School-based sealant programs are highly effective strategies for preventing tooth decay in children. They provide pit and fissure sealants to children in a school setting. When developing such programs, states should use evidence-based practices, promote policies allowing full use of dental personnel's licensure, develop referral networks, and increase efficiency. Applying sealants in schools to low-income children could prevent over 3 million cavities and save up to $300 million in treatment costs. Increased funding and support of school-based programs at federal, state, and local levels can expand access to sealants for more children.