This dissertation proposes a model-based control approach for a reconfigurable robot. The author first develops a methodology to model the kinematics of a reconfigurable robot with variable Denavit-Hartenberg parameters, allowing it to take on different open kinematic structures. Advanced model-based linear and nonlinear control strategies are then employed to control the robot, including mixed sensitivity H-infinity control, H-infinity control, mu-synthesis control, linear parameter varying control, feedback linearization control, sliding mode control, and adaptive control. Simulation results demonstrate the effectiveness of these control approaches. The author also develops an algorithm to select the optimal kinematic structure and control method for a given geometric task to maximize tracking performance.