The homework assignment requires coding for reports 2-5 located in the step-by-step workbook, specifically utilizing Encoder Pro. It details the medical history and treatment plans of several patients, including a 78-year-old female with pelvic metastatic cancer and complications, a 16-year-old with a sprained ankle, a 19-year-old post-kidney transplant patient with sepsis concerns, and ongoing management adjustments for diabetes. Students are instructed to complete a coding template that includes codes and their explanations for each report.