This document discusses the various roles of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in the body. GH and IGF-1 are important for fetal and placental growth, ovarian and testicular development, bone and muscle growth, neuronal development, liver regeneration, and many other processes in the body. They regulate glomerular development and function, as well as play protective and anti-inflammatory roles.

1. I GF-1
Glomerular development,
Function and integrity
Foetal growth
and differentiation
Placental growth
and development
Ovarian folliculogenesis
Testicular function and integrity
Normal
Bone growth
Muscle growth and
development
Prolection, vasodilator
Neuronal development
Myelinization and protection
Amyloid-β clearance
anti-inflammatory
Pituitary GH
GHRH
somatostatin
Hepatocyte
Liver
regeneration
GH I GF-1