Faculty national clinical programme for pathology
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The Royal College of Physicians of Ireland has received approval from the National Director of Quality and Clinical Care of the Health Service Executive to establish a National Clinical Programme in Pathology. This programme will be established jointly between the College and the HSE, following the agreed governance structure. It will require appointing a National Clinical Lead for Pathology and establishing a Clinical Advisory Group in the short term. The former Dean of the Faculty, Dr. Gerard Boran, played a key role in advancing this initiative.
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Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
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There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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Faculty national clinical programme for pathology
- 1. Royal College of Physicians of Ireland Frederick House 19 South Frederick Street, Dublin 2 Telephone: +353 1 863 9700 Facsimile: +353 1 672 4707 Website: www.rcpi.ie 05 January 2011 Dear Fellows, I am very pleased to inform you that we have just received agreement from Dr. Barry White, National Director of Quality and Clinical Care, Health Service Executive to establish a National Clinical Programme in Pathology. As you are aware over 20 such programmes have now been established jointly between the College and the HSE and it is appropriate that the integral role of Pathology across all of these programmes is now to be addressed in a programmatic manner. The Pathology programme will be established in accordance with the governance structure and process already agreed between RCPI and the HSE. In the short term this will require (a) the joint appointment of a National Clinical Lead for Pathology and (b) the establishment of a Clinical Advisory Group. I would like to acknowledge the central role played by Dr. Gerard Boran former Dean of the Faculty in progressing this initiative. We are working very closely with Mr. Leo Kearns, CEO, Royal College of Physicians of Ireland to ensure that this programme is established in line with precedent. I expect to be in a position to provide you with further detail early in the New Year. Yours sincerely, Prof. Conor O’Keane Dean Faculty of Pathology, RCPI Registered Charity in Ireland Ref. CHY1897