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Sandrine Thuret, PhD INSTITUTE OF PSYCHIATRY,
PSYCHOLOGY & NEUROSCIENCE
B a s i c a n d C l i n i c a l
N e u r o s c i e n c e
Cells &
Behaviour Unit
Generation of New Nerve
Cells in the Adult Brain:
Implication for Mental Health
Friday 27th of May 2016
Mental Health Summit
“Once development was ended, the fonts of growth and regeneration of the
axons and dendrites dried up irrevocably. In the adult centers, the nerve paths
are something fixed, and immutable: everything may die, nothing may be
regenerated.”
Santiago Ramon y Cajal, 1928
Adult Neurogenesis?
NEURO
GENESIS?
Adult hippocampal neurogenesis in the human
HIPPOCAMPUS: NEUROGENESIS
NEURO
GENESIS?
Pattern Separation and Post Traumatic Stress Disorder
NEURO
GENESIS?
Alzheimer’s
Disease
Parkinson
Disease
Mood
and
Cognitive
decline
Adult Hippocampal Neurogenesis emerging as Target of choice?
nature neuroscience volume 2 no 3 march 1999
Henriette van Praag1, Gerd Kempermann1,2 and Fred H. Gage1
A D
CONTROLS RUNNERS
Villeda et al., 2011- Nature
Modulation of adult Neurogenesis: Ageing
RESVERATROLVITAMIN E DEFICIENCY HIGH SUGAR
OMEGA 3 FATTY ACIDS HIGH SATURATED FAT
CALORIE RESTRICTION VITAMIN B DEFFICIENCY
SOFT DIET VITAMIN A DEFFICIENCY BLUEBERRIES
FLAVONOIDSZINCFOLIC ACID CURCURMIN
CAFFEINE INTERMITTENT FASTINGETHANOL
FOOD
TEXTURE
FOOD
CONTENT
MEAL
FREQUENCY
CALORIE
INTAKE
NEURO
GENESIS
Mood
Regulation
Memory
Formation
Regulatory
Mechanisms
Molecular
Environmental
Health
Disease
NEURO
GENESIS
Neurogenesis: Future Health – What is needed Next?

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