The complete genome of a foot-and-mouth disease virus (FMDV) type O isolate from Greece in 1994 was sequenced. This virus belongs to the Middle East-South Asia genetic group. Analysis found no differences in the protein coding sequence compared to other viruses in this group, but a 43 nucleotide deletion in the 5' untranslated region shared with only two other viruses. Seven amino acid substitutions were also found in the 3A protein, which has been associated with host specificity.
Coccidioidomycosis is a fungal disease commonly known as valley fever. Caused by inhalation of coccidioides immitis. Mainly disturb western hemisphere of earth.
Sero-evidence of zoonotic viruses in rodents and humans in Kibera informal se...ILRI
Poster prepared Joseph Ogola, Hussein Alburkat, Moses Masika, Essi Korhonen, Ruut Uusitalo, Philip Nyaga, Omu Anzala, Olli Vapalahti, Tarja Sironen and Kristian M. Forbes for the Kenya One Health Online Conference, 6-8 December 2021
Coccidioidomycosis is a fungal disease commonly known as valley fever. Caused by inhalation of coccidioides immitis. Mainly disturb western hemisphere of earth.
Sero-evidence of zoonotic viruses in rodents and humans in Kibera informal se...ILRI
Poster prepared Joseph Ogola, Hussein Alburkat, Moses Masika, Essi Korhonen, Ruut Uusitalo, Philip Nyaga, Omu Anzala, Olli Vapalahti, Tarja Sironen and Kristian M. Forbes for the Kenya One Health Online Conference, 6-8 December 2021
Rapid Impact Assessment of Climatic and Physio-graphic Changes on Flagship G...Arvinder Singh
‘NATIONAL CONFERENCE ON MAN AND ENVIRONMENT’October 15 – 16, 2012
Organized by
Department of Zoology and Environmental Sciences, Punjabi University, Patiala (Pb.) – 147 002, India
Use the Harvard Business Case, West Jet Airlines Information Tec.docxjessiehampson
Use the Harvard Business Case, “West Jet Airlines: Information Technology Governance and Corporate Strategy," as the basis for answering the following questions:
What was West Jet’s strategic plan?
What were the main problems faced by the West Jet IT organization?
Discuss how West Jet transformed their IT organizational structure. How was the structure itself realigned? What methods and processes were introduced or removed?
Discuss IT governance models that were considered to enable IT to function more efficiently at West Jet.
How does IT affect a company’s corporate strategy and the overall strategic impact?
Business School, Cespedes, Frank & Kindley, James
Minimum 2 scholarly Articles References.
Minimum of 500 Words, APA Format
Your paper will be submitted to Turnitin software, No plagiarism.
Contents lists available at ScienceDirect
Infection, Genetics and Evolution
journal homepage: www.elsevier.com/locate/meegid
Short communication
Genetic diversity and evolution of SARS-CoV-2
Tung Phan⁎
Division of Clinical Microbiology, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, USA
A R T I C L E I N F O
Keywords:
Coronavirus
SARS-CoV-2
Mutations
Genomic diversity
A B S T R A C T
COVID-19 is a viral respiratory illness caused by a new coronavirus called SARS-CoV-2. The World Health
Organization declared the SARS-CoV-2 outbreak a global public health emergency. We performed genetic
analyses of eighty-six complete or near-complete genomes of SARS-CoV-2 and revealed many mutations and
deletions on coding and non-coding regions. These observations provided evidence of the genetic diversity and
rapid evolution of this novel coronavirus.
1. The study
A new coronavirus SARS-CoV-2 is spreading cross the world (Phan,
2020). Since the virus emerged at the seafood wholesale market at the
end of last year (Zhu et al., 2019), the number of infected cases has
been rising dramatically (Velavan and Meyer, 2020). Human-to-human
transmission of SARS-CoV-2 has been confirmed (Nishiura et al., 2020).
The virus has been detected in bronchoalveolar-lavage (Zhu et al.,
2019), sputum (Lin et al., 2020), saliva (K.K. To et al., 2020), throat
(Bastola et al., 2020) and nasopharyngeal swabs (To et al., 2020).
Nucleotide substitution has been proposed to be one of the most
important mechanisms of viral evolution in nature (Lauring and
Andino, 2010). The rapid spread of SARS-CoV-2 raises intriguing
questions such as whether its evolution is driven by mutations. To as-
sess the genetic variation, eighty-six complete or near-complete gen-
omes of SARS-CoV-2 were collected from GISAID [https://www.gisaid.
org/]. These SARS-CoV-2 strains were detected in infected patients
from China (50), USA (11), Australia (5), Japan (5), France (4), Sin-
gapore (3), England (2), Taiwan (2), South Korea (1), Belgium (1),
Germany (1), and Vietnam (1). The pair-wise nucleotide sequence
alignment was performed by ClustalX2 (Saitou and Nei, ...
Disrupted development and altered hormone signaling in male Padi2:Padi4 doubl...Cornell University
Background: Peptidylarginine deiminase enzymes (PADs) convert arginine residues to citrulline in a process called citrullination or deimination. Recently, two PADs, PAD2 and PAD4, have been linked to hormone signaling in vitro and the goal of this study was to test for links between PAD2/PAD4 and hormone signaling in vivo.
Methods: Preliminary analysis of Padi2 and Padi4 single knockout (SKO) mice did not find any overt reproductive defects and we predicted that this was likely due to genetic compensation. To test this hypothesis, we created a Padi2/Padi4 double knockout (DKO) mouse model and tested these mice for a range of reproductive defects. Results: Controlled breeding trials found that DKO breeding pairs, particularly males, appeared to take longer to have their first litter than wild-type FVB controls (WT), and that pups and DKO male weanlings weighed significantly less than their WT counterparts. Additionally, DKO males took significantly longer than WT males to reach puberty and had lower serum testosterone levels. Furthermore, DKO males had smaller testes than WT males with increased rates of germ cell apoptosis.
Conclusions: The Padi2/Padi4 DKO mouse model provides a new tool for investigating PAD function and outcomes from our studies provide the first in vivo evidence linking PADs with hormone signaling.
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King et al.
Genome Announcements2 genomea.asm.org May/June 2016 Volume 4 Issue 3 e00353-16
onMay15,2016byguesthttp://genomea.asm.org/Downloadedfrom