Poster about Factors related to cognitive impairment in fibromyalgia, neuropathic and musculoskeletal pain patients. 16th World Congress on Pain - IASP

1. Factors related to cognitive impairment in fibromyalgia, neuropathic and musculoskeletal pain patients.
B Ojedaa
, M Dueñasb
, A Salazara
, JA Micoc
, LM Torresd
, I Faildea
a
Preventive Medicine and Public Health Area, The Observatory of Pain (External Chair of Pain), University of Cádiz, Spain.
b
Salus Infirmorum Faculty of Nursing, University of Cádiz.
c
Department of Neuroscience, Pharmacology and Psychiatry, CIBER of Mental Health, CIBERSAM, Instituto de Salud Carlos III, University of Cádiz, Plaza Fragela 9, 11003 Cádiz, Spain.
d
Department of Anesthesiology-Critical Care and Pain Management, University Hospital “Puerta del Mar”, Avenue Ana de Viya 21, 11009 Cádiz, Spain.
To compare the cognitive function of patients diagnosed with
neuropathic pain (NP), musculoskeletal pain (MSK) and
fibromyalgia (FM), and to analyse the factors associates to
cognitive function in each group.
 Cognitive performance (Test Your Memory scale: TYM).
 Pain intensity (Visual Analogue Scale: VAS).
 Anxiety and depression (Hospital Anxiety and Depression scale: HADs)
 Sleep quality (MOS-sleep).
Results
Conclusion These results highlight the importance of assessing cognitive performance in CP patients depending on the type of pain and analysing the effect of the emotional state of the patient, especially if depression is present.
Acknowledgments: This work was supported by the External Chair of Pain, collabo-
ration between the University of Cádiz and the Grünenthal Foundation. The Grünen-
thal Foundation is a private non-profitable organization that promotes the dissemi-
nation of scientific knowledge and supports research.
Aim of Investigation
Methods
Poster Presentation Board Number: 39
Presentation Date: Friday, September 30 2016
Presentation Time: 3:15-4:15 PM
External Chair of Pain
Grünenthal Foundation -University of Cádiz
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Observatory of Pain
A research group for the study of pain in our social environment
Avda. Ana de Viya, 52
11009 Cádiz (SPAIN)
Design
Subjects
254 chronic pain patients
72 controls (no pain)
104 neuropatic pain
99 musculoskeletal
51 fibromyalgia
Linear regression models to analyse the relationships between cognitive
performance and intensity and duration of pain, sleep quality and anxiety
and depression.
Cross-sectional study
Instruments
and variables
Statistical
analyses
Quadratic relationship between pain duration and
TYM score (NP: n=104).
Demographic and clinical characteristics of the sample.
Chronic Pain
Patients (254)
Controls (72) p Neuropathic
Pain (104)
Musculoskele-
tal Pain (99)
Fibromyalgia
(51)
p
Sex (%)
Men
Women
36.2
63.8
43.1
56.9
0.18 47.1
52.9
41.4
58.6
3.9
96.1
<0.001
Age Mean (SD) 47.42 (8.8) 40 (11.11) <0.001 45.59 (8.68) 47.63 (9.42) 50.76 (6.7) 0.002
Academic level
No education
1ary education
2ary/Vocational training
University studies
11.8
39
40.9
8.3
5.6
22.2
36.1
36.1
<0.001 10.6
47.1
37.5
4.8
14.1
34.3
40.4
11.1
9.8
31.4
49
9.8
0.27
Co-morbidity (% yes) 74.4 43.1 <0.001 73.1 67.7 90.2 0.010
Pharmacological drugs (% yes)
Antidepressant
BZD
Anticonvulsivants
Opioids
NSAID
83.9
32.2
42.1
45.7
53.9
8.3
20.8
5.6
8.3
1.4
0
2.8
<0.001
<0.001
<0.001
<0.001
<0.001
0.082
89.4
33.7
39.4
52.9
61.5
7.7
75.8
27.3
39.4
44.4
52.5
10.1
88.2
58.8
52.9
33.3
41.2
5.9
0.019
0.001
0.216
0.068
0.054
0.648
Intensity Mean (SD) 6.65 (1.87) - - 6.63 (1.85) 6.7 (2) 6.59 (1.67) 0.86
Duration Mean (SD) 108.5 (97.6) - - 92.11 (82.7) 102 (97.42) 154.53 (112.7) 0.001
HADs-A Mean (SD) 9.45 (4.93) 3.61 (4.05) <0.001 9.01 (4.84) 8.89 (5) 11.43 (4.57) 0.004
HADs-D Mean (SD) 7.88 (5.18) 2.06 (2.3) <0.001 7.92 (5.3) 7.35 (5.28) 8.82 (4.66) 0.15
Index 9 Mean (SD) 52.41 (21.68) 29.34 (13.21) <0.001 52.41 (21.78) 49.42 (22.4) 58.19 (19.1) 0.072
Optimal sleep (%) 19.7 52.8 <0.001 18.3 24.2 13.7 0.28
HADs-A: hospital and depression scale-Anxiety; HADs-D: hospital and depression scale-Depression; Optimal sleep: 6 to 8 hours sleep.
Fibrmyalgia
Variables B (SE) CI (95%) p
Academic level
1ary education
2ary/Vocational training
University studies
HADs_Depression
Intensity
Intensity*Depression
2.99(1.86)
5.85(1.79)
7.61(2.35)
-1.08(0.42)
-0.57(0.64)
-1.51(0.46)
(-0.77;6.75)
(2.24;9.46)
(2.87;12.35)
(-1.92;-0.23)
(-1.87;0.71)
(-2.44;-0.58)
0.12
0.002
0.002
0.014
0.37
0.026
n=49; R2
corrected = 0.36
All Chronic Pain Patients
Variables B (SE) CI (95%) p
Age
Academic level
1ary education
2ary/Vocational training
University studies
HADs_Depression
-0.082(0.03)
4.047(0.97)
6.702(0.97)
8.759(1.34)
-0.288(0.06)
(-0.15;-0.02)
(2.14;5.96)
(4.79;8.61)
(6.11;11.41)
(-0.4;-0.17)
0.014
<0.001
<0.001
<0.001
<0.001
N=254; R2
corrected: 0.32
Musculoskeletal Pain
Variables B (SE) CI (95%)
(Inf; Sup)
p
Age
Academic level
1ary education
2ary/Vocational training
University studies
HADs_Depression
-0.09(0.05)
3.04(1.35)
6.42(1.33)
6.89(1.75)
-0.37(0.08)
(-0.18;-0.00)
(0.37;5.72)
(3.78;9.06)
(3.41;10.36)
(-0.53;-0.2)
0.046
0.026
<0.001
<0.001
<0.001
n=99; R2
corrected = 0.41
Neuropathic Pain
Variables B (SE) CI (95%)
(Inf; Sup)
p
Age
Academic level
1ary education
2ary/Vocational training
University studies
HADs_Depression
Duration (quadratic)
Duration (lineal)
-0.12(0.06)
5.29(1.78)
7.67(1.84)
12.96(2.88)
-0.19(0.1)
1.4x10-4(7x10-5)
-0.03(0.02)
(-0.24; 0.01)
(1.77;8.82)
(4.01;11.32)
(7.25;18.67)
(-0.39;0.02)
(1x10-6;2.8x10-4)
(-0.06;0.01)
0.06
0.004
<0.001
<0.001
0.072
0.048
0.20
n=104; R2
corrected = 0.29
Global model
Models for each pain group