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Generic Name Brand Name
Alimemazine Theralen™
Alverine Spasmonal™
Alprazolam Xanax™
Aripiprazole Abilify™
Asenapine Saphris™
Atenolol Tenormin™
Bupropion Wellbutrin™, Zyban™
Captopril Capoten™
Cetirizine Zyrtec™
Chlorthalidone Diuril™, Hygroton™
Cimetidine Tagamet™
Clidinium Librax™
Clorazepate Tranxene™
Codeine Contin™
Colchicine Colcrys™
Desloratadine Clarinex™
Diazepam Valium™
Digoxin Lanoxin™
Dipyridamole Persantine™
Disopyramide Norpace™
Fentanyl Duragesic™, Actiq™
Furosemide Lasix™
Fluvoxamine Luvox™
Haloperidol Haldol™
Hydralazine Apresoline™
Hydrocortisone Cortef™, Cortaid™
Iloperidone Fanapt™
Isosorbide Isordil™, Ismo™
Levocetirizine Xyzal™
Loperamide Immodium™, others
Loratadine Claritin™
Metoprolol Lopressor™,Toprol™
Morphine MS Contin™, Avinza™
Nifedipine Procardia™, Adalat™
Paliperidone Invega™
Prednisone Deltasone™, Sterapred™
Quinidine Quinaglute™
Ranitidine Zantac™
Risperidone Risperdal™
Theophylline Theodur™, Uniphyl™
Trazodone Desyrel™
Triamterene Dyrenium™
Venlafaxine Effexor™
Warfarin Coumadin™
Generic Name Brand Name
Amantadine Symmetrel™
Belladonna Multiple
Carbamazepine Tegretol™
Cyclobenzaprine Flexeril™
Cyproheptadine Periactin™
Loxapine Loxitane™
Meperidine Demerol™
Methotrimeprazine Levoprome™
Molindone Moban™
Nefopam Nefogesic™
Oxcarbazepine Trileptal™
Pimozide Orap™
Generic Name Brand Name
Amitriptyline Elavil™
Amoxapine Asendin™
Atropine Sal-Tropine™
Benztropine Cogentin™
Brompheniramine Dimetapp™
Carbinoxamine Histex™, Carbihist™
Chlorpheniramine Chlor-Trimeton™
Chlorpromazine Thorazine™
Clemastine Tavist™
Clomipramine Anafranil™
Clozapine Clozaril™
Darifenacin Enablex™
Desipramine Norpramin™
Dicyclomine Bentyl™
Dimenhydrinate Dramamine™, others
Diphenhydramine Benadryl™, others
Doxepin Sinequan™
Doxylamine Unisom™, others
Fesoterodine Toviaz™
Flavoxate Urispas™
Hydroxyzine Atarax™, Vistaril™
Hyoscyamine Anaspaz™, Levsin™
Imipramine Tofranil™
Meclizine Antivert™
Methocarbamol Robaxin™
Nortriptyline Pamelor™
Olanzapine Zyprexa™
Orphenadrine Norflex™
Oxybutynin Ditropan™
Paroxetine Paxil™
Perphenazine Trilafon™
Promethazine Phenergan™
Propantheline Pro-Banthine™
Propiverine Detrunorm™
Quetiapine Seroquel™
Scopolamine Transderm Scop™
Solifenacin Vesicare™
Thioridazine Mellaril™
Tolterodine Detrol™
Trifluoperazine Stelazine™
Trihexyphenidyl Artane™
Trimipramine Surmontil™
Trospium Sanctura™
Drugs with ACB Score of 3Drugs with ACB Score of 2Drugs with ACB Score of 1
Categorical Scoring:
Possible anticholinergics include those listed with a
score of 1; Definite anticholinergics include those
listed with a score of 2 or 3
Numerical Scoring:
Add the score contributed to each selected medication
in each scoring category
Add the number of possible or definite Anticholinergic
medications
Notes:
Each definite anticholinergic may increase the risk of
cognitive impairment by 46% over 6 years. 3
For each on point increase in the ACB total score, a
decline in MMSE score of 0.33 points over 2 years has
been suggested. 4
Additionally, each one point increase in the ACB total
score has been correlated with a 26% increase in the
risk of death. 4
Aging Brain Care
www.agingbraincare.org
Medications Added with
Score of 1:
Criteria for Categorization:
Score of 1: Evidence from in vitro data that chemical
entity has antagonist activity at muscarinic receptor.
Score of 2: Evidence from literature, prescriber’s
information, or expert opinion of clinical anticholinergic
effect.
Score of 3: Evidence from literature, expert opinion,
or prescribers information that medication may cause
delirium.
Copyright © 2008, 2012. Regenstrief Institute, Inc. All rights reserved.
Use of the Anti-Cholinergic Burden (ACB) Scale may only be
in accordance with the Terms of Use for the ACB Scale which
are available at http://www.agingbraincare.org/tools/abc-
anticholinergic-cognitive-burden-scale.
To request permission for use, contact us at
acb@agingbraincare.org.
Complete References:
1. Boustani MA, Campbell NL, Munger S, Maidment I, Fox
GC. Impactofanticholinergicsontheagingbrain:areview
andpracticalapplication.AgingHeatlh.2008;4(3):311-320.
2. Campbell N, Boustani M, Limbil T, et al. The cognitive
impact of anticholinergics: a clinical review.
Clinical Interventions in Aging. 2009;4(1):225-233.
3. CampbellN,BoustaniM,LaneK,etal.Useofanticholinergics
and the risk of cognitive impairment in an African-
American population. Neurology. 2010;75:152-159.
4. Fox C, Richardson K, Maidment I, et al. Anticholinergic
medication use and cognitive impairment in the
older population: the Medical Research Council
Cognitive Function and Ageing Study. Journal of the
American Geriatric Society. 2011; 59(8): 1477-1483.
5. Cai X, Campbell N, Khan B, Callahan C, Boustani M.
Long-term anticholinergic use and the aging brain.
Alzheimers Dementia. 2012; epub ahead of print.
Medications Added with
Score of 2:
Medications Reviewed in 2012 Update
Medications Reviewed But NOT Added:
Fexofenadine (Allegra™)
Gabapentin (Neurontin™)
Topiramate (Topamax™)
Levetiracetam (Keppra™)
Tamoxifen (Nolvadex™)
Nizatidine (Axid™)
Duloxetine (Cymbalta™)
Medications Added with
Score of 3:
Aripiprazole (Abilify™)
Asenapine (Saphris™)
Cetirizine (Zyrtec™)
Clidinium (Librax™)
Desloratadine (Clarinex™)
Iloperidone (Fanapt™)
Levocetirizine (Xyzal™)
Loratadine (Claritin™)
Paliperidone (Invega™)
Venlafaxine (Effexor™)
Nefopam (Nefogesic™)
Doxylamine (Unisom™,
others)
Fesoterodine (Toviaz™)
Propiverine (Detrunorm™)
Solifenacin (Vesicare™)
Trospium (Sanctura™)
ANTICHOLINERGIC
COGNITIVE BURDEN
SCALE
Aging Brain Care
2012 Update
Developed by the Aging Brain Program
of the Indiana University Center for
Aging Research

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Escala legal anticolinérgicos

  • 1. Generic Name Brand Name Alimemazine Theralen™ Alverine Spasmonal™ Alprazolam Xanax™ Aripiprazole Abilify™ Asenapine Saphris™ Atenolol Tenormin™ Bupropion Wellbutrin™, Zyban™ Captopril Capoten™ Cetirizine Zyrtec™ Chlorthalidone Diuril™, Hygroton™ Cimetidine Tagamet™ Clidinium Librax™ Clorazepate Tranxene™ Codeine Contin™ Colchicine Colcrys™ Desloratadine Clarinex™ Diazepam Valium™ Digoxin Lanoxin™ Dipyridamole Persantine™ Disopyramide Norpace™ Fentanyl Duragesic™, Actiq™ Furosemide Lasix™ Fluvoxamine Luvox™ Haloperidol Haldol™ Hydralazine Apresoline™ Hydrocortisone Cortef™, Cortaid™ Iloperidone Fanapt™ Isosorbide Isordil™, Ismo™ Levocetirizine Xyzal™ Loperamide Immodium™, others Loratadine Claritin™ Metoprolol Lopressor™,Toprol™ Morphine MS Contin™, Avinza™ Nifedipine Procardia™, Adalat™ Paliperidone Invega™ Prednisone Deltasone™, Sterapred™ Quinidine Quinaglute™ Ranitidine Zantac™ Risperidone Risperdal™ Theophylline Theodur™, Uniphyl™ Trazodone Desyrel™ Triamterene Dyrenium™ Venlafaxine Effexor™ Warfarin Coumadin™ Generic Name Brand Name Amantadine Symmetrel™ Belladonna Multiple Carbamazepine Tegretol™ Cyclobenzaprine Flexeril™ Cyproheptadine Periactin™ Loxapine Loxitane™ Meperidine Demerol™ Methotrimeprazine Levoprome™ Molindone Moban™ Nefopam Nefogesic™ Oxcarbazepine Trileptal™ Pimozide Orap™ Generic Name Brand Name Amitriptyline Elavil™ Amoxapine Asendin™ Atropine Sal-Tropine™ Benztropine Cogentin™ Brompheniramine Dimetapp™ Carbinoxamine Histex™, Carbihist™ Chlorpheniramine Chlor-Trimeton™ Chlorpromazine Thorazine™ Clemastine Tavist™ Clomipramine Anafranil™ Clozapine Clozaril™ Darifenacin Enablex™ Desipramine Norpramin™ Dicyclomine Bentyl™ Dimenhydrinate Dramamine™, others Diphenhydramine Benadryl™, others Doxepin Sinequan™ Doxylamine Unisom™, others Fesoterodine Toviaz™ Flavoxate Urispas™ Hydroxyzine Atarax™, Vistaril™ Hyoscyamine Anaspaz™, Levsin™ Imipramine Tofranil™ Meclizine Antivert™ Methocarbamol Robaxin™ Nortriptyline Pamelor™ Olanzapine Zyprexa™ Orphenadrine Norflex™ Oxybutynin Ditropan™ Paroxetine Paxil™ Perphenazine Trilafon™ Promethazine Phenergan™ Propantheline Pro-Banthine™ Propiverine Detrunorm™ Quetiapine Seroquel™ Scopolamine Transderm Scop™ Solifenacin Vesicare™ Thioridazine Mellaril™ Tolterodine Detrol™ Trifluoperazine Stelazine™ Trihexyphenidyl Artane™ Trimipramine Surmontil™ Trospium Sanctura™ Drugs with ACB Score of 3Drugs with ACB Score of 2Drugs with ACB Score of 1 Categorical Scoring: Possible anticholinergics include those listed with a score of 1; Definite anticholinergics include those listed with a score of 2 or 3 Numerical Scoring: Add the score contributed to each selected medication in each scoring category Add the number of possible or definite Anticholinergic medications Notes: Each definite anticholinergic may increase the risk of cognitive impairment by 46% over 6 years. 3 For each on point increase in the ACB total score, a decline in MMSE score of 0.33 points over 2 years has been suggested. 4 Additionally, each one point increase in the ACB total score has been correlated with a 26% increase in the risk of death. 4 Aging Brain Care www.agingbraincare.org
  • 2. Medications Added with Score of 1: Criteria for Categorization: Score of 1: Evidence from in vitro data that chemical entity has antagonist activity at muscarinic receptor. Score of 2: Evidence from literature, prescriber’s information, or expert opinion of clinical anticholinergic effect. Score of 3: Evidence from literature, expert opinion, or prescribers information that medication may cause delirium. Copyright © 2008, 2012. Regenstrief Institute, Inc. All rights reserved. Use of the Anti-Cholinergic Burden (ACB) Scale may only be in accordance with the Terms of Use for the ACB Scale which are available at http://www.agingbraincare.org/tools/abc- anticholinergic-cognitive-burden-scale. To request permission for use, contact us at acb@agingbraincare.org. Complete References: 1. Boustani MA, Campbell NL, Munger S, Maidment I, Fox GC. Impactofanticholinergicsontheagingbrain:areview andpracticalapplication.AgingHeatlh.2008;4(3):311-320. 2. Campbell N, Boustani M, Limbil T, et al. The cognitive impact of anticholinergics: a clinical review. Clinical Interventions in Aging. 2009;4(1):225-233. 3. CampbellN,BoustaniM,LaneK,etal.Useofanticholinergics and the risk of cognitive impairment in an African- American population. Neurology. 2010;75:152-159. 4. Fox C, Richardson K, Maidment I, et al. Anticholinergic medication use and cognitive impairment in the older population: the Medical Research Council Cognitive Function and Ageing Study. Journal of the American Geriatric Society. 2011; 59(8): 1477-1483. 5. Cai X, Campbell N, Khan B, Callahan C, Boustani M. Long-term anticholinergic use and the aging brain. Alzheimers Dementia. 2012; epub ahead of print. Medications Added with Score of 2: Medications Reviewed in 2012 Update Medications Reviewed But NOT Added: Fexofenadine (Allegra™) Gabapentin (Neurontin™) Topiramate (Topamax™) Levetiracetam (Keppra™) Tamoxifen (Nolvadex™) Nizatidine (Axid™) Duloxetine (Cymbalta™) Medications Added with Score of 3: Aripiprazole (Abilify™) Asenapine (Saphris™) Cetirizine (Zyrtec™) Clidinium (Librax™) Desloratadine (Clarinex™) Iloperidone (Fanapt™) Levocetirizine (Xyzal™) Loratadine (Claritin™) Paliperidone (Invega™) Venlafaxine (Effexor™) Nefopam (Nefogesic™) Doxylamine (Unisom™, others) Fesoterodine (Toviaz™) Propiverine (Detrunorm™) Solifenacin (Vesicare™) Trospium (Sanctura™) ANTICHOLINERGIC COGNITIVE BURDEN SCALE Aging Brain Care 2012 Update Developed by the Aging Brain Program of the Indiana University Center for Aging Research