- The document compares images of an individual before and after 7 months of ecstasy use, showing physical changes.
- It also lists over 40 street names for drugs like nitrous oxide, ecstasy, crack cocaine, and lists characteristics of crack and cocaine like methods of use, effects, costs, and legal implications.
- Finally, it shows check marks evaluating various drugs on criteria like availability, side effects, and addiction potential.
Risk and Protective Factors for Drug Use, Misuse, Abuse and Dependence (Lesso...Jewel Jem
Risk and Protective Factors for Drug Use, Misuse, Abuse and Dependence
Lesson for Grade 9 (Health) MAPEH
Contents:
> Risk & Protective Factors (meaning)
> Factors composed of influences in Life Domains
- Personal
- Family
- Peer and Friends
- School
- Community
The document discusses various types of intentional injuries including suicide, parasuicide, domestic violence, bullying, stalking, extortion, gang violence, and acts of terror. It defines each term and provides examples and characteristics. Suicide is defined as intentionally taking one's own life, while parasuicide refers to suicide attempts where the person does not intend to die. Domestic violence includes physical, sexual, and verbal abuse between intimate partners or family members. Bullying is unwanted aggressive behavior that involves an imbalance of power and is often repeated. Stalking consists of patterns of behavior that make the victim afraid through actions like unwanted contact or surveillance.
Recreation activities that you voluntarily participate in during your free time
Recreational satisfaction needs:
Physiological 4. relaxation
Educational 5. psychological
Social 6. aesthetics
Indoor recreation when the activity is within the premises of your comfort zone at home or inside a building
Outdoor recreation when the activity is undertaken in a natural, rural, or open space outside the confines of buildings, usually large land area that is close to nature
Lifestyle the way you live your life in an everyday basis, it includes eating habits, physical activity participation and recreational choice
Lifestyle change the best way of preventing illness and early death
Engage yourself in a regular physical activity
Eat healthy foods
Find time to manage stress
Follow a good personal healthy habits
The HELP Philosophy in starting a healthy lifestyle change:
Health -- those who believe in the benefits of healthy lifestyle are more likely to engage in healthier behaviour
Everyone – healthy lifestyle can be practiced by everyone “health for
all”
Lifetime – the longer healthy lifestyles are practice, the greater the beneficial benefits
Personal – no two people are exactly the same. Your personal needs is the basis of your lifestyle change
The document provides a history of various dances and dance styles including:
- The Irish DanceSport Federation was founded in 1937 and has gone through several name changes to become the governing body for competitive ballroom dancing in Ireland.
- Formation dancing originated in 1932 in London and involves teams competing in choreographed dances.
- Individual dances like the waltz, tango, foxtrot and others have evolved over time, with figures and techniques being standardized through competitions and demonstrations by champion dancers.
The cha-cha originated in Cuba in the 1940s-1950s as American musicians visiting Cuba fused elements of the mambo and rumba dances. The cha-cha gained popularity in the 1950s and is danced to the music of the same name, which was developed from the Cuban danzón-mambo rhythm. The cha-cha is characterized by compact steps based on the rumba and mambo, with hip and pelvic movements, and incorporates a triple step in place of the slow step from the mambo and rumba. It is danced to 4/4 time music with 2 slow steps followed by 3 quick steps per bar.
1. Students are instructed to create a video advertisement for a product of their choice, using classical music as background.
2. The document provides links to pieces from Mozart, Beethoven, and Haydn that can be used for the background music.
3. Students will submit their video advertisements through the class Facebook page or messenger, and they will be graded based on their choice of appropriate classical music, original concept for the product, and creative use of props or costumes.
Risk factors predict increased likelihood of problem behaviors like drug use and delinquency. These include characteristics of environments like schools, communities, families, and peer groups. Protective factors reduce the influence of risk and likelihood of problem behaviors through bonding, beliefs, standards, and individual characteristics. Research on risk and protective factors informs prevention programs, which address elevated risks and increase protections to promote positive youth development.
Badminton originated in India as a game called "Poona" and involves hitting a shuttlecock back and forth over a net using rackets. It is played on a court by one or two people and requires gripping techniques, serving skills, and various strokes like backhands, forehands, drives, drop shots, and smashes. The rules dictate serving from the right or left side depending on whether the score is even or odd.
Risk and Protective Factors for Drug Use, Misuse, Abuse and Dependence (Lesso...Jewel Jem
Risk and Protective Factors for Drug Use, Misuse, Abuse and Dependence
Lesson for Grade 9 (Health) MAPEH
Contents:
> Risk & Protective Factors (meaning)
> Factors composed of influences in Life Domains
- Personal
- Family
- Peer and Friends
- School
- Community
The document discusses various types of intentional injuries including suicide, parasuicide, domestic violence, bullying, stalking, extortion, gang violence, and acts of terror. It defines each term and provides examples and characteristics. Suicide is defined as intentionally taking one's own life, while parasuicide refers to suicide attempts where the person does not intend to die. Domestic violence includes physical, sexual, and verbal abuse between intimate partners or family members. Bullying is unwanted aggressive behavior that involves an imbalance of power and is often repeated. Stalking consists of patterns of behavior that make the victim afraid through actions like unwanted contact or surveillance.
Recreation activities that you voluntarily participate in during your free time
Recreational satisfaction needs:
Physiological 4. relaxation
Educational 5. psychological
Social 6. aesthetics
Indoor recreation when the activity is within the premises of your comfort zone at home or inside a building
Outdoor recreation when the activity is undertaken in a natural, rural, or open space outside the confines of buildings, usually large land area that is close to nature
Lifestyle the way you live your life in an everyday basis, it includes eating habits, physical activity participation and recreational choice
Lifestyle change the best way of preventing illness and early death
Engage yourself in a regular physical activity
Eat healthy foods
Find time to manage stress
Follow a good personal healthy habits
The HELP Philosophy in starting a healthy lifestyle change:
Health -- those who believe in the benefits of healthy lifestyle are more likely to engage in healthier behaviour
Everyone – healthy lifestyle can be practiced by everyone “health for
all”
Lifetime – the longer healthy lifestyles are practice, the greater the beneficial benefits
Personal – no two people are exactly the same. Your personal needs is the basis of your lifestyle change
The document provides a history of various dances and dance styles including:
- The Irish DanceSport Federation was founded in 1937 and has gone through several name changes to become the governing body for competitive ballroom dancing in Ireland.
- Formation dancing originated in 1932 in London and involves teams competing in choreographed dances.
- Individual dances like the waltz, tango, foxtrot and others have evolved over time, with figures and techniques being standardized through competitions and demonstrations by champion dancers.
The cha-cha originated in Cuba in the 1940s-1950s as American musicians visiting Cuba fused elements of the mambo and rumba dances. The cha-cha gained popularity in the 1950s and is danced to the music of the same name, which was developed from the Cuban danzón-mambo rhythm. The cha-cha is characterized by compact steps based on the rumba and mambo, with hip and pelvic movements, and incorporates a triple step in place of the slow step from the mambo and rumba. It is danced to 4/4 time music with 2 slow steps followed by 3 quick steps per bar.
1. Students are instructed to create a video advertisement for a product of their choice, using classical music as background.
2. The document provides links to pieces from Mozart, Beethoven, and Haydn that can be used for the background music.
3. Students will submit their video advertisements through the class Facebook page or messenger, and they will be graded based on their choice of appropriate classical music, original concept for the product, and creative use of props or costumes.
Risk factors predict increased likelihood of problem behaviors like drug use and delinquency. These include characteristics of environments like schools, communities, families, and peer groups. Protective factors reduce the influence of risk and likelihood of problem behaviors through bonding, beliefs, standards, and individual characteristics. Research on risk and protective factors informs prevention programs, which address elevated risks and increase protections to promote positive youth development.
Badminton originated in India as a game called "Poona" and involves hitting a shuttlecock back and forth over a net using rackets. It is played on a court by one or two people and requires gripping techniques, serving skills, and various strokes like backhands, forehands, drives, drop shots, and smashes. The rules dictate serving from the right or left side depending on whether the score is even or odd.
The document provides information about volleyball, including its history and the basic skills and dimensions involved in playing the game. It was invented in 1895 by William G. Morgan and originally called 'mintonette.' The key skills discussed are serving, passing, setting, spiking, and blocking. The court has boundaries, a net, attack lines, and a service area. The three main types of serves are underhand, overhead, and jump serves.
This document provides information about dance, including its objectives, nature, and importance as a form of communication. It discusses several key elements of dance including time, space, and force. It also describes different choreographic forms like theme and variations and rondo. Additionally, it outlines characteristics of different dance styles such as ballet, tap, jazz, and modern. It emphasizes that dance is a way to convey ideas and tell stories through movement.
Includes the Natural resources of the country, outdoor recreation (land, water & air), nature of mountaineering, trail class, classification, top mountains visited in the country.
Baseball is a ball game played between two teams of nine players on a field with four bases laid out in a diamond shape. Throwing, pitching, fielding, batting, and base running are important skills in baseball. To perform these skills effectively, players must master techniques like grip, stance, stride, swing, wind-up, pivot, and follow-through. Mastering these elements is key to preventing opponents from advancing and helping your team earn runs.
Badminton originated in India in the 17th century and was brought to England in the 1870s. It became an Olympic sport in 1992. Badminton is played indoors and involves skills like serving and stroke techniques. It is played in singles, doubles, or mixed doubles, and a match is won by winning two out of three sets.
Volleyball traces its beginnings to 1895 in Massachusetts. It was initially called mintonette but later became known as volleyball. The game was brought to the Philippines in 1910 where skills like spiking were added. Volleyball became an Olympic sport in 1964 and is played by two teams of six players across a net. Scoring follows a rally point system and a match is
Organization and Management of Sports EventsLeelet1121
This document discusses the importance of management in physical education and sports programs. It outlines several key aspects and principles of management, including planning strategies and objectives, developing an organizational structure with defined roles, recruiting and selecting team members, directing and motivating individuals, and monitoring progress and evaluating outcomes. Effective management is essential for cooperation, accomplishing goals, and the long-term success of any physical education or sports program.
Here are some other common social dances:
1. Waltz - A smooth, flowing dance performed to 3/4 time music. Partners hold each other in a closed position.
2. Foxtrot - A smooth dance performed to 4/4 time music at moderate tempo. Partners hold each other in an open position.
3. Tango - A passionate dance originating from Argentina, performed to tango music. Features sharp, dramatic movements and footwork.
4. Salsa - A lively partner dance from Latin America incorporating steps from mambo, cha-cha and other Latin styles. Danced to salsa music.
5. Rumba - A smooth, sensual dance from Cuba. Features hip
The document discusses three dimensions of human sexuality: biological, sociocultural, and psychological. The biological dimension refers to physical sexual characteristics determined by sex chromosomes and hormones. The sociocultural dimension relates to behaviors and attitudes expected based on sex as well as roles and activities deemed appropriate by society. The psychological dimension addresses how one thinks about and expresses their own sexuality, including factors like self-esteem, attitudes, and body image.
The document discusses drugs and factors related to drug use. It defines different types of drugs including gateway drugs, depressants, stimulants, narcotics, hallucinogens, and inhalants. It also discusses risk and protective factors for drug use across different domains of life like personal, family, peers, school, and community. Finally, it outlines requirements, steps, and modes of treatment for drug dependency.
This document discusses different types of media including printed, digital, photography, film and animation. It provides details on printed media such as comic books, newspapers and magazines. It also describes the history and role of photography, film and digital media in the Philippines. Key events discussed include the first comic strips and films created in the country as well as the first photographs taken during Spanish colonization. The document notes that different techniques such as cinematography, mise-en-scene and editing are used in film to influence how viewers perceive the images.
Physical Education 8- TEAM SPORTS (Baseball and Softball)Cyra Micu
Baseball and softball are similar team sports that both involve hitting a ball with a bat and running bases. While the basic structure and goals are the same, there are key differences in field dimensions, pitching areas, ball and bat sizes that affect gameplay strategies. Baseball fields are larger with bases 90 feet apart and a pitcher's mound, while softball fields are smaller with bases 60 feet apart and a flat pitching circle. These differences are due to the softball being larger than a baseball.
This document discusses a lesson on drugs and substance abuse for students. It includes activities where students role play agreeing, disagreeing or being undecided on statements about smoking, alcohol and drug use. Statistics on drug use in the Philippines from 2004 to 2008 are provided, showing a decline in reported drug users. Common drug terms and concepts in drug education are defined. Students are assigned to write a short essay on the current drug scenario and ways to combat drugs. They also draw a figure labeling ways drugs enter the body.
The document discusses lifestyle, weight management, and classifications of weight. It defines lifestyle as a person's way of living and the behavioral patterns they exhibit. Weight management is keeping one's weight at a healthy level through long-term healthy living practices and behaviors. Weight is classified as underweight, normal, overweight, or obese based on a person's BMI and how their weight compares to healthy ranges for their age, gender and height.
The document discusses several environmental problems facing the Philippines: deforestation resulting from removal of forests for other land uses; flash floods from heavy rains that overwhelm drainage systems; soil erosion from removal of soil and sediments; oil spills polluting the ocean; degradation of coral reefs through explosives and cyanide; illegal mining using heavy equipment; and climate change as one of the greatest challenges of the 20th century. It also outlines the Community Health Action Project approach of encouraging community participation and involvement to address health issues, and lists several government agencies and their roles in promoting community health in the Philippines.
Folk dance reflects the traditional life of a certain country or region. The document describes several traditional Filipino folk dances and their characteristic movements. These include the kumintang where partners stand side by side with locked elbows, the abrasete where dancers raise their arms gracefully from side to side, and the bilao where partners pass each other while moving backward without turning around. The final dance described is the saludo where partners bow to each other, the audience, or opposite dancers to open or close a dance.
This document outlines several environmental problems including deforestation, flash floods, oil spills, coral reef degradation, and illegal mining. Deforestation can lead to soil erosion, landslides, and the greenhouse effect. Flash floods can cause diseases, loss of life, and water contamination. Oil spills suffocate marine mammals and kill trees. Coral reef degradation reduces fish, species diversity, and alters fish sizes. Illegal mining poisons water, destroys coral reefs, and leaves land barren.
Drug use is still a concern in the Philippines. According to a 2008 study, Filipino males are 10 times more likely to use drugs than females. Teenagers are vulnerable to drug use due to several risk factors. While some drugs have medical purposes, others can lead to abuse, addiction, illness and death when misused. Drugs alter brain function and how a person thinks and processes information. There are healthy alternatives to drugs such as sports, hobbies and other activities. Commonly abused drugs in the Philippines include shabu, marijuana and inhalants.
This document provides an overview of the music of Latin America. It was influenced by the ancient tribes who originally inhabited the regions, as well as the European colonizers like Spain and Portugal and the African slaves they brought. The ancient tribes used music for storytelling, celebrations, and rituals, playing indigenous instruments and favoring high notes. European influences introduced string instruments, while Africans contributed rhythmic percussion and dance styles. Syncopation, or accented off-beats, became a hallmark of Latin American music. Popular genres that developed included the tonada love songs, gato dance, habanera aristocratic rhythm, tango with its skipped beat, and faster rumba dance music.
Drugs are any substances that have psychological or behavioral effects when introduced to the body. Common drugs of abuse in the Philippines include shabu, marijuana, and inhalants. Drug dependence occurs when drug use becomes a high priority, creating a strong desire for the substance. Drug misuse is taking a substance in a way that differs from prescribed dosage or frequency, while drug abuse is non-medical use and can damage organs and lead to addiction or troubled behavior. Drug tolerance develops as the body adapts to a substance and requires higher amounts to feel the same effects of smaller doses.
The document discusses two sports - futsal and basketball. It describes the origins and introduction of futsal in Uruguay and the Philippines. The basic skills needed for futsal are also outlined, including kicking, dribbling, passing, heading, and tackling. For basketball, the goal is to shoot the ball through the hoop, and key skills include shooting, dribbling, passing, and rebounding. Examples of defensive formations in futsal are also provided.
Hiranandani Hospital in Powai, Mumbai, is a premier healthcare institution that has been serving the community with exceptional medical care since its establishment. As a part of the renowned Hiranandani Group, the hospital is committed to delivering world-class healthcare services across a wide range of specialties, including kidney transplantation. With its state-of-the-art facilities, advanced medical technology, and a team of highly skilled healthcare professionals, Hiranandani Hospital has earned a reputation as a trusted name in the healthcare industry. The hospital's patient-centric approach, coupled with its focus on innovation and excellence, ensures that patients receive the highest standard of care in a compassionate and supportive environment.
The document provides information about volleyball, including its history and the basic skills and dimensions involved in playing the game. It was invented in 1895 by William G. Morgan and originally called 'mintonette.' The key skills discussed are serving, passing, setting, spiking, and blocking. The court has boundaries, a net, attack lines, and a service area. The three main types of serves are underhand, overhead, and jump serves.
This document provides information about dance, including its objectives, nature, and importance as a form of communication. It discusses several key elements of dance including time, space, and force. It also describes different choreographic forms like theme and variations and rondo. Additionally, it outlines characteristics of different dance styles such as ballet, tap, jazz, and modern. It emphasizes that dance is a way to convey ideas and tell stories through movement.
Includes the Natural resources of the country, outdoor recreation (land, water & air), nature of mountaineering, trail class, classification, top mountains visited in the country.
Baseball is a ball game played between two teams of nine players on a field with four bases laid out in a diamond shape. Throwing, pitching, fielding, batting, and base running are important skills in baseball. To perform these skills effectively, players must master techniques like grip, stance, stride, swing, wind-up, pivot, and follow-through. Mastering these elements is key to preventing opponents from advancing and helping your team earn runs.
Badminton originated in India in the 17th century and was brought to England in the 1870s. It became an Olympic sport in 1992. Badminton is played indoors and involves skills like serving and stroke techniques. It is played in singles, doubles, or mixed doubles, and a match is won by winning two out of three sets.
Volleyball traces its beginnings to 1895 in Massachusetts. It was initially called mintonette but later became known as volleyball. The game was brought to the Philippines in 1910 where skills like spiking were added. Volleyball became an Olympic sport in 1964 and is played by two teams of six players across a net. Scoring follows a rally point system and a match is
Organization and Management of Sports EventsLeelet1121
This document discusses the importance of management in physical education and sports programs. It outlines several key aspects and principles of management, including planning strategies and objectives, developing an organizational structure with defined roles, recruiting and selecting team members, directing and motivating individuals, and monitoring progress and evaluating outcomes. Effective management is essential for cooperation, accomplishing goals, and the long-term success of any physical education or sports program.
Here are some other common social dances:
1. Waltz - A smooth, flowing dance performed to 3/4 time music. Partners hold each other in a closed position.
2. Foxtrot - A smooth dance performed to 4/4 time music at moderate tempo. Partners hold each other in an open position.
3. Tango - A passionate dance originating from Argentina, performed to tango music. Features sharp, dramatic movements and footwork.
4. Salsa - A lively partner dance from Latin America incorporating steps from mambo, cha-cha and other Latin styles. Danced to salsa music.
5. Rumba - A smooth, sensual dance from Cuba. Features hip
The document discusses three dimensions of human sexuality: biological, sociocultural, and psychological. The biological dimension refers to physical sexual characteristics determined by sex chromosomes and hormones. The sociocultural dimension relates to behaviors and attitudes expected based on sex as well as roles and activities deemed appropriate by society. The psychological dimension addresses how one thinks about and expresses their own sexuality, including factors like self-esteem, attitudes, and body image.
The document discusses drugs and factors related to drug use. It defines different types of drugs including gateway drugs, depressants, stimulants, narcotics, hallucinogens, and inhalants. It also discusses risk and protective factors for drug use across different domains of life like personal, family, peers, school, and community. Finally, it outlines requirements, steps, and modes of treatment for drug dependency.
This document discusses different types of media including printed, digital, photography, film and animation. It provides details on printed media such as comic books, newspapers and magazines. It also describes the history and role of photography, film and digital media in the Philippines. Key events discussed include the first comic strips and films created in the country as well as the first photographs taken during Spanish colonization. The document notes that different techniques such as cinematography, mise-en-scene and editing are used in film to influence how viewers perceive the images.
Physical Education 8- TEAM SPORTS (Baseball and Softball)Cyra Micu
Baseball and softball are similar team sports that both involve hitting a ball with a bat and running bases. While the basic structure and goals are the same, there are key differences in field dimensions, pitching areas, ball and bat sizes that affect gameplay strategies. Baseball fields are larger with bases 90 feet apart and a pitcher's mound, while softball fields are smaller with bases 60 feet apart and a flat pitching circle. These differences are due to the softball being larger than a baseball.
This document discusses a lesson on drugs and substance abuse for students. It includes activities where students role play agreeing, disagreeing or being undecided on statements about smoking, alcohol and drug use. Statistics on drug use in the Philippines from 2004 to 2008 are provided, showing a decline in reported drug users. Common drug terms and concepts in drug education are defined. Students are assigned to write a short essay on the current drug scenario and ways to combat drugs. They also draw a figure labeling ways drugs enter the body.
The document discusses lifestyle, weight management, and classifications of weight. It defines lifestyle as a person's way of living and the behavioral patterns they exhibit. Weight management is keeping one's weight at a healthy level through long-term healthy living practices and behaviors. Weight is classified as underweight, normal, overweight, or obese based on a person's BMI and how their weight compares to healthy ranges for their age, gender and height.
The document discusses several environmental problems facing the Philippines: deforestation resulting from removal of forests for other land uses; flash floods from heavy rains that overwhelm drainage systems; soil erosion from removal of soil and sediments; oil spills polluting the ocean; degradation of coral reefs through explosives and cyanide; illegal mining using heavy equipment; and climate change as one of the greatest challenges of the 20th century. It also outlines the Community Health Action Project approach of encouraging community participation and involvement to address health issues, and lists several government agencies and their roles in promoting community health in the Philippines.
Folk dance reflects the traditional life of a certain country or region. The document describes several traditional Filipino folk dances and their characteristic movements. These include the kumintang where partners stand side by side with locked elbows, the abrasete where dancers raise their arms gracefully from side to side, and the bilao where partners pass each other while moving backward without turning around. The final dance described is the saludo where partners bow to each other, the audience, or opposite dancers to open or close a dance.
This document outlines several environmental problems including deforestation, flash floods, oil spills, coral reef degradation, and illegal mining. Deforestation can lead to soil erosion, landslides, and the greenhouse effect. Flash floods can cause diseases, loss of life, and water contamination. Oil spills suffocate marine mammals and kill trees. Coral reef degradation reduces fish, species diversity, and alters fish sizes. Illegal mining poisons water, destroys coral reefs, and leaves land barren.
Drug use is still a concern in the Philippines. According to a 2008 study, Filipino males are 10 times more likely to use drugs than females. Teenagers are vulnerable to drug use due to several risk factors. While some drugs have medical purposes, others can lead to abuse, addiction, illness and death when misused. Drugs alter brain function and how a person thinks and processes information. There are healthy alternatives to drugs such as sports, hobbies and other activities. Commonly abused drugs in the Philippines include shabu, marijuana and inhalants.
This document provides an overview of the music of Latin America. It was influenced by the ancient tribes who originally inhabited the regions, as well as the European colonizers like Spain and Portugal and the African slaves they brought. The ancient tribes used music for storytelling, celebrations, and rituals, playing indigenous instruments and favoring high notes. European influences introduced string instruments, while Africans contributed rhythmic percussion and dance styles. Syncopation, or accented off-beats, became a hallmark of Latin American music. Popular genres that developed included the tonada love songs, gato dance, habanera aristocratic rhythm, tango with its skipped beat, and faster rumba dance music.
Drugs are any substances that have psychological or behavioral effects when introduced to the body. Common drugs of abuse in the Philippines include shabu, marijuana, and inhalants. Drug dependence occurs when drug use becomes a high priority, creating a strong desire for the substance. Drug misuse is taking a substance in a way that differs from prescribed dosage or frequency, while drug abuse is non-medical use and can damage organs and lead to addiction or troubled behavior. Drug tolerance develops as the body adapts to a substance and requires higher amounts to feel the same effects of smaller doses.
The document discusses two sports - futsal and basketball. It describes the origins and introduction of futsal in Uruguay and the Philippines. The basic skills needed for futsal are also outlined, including kicking, dribbling, passing, heading, and tackling. For basketball, the goal is to shoot the ball through the hoop, and key skills include shooting, dribbling, passing, and rebounding. Examples of defensive formations in futsal are also provided.
Hiranandani Hospital in Powai, Mumbai, is a premier healthcare institution that has been serving the community with exceptional medical care since its establishment. As a part of the renowned Hiranandani Group, the hospital is committed to delivering world-class healthcare services across a wide range of specialties, including kidney transplantation. With its state-of-the-art facilities, advanced medical technology, and a team of highly skilled healthcare professionals, Hiranandani Hospital has earned a reputation as a trusted name in the healthcare industry. The hospital's patient-centric approach, coupled with its focus on innovation and excellence, ensures that patients receive the highest standard of care in a compassionate and supportive environment.
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
One health condition that is becoming more common day by day is diabetes.
According to research conducted by the National Family Health Survey of India, diabetic cases show a projection which might increase to 10.4% by 2030.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
15. •
The LEFT image was taken when the subject first used ecstasy in
2001 and the RIGHT image was taken in 2008.
16. •
Changes in the ecstasy user's face for 8 months
The LEFT picture was taken in January 2008 and the RIGHT picture
was taken, AFTER 7 MONTHS of ECSTASY INTAKE, in August 2008.
Psychoactive drug- a mind-altering drug that can produce mood changes and distorted perceptions, example of which are alcohol, caffeine, tobacco, marijuana, LSD etc.
Depressants are drugs that inhibit the function of the central nervous system and are among the most widely used drugs in the world.
Ecstasy as a cure for Cancer* - A study published in 2006, by a team of researchers from the University of Birmingham, showed that ecstasy and anti-depressants, had tumor-killing properties that were potentially effective in stopping the growth of cancer cells in blood. The bad news was that the doses required for treatment were so high they could kill a patient or any human being. However, the research team, in collaboration with the University of Western Australia, has redesigned the MDMA molecule (as the drug is known chemically) making its anti-cancer properties up to a 100 times more effective, featured in the Investigational New Drugs journal. This not only reduces the amount of drug needed to produce the desired effect in blood-type cancers, such as leukemia, lymphoma and melanoma, but it also decreases the toxic impact in the brain. Researchers believe the drug feels high affinity for fats in the cancer cells’ membrane, which “becomes soapy”, causing it to break down, killing the cell. Since the studies have only been demonstrated on sample tubes, it may take further studies, clinical trials and maybe another decade or so before doctors start prescribing Ecstasy for cancer treatment, but as Dr. David Grant, scientific director of the charity Leukemia and Lymphoma Research stated: “Further work is required, but this research is a significant step forward in developing a potential new cancer drug”.Reference: http://factualfacts.com/science-facts/ecstasy-could-be-a-cure-for-cancer/
REASONS WHY:First, there have not been enough clinical trials showing that marijuana’s benefits outweigh its risks in patients with the symptoms it is meant to treat. The FDA requires carefully conducted studies in large numbers of patients (hundreds to thousands) to accurately assess the benefits and risks of a potential medication.Second, to be considered a legitimate medicine, a substance must have well-defined and measureable ingredients that are consistent from one unit (such as a pill or injection) to the next. This consistency allows doctors to determine the dose and frequency.Along with THC, the marijuana plant contains over 400 other chemical compounds, including other cannabinoids that may be biologically active and vary from plant to plant. This makes it difficult to consider its use as a medicine even though some of marijuana’s specific ingredients may offer benefits.Finally, marijuana has certain adverse health effects that also must be taken into account. Because it is usually smoked, marijuana can cause or worsen respiratory symptoms (e.g., bronchitis, chronic cough). It also impairs short-term memory and motor coordination; slows reaction time; alters mood, judgment, and decision-making; and in some people can cause severe anxiety (paranoia) or psychosis (loss of touch with reality). And marijuana is addictive—about 4.5 million people in this country meet clinical criteria for marijuana abuse or dependence.
Short-Term Effects* - Most inhalants act directly on the nervous system to produce mind-altering effects. Within seconds, the user experiences intoxication and other effects similar to those from alcohol. There are a variety of effects that may be experienced during or shortly after use, including:
The chronic use of inhalants has been associated with a number of serious health problems. Sniffing glue and paint thinner causes kidney problems. Sniffing toluene and other solvents causes liver damage. Inhalant abuse has also resulted in memory impairment and diminished intelligence.
OpiumOpium is the hardened juice from the unripe seed pods of the opium poppy. It is a yellow-brown or brownish-black substance that can have a solid or sticky texture. It has been used medicinally as a painkiller, and recreationally it has been abused for its euphoric effects. It can be smoked or eaten.Street names include:
Heroin is a highly addictive drug that can come in varying forms, from white powder to a black, tar-like substance. The presence of impurities creates the darker shades. White heroin is the purest and most potent kind, although it is sometimes mixed with things like sugar or powdered milk to create the appearance of purity. Heroin is injected, snorted or smoked.
Fentanyl is a powerful painkilling narcotic that is about 80 percent more potent than morphine. Prescriptions such as Actiq, Duragesic and Sublimaze include fentanyl. It has been prescribed to treat patients with severe chronic pain, cancer patients or patients in severe pain who have developed a tolerance to other opiates. Fentanyl is very strong, and abuses of this drug especially can be fatal. It can be taken through oral, transdermal or injection
Morphine is used to treat severe pain or to manage pain after surgery. It is found in the forms of powder, liquid and tablets. Morphine is the primary derivative of opium. It can be injected,inhaled, smoked or swallowed.
Codeine, hydrocodone, and oxycodone are used in painkillers. Codeine is a weak narcotic sometimes combined with other medicines. Hydrocodone has been used in medications such as Vicodin, Lorcet, Lortab and Tramadol. Oxycodone is a main ingredient in the prescription medication OxyContin.
WITHDRAWAL SYMPTOMS:These include restlessness, muscle and bone pain, insomnia, diarrhea, vomiting, and cold flashes with goose bumps (“cold turkey”).
*The act banned nonmedical use of the drug and imposed the same criminal penalties for cocaine use and possession as already in place for opium, morphine, and heroine.
When cocaine is used in combination with alcohol, the body converts the two substances into cocaethylene.This toxic combination causes a greater duration of drug effects in the brain and is the cause of more deaths than any other drug combination.
IMAGE 1: A 54-year-old woman presented with a 2-day history of a painful, enlarging rash over her face (Panel A), ears (Panel B), breasts, and extremities which is mainly caused by LEVAMISOLE. Laboratory studies revealed neutropenia (abnormally low number of neutrophils) and lymphopenia (abnormally low number of lymphocytes). With these findings, the woman is more susceptible to bacterial infections and, without prompt medical attention, the condition may become life-threatening and deadly.ALEVAMISOLE, an antihelmintic agent for use in animals, is a common additive to cocaine and is speculated to enhance the euphoric effect. IMAGE 2Chronic consumption of Cocaine through snorting leads to damage of nasal membrane.