This document discusses childhood depression, including its causes, signs and symptoms, differences from regular sadness or blues, potential prevention methods, and treatment options. Childhood depression is defined as persistent sadness lasting weeks or longer that disrupts a child's life. It can be caused by physical, environmental, genetic or other factors. Signs include changes in appetite, sleep, mood and interests. Treatment involves psychotherapy and may also include antidepressant medication, with the most effective approach being a combination of the two.