This document summarizes research on the SHADE Project, which uses a computerized cognitive behavioral therapy (CBT) and motivational interviewing (MI) program to treat comorbid depression and alcohol/other drug use problems. It finds that comorbidity is associated with greater disease burden and difficulties accessing treatment. The SHADE Project developed and tested an e-health intervention that could potentially improve treatment accessibility and outcomes for comorbid conditions. Results showed the e-health program was as effective as face-to-face CBT in reducing depression, alcohol and cannabis use, with benefits for adherence and empowering self-management. However, wider adoption of e-health faces challenges around technology access, clinical acceptance, and understanding of potential benefits