Uterine fibroids are benign muscle tumors that are the most common pelvic tumor in women. Symptoms include heavy bleeding, pelvic pressure, and reproductive issues. Evaluation involves physical exam, ultrasound, and sometimes MRI. Treatment options include medical management, minimally invasive procedures like uterine artery embolization, and surgical options like myomectomy or hysterectomy.
Cervical and broad ligament fibroids are rare; with incidence of only 2% and 1% respectively.
Cervical fibroid often present with pressure symptoms and often pose surgical difficulties due to its proximity to bladder and rectum.
Broad ligament fibroid though rare , but have the propensity of growing into large adnexal masses and may mimic ovarian malignancy.
Cervical and broad ligament fibroids are rare; with incidence of only 2% and 1% respectively.
Cervical fibroid often present with pressure symptoms and often pose surgical difficulties due to its proximity to bladder and rectum.
Broad ligament fibroid though rare , but have the propensity of growing into large adnexal masses and may mimic ovarian malignancy.
Benign growths in the uterus that can develop during a woman's childbearing years.Highest incidence was seen in Pakistani women 78%, then rural Indian women 37.65%, urban India 24% and Nigerian women 30%. Arobosoba from Nigeria has reported prevalence of uterine fibroids in black women was more (26%), in comparison to Caucasian women (17.9%).
Uterine Fibroids (Leiomyomata): Investigations and Treatment Michelle Fynes
Uterine fibroids (UF) are the most common benign neoplastic threat to women's health, costing hundreds of billions of health care dollars worldwide. The objective of this presentation is to review risk factors, aetiology, classification and clinical presentation of Uterine fibroids.
Get relief from pain and suffering caused by fibroid, successful low cost fibroid surgery in India is now available through leading medical tourism company.
Benign growths in the uterus that can develop during a woman's childbearing years.Highest incidence was seen in Pakistani women 78%, then rural Indian women 37.65%, urban India 24% and Nigerian women 30%. Arobosoba from Nigeria has reported prevalence of uterine fibroids in black women was more (26%), in comparison to Caucasian women (17.9%).
Uterine Fibroids (Leiomyomata): Investigations and Treatment Michelle Fynes
Uterine fibroids (UF) are the most common benign neoplastic threat to women's health, costing hundreds of billions of health care dollars worldwide. The objective of this presentation is to review risk factors, aetiology, classification and clinical presentation of Uterine fibroids.
Get relief from pain and suffering caused by fibroid, successful low cost fibroid surgery in India is now available through leading medical tourism company.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
3. • Uterine leiomyomas (also referred to as fibroids or myomas) are the most
common pelvic tumor in women
• They are benign monoclonal tumors arising from the smooth muscle cells of
the myometrium.
6. • Submucosal myomas (FIGO type 0, 1, 2) – These leiomyomas derive from
myometrial cells just below the endometrium (lining of the uterine cavity).
These neoplasms protrude into the uterine cavity.
• The extent of this protrusion is described by the FIGO/European Society of
Hysteroscopy classification system and is clinically relevant for predicting
outcomes of hysteroscopic myomectomy
• •Type 0 – Completely within the endometrial cavity
• •Type 1 – Extend less than 50 percent into the myometrium
• •Type 2 – Extend 50 percent or more within the myometrium
7. • Intramural myomas (FIGO type 3, 4, 5) – These leiomyomas are located
within the uterine wall. They may enlarge sufficiently to distort the uterine
cavity or serosal surface. Some fibroids may be transmural and extend from
the serosal to the mucosal surface.
• Subserosal myomas (FIGO type 6, 7) – These leiomyomas originate from the
myometrium at the serosal surface of the uterus. They may have a broad or
pedunculated base and may be intraligamentary (ie, extending between the
folds of the broad ligament).
• Cervical myomas (FIGO type 8) – These leiomyomas are located in the
cervix rather than the uterine corpus.
11. CASE 1
Mrs XYZ 45yr old P2L2 (FTND), with complaints of
• Heaviness in abdomen
• Irregular heavy menses
• Dysmenorrhea , since 2 – 3 months
• On Examination:
• P/A – soft, non tender
• P/S - cervix , vagina healthy
• P/V – uterus bulky firm mobile, AV, soft to cystic mass 4x5 cm in right and
posterior fornix separate from uterus. Left fornix free and non tender.
• P/R – bogginess felt anteriorly, rectal mucosa and parametrium free.
• Tumour Marker - WNL
12. • Investigations:
USG Pelvis: solid, hypoechoic, well-circumscribed right adnexal mass of size
3.6x4.6 cm
15. • How will You differentiate between a True and False Broad Ligament
Fibroid ?
• What will be relation of the Ureter to this fibroid?
16. True Broad Ligament False Broad Ligament
Originates from the muscle fibres normally
found in the mesometrium (in the round
ligament, ovario-uterine ligament, and the
connective tissue around the uterine and
ovarian vessels)
Arises from the lateral wall of the uterine
corpus or of the cervix, and bulges outward
between the layers of the broad ligament.
Ureter is medial to mass Ureter is lateral to mass
No groove felt between mass and uterus Groove felt between mass and uterus
17. • In this case
• the right ureter was safeguarded by dissection and enucleation
could be carried out rather easily.
18. RISK FACTORS
• Race — The incidence rates of fibroids are typically found to be two- to threefold
greater in black women than in white women
• Parity — Parity (having one or more pregnancies extending beyond 20 weeks of
gestation) decreases the chance of fibroid formation
• Early menarche — Early menarche (<10 years old) is associated with an increased
risk of developing fibroids.
• Hormonal contraception — Use of standard or lower dose oral contraceptives (≤35
mcg ethinyl estradiol/day) do not appear to cause fibroids to grow
19. • Other endocrine factors — Prenatal exposure to diethylstilbestrol is
associated with an increased risk of fibroids
• Smoking – Early studies showed that smoking decreased the risk of having
fibroids, possibly through the inhibition of aromatase
• Others - Diet, Alcohol, Obesity
20. PATHOGENESIS
• Transformation of normal myocytes into abnormal myocytes, in most instances
through somatic mutations
• Growth of abnormal myocytes into clinically apparent tumors
21. HISTOLOGY
• Smooth muscle bundles arranged in
whorl patterns
• Abndant amount of Collagen 1 & 3
present
22. GENETIC PREDISPOSITION
• Uterine leiomyomas are a common phenotype with many underlying
genotypes. Both somatic and inherited mutations account for the majority of
uterine fibroids, with the most common mutations occurring in
the MED12, HMGA1 and HMGA2, FH, collagen type IV, alpha-5 (COL4A5)
and collagen type IV alpha-6 (COL4A6) genes
23. • Steroid hormone factors that influence leiomyoma development include
upregulation of aromatase, estrogen, and progesterone receptors as well as
a potential role of gonadotropins.
• Stem cells appear to also play a key role in fibroid pathogenesis
24. CLINICAL FEATURES
• The majority of myomas are small and asymptomatic, but many women with
fibroids have significant problems that interfere with some aspect of their
lives and warrant therapy.
• These symptoms are related to the number, size, and location of the tumors.
• Myomas can occur as single or multiple tumors and range in size from
microscopic to tens of centimeters.
• The size of the myomatous uterus is described in menstrual weeks as with
the gravid uterus.
25. • Symptoms are classified into three categories :
• ●Heavy or prolonged menstrual bleeding
• ●Bulk-related symptoms, such as pelvic pressure and pain
• ●Reproductive dysfunction (ie, infertility or obstetric complications)
26. HEAVY OR PROLONGED MENSTRUAL
BLEEDING
• Heavy or prolonged menses is the typical bleeding pattern with leiomyomas
and the most common fibroid symptom
• Submucosal myomas that protrude into the uterine cavity (eg, types 0 and
1)are most frequently related to significant heavy menstrual bleeding
27. BULK-RELATED SYMPTOMS
• Pelvic pressure or pain — In general, pelvic discomfort is common in women
with fibroids but less common than AUB. If discomfort is present, it is likely to
be chronic, intermittent, dull pressure or pain
• Bowel symptoms – Fibroids that place pressure on the rectum can result in
constipation
28. • Urinary symptoms – A heterogeneous group of urinary symptoms including
• frequency,
• difficulty emptying the bladder, or, rarely,
• complete urinary obstruction may all occur in up to 60 percent of women with
fibroids .
• Bladder symptoms sometimes arise when an anterior fibroid presses directly
on the bladder or a posterior fibroid pushes the entire uterus forward
29. INFERTILITY OR OBSTETRIC
COMPLICATIONS
• Leiomyomas that distort the uterine cavity
(submucosal or intramural with an intracavitary
component) result in difficulty conceiving a
pregnancy and an increased risk of miscarriage
• In addition, leiomyomas have been associated with
adverse pregnancy outcomes (eg, placental
abruption, fetal growth restriction, malpresentation,
and preterm labor and birth)
30. OTHERS
• Painful menses — Painful menses is reported by many women with fibroids
• Painful intercourse — It is controversial whether women with fibroids are more likely
to experience painful intercourse than women without fibroids
• Fibroid degeneration or torsion
31. DIAGNOSIS
• History Taking –
• It is important to assess the severity of heavy or prolonged menstrual
bleeding.
• A menstrual history is taken and the volume and duration of bleeding elicited
• For women with pelvic pain or pressure, the location, severity, and
characteristics of the pain should be assessed
32. • Patients should be asked about other potential pain or bulk-related
symptoms, including dyspareunia, urinary retention, or constipation.
• The patient should be asked about infertility, recurrent miscarriage, or
obstetric complications that may be related to fibroids.
33. • Physical Examination
• A thorough pelvic examination is performed.
• On bimanual pelvic examination, the size, contour, and mobility should be
noted.
• An enlarged, mobile uterus with an irregular contour is consistent with a
leiomyomatous uterus.
• Size, shape, surface, consistency, mobility, fluctuation
34. PELVIC ULTRASOUND
• Pelvic ultrasound is the first-line study used to evaluate for uterine fibroids.
• Transvaginal ultrasound has high sensitivity (95 to 100 percent) for detecting
myomas in uteri less than 10 gestational weeks' size.
• Precise localization of fibroids is limited in larger uteri or when there are
many tumors.
35. • Fibroids are seen on ultrasound usually as hypoechoic, well-circumscribed
round masses, frequently with shadowing
36. • Calcification in a fibroid generally implies that it has degenerated. These
calcifications can be seen on plain film as "popcorn" calcifications in the
pelvis.
• On ultrasound, the calcifications may appear as clumps or rim-like
calcifications within a mass
37. EVALUATE THE UTERINE CAVITY
• Saline infusion sonography — Saline infusion sonography
(sonohysterography) is an imaging study in which pelvic ultrasound is
performed while saline is infused into the uterine cavity.
• Use of this technique allows identification of submucosal lesions (some of
which may not be seen on routine ultrasonography) and intramural myomas
that protrude into the cavity and characterizes the extent of protrusion into
the endometrial cavity
38. • Hysteroscopy — Diagnostic hysteroscopy is useful for visualizing the
endometrial cavity.
• Similar to saline infusion sonography, this allows evaluation for submucosal
or protruding myometrial fibroids and can characterize the extent of
protrusion.
• This can be performed in the office or operating room
39.
40. • Magnetic resonance imaging — Magnetic resonance imaging (MRI) is the
most effective modality for visualizing the size and location of all uterine
myomas and can distinguish among leiomyomas, adenomyosis, and
adenomyomas.
41.
42. MRI MAPPING
• Prior to myomectomy, it is very important to detect all the fibroids in the
uterus however small and if not removed will lead to higher chances of
recurrence.
• Ultrasound cannot detect fibroid less than 2 cm i.e seedling fibroids
• MRI is superior imaging technique for mapping all the fibroids because it can
detect small seedling fibroids also
49. SUMMARY
• Uterine leiomyomas are the most common pelvic tumor in women.
• Leiomyomas are benign monoclonal tumors arising from the smooth muscle
cells of the myometrium
• Symptoms attributable to uterine myomas can generally be classified into
three distinct categories: abnormal uterine bleeding (AUB), pelvic pressure
and pain, and reproductive dysfunction
• Transvaginal ultrasound is the most widely used imaging modality for
evaluating fibroids due to its availability and cost-effectiveness.
• Laparoscopic rather than abdominal myomectomy for women with
leiomyomas for whom laparoscopic removal is technically feasible (by size,
number, and location) and who have access to a surgeon with advanced
laparoscopic skills