Heart disease is the leading cause of death worldwide. It is caused by a buildup of plaque in the arteries called atherosclerosis. Risk factors include high cholesterol, smoking, high blood pressure, diabetes, obesity, and physical inactivity. The document recommends maintaining a healthy diet low in saturated fat and cholesterol, exercising regularly, not smoking, monitoring cholesterol and other health numbers, and taking medication as prescribed to prevent heart disease. Making lifestyle changes can significantly reduce risk even for those with a family history or existing conditions.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. What is Heart Disease?
What is Heart Disease?
• Heart
Heart : The most hard-working muscle of
our body – pumps 4-5 liters of blood every
minute during rest
• Supplies nutrients and oxygen rich blood to
all body parts, including itself
• Coronary arteries
surrounding the heart
keep it nourished with
blood
3. What is Atherosclerosis
What is Atherosclerosis
what is coronary artery disease?
what is coronary artery disease?
• Over time, fatty deposits called plaque
plaque build up within the artery
walls. The artery becomes narrow. This is atherosclerosis
• When this occurs in the coronary arteries, heart does not get
sufficient blood, the condition is called coronary artery disease,
or coronary heart disease
4. Myth : fat deposits at old age!
Myth : fat deposits at old age!
It starts from 2 years of age
It starts from 2 years of age
Foam
Cells
Fatty
Streak
Intermediate
Lesion Atheroma
Fibrous
Plaque
Complicated
Lesion/
Rupture
Adapted from Pepine CJ. Am J Cardio. 1998;82(suppl 104).
From First
Decade
From Third
Decade
From Fourth
Decade
5. Are Other organs Affected?
Are Other organs Affected?
Ischemic Stroke
Ischemic Stroke
Peripheral Vascular
Peripheral Vascular
Disease
Disease
Coronary Heart Disease
Coronary Heart Disease
• Angina
Angina
• MI (Heart Attack)
MI (Heart Attack)
• Sudden Cardiac Death
Sudden Cardiac Death
6. What are the symptoms of
What are the symptoms of
Coronary artery disease?
Coronary artery disease?
• No symptoms for long period
• Chest pain for short period on exertion
also known as Angina or minor heart
attack
• Myocardial Infarction or major heart
attack-Severe chest pain, death of
heart muscle, heart failure, irregular
heart beats
• Sudden Death
7. How Big is the Problem ?
How Big is the Problem ?
• No. 1 killer disease worldwide
– 12 Million deaths annually
• During last 30 years large declines in
developed countries -rising health
awareness and government
programmes
• Alarming increase in developing
countries especially India
8. Why Me ?
Why Me ?
• Genetic predisposition
• Poor handling of fats and metabolic
syndrome
– Diabetes, obesity, high BP, Coronary artery
disease
Environmental insults
• Urbanization
• Sudden change in lifestyle
9. What Increases Risk?
What Increases Risk?
You can’t help it !
• Age:
Men > 45;
Women > 55
• Sex
• Race
• Family History
You can !!
• High Cholesterol
• Smoking
• High Blood Pressure
• Diabetes
• Obesity
• Alcohol
• Physical Inactivity
10. Cholesterol ( A type of fat)
Cholesterol ( A type of fat)
• Everybody needs cholesterol, it serves
a vital function in the body.
• It circulates in the blood.
• Too much cholesterol
can deposit in the
arteries in the form of
plaque and block them
• No symptoms till heart
attack
11. Where does it come from ?
Where does it come from ?
• Two sources of
cholesterol: Food
& made in your
body
• Food sources: All
foods containing
animal fat and meat
products
65%
65% 35%
35%
12. Good vs. BAD Cholesterol
Good vs. BAD Cholesterol
• LDL cholesterol is known as bad
cholesterol. It has a tendency to
increase risk of heart disease
• LDL cholesterol is a major component
of the plaque that clogs arteries
• HDL cholesterol is known as the good
cholesterol. Higher in women,
increases with exercise
• HDL cholesterol helps carry some of
the bad cholesterol out of arteries.
13. Obesity
Obesity
• People who are overweight (10-30 % more
than their normal body weight)
• Obese have 2 to 6 times the risk of
developing heart disease
• Normal Waist-Hip Ratio
< 0.85 for women;
< 0.95 for men
• Pears or apples?
14. Pears and Apples
Pears and Apples
Apple-shaped paunch store body fat
around the abdomen and chest,
surrounding internal organs
Pear-shaped paunch store fat on the
hips and thighs, just below the surface of
the skin.
Apple- shaped are at a higher risk
Apple- shaped are at a higher risk
18. Alcohol Consumption
Alcohol Consumption
• In small amounts it is beneficial: 1-2
drinks
• In large amounts it adds fat and
calories & raises BP!
• 4 drinks per day. You end up with
gastroenterologist instead of
cardiologist
• This is a very fine line! Finer for
women as they are at higher risk
19. Diabetes
Diabetes
• At any given cholesterol level, diabetic
persons have a 2 or 3 x higher risk of heart
attack or stroke
• A diabetic is more likely to die of a heart
attack than a non-diabetic
• ~80% Diabetics die from heart disease
• Risk of sudden death from a heart attack
for a diabetic is the same as that of
someone who has already had a heart
attack.
20. ➨Risk operates across a continuum - no clear-cut line
(Blood Pressure; Cholesterol; overweight; Smoking)
➨The risk is multiplicative when many risk factors co-
exist; risk factors often cluster together
➨Majority of events arise in individuals with modest
elevations of many risk factors than from marked
elevation of a single risk factor
Interactions of Risk Factors
Interactions of Risk Factors
21. Misfortunes always come in
Misfortunes always come in
by a door that has been left
by a door that has been left
open for them.
open for them.
Wise proverb
22. Everyday you make choices to try to
help protect yourself and your family.
In fact, protecting yourself has
become second nature—you just do
it.
But do you know what you can do to
help protect yourself from this
number 1 cause of death- Heart
Disease?
23. For my car, I want the best
For my car, I want the best
mechanic.
mechanic.
But for my own body, I follow
hearsay and advice from friends,
kitty party, local quacks….
Just anyone
And decide for the worst
24. Creative strategies do not work !
Creative strategies do not work !
• Never had a test or retest
• Never been to Doctor !
I hate them
• Never take medicines!
• My BP is normal, so
stopped meds!
• Miracle men and Miracle
Medicines! So many of
them
• I am my own doctor! No
fees too
25. Preventing Heart Disease
Preventing Heart Disease
Rule #1 Look before your eat
Rule #1 Look before your eat
• Eat a variety of fruits and vegetables every day.
(5 servings - they are naturally low in fat and
high in vitamins and minerals and anti
oxidants). Eat colored vegetables and fruits
• Eat a variety of grain products
• Choose nonfat or low-fat products.
• Use less fat meats- chicken, fish and lean cuts
Switch to fat-free milk—toned/skimmed milk
26. Dietary Guidelines
Dietary Guidelines
• Limit your intake of foods high in
calories and low in nutrition, including
foods like soft drinks, candy, junk food
• Limit foods high in saturated fat, trans-
fat and cholesterol
• Eat less than 6 gms of salt a day
• Have no more than1-2 alcoholic drink a
day if you are a regular drinker
27. Limit / Avoid
Limit / Avoid
• Foods rich in Cholesterol and Saturated
fats
– Egg Yolk
– Fatty meat & organ meat( Liver)
– Butter chicken / Batter fried fish !
– Milk fat – Desi Ghee, Butter, Cheese, Malai,
Rabri, Khurchan, Doda, Ice Cream, full
cream milk,
– Hidden Fat like Bakery biscuits, Patties (!),
Cakes, Pastries,
28. Cooking Oils: The mystery of
Cooking Oils: The mystery of
PUFA / MUFA
PUFA / MUFA
• Saturated Fats : Increase Cholesterol – Avoid
– Coconut oil, Palm oil, ghee
• Monounsaturated Fats (MUFA): Heart healthy
– Olive oil, Groundnut oil, Canola oil, Mustard oil
• Polyunsaturated Fats (PUFA): Heart healthy
– Sunflower oil, Soybean oil
• Omega-3-Fatty acids Fish oil : Heart Healthy
Rotate the oils or Mixture of oils
29. Preventing Heart Disease
Preventing Heart Disease
Rule #2 Exercise
Rule #2 Exercise
• Maintain a level of physical activity that
keeps you fit and matches the calories
you eat
• Serves several functions in preventing
and treating those at high risk
• Reduces incidence of obesity
• Increases HDL
• Lowers LDL and total cholesterol
• Helps control diabetes and hypertension
30. Exercise, Exercise, Exercise
Exercise, Exercise, Exercise
•Mortality is halved in retired men who walk
more than two miles every day
•Regular exercise can halve the risk of heart
disease, particularly in men who walk briskly
•Someone who is inactive has as great a risk of
having heart disease as someone who
smokes, has high blood pressure or has high
cholesterol
•Exercise significantly reduces the chances of
diabetes and stroke
•With regular exercise, blood pressure in those
with hypertension is reduced by as much as
20mms Hg
31. Exercise and Heart Disease
Exercise and Heart Disease
Moderate to intense physical activity for 30-45
minutes on most days of the week is recommended
32. Walking for a healthy heart
Walking for a healthy heart
• Complicated exercise machines or
sweating it out in the gym not essential
JUST WALK!
33. Rule # 3 Stop Smoking NOW!
Rule # 3 Stop Smoking NOW!
• The risk of heart attack starts decreasing
within 24 hours of quitting smoking, within
1 year of quitting, CHD risk decreases
significantly, within 2 years it reaches the
level of a nonsmoker
• Smell and taste improve within days
• Within three months of quitting, the
smokers' cough disappears in most people
36. Rule # 4 Know your Number!
Rule # 4 Know your Number!
Desirable numbers
• Total cholesterol < 200;
• LDL < 100
• HDL > 40
• triglycerides < 200
• Get the levels tested routinely and keep them
under control
• The only thing worse than finding out that
you have one of these conditions is…….NOT
finding out that you have it!!
And that’s not your Mobile Number!
And that’s not your Mobile Number!
37. 10% reduction of blood
cholesterol produces 20-30%
decline in CHD deaths
Benefits of reducing
Benefits of reducing
cholesterol
cholesterol
All Adults >20 yrs must get tested- if normal test again
after 5 years, if elevated, work towards normalizing the
levels with lifestyle modification and drugs as needed
38. Controlling Blood Pressure
Controlling Blood Pressure
• Adults should have their blood pressure
checked at least once every two years, as
there are no symptoms to tell if you have
high blood pressure
• Optimal levels : 120 /80 mm Hg
• If high
– Modify your lifestyle – Diet, Weight, Exercise,
Salt restriction
– Adhere to the prescribed medication without fail,
to decrease chances of getting heart disease – Do
not stop your medicines without consulting your
doctor, even if the blood pressure becomes normal
39. Controlling Blood Sugar
Controlling Blood Sugar
• All adults should have their blood sugar
checked regularly, as there are no early
symptoms of diabetes
• Normal blood sugar:
• Fasting < 100; post meals <140
• If high
– Modify your lifestyle – Diet, Weight, Exercise
– Adhere to the prescribed medication without fail,
to decrease chances of getting heart disease – Do
not stop your medicines without consulting your
doctor, even if the blood sugar becomes normal
40. If you or someone in your family
If you or someone in your family
already diagnosed with heart disease
already diagnosed with heart disease
• Don’t get disheartened – science has made
significant progress
• Just monitor risk factors much more aggressively
– Eat healthy
– Walk regularly
– Watch your weight
– Quit smoking immediately
– Keep your weight under control
– In addition to improving your heart – health these measures
are sure to enhance your appearance !!
• Adhere to you medicines & listen to your doctor
41. Don’t wait for a heart attack to take
Don’t wait for a heart attack to take
an action !
an action !
Don’t wait for a second life we
Don’t wait for a second life we
are not cats!
are not cats!
42. Heart disease is often avoidable. Following a heart-
healthy lifestyle doesn't have to be complicated, and it
doesn't mean you need to live a life of self-deprivation.
Instead, find ways to incorporate heart-healthy habits
into your lifestyle — and you may well enjoy a healthier
life for years to come.