I. ASP.NET is a web development platform from Microsoft used to build web applications. It provides advantages over classic ASP like separation of presentation and code for easier maintenance.
II. The ASP.NET architecture includes layers for the browser, web server, application server, business logic, and database. It uses HTTP for communication and HTML/XHTML pages.
III. Key challenges in designing web application interfaces include the stateless nature of the web, ensuring responsive and intuitive user interfaces, achieving scalability and performance, and addressing security issues.