The document discusses a woman's long search for relief from restless leg syndrome (RLS) symptoms. Over many years, she tried various alternative treatments, including special diets, herbs, chiropractic care, acupuncture, and massage. Nothing provided lasting relief until she reluctantly tried prescription medications including Requip, Klonopin, and codeine recommended by a neurologist. While the drugs help control her RLS symptoms, she continues investigating potential natural solutions and hopes to find a cure.
Evox® 2010 Enterprise Edition e' una soluzione che offre la possibilità di essere utilizzata sia in locazione sia in licenza d’uso. Prevede l’utilizzo completo del software e dei relativi servizi necessari alla gestione avanzata di un negozio B2B.
Studio e sviluppo di una libreria java per la lettura di smart card su decoder tv digitale terrestre - Federica Gelli - AA 2009-2010 Relatori: Dr. Alessandro Piva, Dr. Roberto Caldelli, Ing. Rudy Becarelli, Ing. Matteo Casini
Evox® 2010 Enterprise Edition e' una soluzione che offre la possibilità di essere utilizzata sia in locazione sia in licenza d’uso. Prevede l’utilizzo completo del software e dei relativi servizi necessari alla gestione avanzata di un negozio B2B.
Studio e sviluppo di una libreria java per la lettura di smart card su decoder tv digitale terrestre - Federica Gelli - AA 2009-2010 Relatori: Dr. Alessandro Piva, Dr. Roberto Caldelli, Ing. Rudy Becarelli, Ing. Matteo Casini
ATTENTION Insomnia Sufferers: True Cause Of InsomniaVick Caulmont
A new scientific breakthrough has finally revealed the true neurological cause of your insomnia… and researchers at the University of Oxford have discovered a simple, natural technique to cure your insomnia as soon as tonight. Read more ....
This presentation was given by Steve Peha at the Missouri Write to Learn conference in February 2017. Designed for K12 teachers, parents and students, the deck explains when and how to revise any kind of writing. It features strategies outlined in Steve Peha's book, Be a Better Writer.
Daylight Savings Time 2012 - At 2 a.m. on the morning of Sunday, March 11, we'll be springing our clocks forward—and losing an hour of the day, for Daylight Saving Time. The good news: sunset will be an hour later
Daylight Savings Time - You may have noticed the annual tradition of Daylight Saving Time has crept forward a bit. We used to spring forward on the first Sunday in April and fall back on last Sunday in October. But a couple years ago, Congress changed the date—adding more Daylight Saving Time to the calendar. This year, it will run from March 11 until Nov. 4.
Big East Basketball - Pittsburgh and Seton Hall also advanced to the second round. Pitt won 73-59 against St. John’s as Ashton Gibbs scored 20 points for the Panthers, and Seton Hall got 16
Clonazepam vs xanax information . elow is some information on Clonazepam, though not a complete summary on this medication. This information is provided to assist you with facts before you start taking this medication.
Zoloft weight gain information - If you are overweight and have been prescribed an antidepressant to provide you with the lift that you need to get your body and life back in order then you may be doing yourself more harm than good. The irony is that almost all antidepressants and anti-psychotic medications have weight gain as a side effect.
Klonopin xr data - One of the most severe psychiatric disorders is the bipolar disorder. This is a condition of alternating periods of high creativity and energy, mania and depression with varying degrees of severity.
ATTENTION Insomnia Sufferers: True Cause Of InsomniaVick Caulmont
A new scientific breakthrough has finally revealed the true neurological cause of your insomnia… and researchers at the University of Oxford have discovered a simple, natural technique to cure your insomnia as soon as tonight. Read more ....
This presentation was given by Steve Peha at the Missouri Write to Learn conference in February 2017. Designed for K12 teachers, parents and students, the deck explains when and how to revise any kind of writing. It features strategies outlined in Steve Peha's book, Be a Better Writer.
Daylight Savings Time 2012 - At 2 a.m. on the morning of Sunday, March 11, we'll be springing our clocks forward—and losing an hour of the day, for Daylight Saving Time. The good news: sunset will be an hour later
Daylight Savings Time - You may have noticed the annual tradition of Daylight Saving Time has crept forward a bit. We used to spring forward on the first Sunday in April and fall back on last Sunday in October. But a couple years ago, Congress changed the date—adding more Daylight Saving Time to the calendar. This year, it will run from March 11 until Nov. 4.
Big East Basketball - Pittsburgh and Seton Hall also advanced to the second round. Pitt won 73-59 against St. John’s as Ashton Gibbs scored 20 points for the Panthers, and Seton Hall got 16
Clonazepam vs xanax information . elow is some information on Clonazepam, though not a complete summary on this medication. This information is provided to assist you with facts before you start taking this medication.
Zoloft weight gain information - If you are overweight and have been prescribed an antidepressant to provide you with the lift that you need to get your body and life back in order then you may be doing yourself more harm than good. The irony is that almost all antidepressants and anti-psychotic medications have weight gain as a side effect.
Klonopin xr data - One of the most severe psychiatric disorders is the bipolar disorder. This is a condition of alternating periods of high creativity and energy, mania and depression with varying degrees of severity.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Wednesday, June, 2011 6:00 PM Posted by SuperbSite
Restless Leg Syndrome, My Search For a Cure
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By Gail Manishor
A popular comedian who has a regular TV show
said, "People complain about Restless Leg
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lazy fat a...." At the time I was walking three
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miles a day. He thought it was funny and it is
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unless you have it.
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Restless Leg Syndrome (RLS) is very hard to
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Determined not to take drugs, I've bought and read nearly everything recommended on the internet that sounds like it
might work. I have half a file cabinet drawer filled with the research. Some people stand up all night and try to sleep
leaning against a wall. I've spent half the night playing solitaire while standing.
I've gone through thousands of dollars looking for a cure and avoiding drugs. I paid $30 for a book on the Internet that
says they have the answer and the cure. Their answer was: "stop eating salt." I stopped eating salt and it did help. But
it didn't completely stop the symptoms.
I went to a highly recommended herbologist. I am the only person with RLS he has not been able to help.
A chiropractor recommended a sleep set that included mattress, blanket and pillow that had special magnets. She even
lent me her mattress for a week. I spent $2,500 for the mattress, blanket and pillow. It was a miracle! It worked!-for 6
weeks! Then it stopped. I took it off my bed. It did not work ever again. My body adjusted to it and that was that.
Next I went to an intuitive acupuncturist and Doctor of Oriental Medicine who has literally saved the lives of many
people.
I tried an M.D. who practiced homeopathic medicine.
I took a special and expensive juice made from an exotic fruit.
I've tried various creams to rub on my legs.
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2. Some of these things do help. I've noticed a difference when I take more magnesium.
I'm sorry to report that sugar definitely sets RLS off for me. A glass of orange juice or one glass of wine and I am up all
night. Believe me it is not worth it to have even one piece of chocolate.
I didn't want to take medication and resisted it for years. I tried anything and everything that didn't sound like a complete
hoax.
In desperation I waved the white flag of surrender and went to a neurologist and said, "Please, help me."
"What causes RLS?" I asked. The neurologist said, "We don't know the cause. It is related to Parkinson's. It seems to be
hereditary."
He started out cautiously with the medication and we first tried 2 Requip before bed. I still couldn't sit down and watch
TV in the evening. He added 1 more Requip. Then he added one Klonopin.5 mg a day before bed. The last thing he
added was Codeine. He convinced me that I did not have an addictive personality and so should take it. Now, I sleep
through the night provided I do not take any sugar.
I realize this is discouraging, but it may help to know that you are not alone. I have not given up. I know there must be
something out there that will help me and all the other sufferers of this wide-spread condition. I continue to investigate
and so should you.
Visit and contact me on my website at http://gmanishor.com/.
From Here to Serenity, A Spiritual Guide to Transform Your Life is about YOU! It helps you move from wherever you are
on your spiritual path to a place of tranquility. It's a step by step map to a deep sense of peace and harmony.
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Wednesday,June, 2011 6:00 PM Posted by SuperbSite
Restless Leg Syndrome (RLS) is very hard to define. My legs have ached at night since
I was a child. My mother used to say it was just "growing pains." More women than
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3. COPYRIGHT (C) 2011 SUPERBSITE.INFO. ALL RIGHTS RESERVED.
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