This document discusses best practices for health care venture capital investing and value creation for health care startups. It provides insights from top VCs and CEOs on company growth plans, valuations, exit strategies, and fundraising. Specifically, it discusses that successful health care startups often demonstrate a unique technology with clinical impact, efficient execution to hit milestones, and the ability to establish a sustainable franchise. Franchise value and strategic need are key value drivers in acquisition exits. Early-stage valuations are often based on ownership percentages and financial models of future funding needs.