1. What is Stress?
2. Mechanism
Neuro-Anatomy of Stress
Neuro-Endocrine of Stress
Inflammation and Stress
3. Stress and Disease
Stress and Food Addiction
4. Stress and Central Regulation of Metabolism
1. What is Stress?
2. Mechanism
Neuro-Anatomy of Stress
Neuro-Endocrine of Stress
Inflammation and Stress
3. Stress and Disease
Stress and Food Addiction
4. Stress and Central Regulation of Metabolism
My Knee Hurts! A Look at Joint Pain in Children - Marla Guzman, MD - 1.12.2021Summit Health
Is your child complaining of joint pain? Learn about concerning symptoms and when to seek medical advice. Our expert discusses the various causes of joint pains in children, how a pediatric rheumatologist evaluates musculoskeletal complaints, and available treatment options.
Anderson, Unorthodox Health Care Cost Reductionsjwanderso
Novel Big Hitter interventions that will have dramatic cost savings due to improved health. Chronic diseases of aging and how to prevent them with unorthodox, effective interventions.
An introduction to the paleo diet and its health benefits. A short summary of research is presented as well as a description of blood sugar managment.
Best Nutritionist in Sarastoa, Cynthia Clark, http://www.cranehealth.net
Table of Contents
1. Meaning, Definitions, Concepts and Causes of Obesity
2. Eating Disorders and Health Risks Associated with Obesity
3. Assessment of Obesity
Sugar, the New Baddie on the Block
How can the addiction community help the obesity crisis and is sugar really an addiction? How do we currently treat binge eating and the CBT versus 12 step dilemna
How to get involved with Sweet Dreams as an affiliate partner
My Knee Hurts! A Look at Joint Pain in Children - Marla Guzman, MD - 1.12.2021Summit Health
Is your child complaining of joint pain? Learn about concerning symptoms and when to seek medical advice. Our expert discusses the various causes of joint pains in children, how a pediatric rheumatologist evaluates musculoskeletal complaints, and available treatment options.
Anderson, Unorthodox Health Care Cost Reductionsjwanderso
Novel Big Hitter interventions that will have dramatic cost savings due to improved health. Chronic diseases of aging and how to prevent them with unorthodox, effective interventions.
An introduction to the paleo diet and its health benefits. A short summary of research is presented as well as a description of blood sugar managment.
Best Nutritionist in Sarastoa, Cynthia Clark, http://www.cranehealth.net
Table of Contents
1. Meaning, Definitions, Concepts and Causes of Obesity
2. Eating Disorders and Health Risks Associated with Obesity
3. Assessment of Obesity
Sugar, the New Baddie on the Block
How can the addiction community help the obesity crisis and is sugar really an addiction? How do we currently treat binge eating and the CBT versus 12 step dilemna
How to get involved with Sweet Dreams as an affiliate partner
The diabetes cure (the 5 step plan to eliminate hunger, lose weight, and rev...Aqileditz
This is a food plan for diabetes patients and we also provided you with a product specially for diabetes patients,that is smart blood sugar with a special offer.
This is a presentation on weight loss we have given here in the community (Port Arthur, Port Neches, Nederland, Bridge City, Groves, Oranges, All of Southeast Texas /tx) It shows how Chiropractic can benefit those who want to lose weight. Dr Kerr, Chiropractor 409-962-3123
Lifestyle Medicine: The Power of Personal Choices, North American Vegetarian...EsserHealth
Learn about the leading chronic diseases in America and how Lifestyle Medicine can radically shift the burden of disease in your life and western society at large.
Red Light Therapy for Diabetes and Insulin ResistanceMarkSloan21
For the Show Notes and to sign up for our free monthly newsletter visit: https://endalldisease.com/episode20
Over 30 million people in the United States have been diagnosed with diabetes, all of whom were told they have a terminal disease that cannot be cured. They’re told that all they can do is manage their symptoms by eating less sugar and getting regular insulin injections. However, as you’re about to find out, the root cause of diabetes and how to reverse it has been known scientifically for over 70 years. Obviously, profiting from selling insulin is far more important to the medical industry than reducing humanity’s suffering.
In 1947, a Nobel Prize-winning scientist discovered that overconsumption of polyunsaturated fatty acids can cause diabetes. This means that every time you eat a large amount of polyunsaturated fats like vegetable oil you’re becoming temporarily diabetic and insulin resistant. And if you enough of these fats, the diabetes metabolism will become chronic.
In the decades since this landmark study, researchers have shown in both animals and in humans that eating a diet low in polyunsaturated fat can completely reverse diabetes.
In 2001, a paper in the New England Journal of Medicine admitted that “Type 2 diabetes can be prevented by changes in the lifestyles of high-risk subjects”[1] so contrary to popular belief, diabetes is a metabolic disease not a genetic one and it can be completely reversed.
In this video, you’ll learn what causes diabetes and how to use treatments like red light therapy and dietary changes to help you safely and effectively prevent or reverse the disease.
For the show notes visit:
https://endalldisease.com/episode20
If you liked this video and want to support my work, you can do so by donating, or by buying one of my bestselling books or red light therapy devices below.
Check out our red light therapy store:
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Read my books:
https://endalldisease.com/books
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Thanks for listening! Don't forget to subscribe, will see you in the next episode.
Type 2 diabetes is a lifelong disease that keeps your body from using insulin the way it should. People with type 2 diabetes are said to have insulin resistance.
People who are middle-aged or older are most likely to get this kind of diabetes, so it used to be called adult-onset diabetes. But type 2 diabetes also affects kids and teens, mainly because of childhood obesity.
It’s the most common type of diabetes. There are about 29 million people in the U.S. with type 2. Another 84 million have prediabetes, meaning their blood sugar (or blood glucose) is high but not high enough to be diabetes yet.
Sweet Misery. Cover story featured in 'North and South'Simon Thornley
A major print magazine in New Zealand read our book and asked nutrition researchers in New Zealand for comment. This was published in the November edition of 'North and South'. It is hosted here with permission from the editor-at-large Donna Chisholm.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
5. What is science?
“In God we trust, all others bring data”
“First establish the facts, then seek to
explain them” Aristotle
Anarchistic
Consensus not useful
Hypothesis and argument
Disproof useful, not proof.
Probabilities over absolutes
6. The obesity epidemic
Where has it occurred?
Over what time period?
Explanations?
What have we been told to eat?
Is it working?
8. What happened in the 1960s?
Diet-Heart Hypothesis
Heart disease caused by saturated fat
Response: reduce fat (↑sugar or carb.)
Cheap sugar (HFCS)
American Heart Assoc.– spread to other
English speaking countries
Taubes G. The Diet Delusion. New York: Vermilion; 2007.
9. Laws of thermodynamics
A–B=C
A = Energy in (food)
B = Energy out (burned, exercise/basal
metabolic rate)
C = Energy stored (as fat)
δA - environmental change (Coke ads/vending
machines)
11. My thoughts on obesity
Medical training Public Health Research Research
Traditional Understanding Similarities Critique of
Nutritional theory addiction between energy density
- Energy density obesity and Focus on sugar
smoking
1994 2005 2007 2011
14. Addiction? Automatic behaviour
Rational behaviour Automatic Addiction –
e.g. Planning, behaviour? Automatic,
Picking up children e.g. breathing withdrawal, can‘t
after work stop, causes harm
e.g. heroine
Mid brain/brain
Cortex
stem
19. Eating and addiction?
―Atkins Diet‖
An executive who had tried obesity surgery,
laxatives, diets, everything…
“Often I would shake until I could put
some sugar in my mouth”
20. “Ihad an hour’s drive from my office to
my home, and I knew every
restaurant, every candy machine and
every soft drink dispenser along the
whole route.”
21. What about glucose?
Glycemic index very similar for glucose
Is carbohydrate the same as nicotine?
Is low GI a way out like nicotine patch or
gum?
29. What does the good book say?
“It is not yet clear whether any single
attribute of the Western way of life is
particularly important in increasing the risk
of diabetes. Excess sucrose has largely
been exonerated as an important dietary
factor in the aetiology of type 2 diabetes...”
J. I. Mann and A. S. Truswell
Diseases of overnourished societies and the need for dietary change: in the Oxford
Textbook of Medicine, 4th Edition.
30. Sugar – traditional views
30% increase over last 30 years
Popkin BM, Nielsen SJ. The sweetening of the world's diet. Obesity Research 2003;11(11):1325-32.
―empty calorie‖
Nestle M. Soft drink "pouring rights": marketing empty calories to children. Public Health Reports
2000;115(4):308-19.
Sucrose and other free sugars restricted to
up to <15% of total caloric intake, due to
excess energy and dental caries.
Food and nutrition guidelines (Ministry of Health) 2003.
Fructose not mentioned
31. Average NZ consumption:
UN statistics (‗07)– 153g/day
= 38 teaspoons/ day
17% of total energy
Compare – 1961 – 33 teaspoons/day
34. Recent guidelines
American Heart Association 2002
Circulation 2002;106;523-527
“No definitive evidence... Rely on
professional judgement”
“Consuming fructose either free or in the
form of sucrose has neither beneficial or
adverse effects”
37. Update...
“Originally proposed as the ideal sweetener
for people with diabetes... Fructose... has
been indirectly implicated in the epidemics
of obesity and type 2 diabetes”
Circulation 2009;120;1011-1020
38. Update
Upper limit set to reduce heart disease risk
and maintain healthy weight
“6 teaspoons per day” for women
“9 teaspoons per day” for men
39. Health effects?
1990s ADA encouraged diabetics to eat
sugar/HFCS
2000s about face due to ↑triglycerides
Small RCTs:
Rots teeth; raises triglycerides, ↓HDL, ↑BP,
↑urate.
Johnson, R.J., et al., Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes? Endocr
Rev, 2009. 30(1): p. 96-116.
Segal, M.S., E. Gollub, and R.J. Johnson, Is the fructose index more relevant with regards to cardiovascular disease
than the glycemic index? European Journal of Nutrition, 2007. 46(7): p. 406-17.
40. Sugar - What has changed?
GI ignores fructose –Sugar half fructose (half
glucose)
4x as sweet as glucose
Links to gout, diabetes
Human studies limited,
Does not trigger satiety hormones→↑hunger
E.g. Insulin, CCK
Johnson, R.J., et al., Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes? Endocr Rev, 2009. 30(1): p. 96-
116.
Segal, M.S., E. Gollub, and R.J. Johnson, Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index?
European Journal of Nutrition, 2007. 46(7): p. 406-17.
41. Refined carbohydrate (high GI)
Reduced risk of chronic disease
Heart disease, cancer, gallstones.
Barclay A, Petocz P, McMillan-Price J, Flood V, Prvan T, Mitchell P, et al. Glycemic
index, glycemic load, and chronic disease risk—a metaanalysis of observational
studies. Am J Clin Nutr 2008;87:627-37
Modest weight loss
Thomas D, Elliott E, Baur L. Low glycaemic index or low glycaemic load diets for
overweight and obesity. Cochrane Database of Systematic Reviews 2007;Art. No.:
CD005105. DOI: 10.1002/14651858.CD005105.pub2(3).
42. What about saturated fat?
Meta-analyses now show no link between
eating saturated fat and heart disease.
Skeaff CM, Miller J. Dietary Fat and Coronary Heart Disease: Summary of Evidence
from Prospective Cohort and Randomised Controlled Trials. Ann Nutr Metab
2009;55:173–201
Mente A, de Koning L, Shannon HS, Anand SS (April 2009). A systematic review of the
evidence supporting a causal link between dietary factors and coronary heart
disease. Arch. Intern. Med. 169 (7): 659–69.
45. Food addiction-evidence
Neural pathways (dopamine)
Correlation between obesity & receptor
density like other addictions
Automaticity – serving size, availability
Rise in sugar consumption worldwide over
last 40 years.
Rodents – sugar induces withdrawal; fat
does not.
48. After the publicity... my inbox...
“For the first three weeks I cut all
processed sugar and flour from my diet
and suffered mood swings with extreme
tension and depression, even a sense of
hopelessness at times, I had horrible
stomach pains, all my joints and muscles
throbbed, and I had the shakes
constantly.”
49. “I don't even know how to describe the
horrible headaches that went along with
all this. People who knew me started
thinking I was hiding a drug problem.”
50. “The worst physical symptoms have been
gone for about two weeks now, and the
cravings are finally starting to subside… I
look at birthday cake today and all I see is
myself curled up in the foetal position
crying in bed. “
51. Overeater’s Anonymous
“When you are addicted to drugs you put
the tiger in the cage to recover; when you
are addicted to food, you put the tiger in the
cage, but take it out three times for a walk”
Kerri-Lynn Murphy Kriz
52. Critique: Academia
“Any addictive type of hypothesis can't
explain the rise that we've seen over the
last 20 to 30 years of obesity. It's not that
the whole population becoming more of
an addictive personality type or whatever.
I think there are other factors to explain
obesity at a population level.”
Prof. Boyd Swinburn, Professor of Population Health,
Deakin University 13 Jan 2009
53. Citique: Academia and Industry
“We write in response to Thornley et al’s
viewpoint article “The New Zealand sugar
(fructose) fountain...” The data quoted on
sugar consumption in New Zealand are
presented misleadingly and are not
correctly referenced to primary sources.”
Parnell and colleagues NZMJ 2010
58. Conclusions
Nutrition ignores motivation to eat, instead
focuses on energy
Low energy or low fat approach has been
unhelpful for populations
Sugar intake continues to rise
Likely subtle addiction to refined carb and
sugar
59. Conclusions
↓ sugar likely to ↓
Heart disease
Obesity
Diabetes
Dental caries
Other diseases?
No downsides except $$$
61. My advice…
Zero sugar (alternatives)
Whole grains over white flour (low GI)
No low fat food – tends to be high in
sugar or refined carbohydrate
62. Other lessons
Ink is a powerful weapon
The ideals of science are only that
‗Authorities‘ hold power over junior
scientists (jobs, grants)
Going alone takes courage
History over latest and greatest
63. The book
―Sickly sweet: sugar, refined carbohydrate,
addiction and global obesity‖
Nova
To be released in about three months.
64. Publications
Thornley S et al. The New Zealand sugar (fructose) fountain: time
to turn the tide? NZMJ 2010.
Thornley S et al. Carbohydrate withdrawal: is recognition the first
step to recovery? NZMJ 2010
Thornley S et al. Per capita sugar consumption is associated with
childhood asthma prevalence. Primary Care Respiratory Journal.
2011.
Thornley S et al. The obesity epidemic: is glycemic index the key to
unlocking a hidden addiction? Medical Hypotheses. 2008
65. Other reading
Freedman ―Wrong: Why experts keep
failing us and how to know when not to
trust them‖. Little, Brown and Company,
2010. (journalist)
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