic acid and (e.g. 5-HT, dopamine,
valepotriatesàStimulate GABA) by:
5- Mode of
GABA à decrease CNS 1-MAOI: hypericin
Action:
activity à Sedation and 2-inhibition of reuptake:
anxiolytic. hyperforin
àantidepressant
1-Gastric upset:
(Nausea& vomiting)
1-Gastric upset: 2-Drug induced
6- Side Effects:
(Nausea& vomiting) photosensitivity.
NB: fair skinned people
should avoid prolonged
exposure to sunlight.

2. 6- Food Tyramine (old cheese) à
interaction: hypertensive crisis
The formula should NOT be taken during driving and
operating machine due to Drowsiness.
7- Precautions:
The formula should not be taken during pregnancy and
lactation.
valerenic acid dry
extract in form of
capsule or tablets à
400 mg taken from
30~60 minutes before
bedtime
3% hypericin, recently set to
8- Information of NB:
6% hyperforin in the form of
any standardized -Dry: because irridoids
tablets in dose of 300 mg
extract: are unstable and to
three times daily.
prevent hydrolysis of
esters
-Valerian is so hard to
extract because of
esters present that are
easily hydrolyzed.

3. Disease:
Anxiety
1-Defination: a chronic psychiatric condition of excessive worry or fear.
2-Signs and Symptoms:
-excessive fear
-tachycardia
-dyspnea
-sweating
-impaired concentration
-sleep disturbances
-depression
3-Etiology:
1-Specific life conditions.
2- Genetic factors.
4-Complementary and alternative therapy:
A- Daily routine:
1-spend more time outdoor
2-Exercise
B- Nutrition:
1-eat proteins (food rich in tryptophan)
2-eat fresh vegetables and whole grains
3-eat fish and food rich in omega 3 fatty acid
4-cut back on caffeine and alcohol.
C- Supplement:
1-Vitamins (B complex) and minerals (Ca & Mg)
2-OMEGA 3
D- Herbs in combinations: (Anxiety)
1-Kava Kava
2-Passion flower
3-Lavender
4-Lemon balms
5-Humulus
Herbal products in Egyptian market:
1- Sedaneurin (Hypericum and Valerian)
2- Dormival (Valerian + extract humulus)
3- Safamood (Hypericin + Vit. C)