Dr. Coşkunseven "The New Keraring 340 Degree Segment"Mediphacos
This document summarizes a presentation on KeraRing 340 implantation for treating keratoconus. It includes patient inclusion/exclusion criteria, pre-op and post-op data from one patient, and conclusions. KeraRing 340 implantation provided over 11 diopters of flattening, and improved the patient's UCVA and BCVA. The procedure is effective and safe for improving vision in central or paracentral keratoconic eyes, with about 7D of flattening from a 200 micron segment and 13D from a 300 micron segment. However, long-term follow up of more patients is still needed to fully validate the approach.
This document discusses using corneal asphericity (Q value) to select intracorneal ring segments for keratoconus patients. It provides data on how Q and keratometry (K) values change based on single or paired segment thickness. The general guidelines are to use thinner segments for oblate corneas and thicker paired segments for hyperprolate corneas. The document also presents several clinical case examples and the surgical strategies used based on preoperative Q and cylinder values. The conclusion emphasizes that asphericity should be the main factor considered and the goal is to reshape the cornea close to a Q value of -0.23 postoperatively.
Dr. Coşkunseven "Combination of Keraring and Toric phakic implantable collame...Mediphacos
This document summarizes a study that evaluated combining keraring intracorneal ring segments with toric phakic implantable collamer lenses (ICL) to treat keratoconus. Fourteen eyes of 9 patients underwent keraring implantation followed by corneal collagen crosslinking (CXL). After 7 months, toric ICLs were implanted. Visual acuity and refraction improved after each step. By 1 year post-ICL implantation, uncorrected and best-corrected visual acuity increased while cylinder, maximum keratometry, and irregularity decreased. The study concluded this combination treatment can stop keratoconus progression and improve vision but longer-term studies in more patients are needed.
Dr. Minoru Tomita presentation at the Mediphacos User Meeting 2013Mediphacos
This document summarizes a study evaluating the effect of simultaneous Keraring implantation using OCT-guided femtosecond laser and corneal crosslinking (CXL) for the treatment of keratectasia. Ten eyes of 9 patients underwent Keraring implantation using an OCT-guided femtosecond laser to create the tunnel, followed by CXL. At 3 months post-op, uncorrected and corrected visual acuity, cylinder, K-values, and corneal HOAs were significantly improved, while endothelial cell density and central corneal thickness were not significantly changed. Corneal topography also improved. The study concluded that simultaneous Keraring implantation using OCT-guided femtosecond laser and CXL was effective for treating keratectasia.
This presentation describes indications of intrastromal corneal rings implantation in keratoconus cases and how they are beneficial even in advanced cases.
This document describes yellow Ferrara rings, which are plastic intracorneal rings used to treat keratoconus. The rings contain a yellow filter and prismatic effect to reduce light scattering. Studies using C-Quant and point spread function measurements found the rings decreased straylight parameters, indicating less retinal light scattering. Clinical evidence showed the rings resolved patients' complaints of halos after exchanging a clear ring for a yellow one. The pigmented ring is better because it absorbs wavelengths that cause more light scattering.
Dr. Francisco Sanchez presentation at the Mediphacos User Meeting 2013 - KERA...Mediphacos
This document discusses a new 355 degree Keraring for keratoconus correction. It presents the design of the Keraring, which has a larger arc length than previous models to improve central corneal flattening for advanced nipple cone cases. Surgical techniques for implanting the Keraring using either femtosecond laser ring dissection or pocket creation are shown. Preliminary results on 7 eyes found improvement in visual acuity and refractive error, with 100% of eyes within 1 diopter of the target refraction at 6 months. The conclusion is that the new 355 degree Keraring provides reasonable outcomes, indicating it is an option for nipple cone keratoconus correction.
Dr. Coşkunseven "The New Keraring 340 Degree Segment"Mediphacos
This document summarizes a presentation on KeraRing 340 implantation for treating keratoconus. It includes patient inclusion/exclusion criteria, pre-op and post-op data from one patient, and conclusions. KeraRing 340 implantation provided over 11 diopters of flattening, and improved the patient's UCVA and BCVA. The procedure is effective and safe for improving vision in central or paracentral keratoconic eyes, with about 7D of flattening from a 200 micron segment and 13D from a 300 micron segment. However, long-term follow up of more patients is still needed to fully validate the approach.
This document discusses using corneal asphericity (Q value) to select intracorneal ring segments for keratoconus patients. It provides data on how Q and keratometry (K) values change based on single or paired segment thickness. The general guidelines are to use thinner segments for oblate corneas and thicker paired segments for hyperprolate corneas. The document also presents several clinical case examples and the surgical strategies used based on preoperative Q and cylinder values. The conclusion emphasizes that asphericity should be the main factor considered and the goal is to reshape the cornea close to a Q value of -0.23 postoperatively.
Dr. Coşkunseven "Combination of Keraring and Toric phakic implantable collame...Mediphacos
This document summarizes a study that evaluated combining keraring intracorneal ring segments with toric phakic implantable collamer lenses (ICL) to treat keratoconus. Fourteen eyes of 9 patients underwent keraring implantation followed by corneal collagen crosslinking (CXL). After 7 months, toric ICLs were implanted. Visual acuity and refraction improved after each step. By 1 year post-ICL implantation, uncorrected and best-corrected visual acuity increased while cylinder, maximum keratometry, and irregularity decreased. The study concluded this combination treatment can stop keratoconus progression and improve vision but longer-term studies in more patients are needed.
Dr. Minoru Tomita presentation at the Mediphacos User Meeting 2013Mediphacos
This document summarizes a study evaluating the effect of simultaneous Keraring implantation using OCT-guided femtosecond laser and corneal crosslinking (CXL) for the treatment of keratectasia. Ten eyes of 9 patients underwent Keraring implantation using an OCT-guided femtosecond laser to create the tunnel, followed by CXL. At 3 months post-op, uncorrected and corrected visual acuity, cylinder, K-values, and corneal HOAs were significantly improved, while endothelial cell density and central corneal thickness were not significantly changed. Corneal topography also improved. The study concluded that simultaneous Keraring implantation using OCT-guided femtosecond laser and CXL was effective for treating keratectasia.
This presentation describes indications of intrastromal corneal rings implantation in keratoconus cases and how they are beneficial even in advanced cases.
This document describes yellow Ferrara rings, which are plastic intracorneal rings used to treat keratoconus. The rings contain a yellow filter and prismatic effect to reduce light scattering. Studies using C-Quant and point spread function measurements found the rings decreased straylight parameters, indicating less retinal light scattering. Clinical evidence showed the rings resolved patients' complaints of halos after exchanging a clear ring for a yellow one. The pigmented ring is better because it absorbs wavelengths that cause more light scattering.
Dr. Francisco Sanchez presentation at the Mediphacos User Meeting 2013 - KERA...Mediphacos
This document discusses a new 355 degree Keraring for keratoconus correction. It presents the design of the Keraring, which has a larger arc length than previous models to improve central corneal flattening for advanced nipple cone cases. Surgical techniques for implanting the Keraring using either femtosecond laser ring dissection or pocket creation are shown. Preliminary results on 7 eyes found improvement in visual acuity and refractive error, with 100% of eyes within 1 diopter of the target refraction at 6 months. The conclusion is that the new 355 degree Keraring provides reasonable outcomes, indicating it is an option for nipple cone keratoconus correction.
Keraring intracorneal ring segments are designed to treat keratoconus and other corneal ectatic disorders. They work by remodeling the cornea to regularize its surface and reduce refractive errors through addition techniques. Keraring comes in different sizes and thicknesses to customize treatment and provides long-term stabilization and improvement in vision. Extensive clinical use has demonstrated its safety and effectiveness for correcting refractive errors.
The document describes a new device called ZEPTO for performing cataract surgery capsulotomies. It uses precision-pulse technology to create an accurate, reproducible capsulotomy that is quick, safe, and affordable. The device applies suction and uses low-energy pulses to precisely cleave the lens capsule. Testing showed it created capsulotomies in rabbit and cadaver eyes without causing temperature increases in surrounding tissues. It was also shown to be safer for the zonules and create stronger capsule edges compared to the conventional capsulorhexis technique. The ZEPTO device aims to automate capsulotomies, reduce procedure time, improve centration, and lower costs.
Presentation from OIS@ASCRS 2016
John Hendrick, President & CEO
Video Presentation:
https://www.youtube.com/watch?v=c2J1g7HYuek&index=24&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
This study evaluated the outcomes of MyoRing intracorneal implantation in 15 eyes of 15 patients with pellucid marginal degeneration (PMD). Following MyoRing implantation, uncorrected and best corrected visual acuity improved significantly, refractive errors were reduced, and keratometry values decreased. Patients reported low rates of visual symptoms and high satisfaction scores. The study demonstrated that MyoRing implantation via microkeratome is a safe and effective procedure for treating PMD.
Slides do curso avançado de atualização em implante de Anel de Ferrara, elaborado por Ferrara Ophtalmics. Para material completo, acesse www.aneldeferrara.com.br
The document describes the NeoGuideSystem for digital implant planning. It provides full digital workflow to quickly fabricate surgical guides for accurate, safe implant surgery. The system includes NeoGuide software for implant planning, surgical guides for guiding surgery, and a NeoGuide kit with drills and other tools. The full digital process takes only 5 days from scan to surgery. The system aims to provide faster, safer, and more accurate implant placement for patients, clinics, and dental labs.
The Ferrara Intrastromal Corneal Ring is a minimally invasive surgical option to treat ectatic corneal disorders like keratoconus. It improves the shape of the cornea, decreases astigmatism, and improves vision. The PMMA ring segments are inserted into the peripheral stroma, preserving the anterior corneal shape. A review of 340 patients found the procedure improved uncorrected and best corrected visual acuity for keratoconus grades 1 through 3. By 3 months post-op, patients achieved visual rehabilitation and refractive stability. Complications were low at 3-5% but higher for more advanced keratoconus.
The document describes the features and functions of the CEM-530 specular microscope from NIDEK, including its ability to capture 16 images within 2 seconds through an automated process. It can analyze the images fully automatically by tracing cell size, shape, and other parameters. The microscope also allows paracentral image capture to provide a wider field of observation and more accurate analysis, especially for conditions like post-surgery, corneal dystrophy, or keratoconus where pathology may not be at the corneal center. It compares the CEM-530 to other specular microscopes from Topcon and Tomey, noting advantages like faster analysis speed and larger monitor.
1) The document summarizes global experience with the Staar Surgical EVO Visian ICL and the evolution to the EVO+ Visian ICL for correcting myopia.
2) Over 1,400 EVO ICL implants were discussed, with follow up data on 306 patients showing high predictability, safety, and stability over 4 years.
3) The EVO+ ICL was developed with an increased optical zone while maintaining the same overall height, providing superior high definition quality vision without dry eye issues compared to LASIK. The ICL leaves the cornea and crystalline lens untouched for future vision correction options.
This document provides information on various dental implant components and tools that are compatible with different implant systems. It includes specifications and part numbers for titanium abutments, healing abutments, impression components, and surgical tools. The components are organized by connection type (conical or internal hex) and platform size (regular, narrow, slim). Product images and diagrams are also provided showing the features and dimensions.
The document discusses the AcrySof Toric IOL for correcting astigmatism during cataract surgery. It has three key features: 1) it is a single piece, foldable acrylic lens with axis marks to ensure proper alignment; 2) it has a blue light filter and is injected similar to conventional IOLs; 3) clinical studies show it has excellent rotational stability after implantation and is more effective at correcting astigmatism than spherical IOLs with limbal relaxing incisions.
The AL-Scan device performs a variety of eye scanning and measurement functions in a single, compact unit. It uses low coherence interferometry, dual keratometry, Scheimpflug imaging, and optional ultrasound to measure corneal thickness, anterior chamber depth, toric lens parameters, and more. Measurements can be automatically captured and printed or sent to a PC for further analysis.
Intrastromal corneal ring segments are devices used to correct mild to moderate myopia by flattening the cornea. They are inserted through a peripheral incision and come in various thicknesses to determine the degree of correction. Intrastromal corneal ring segments work by shortening the corneal cord length and producing flattening across the entire cornea. They are indicated for mild myopia up to -3.00 diopters with minimal astigmatism in patients over 21 with stable refraction, and can also be used to treat keratoconus and post-LASIK ectasia. Complications are generally rare and reversible.
The document is Neobiotech's 2015 product catalog. It includes:
- An introduction to Neobiotech's corporate philosophy and history of developing simpler, safer, and faster implant products.
- Details on Neobiotech's research and development facilities and production process.
- An overview of Neobiotech's implant systems including the IS-II active, IT-II active, EB-II active, and S-mini implants.
- Descriptions of the surgical kits, guides, prosthetic components, and digital solutions that accompany the implant systems.
Доклад на Пятой научно-практической конференции с международным участием «Основные тенденции в современной офтальмологии», организованной клиникой профессора Эскиной Э.Н. «Сфера», совместно с кафедрой офтальмологии ФГБОУ ДПО ИПК ФМБА России —→ http://www.sfe.ru/information/ophthalmology-news/conference2015.html
Premier IOL choices Technique & Decision Making do we really need femtosecond...presmedaustralia
This document discusses techniques for cataract surgery and considerations for improving patient outcomes and satisfaction. It recommends performing cataract surgery earlier based on symptoms to improve vision and quality of life. Achieving accurate refractive outcomes is emphasized through repeatable capsulorhexis, minimizing induced astigmatism, and using toric and multifocal IOLs. Sources of refractive surprise are examined. Markings and alignment of toric IOLs are covered. Stable lens position is important for predictable results. Multifocal IOLs are presented as an option for reducing glasses dependence.
This document provides tips for removing an acetabular cup during revision hip surgery. It discusses exposing the bone-prosthesis interface using adequate exposure of the acetabulum and circumferential reaming. It also covers removing the liner, screws, and shell. Finally, it mentions determining if the shell can be left in place or if augmentation devices can provide further constraint based on the Paprosky classification system and specific implant characteristics.
Depth perception allows humans to determine distance and is achieved through three means: the size of retinal images, moving parallax, and binocular vision. Stereopsis provides much greater depth perception for nearby objects but is useless beyond 50-200 feet. Eye movements include fixation, where the eyes bring an object into focus on the fovea, and saccades, where the eyes rapidly jump between objects in the visual field. Color vision is achieved through three types of cone cells sensitive to different wavelengths, allowing the perception of different colors.
The document discusses the anatomy and physiology of the retina. It describes the layers of the retina including the photoreceptor layer containing rods and cones. The fovea contains only cones which provide sharp, detailed central vision. Rhodopsin and color pigments in the photoreceptors absorb light and initiate a signaling cascade. The retina contains a high density of photoreceptors centrally which decreases peripherally. Adaptation mechanisms allow vision in varying light levels by adjusting photoreceptor sensitivity.
Keraring intracorneal ring segments are designed to treat keratoconus and other corneal ectatic disorders. They work by remodeling the cornea to regularize its surface and reduce refractive errors through addition techniques. Keraring comes in different sizes and thicknesses to customize treatment and provides long-term stabilization and improvement in vision. Extensive clinical use has demonstrated its safety and effectiveness for correcting refractive errors.
The document describes a new device called ZEPTO for performing cataract surgery capsulotomies. It uses precision-pulse technology to create an accurate, reproducible capsulotomy that is quick, safe, and affordable. The device applies suction and uses low-energy pulses to precisely cleave the lens capsule. Testing showed it created capsulotomies in rabbit and cadaver eyes without causing temperature increases in surrounding tissues. It was also shown to be safer for the zonules and create stronger capsule edges compared to the conventional capsulorhexis technique. The ZEPTO device aims to automate capsulotomies, reduce procedure time, improve centration, and lower costs.
Presentation from OIS@ASCRS 2016
John Hendrick, President & CEO
Video Presentation:
https://www.youtube.com/watch?v=c2J1g7HYuek&index=24&list=PL1dmdBNnPTZJBhQxPOp0vdNg3s3wtN2yw
This study evaluated the outcomes of MyoRing intracorneal implantation in 15 eyes of 15 patients with pellucid marginal degeneration (PMD). Following MyoRing implantation, uncorrected and best corrected visual acuity improved significantly, refractive errors were reduced, and keratometry values decreased. Patients reported low rates of visual symptoms and high satisfaction scores. The study demonstrated that MyoRing implantation via microkeratome is a safe and effective procedure for treating PMD.
Slides do curso avançado de atualização em implante de Anel de Ferrara, elaborado por Ferrara Ophtalmics. Para material completo, acesse www.aneldeferrara.com.br
The document describes the NeoGuideSystem for digital implant planning. It provides full digital workflow to quickly fabricate surgical guides for accurate, safe implant surgery. The system includes NeoGuide software for implant planning, surgical guides for guiding surgery, and a NeoGuide kit with drills and other tools. The full digital process takes only 5 days from scan to surgery. The system aims to provide faster, safer, and more accurate implant placement for patients, clinics, and dental labs.
The Ferrara Intrastromal Corneal Ring is a minimally invasive surgical option to treat ectatic corneal disorders like keratoconus. It improves the shape of the cornea, decreases astigmatism, and improves vision. The PMMA ring segments are inserted into the peripheral stroma, preserving the anterior corneal shape. A review of 340 patients found the procedure improved uncorrected and best corrected visual acuity for keratoconus grades 1 through 3. By 3 months post-op, patients achieved visual rehabilitation and refractive stability. Complications were low at 3-5% but higher for more advanced keratoconus.
The document describes the features and functions of the CEM-530 specular microscope from NIDEK, including its ability to capture 16 images within 2 seconds through an automated process. It can analyze the images fully automatically by tracing cell size, shape, and other parameters. The microscope also allows paracentral image capture to provide a wider field of observation and more accurate analysis, especially for conditions like post-surgery, corneal dystrophy, or keratoconus where pathology may not be at the corneal center. It compares the CEM-530 to other specular microscopes from Topcon and Tomey, noting advantages like faster analysis speed and larger monitor.
1) The document summarizes global experience with the Staar Surgical EVO Visian ICL and the evolution to the EVO+ Visian ICL for correcting myopia.
2) Over 1,400 EVO ICL implants were discussed, with follow up data on 306 patients showing high predictability, safety, and stability over 4 years.
3) The EVO+ ICL was developed with an increased optical zone while maintaining the same overall height, providing superior high definition quality vision without dry eye issues compared to LASIK. The ICL leaves the cornea and crystalline lens untouched for future vision correction options.
This document provides information on various dental implant components and tools that are compatible with different implant systems. It includes specifications and part numbers for titanium abutments, healing abutments, impression components, and surgical tools. The components are organized by connection type (conical or internal hex) and platform size (regular, narrow, slim). Product images and diagrams are also provided showing the features and dimensions.
The document discusses the AcrySof Toric IOL for correcting astigmatism during cataract surgery. It has three key features: 1) it is a single piece, foldable acrylic lens with axis marks to ensure proper alignment; 2) it has a blue light filter and is injected similar to conventional IOLs; 3) clinical studies show it has excellent rotational stability after implantation and is more effective at correcting astigmatism than spherical IOLs with limbal relaxing incisions.
The AL-Scan device performs a variety of eye scanning and measurement functions in a single, compact unit. It uses low coherence interferometry, dual keratometry, Scheimpflug imaging, and optional ultrasound to measure corneal thickness, anterior chamber depth, toric lens parameters, and more. Measurements can be automatically captured and printed or sent to a PC for further analysis.
Intrastromal corneal ring segments are devices used to correct mild to moderate myopia by flattening the cornea. They are inserted through a peripheral incision and come in various thicknesses to determine the degree of correction. Intrastromal corneal ring segments work by shortening the corneal cord length and producing flattening across the entire cornea. They are indicated for mild myopia up to -3.00 diopters with minimal astigmatism in patients over 21 with stable refraction, and can also be used to treat keratoconus and post-LASIK ectasia. Complications are generally rare and reversible.
The document is Neobiotech's 2015 product catalog. It includes:
- An introduction to Neobiotech's corporate philosophy and history of developing simpler, safer, and faster implant products.
- Details on Neobiotech's research and development facilities and production process.
- An overview of Neobiotech's implant systems including the IS-II active, IT-II active, EB-II active, and S-mini implants.
- Descriptions of the surgical kits, guides, prosthetic components, and digital solutions that accompany the implant systems.
Доклад на Пятой научно-практической конференции с международным участием «Основные тенденции в современной офтальмологии», организованной клиникой профессора Эскиной Э.Н. «Сфера», совместно с кафедрой офтальмологии ФГБОУ ДПО ИПК ФМБА России —→ http://www.sfe.ru/information/ophthalmology-news/conference2015.html
Premier IOL choices Technique & Decision Making do we really need femtosecond...presmedaustralia
This document discusses techniques for cataract surgery and considerations for improving patient outcomes and satisfaction. It recommends performing cataract surgery earlier based on symptoms to improve vision and quality of life. Achieving accurate refractive outcomes is emphasized through repeatable capsulorhexis, minimizing induced astigmatism, and using toric and multifocal IOLs. Sources of refractive surprise are examined. Markings and alignment of toric IOLs are covered. Stable lens position is important for predictable results. Multifocal IOLs are presented as an option for reducing glasses dependence.
This document provides tips for removing an acetabular cup during revision hip surgery. It discusses exposing the bone-prosthesis interface using adequate exposure of the acetabulum and circumferential reaming. It also covers removing the liner, screws, and shell. Finally, it mentions determining if the shell can be left in place or if augmentation devices can provide further constraint based on the Paprosky classification system and specific implant characteristics.
Depth perception allows humans to determine distance and is achieved through three means: the size of retinal images, moving parallax, and binocular vision. Stereopsis provides much greater depth perception for nearby objects but is useless beyond 50-200 feet. Eye movements include fixation, where the eyes bring an object into focus on the fovea, and saccades, where the eyes rapidly jump between objects in the visual field. Color vision is achieved through three types of cone cells sensitive to different wavelengths, allowing the perception of different colors.
The document discusses the anatomy and physiology of the retina. It describes the layers of the retina including the photoreceptor layer containing rods and cones. The fovea contains only cones which provide sharp, detailed central vision. Rhodopsin and color pigments in the photoreceptors absorb light and initiate a signaling cascade. The retina contains a high density of photoreceptors centrally which decreases peripherally. Adaptation mechanisms allow vision in varying light levels by adjusting photoreceptor sensitivity.
The visual system consists of the retina, optic nerve, optic chiasm, optic tract, lateral geniculate body, optic radiation, and visual cortex. Light signals from the eyes travel through these structures. At the optic chiasm, nerve fibers from the nasal retina cross to the opposite side, while temporal fibers remain on the same side. The fibers then synapse in the lateral geniculate nucleus before projecting to the primary visual cortex via the optic radiation. Specific lesions along this pathway can cause distinct visual field defects such as homonymous hemianopia.
The document describes the anatomy and function of the retina and visual pathway. It discusses the five major cell types in the retina - photoreceptors, horizontal cells, bipolar cells, amacrine cells, and ganglion cells - and their roles in transmitting visual signals from the eyes to the brain. It also explains how signals are processed as they move from the retina to the primary and secondary visual cortices, allowing for the perception of color, motion, depth, and form.
Motor physiology of extraocular muscles.
1) The document discusses the basic anatomy and physiology of the extraocular muscles, including definitions of eye movements, the actions of individual muscles, and laws governing ocular motility.
2) Key points covered include the center of rotation of the eye, cardinal movements like adduction and elevation, and terms like tangential point and muscle plane.
3) Laws of ocular motility such as Listing's law, Sherrington's law of reciprocal innervation, and Hering's law of equal innervation are explained in relation to eye muscle function.
4) Clinical testing for muscle weakness and restriction through passive duction is described.
The document discusses several key aspects of eye anatomy and function:
1) It describes the macula lutea, fovea centralis, and risks of macular degeneration.
2) It explains accommodation and how the lens and ciliary muscles work together to focus on near and far objects.
3) Accommodation decreases with age due to a stiffening lens, causing presbyopia.
Corneal topography provides a graphic representation of the geometrical properties of the corneal surface. It uses techniques such as Placido disk, photokeratoscopy, videokeratoscopy, and slit imaging to map over 8000 points across the corneal surface. This provides detailed information about the shape and irregularities of the cornea which can then be used to diagnose conditions that degrade vision and guide treatment.
This document discusses corneal topography, which refers to studying the shape of the corneal surface. Various techniques for corneal topography are described, including keratometry, keratoscopy, rasterstereography, and interferometry. Key corneal topography systems such as Placido disc topographers, slit imaging topographers, and laser holographic interferometry systems are summarized. The document also reviews display formats for topography data and clinical applications of corneal topography analysis.
Keratometers measure the radius of curvature of the central cornea using the principle of reflected light and angular size measurements. They utilize a doubling principle to measure the size of the reflected corneal image. Modern automated keratometers focus the corneal image electronically without the need for doubling. Keratometry is used to determine refractive power and monitor corneal shape changes.
This document discusses corneal topography, which is the examination and mapping of the shape and curvature of the cornea. It describes different techniques for measuring corneal topography including keratometry, photokeratoscopy, and videokeratography. It outlines the major regions of the cornea and indices used to characterize topography maps. Examples of topography patterns are shown for normal, astigmatic, and diseased corneas. Clinical applications of topography including refractive surgery planning and evaluation, contact lens fitting, and diagnosing corneal conditions are also summarized.
This document provides information about corneal topography and keratometry. It defines the cornea and its dimensions. It describes the historical evolution of keratometry from its first description in 1619 to modern computerized corneal topography systems. The document explains the principles, procedures, techniques, and applications of keratometry and corneal topography in evaluating the cornea. It also discusses the limitations and assumptions of keratometry measurements.
The document summarizes key structures and physiology of the eye. It describes the accessory structures like eyelids, lacrimal apparatus and extraocular muscles. It then details the three tunics that make up the eyeball: the fibrous tunic (sclera and cornea), vascular tunic (choroid, ciliary body and iris) and nervous tunic (retina). It explains the layers of the retina and how photoreceptors convert light to electrical signals via the ON-OFF bipolar cell mechanism. The summary provides an overview of the essential anatomy and physiology discussed in the document.
The document discusses the physiology of vision. It describes the main mechanisms of vision including light incidence, transduction, transmission of visual sensations, and visual perceptions. It then discusses the anatomy of the eye, including the cornea, lens, retina, and aberrations like spherical aberration. It also covers topics like accommodation, visual processing in the retina, visual pathway to the brain, and analysis in the primary and secondary visual cortices.
anatomy and physiology of lacrimal apparatus pptRohit Rao
This document summarizes key aspects of the lacrimal system including its embryology, anatomy, physiology and role in tear formation and drainage. It discusses the lacrimal gland, canaliculi, lacrimal sac, nasolacrimal duct and meibomian glands. It also describes the layers of the tear film - glycocalyx, mucous, aqueous and lipid layers - and their functions in lubricating and protecting the eye. The document is a comprehensive overview of the lacrimal system and tear film.
This document summarizes results from three studies comparing treatments for keratoconus: femtosecond laser-assisted circular keratotomy (FSCKT), corneal crosslinking (CXL), and iontophoresis-assisted corneal crosslinking (ICXL). FSCKT showed improvement in best-corrected visual acuity over 3 years with stable corneal thickness, keratometry, and ectasia values. CXL showed improvements in all outcomes over 5 years. ICXL results after 1 year were less clear, with no significant changes observed. The document concludes CXL may be most effective but longer-term ICXL data is needed, and direct comparative studies could improve comparisons between treatments.
Three-Years Results After Femtosecond Laser-Assisted Circular Keratotomy As a Treatment for Keratoconus Stages I-II:
Comparison with (Iontophoresis-Assisted) CXL, presented at ASCRS 2018 – by Detlev Breyer, H. Kaymak, K. Klabe, P. Hagen, T. Ax, F. Kretz, G. Auffarth
Presentation of Detlev Breyer (MD) at the ASCRS 2017 in Los Angeles. Title: Impact of increased PTA values on Visual Outcomes One Year after Refractive Lenticule Extraction (ReLEx) SMILE.
Five-Year Results of Small-Incision Lenticule Extraction Compared with Femtosecond Laser-Assisted LASIK, presented at ASCRS 2018 – by Detlev Breyer, H. Kaymak, K. Klabe, P. Hagen, T. Ax, F. Kretz, G. Auffarth
This document discusses various techniques for measuring eye dimensions needed for accurate intraocular lens (IOL) power calculations, including:
- Applanation A-scan, immersion A-scan, and immersion vector A/B-scan techniques
- Using the IOL Master, which utilizes partial coherence interferometry, to obtain highly precise measurements
- Factors that can affect IOL power calculations like axial length, corneal power, anterior chamber depth, prior refractive surgery, and placement of IOL in bag vs sulcus
- Recommendations for validating biometry measurements and identifying potential errors in IOL power calculations based on certain parameters outside of expected ranges.
This document presents a case study of a patient with branch retinal vein occlusion (BRVO) who was treated with multiple injections of Avastin and Ozurdex over 27 months. The study compares measurements from the patient's optical coherence tomography (OCT) scans, including central subfield thickness (CST), cube volume (CV), cube average thickness (CAT), and thickness in the superior 3mm and 6mm quadrants. It finds that changes in the superior 6mm quadrant measurement provided the greatest sensitivity in detecting progression or regression of intraretinal fluid, ranging 325 microns over the course of treatment, compared to smaller ranges of change for the other measurements. The study concludes that physicians should consider using OCT quadrant measurements in addition to C
Flexscore: Ensemble-based evaluation for protein Structure modelsPurdue University
Presentation at ISMB 2016 for the paper on Flexscore. Score for evaluating computational protein models by considering flexibility derived from NMR or molecular dynamics simluation. Paper published on Bioinformatics: http://www.ncbi.nlm.nih.gov/pubmed/27307633
by Kihara Lab http://kiharalab.org
SPECTRAL-BASED FATIGUE ASSESSMENT OF FSOSUMARDIONO .
The document discusses fatigue analysis of an offshore floating storage vessel (FSO) hull construction using spectral-based fatigue analysis methods. It outlines the objectives to determine long-term wave load characteristics, stress distributions, and fatigue life of critical locations. The methodology involves regular wave load analysis, finite element modeling, spectral analysis of long-term wave loads and stresses, and fatigue analysis to estimate the fatigue life. Critical locations on the hull are identified for further stress analysis and fatigue life estimation.
Centration of Hyperopic Corneal Ablations: Corneal Vertex vs. Pupil CenterLondon Vision Clinic
This study compared centering hyperopic corneal refractive surgery ablations on the corneal vertex versus the pupil center. The study included 60 eyes divided into groups with small or large angle kappa. All ablations were centered on the corneal vertex. The study found no significant differences in accuracy, safety, or night vision between groups. However, eyes with large angle kappa had significantly worse contrast sensitivity and increased coma and spherical aberration when measured at the pupil center, but not at the corneal vertex. The conclusion was that ablations should be centered on the corneal vertex rather than the pupil center.
The document discusses optimization of micro-machining processes. It outlines various micro-machining processes like electric discharge machining (EDM), abrasive water jet machining (AWJM), and micro-milling. It formulates optimization problems to maximize material removal rate and minimize surface roughness for EDM and to minimize taper angle and surface roughness for AWJM. Multi-cohort intelligence is proposed as an optimization technique and shown to find better solutions than genetic algorithm, simulated annealing, particle swarm optimization and other methods for the problems formulated. Tool-based micro-machining processes like micro-milling are also discussed for miniaturized manufacturing.
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Adaptive Aperture Commissioning Presentation at 57th PTCOG Minglei Kang
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The document discusses the stability and ease of manipulation of the Miniflex Toric intraocular lens. It notes that the lens has an anti-rotate system, haptic stress absorption cavity, step-vaulted haptic angulation, and self-centering double haptics that contribute to its stability. It also states that the lens can be safely rotated within 2 weeks after implantation if necessary, and demonstrates how to rotate the lens before and after insertion.
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
2. KC; Bilateral, Progressive, Non-inflammatory disease
Exact etiology is unknown
ICRS shown to be very effective
Keraring 355º, a new option for ring selection
Specifically designed for nipple type KC
3. BEHRC
Keratoconic &PMD
Patients
Baseline ophthalmology exam
Keraring 355º implantation
Analysis
•>20 years old
• Confirm diagnosis
• Min CT 360 μ
• Mean k 45 to 52 D
• UCVA ≤ 20/50
•Without h/o severe
ocular & systemic
pathologies
• hyperopia
To determine
efficacy and
safety of
Keraring 355º
implantation
for a 6 months
duration
1 day, 1,3 &6 months
4. The Bina Eye Hospital Research Center Study data set
contains information on 105 subjects with Keraring 355º
implantation
Patients with keratoconic eyes and pellucid marginal
degeneration cases that completed at least 6 months follow-up
were extracted
5. Keraring 355º ICR Dimension
spherical equivalent Diameter (mm) Thickness(μm)
< 6 D 5.7mm 200μm
> 6 D. 5.7mm 300μm
9. DEMOGRAPHIC DATA for KERATOCONUS PATIENTS
Number of Eyes 15
OD (%) 7 (46.7%)
OS (%) 8 (53.3%)
Sex
Male (%) 12 (80%)
Female (%) 3 (20%)
Age
Mean (SD) 27.87 (6.94)
Range 21-49
10. Preoperative 1 Months
Postoperatio
n
3 Months
Postoperatio
n
6 Months
Postoperatio
n
p-value
3 vs. pre p-value
6 vs. pre
p-value
6 vs. 3
UCVA
(LogMAR)
Mean (SD)
0.79 (0.48) 0.50 (0.26) 0.44 (0.25) 0.28 (0.15) 0.005** 0.001** 0.002**
BSCVA
(LogMAR)
Mean (SD) 0.36 (0.21) 0.34 (0.19) 0.29 (0.17) 0.18 (0.09) 0.19 0.009** 0.007**
Sphere (D)
Mean (SD) -2.38 (1.85) -0.33 (2.34) -0.62 (2.79) -0.25 (2.27) 0.052 0.019* 0.242
Cylinder (D)
Mean (SD) -4.27 (1.25) -2.18 (0.82) -1.78 (1.22) -1.88 (0.95) <0.001** <0.001** 0.714
SE (D)
Mean (SD) -5.46 (1.52) -2.35 (1.67) -2.09 (2.19) -2.01 (1.63) <0.001** <0.001** 0.822
11.
12.
13. Preoperative 6 Months
Postoperation
p-value
K.Max Value (D)
Mean (SD)
50.39 (2.14) 44.22 (2.17)
<0.001**
K.Min Value(D)
Mean (SD)
45.85 (1.94) 42.14 (2.53)
<0.001**
K.Mean Value (D)
Mean (SD)
48.11 (1.95) 43.31 (2.31)
<0.001**
15. Satisfaction Score
(N=15)
Frequency (%) Mean (SD)
No 0.0 (0.0%)
4.27 (1.16)
Very little 2.0 (13.3%)
Little 0.0 (0.0%)
Moderate 7.0 (46.7%)
Much 4.0 (26.7%)
Very much 2.0 (13.3%)
16.
17. Characteristic Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 Patient 6
Demographics
Sex Male Male Male Male Male female
Age,yr 21 36 29 30 40 33
Eye Os OD OS Os Os Os
Diagnosis PMD PMD PMD PMD PMD PMD
18. Characteristic Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 Patient 6
UCVA
Pre op. 0.05 0.1 0.05 0.3
1 M post op. 0.6 0.4 0.5 0.2
3 M post op. 0.7 0.7 0.6 0.4
6 M post op. 0.9 0.6 0.5 0.5
BCVA
Pre op. 0.5 0.3 0.6 0.6
1 M post op. 0.6 0.5 0.7 0.4
3 M post op. 0.7 0.8 0.7 0.7
6 M post op. 0.9 0.7 0.9 0.7
Sphere (D)
Pre op. -3.25 -2 -2 -2 -1
1 M post op. 0 0.5 1 -2 2
3 M post op. 1.5 1 2 1.5 1.5
6 M post op. 1.5 1.5 2 2 1.5
19. Cylinder (D)
Pre op. -2 -6 -3.25 -6 -4
1 M post op. -3 -1.5 -3 -3 -3.5
3 M post op. -2 -1 -2 -3 -3.5
6 M post op. -1 -1 -3 -3 -3
K.Max (D)
Pre op. 50.8 51 49.9 46.5 50.6
1 M post op. 39.8 39.2 40 37.8 41.6
3 M post op. 42.2 38.5 42.9 40.2 43.4
6 M post op. 44 37.3 43.3 40.6 43
K.Min(D)
Pre op. 47.7 45.1 46.7 38.7 44.7
1 M post op. 36 36.2 37.6 36.1 38.3
3 M post op. 38.9 37.2 39.7 36.6 40.1
6 M post op. 39.4 35.7 39.8 37.1 39.1
K.Mean (D)
Pre op. 49.1 48.5 48.3 46 47.6
1 M post op. 37.9 37.7 38.8 36.9 39.9
3 M post op. 40.5 37.8 41.3 38.4 41.7
6 mo postoperative 41.7 41.5 36.7 41.5 38.8 41
20. Satisfaction Score (N=6) Frequency (%) Median (25th,75th)
No 0.0 (0.0%)
3.5 (1.25,5.00)
Very little 2.0 (25.0%)
Little 1.0 (12.5%)
Moderate 1.0 (12.5%)
Much 1.0 (12.5%)
Very much 3.0(37.0%)
29. ICRS (KeraRing 355°) implantation appears to be an efficient
and minimally invasive procedure in keratoconic & PMD
patients .
Further follow-up and additional cases are needed to draw
final conclusions
30. Pocket better than tunnel
Location of incision adjust to steep meridian
Surgury must be performed in the operating room
especially with surgical microscope
Centralization of ring should be done with
keratoscope(not pupil centre)
Last but not least for beter astigmatism
correction make use of arcuate incision
31. Comparison between Myoring and Keraring 355° Implantation for treatment of
Keratoconus: A Randomised, Double-blind, Two Parallel-groups clinical trial
Clinical Outcomes After Keraring 355° Implantation in post-LASIK Corneal
Ectasia Using the pocket maker microkeratom Technology: one year follow-up
Comparison of manual and pocket maker surgical techniques
Clinical Outcomes After Keraring 355° Implantation in pellucid marginal
degeneration Using the pocket maker microkeratom Technology: one year follow-up
Modelling of intraocular lens power calculation after implantation of ICRS
Aberrometric Outcomes of Intrastromal Corneal Ring(KeraRing 355) in
Patients with Keratoconus