This document discusses thromboprophylaxis, or the prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE) in hospitalized patients. It notes that evidence-based guidelines for venous thromboembolism prophylaxis have been available for over 15 years, but are still underused globally. It provides the rationale for thromboprophylaxis, stating that DVT is prevalent in at-risk patients, often clinically silent, and difficult to predict; complications are also difficult to manage. Thromboprophylaxis, it concludes, is highly effective at preventing DVT and PE, and cost-effective.