This document summarizes information about the drug aspirin, including its pharmacological name, trade names, actions, pharmacokinetics, indications, contraindications, dosage, precautions, side effects, and nursing responsibilities. It describes aspirin's mechanism for reducing pain and inflammation. It provides details on aspirin's absorption, metabolism, half-life, and protein binding. Recommended dosages for adults, adolescents and children are listed. Common side effects include stomach pain, nausea, vomiting, dizziness and headache. Nurses should carefully assess patients for cautions and contraindications and monitor for adverse effects.

1. DRUG
PRESENTATION
ASPIRIN

2. DRUG PRESENTATION
 NAME OF DRUG :- Aspirin
 PHARMACOLOGICAL NAME :-Albendazolum
 TRADE NAME :-Albenza, Zentel, Valbazen
 ACTION:- Aspirin blocks pain impulses by blocking COX-1 in CNS, Reduces
inflammation by inhibition of prostaglandin synthesis; Antipyretic action results from
vasodilation of peripheral vessels; Decreases platelet aggregation.

3. PHARMACOKINESTICS
Enteric metabolized by liver, Inactive metabolites excreted by kidneys; crosses
placenta; Excreted in breast milk; Half life 15-20 min, up to 9hr in large dose; Rectal
products may be erratic; protein binding 90%.
 PO: Onset 15-30min ,peak 1-2hr, duration 4-6 hr, well absorbed
 PO: Enteric coated: onset 10-30min ,duration 2-4 hr; Solution: onset 10-30min, peak
15-30 min, duration 2-4hr
 RECT: Onset slow, duration 4-6hr.

4. INDICATION
 For the treatment of mild to moderate pain or fever, including rheumatoid arthritis
(RA).
 For the treatment of osteoarthritis, thromboembolic disorders
 For the treatment of rheumatic fever
 For the treatment or secondary prophylaxis of MI, ischemic stroke, angina, acute MI,
Kawasaki disease.

5. CONTRA-INDICATION
 It is contraindicated in any person with known hypersensitivity to albedazole, the
benzimidazole class of compound or any product component.

6. DOSAGE
 ADULTS :- 3200mg/day
 ADOLESCENTS:-800mg/day
 CHILDREN:-800mg/day
 ROUTE:- Oral

7. PRECAUTION
 Pregnancy, children, infants, neonates, seizures, anemia, hepatic disease, biliary
tract disease, severe hypertention.

8. SIDE- EFFECT:-
 Stomach pain, nausea, vomiting
 dizziness, spinning sensation
 headache
 temporary hair loss

9. NURSING RESPONSIBILITIES
 These are the imp things the nurse should include in conducting assessment,
history taking and examination.
 Assess for mentioned cautions and contraindications to prevent any untoward
complications.
 Perform a through physical assessment to establish baseline data before drug
therapy and to evaluate for occurrence of any adverse effects associated with drug
therapy.
 Assess the patient’s liver function, including liver function test to determine
appropriateness of therapy and to monitor for toxicity.
 Assess the abdomen to evaluate for any changes from baseline related to the
infection, identify possible adverse effects and monitor for improvement.

10.  ‘McGraw-hill, nurse’s drug handbook’ seventh edition, Mac Graw Hill education ltd.
 www.Rxlist.apk
 www.nurseslist.com
 www.PDR.net
 www.wikipedia.org
REFERENCES