The document outlines the four stages of wound healing: 1. Hemostasis phase occurs within 5-15 minutes and involves vasoconstriction, platelet degranulation, fibrin clot formation, and release of growth factors. 2. Inflammatory phase lasts 24-48 hours and involves neutrophils and macrophages cleaning debris and releasing cytokines and growth factors. 3. Proliferation phase takes 3-4 days and involves re-epithelialization, granulation, angiogenesis, and fibroplasia. 4. Maturation phase occurs over days to years and involves collagen organization, wound contraction, and scar maturation.

1. Stage02Stage03
Stage04
Stage 01
Defensive/Inflammatory Phase
• Platelet-Derived chemoattractants and growth factors.
• Neutrophils and macrophages clean & remove debris and forign particles.
• Macrophages perform phagocytosis & release cytokines and growth factors.
(24 - 48 hrs, up to 2 weeks)
02
Proliferation Phase
• Re-epithelialization • Granulation
• Angiogenisis • Fibroplasia
(3 -4 days after injury, up to 21 days).
03
01
Hemostasis Phase
• Vasoconstriction • Platelet Degranulation • Inhibition of Clotting Cascade
• Fibrin Clot Formation.
• Release of Vasoactive Mediators, Cyclokines & Growth Factors
(5 - 15 minutes)
04
Maturation Phase
• Collagen and extracelluar matrix organization.
• Wound contraction.
• Scar maturation.
(Few days after injury, up to 2 years)
WOUND
HEALING
STAGES

2. Stage02Stage03
Stage04
Stage 01
Defensive/Inflammatory Phase
• Natural sterols (Beta sitosterol, Lupeol and Campsterol) and Essential faty acid
(Linolenic acid) have antiinflammatory effect and is important incase of prolonged
and not likable wound inflammation (Emu oil, Aloe vera).
02
Proliferation Phase
• Hasten re-epithelialization and keratinization of wound (Emu oil, Aloe vera).
• Glucomannan affect fibroblast growth factor and stimulate the activity and proliferation of the cells (Aloe vera).
• Increase angiogenisis (Beta sitosterol, Lupeol and Camsterol) as well as granulated tissue s (Aloe vera).
• Possess antioxidant enzymetic system like glutathion peroxidase and superoxide dismutase which increase
healing process (Emu oil, Aloe vera).
03
01
Hemostasis Phase
• Bleeding will stop normally and naturally.
• Prevent wound from infections (Tea tree oil).
• Easing of wound pain (Natural sterols & Linolenic acid), (Emu oil, Aloe vera)
04
Maturation Phase
• Increase amount of collagen on wound site and change in collagen structure (Emu
oil, Aloe vera).
EFFECT ON
WOUND
HEALING