The film "Isolation" follows three friends - Charlie, Eddie, and Katie - in the week leading up to a Friday night where one of them will be murdered. It explores the emotional instability of Eddie after he is excluded from plans. Events throughout the week escalate tensions between Eddie and the others. In the end, it is revealed that Eddie, who has become fascinated by violence, is the murderer who kills Charlie with a chain, the same weapon he used to kill someone else earlier.