Eating a diet high in saturated fat and breathing polluted city air can dangerously promote heart disease through atherosclerosis. Pollution particles cause lung inflammation and damage artery walls, leading to plaque buildup. A study found that mice fed a high-fat diet and exposed to polluted air had 42% of blood vessels clogged, compared to 19% for normal-diet mice in pollution and 13% for high-fat mice in filtered air. Pollution combined with an unhealthy diet increased cholesterol levels and blood vessel abnormalities in mice genetically prone to heart issues.