How Can AI Champion Great Storytelling? - Mary Brendza (Storyfit), Monica La...BookNet Canada
Can machines work alongside humans to improve the storytelling process? We’ll share how an AI-powered analysis can help storytellers visualize and understand their stories — including character network, personality traits, emotional valence, and whether or not you’ve got a dynamic protagonist leaping from the pages. StoryFit identifies features applicable to all stages of book development, from acquisitions to marketing, and we’ll provide real-life examples to support your publishing decisions.
March 20, 2019
techforum.booknetcanada.ca
#TechForum
Republican Candidate Scorecard: Mike HuckabeeTonya Green
The 2016 US presidential race is on. Frequently we hear the results of political polls, ranking the popularity of candidates. However, both social media and traditional news are useful sources to learn about the candidates, the issues to be addressed, the candidates most discussed, and sentiment around discussions of the candidates. This report includes the results of the analysis of candidate mentions in social media and major news sources over one month. The ranking of candidates by mentions overall and by media source are provided on the Republican Candidate Scorecard. This report also includes a detailed analysis of the mentions of Mike Huckabee in social media and major new sources. It answers many questions, including:
- How many mentions of Huckabee were observed and how does he rank among the Republican candidates?
- What is the trend of discussions and when do mentions peak? What topic is discussed at the peak of discussions?
- What other key terms are also mentioned with Huckabee?
- Where do mentions of Huckabee most occur?
- Who are the influencers of discussions of Huckabee, in blogs, traditional news sources and Twitter?
- How engaged is Huckabee on Twitter? How many times did Huckabee tweet and how many tweets were directed to Huckabee?
The inaugural PEORIA Project from George Washington University's Graduate School of Political Management, measuring how presidential candidates' messages are resonating and being echoed by the public.
PEORIA Report 3: The GOP Debates Begin, Late Summer 2015GSPMgwu
-WORDS IN EDGEWISE: You can probably guess which candidate dominated the conversation. But you might be surprised at who else has been talked about most.
-BAD, BAD MOOD: We will identify the only candidate for whom mentions with positive sentiments outnumbered those with negative sentiments.
-THE NEW SPIN ROOM: We will display the top three retweets from each party after both debates, and the top retweet from each of the Republican candidates.
-BELTWAY DIFFERENCES: We will distinguish between candidates who got more attention in mainstream than in social media, and vice versa.
-RATINGS: And, as is our custom, we will evaluate how well each candidate’s campaign garnered and leveraged public echoes of what they said during the time period on our scale of 1 to 11.
Trust and Information Disorders - a Dispute of NarrativesDaniel Schwabe
Keynote presentation given at the 1st International Workshop on Knowledge Graphs for Online Discourse Αnalysis (KnOD 2021), part of The Web Conference 2021, on April 14 2021.
Video available at https://youtu.be/41IrrErai70
How Can AI Champion Great Storytelling? - Mary Brendza (Storyfit), Monica La...BookNet Canada
Can machines work alongside humans to improve the storytelling process? We’ll share how an AI-powered analysis can help storytellers visualize and understand their stories — including character network, personality traits, emotional valence, and whether or not you’ve got a dynamic protagonist leaping from the pages. StoryFit identifies features applicable to all stages of book development, from acquisitions to marketing, and we’ll provide real-life examples to support your publishing decisions.
March 20, 2019
techforum.booknetcanada.ca
#TechForum
Republican Candidate Scorecard: Mike HuckabeeTonya Green
The 2016 US presidential race is on. Frequently we hear the results of political polls, ranking the popularity of candidates. However, both social media and traditional news are useful sources to learn about the candidates, the issues to be addressed, the candidates most discussed, and sentiment around discussions of the candidates. This report includes the results of the analysis of candidate mentions in social media and major news sources over one month. The ranking of candidates by mentions overall and by media source are provided on the Republican Candidate Scorecard. This report also includes a detailed analysis of the mentions of Mike Huckabee in social media and major new sources. It answers many questions, including:
- How many mentions of Huckabee were observed and how does he rank among the Republican candidates?
- What is the trend of discussions and when do mentions peak? What topic is discussed at the peak of discussions?
- What other key terms are also mentioned with Huckabee?
- Where do mentions of Huckabee most occur?
- Who are the influencers of discussions of Huckabee, in blogs, traditional news sources and Twitter?
- How engaged is Huckabee on Twitter? How many times did Huckabee tweet and how many tweets were directed to Huckabee?
The inaugural PEORIA Project from George Washington University's Graduate School of Political Management, measuring how presidential candidates' messages are resonating and being echoed by the public.
PEORIA Report 3: The GOP Debates Begin, Late Summer 2015GSPMgwu
-WORDS IN EDGEWISE: You can probably guess which candidate dominated the conversation. But you might be surprised at who else has been talked about most.
-BAD, BAD MOOD: We will identify the only candidate for whom mentions with positive sentiments outnumbered those with negative sentiments.
-THE NEW SPIN ROOM: We will display the top three retweets from each party after both debates, and the top retweet from each of the Republican candidates.
-BELTWAY DIFFERENCES: We will distinguish between candidates who got more attention in mainstream than in social media, and vice versa.
-RATINGS: And, as is our custom, we will evaluate how well each candidate’s campaign garnered and leveraged public echoes of what they said during the time period on our scale of 1 to 11.
Trust and Information Disorders - a Dispute of NarrativesDaniel Schwabe
Keynote presentation given at the 1st International Workshop on Knowledge Graphs for Online Discourse Αnalysis (KnOD 2021), part of The Web Conference 2021, on April 14 2021.
Video available at https://youtu.be/41IrrErai70
Part of the "2016 Annual Conference: Big Data, Health Law, and Bioethics" held at Harvard Law School on May 6, 2016.
This conference aimed to: (1) identify the various ways in which law and ethics intersect with the use of big data in health care and health research, particularly in the United States; (2) understand the way U.S. law (and potentially other legal systems) currently promotes or stands as an obstacle to these potential uses; (3) determine what might be learned from the legal and ethical treatment of uses of big data in other sectors and countries; and (4) examine potential solutions (industry best practices, common law, legislative, executive, domestic and international) for better use of big data in health care and health research in the U.S.
The Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics at Harvard Law School 2016 annual conference was organized in collaboration with the Berkman Center for Internet & Society at Harvard University and the Health Ethics and Policy Lab, University of Zurich.
Learn more at http://petrieflom.law.harvard.edu/events/details/2016-annual-conference.
These slides accompanied a Civics 101 Workshop presented at the Penn Yan Public Library on April 12, 2018. The slides do not contain all of my speaker's notes, unfortunately.
This is a webinar organised by the Nigerian Library Association, Delta State Chapter, in collaboration with Digital Citizens.
The aim of the webinar is to equip library and information professionals with necessary technologies and strategies needed to play key roles in the dissemination of correct information, and in the information literacy of citizens, in this era of fake news and misinformation.
Chapter 66 Reporting, Story Development, and Editing Top of For.docxchristinemaritza
Chapter 66: Reporting, Story Development, and Editing
Top of Form
Bottom of Form
Top of Form
Bottom of Form
Telling a good story is the heart and soul of journalism; however, you can't tell a good story without doing a good job of reporting—gathering information to share with your audience. Identifying important and interesting issues, events, and people to report about is a critical part of the reporting process. In addition, carefully editing the semifinished product to ensure that it fits the allotted time or space and to ensure accuracy, plus to check for proper grammar, spelling, punctuation, and style, is necessary to increase the chances that audience members will find the story interesting, informative, entertaining, and thought provoking.
Story Selection
Selecting interesting and/or important aspects of life to report about would seem to be a relatively easy thing to do, but declining readership, listenership, and viewer-ship for many of the traditional news media clearly contradicts that assumption. The key to identifying and developing compelling news stories is always to keep in mind what's likely to be relevant to audience members (Brooks, Kennedy, Moen, & Ranly, 2008, p. 4; Hansen & Paul, 2004, pp. 31–39). What people, places, things, and issues are audience members interested in, and what do they care about the most? Perhaps a time-honored prescription about what is good journalism sums it up best: “Make the important story interesting and the interesting story important.”
Years of practice and research in journalism have identified a number of factors that play a part in the process of achieving that critical goal. Among these are the “uses and gratifications” (see also Chapter 56, this volume) that people associate with news media messages; the news values/elements/qualities used by journalists to help them select which issues, events, and people to report about; and the traditional five Ws and the H—who, what, where, when, why, and how.
Uses and Gratifications
People have told researchers that they become news consumers for a variety of interesting reasons. They have a number of “uses” for the information they obtain, and they obtain a number of “gratifications” from consuming such information (Levy, 1978; Levy & Windahl, 1984; Vishwanath, 2008). By knowing about and understanding such uses and gratifications, reporters can begin to build a framework for their information-gathering mission. Among the major uses and gratifications are surveillance, reassurance, intellectual stimulation, emotional fulfillment, and diversion.
Surveillance deals with simply keeping up with what's happening in your town, city, state, region, country, and world. Reporters who can find interesting information about the important happenings of each day will be successful.
Reassurance deals with information that helps people feel better about themselves, the decisions they make, and their lives in general. Examples include providing the views of ex ...
4182020 Opinion Why Do People Fall for Fake News - The Ne.docxtaishao1
4/18/2020 Opinion | Why Do People Fall for Fake News? - The New York Times
https://www.nytimes.com/2019/01/19/opinion/sunday/fake-news.html 1/2
GRAY MATTER
Why Do People Fall for Fake News?
Are they blinded by their political passions? Or are they just intellectually lazy?
By Gordon Pennycook and David Rand
Dr. Pennycook and Dr. Rand are psychologists.
Jan. 19, 2019
What makes people susceptible to fake news and other forms of strategic misinformation? And what, if anything, can
be done about it?
These questions have become more urgent in recent years, not least because of revelations about the Russian
campaign to influence the 2016 United States presidential election by disseminating propaganda through social
media platforms. In general, our political culture seems to be increasingly populated by people who espouse
outlandish or demonstrably false claims that often align with their political ideology.
The good news is that psychologists and other social scientists are working hard to understand what prevents people
from seeing through propaganda. The bad news is that there is not yet a consensus on the answer. Much of the
debate among researchers falls into two opposing camps. One group claims that our ability to reason is hijacked by
our partisan convictions: that is, we’re prone to rationalization. The other group — to which the two of us belong —
claims that the problem is that we often fail to exercise our critical faculties: that is, we’re mentally lazy.
However, recent research suggests a silver lining to the dispute: Both camps appear to be capturing an aspect of the
problem. Once we understand how much of the problem is a result of rationalization and how much a result of
laziness, and as we learn more about which factor plays a role in what types of situations, we’ll be better able to
design policy solutions to help combat the problem.
The rationalization camp, which has gained considerable prominence in recent years, is built around a set of theories
contending that when it comes to politically charged issues, people use their intellectual abilities to persuade
themselves to believe what they want to be true rather than attempting to actually discover the truth. According to
this view, political passions essentially make people unreasonable, even — indeed, especially — if they tend to be
good at reasoning in other contexts. (Roughly: The smarter you are, the better you are at rationalizing.)
Some of the most striking evidence used to support this position comes from an influential 2012 study in which the
law professor Dan Kahan and his colleagues found that the degree of political polarization on the issue of climate
change was greater among people who scored higher on measures of science literary and numerical ability than it
was among those who scored lower on these tests. Apparently, more “analytical” Democrats were better able to
convince themselves that climate change was a problem, while more “analytical” Republica.
On October 31 and November 1, 2017, Google, Twitter and Facebook sent their general counsels to testify before House and Senate intelligence committees to answer questions about the role their platforms played in the dissemination of Russian-instigated disinformation designed to disrupt the 2016 U.S. presidential election.
In the days immediately after the hearings, Edelman fielded a flash poll among the U.S. general population. The survey examined the various definitions people have for fake news, the role people believe social platforms play in disseminating fake news, and whether the social platforms require more oversight and regulation.
Part of the "2016 Annual Conference: Big Data, Health Law, and Bioethics" held at Harvard Law School on May 6, 2016.
This conference aimed to: (1) identify the various ways in which law and ethics intersect with the use of big data in health care and health research, particularly in the United States; (2) understand the way U.S. law (and potentially other legal systems) currently promotes or stands as an obstacle to these potential uses; (3) determine what might be learned from the legal and ethical treatment of uses of big data in other sectors and countries; and (4) examine potential solutions (industry best practices, common law, legislative, executive, domestic and international) for better use of big data in health care and health research in the U.S.
The Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics at Harvard Law School 2016 annual conference was organized in collaboration with the Berkman Center for Internet & Society at Harvard University and the Health Ethics and Policy Lab, University of Zurich.
Learn more at http://petrieflom.law.harvard.edu/events/details/2016-annual-conference.
These slides accompanied a Civics 101 Workshop presented at the Penn Yan Public Library on April 12, 2018. The slides do not contain all of my speaker's notes, unfortunately.
This is a webinar organised by the Nigerian Library Association, Delta State Chapter, in collaboration with Digital Citizens.
The aim of the webinar is to equip library and information professionals with necessary technologies and strategies needed to play key roles in the dissemination of correct information, and in the information literacy of citizens, in this era of fake news and misinformation.
Chapter 66 Reporting, Story Development, and Editing Top of For.docxchristinemaritza
Chapter 66: Reporting, Story Development, and Editing
Top of Form
Bottom of Form
Top of Form
Bottom of Form
Telling a good story is the heart and soul of journalism; however, you can't tell a good story without doing a good job of reporting—gathering information to share with your audience. Identifying important and interesting issues, events, and people to report about is a critical part of the reporting process. In addition, carefully editing the semifinished product to ensure that it fits the allotted time or space and to ensure accuracy, plus to check for proper grammar, spelling, punctuation, and style, is necessary to increase the chances that audience members will find the story interesting, informative, entertaining, and thought provoking.
Story Selection
Selecting interesting and/or important aspects of life to report about would seem to be a relatively easy thing to do, but declining readership, listenership, and viewer-ship for many of the traditional news media clearly contradicts that assumption. The key to identifying and developing compelling news stories is always to keep in mind what's likely to be relevant to audience members (Brooks, Kennedy, Moen, & Ranly, 2008, p. 4; Hansen & Paul, 2004, pp. 31–39). What people, places, things, and issues are audience members interested in, and what do they care about the most? Perhaps a time-honored prescription about what is good journalism sums it up best: “Make the important story interesting and the interesting story important.”
Years of practice and research in journalism have identified a number of factors that play a part in the process of achieving that critical goal. Among these are the “uses and gratifications” (see also Chapter 56, this volume) that people associate with news media messages; the news values/elements/qualities used by journalists to help them select which issues, events, and people to report about; and the traditional five Ws and the H—who, what, where, when, why, and how.
Uses and Gratifications
People have told researchers that they become news consumers for a variety of interesting reasons. They have a number of “uses” for the information they obtain, and they obtain a number of “gratifications” from consuming such information (Levy, 1978; Levy & Windahl, 1984; Vishwanath, 2008). By knowing about and understanding such uses and gratifications, reporters can begin to build a framework for their information-gathering mission. Among the major uses and gratifications are surveillance, reassurance, intellectual stimulation, emotional fulfillment, and diversion.
Surveillance deals with simply keeping up with what's happening in your town, city, state, region, country, and world. Reporters who can find interesting information about the important happenings of each day will be successful.
Reassurance deals with information that helps people feel better about themselves, the decisions they make, and their lives in general. Examples include providing the views of ex ...
4182020 Opinion Why Do People Fall for Fake News - The Ne.docxtaishao1
4/18/2020 Opinion | Why Do People Fall for Fake News? - The New York Times
https://www.nytimes.com/2019/01/19/opinion/sunday/fake-news.html 1/2
GRAY MATTER
Why Do People Fall for Fake News?
Are they blinded by their political passions? Or are they just intellectually lazy?
By Gordon Pennycook and David Rand
Dr. Pennycook and Dr. Rand are psychologists.
Jan. 19, 2019
What makes people susceptible to fake news and other forms of strategic misinformation? And what, if anything, can
be done about it?
These questions have become more urgent in recent years, not least because of revelations about the Russian
campaign to influence the 2016 United States presidential election by disseminating propaganda through social
media platforms. In general, our political culture seems to be increasingly populated by people who espouse
outlandish or demonstrably false claims that often align with their political ideology.
The good news is that psychologists and other social scientists are working hard to understand what prevents people
from seeing through propaganda. The bad news is that there is not yet a consensus on the answer. Much of the
debate among researchers falls into two opposing camps. One group claims that our ability to reason is hijacked by
our partisan convictions: that is, we’re prone to rationalization. The other group — to which the two of us belong —
claims that the problem is that we often fail to exercise our critical faculties: that is, we’re mentally lazy.
However, recent research suggests a silver lining to the dispute: Both camps appear to be capturing an aspect of the
problem. Once we understand how much of the problem is a result of rationalization and how much a result of
laziness, and as we learn more about which factor plays a role in what types of situations, we’ll be better able to
design policy solutions to help combat the problem.
The rationalization camp, which has gained considerable prominence in recent years, is built around a set of theories
contending that when it comes to politically charged issues, people use their intellectual abilities to persuade
themselves to believe what they want to be true rather than attempting to actually discover the truth. According to
this view, political passions essentially make people unreasonable, even — indeed, especially — if they tend to be
good at reasoning in other contexts. (Roughly: The smarter you are, the better you are at rationalizing.)
Some of the most striking evidence used to support this position comes from an influential 2012 study in which the
law professor Dan Kahan and his colleagues found that the degree of political polarization on the issue of climate
change was greater among people who scored higher on measures of science literary and numerical ability than it
was among those who scored lower on these tests. Apparently, more “analytical” Democrats were better able to
convince themselves that climate change was a problem, while more “analytical” Republica.
On October 31 and November 1, 2017, Google, Twitter and Facebook sent their general counsels to testify before House and Senate intelligence committees to answer questions about the role their platforms played in the dissemination of Russian-instigated disinformation designed to disrupt the 2016 U.S. presidential election.
In the days immediately after the hearings, Edelman fielded a flash poll among the U.S. general population. The survey examined the various definitions people have for fake news, the role people believe social platforms play in disseminating fake news, and whether the social platforms require more oversight and regulation.
National identity predicts public health support during a pandemicJay Van Bavel
Presentation at the annual meeting of the American Political Science Association in 2020 entitled "National identity predicts public health support during a pandemic"
Making your research and teaching more efficient, transparent and impactfulJay Van Bavel
Science is hard and keeping up with the latest changes in technology and research practices can feel overwhelming. This workshop is designed to increase your productivity by making your research and teaching more efficient, transparent, and impactful. This will introduce you to a wide variety of strategies and technologies that you can employ in your work.
The role of brain-to-brain synchrony in collective performanceJay Van Bavel
The is a summary of our research on collective intelligence, group cooperation, social identity and brain-to-brain synchrony presented by Diego Reinero at the 2019 Social & Affective Neuroscience Society Conference.
This is the presentation I gave at SPSP 2019 examine differences in moral contagion among Democrat and Republican leaders. We analyzed the language leaders used on Twitter and examined the retweet rate for moral and emotional words.
A talk on the neuroscience of cooperation I gave at the Summer Institute for Cognitive Neuroscience in Lake Tahoe in July 2018. The talk reviews research and theory on the psychology and neuroscience underlying human cooperative decision-making.
This is a short talk I gave about the Partisan Brain as part of symposium on Neuropolitics at the International Neuropsychological Society’s annual meeting in Washington, DC (Feb 2018)
2017 demystifying the academic job marketJay Van Bavel
This is a slide deck for navigating the academic job market for phd students and postdocs in psychology (as well as the social and cognitive sciences). It describes the job market, offers concrete advice on preparing materials, explains the interview process, and discusses negotiation strategies.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
7. Sharing Fake news
“Falsehood diffused significantly farther, faster, deeper, and
more broadly than the truth in all categories of information,
and the effects were more pronounced for false political news
than for false news about terrorism, natural disasters, science,
urban legends, or financial information.” (Science, 2018)
19. Summary
•Democrats & Republicans are both more likely to believe
news when that belief fulfills identity goals:
•Ingroup value-upholding behavior
•Outgroup value-undermining behavior
28. Summary
•Democrats & Republicans are both more likely to believe
news when that belief fulfills identity goals:
•Ingroup value-upholding behavior
•Outgroup value-undermining behavior
29. Summary
•Democrats & Republicans are both more likely to believe
news when that belief fulfills identity goals:
•Ingroup value-upholding behavior
•Outgroup value-undermining behavior
•Republicans are more likely to share news on social
media when that fulfills identity goals
30. Summary
•Democrats & Republicans are both more likely to believe
news when that belief fulfills identity goals:
•Ingroup value-upholding behavior
•Outgroup value-undermining behavior
•Republicans are more likely to share news on social
media when that fulfills identity goals
•Republicans are more likely to believe apolitical news
34. Partisan Backfire
Reinero, Harris, Duke &Van Bavel
Replicate Backfire effect
N = 385 (Prolific)
Climate change, military,
immigration, health care,
planned parenthood
Facts and factcheck from
political leaders
43. Summary
•Democrats & Republicans are both
likely to weakly update their beliefs
to a fact check
•But Democrats & Republicans
strongly base their beliefs on
whatever their in-group leaders tell
them
•Party identity trumps reality—
effect size of partisanship is 10X
larger than fact checking effect
