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God A fte o
  o      rnon
GUIDED BY:          PRESENTED BY:
Dr S.R.PANAT        SWATI SHARDA
Dr S.TALUKDAR       ROLL NO. 51
Dr PRASHANT GUPTA   4th batch
Dr PARAG AGARWAL
Dr SONAL
SEMINAR ON
       DISORDERS OF
   SALIVARY GLANDS.
CLASSIFICATION OF SALIVARY
GLAND DISORDERS
A) Developmental disorders
 Aberrancy
 Aplasia & Hypoplasia
 Hyperplasia
 Atresia
 Accessory ducts
 Diverticuli
 Congenital fistula
B) Functional disorders
  Sialorrhoea
  Xerostomia

C) Obstructive disorders
 Sialolithiasis
 Mucus plug
 Stricture & stenosis
 Foreign bodies
 Extra ductal causes
D) Cyst
 Mucocele
 Ranula

E) Asymptomatic enlargement
  Sialosis
  Allergic
  Associated with malnutrition and
  alcoholism
F) Infection
  Viral
  Bacterial
  Mycotic

G) Autoimmune disorders
 Sjogren’s syndrome
 Mikulicz’s disease
 Uveoparotid fever
 Recurrent non specific parotitis
Developmental anomalies
 Aberrant salivary glands
  An aberrant or ectopic is salivary gland
  tissue that develops at a site where it is not
  normally found.
 Clinical features
  Site – cervical region near the parotid gland
  or body of mandible.
 Posterior to first molar
  Clinical signifance
 Site for development of retention cyst or
  neoplasm
Aplasia & hypoplasia
It is congenitally absence of salivary gland.
  Aplasia occurs in combination with congenital
  anomalies.
  Hypoplasia in patient with Melkersen Rosenthal
  syndrome.
Clinical features
  One or group of glands missing unilaterally or
  bilaterally.
  Xerostomia
  Dental caries
  Early loss of teeth
  Dry & smooth oral mucosa
  Cracking & Fissuring at corner of mouth.
Management Good oral hygiene.
Hyperplasia
  Cause- Hormonal
           Metabolic
Clinical features
  Site minor salivary glands of palate.
  Asymptomatic when surface firm,sessile
  & normal in color.
Management
   Excision for microscopic examination.
Accesory ducts
Most common developmental anomoli.
  Site- superior and anterior to normal
 stenson’s duct orifice.

Atresia
 Congenital occlusion or absence of
  one or two major salivary gland ducts.
   Site- submandibular duct in floor of
  mouth.
   Causes severe xerostomia.
Diverticuli
   Small pouches or outpocketing of
  ductal system of one of the major
  salivary glands.



Congenital fistula
  Sinus tract form either in crease behind
 the pinna or in front of tragus.
 Management
 Complete surgical excision of sinus
 tract.
Functional disorders
Sialorrhoea or ptyalism
  It is increase salivary secretion.
  Stimulation of parasympathetic causes
  profuse secretion of watery saliva.

 Etiology
  Drugs like sialogogues
  Local factors ANUG,erythema multiforme
  Systemic like paralysis
  Misc. like metal poisoning
Clinical features
    Drooling from mouth
    Lip chapping
    Infection from constant exposure to saliva
    Cheek scarring.

Management
   Oral motor draining
   Biofeed
   Removal of local factors
   Anti cholinergic drugs (atropine sulphate
                        0.4 mg in adults
                       .01 mg / kg in children upto 0.4
  Surgery
Xerostomia
 Dryness of mouth.

Etiology
    Radiation induced
    Drug induced
     Nutritional
Clinical features
    Increase thirst                          Dry leathery tongue
    Difficulty in speech, swallowing & eating dry food
    Burning sensation
    Blurred vision
    Fissuring of tongue.
Management
     Preventive therapy
     Symptomatic treatment
     Topical salivary stimulation
     Systemic salivary stimulation
                 Bromhexiene 8mg T.D.S. adult
                              4mg B.D. children
Obstructive disorders
Sialolithiasis
  Salivary gland stone or salivary gland calculus within major &
   minor salivary gland.

Clinical features
   Site Submandibular 83%
        Parotid          10%
        Sublingual        7%
   Severe pain
   Swelling during meals
   Pus from duct orifice
   Inflammatory reaction to surrounding soft tissue
   Overlying mucosa may ulcerate along calculus to extend into
   oral floor
   Radiographically almost radio opaque, oval shape & with
   multiple layers of calcification, smooth borders.
Management
 Manual manipulation of stone within duct.
 If in submandibular duct then incision is made
 directly over it.
 If in gland then excision is done
 Antibiotics if acute infection is present.


Mucus plug
 Incompletely mineralized sialolithes.
Hard mass




            Minor salivary gland sialolith
Strictures & stenosis
Etiology
  Irritation
  Acute trauma
  Tumour
Types
  Papillary obstruction
  Duct obstruction
Management
  Saline rinses
  Salivary gland massage
  Ductoplasty
Foreign Bodies
  Tooth brush bristles
  Tooth picks
  Spikes of wheat
  Finger nails

Extraductal causes
  Muscle pressure
  Tumors
  Enlarged lymph nodes
 Denture flanges associated with the
 primary salivary duct.
Cysts of salivary gland
Mucocele
  Swelling caused by pooling of saliva at site of injured minor
  salivary gland.

Types
  Mucous extravasation cyst
  Mucous retention cyst

Clinical features
   Site inner aspect of lower lip, palate, cheek,tongue,floor of
   mouth.
   Painless swelling which is frequently recurrent develops at
   meal time and drains simultaneously at intervals.
   Shape round or oval & smooth.
   Consistency soft or hard depend upon tension of fluid.
Blue pigmented nodule     Exophytic lesion




Superficial vesicle like       Nodule
Management
 Complete excision of cyst under L.A.
 Injection steroid & cryosurgery.
Ranula
  It is used for the mucoceles occurring in the
  floor of the mouth in association with ducts of
  sub mandibular or sub lingual glands
Types
  Superficial
  Plunging

Clinical features
  Site – floor of mouth on side of frenum
  Unilateral bluish swelling
  Shape – spherical or dome shaped only top
  visible
Fluctuation & Transillumination –
  positive brilliantly translucent
  On aspiration – sticky clear fluid
  Slowly enlarging swelling on side of floor
  of big ranula may cause difficulty in
  speech or eating.
Plunging ranula
   when intra buccal ranula has cervical
  prolongation it is called deep or plunging
  ranula.
   It is located along post border of
  mylohyoid muscles in submandibular
  region.
Management

  Surgical excision including portion of
 surrounding tissue.
  Partial excision & marsupilization.
Blue pigmented swelling




       Ranula             Plunging Ranula
Viral Infections
Mumps
Contagious viral infection caused by para myxo virus

Clinical features
    Unilateral & bilateral swelling of salivary gland
    Fever, malaise, anorexia.
    Tender & pain on eating sore food
    Involved gland continues to enlarge for 2-3 days &
   comes back to normal.

Complication
oophritis, orchitis, meningitis, encephalitis.
Management
  Self limiting
  MMR vaccine
  Systemic corticosteroids
Unilateral                         Bilateral
             Parotid enlargement
Bacterial Infection
Acute bacterial sialadenitis (acute supprative parotitis)
Causes
Staph aureus
Staph viridans

Clinical features
    Site- unilateral involvement of parotid
    Fever
    Pain at angle of jaw
    Elevation of ear lobule
    Cervical lymphadenopathy


Management
  Oral hygiene
  Soft diet
  I.V. fluids
  Parentral antibodies active against pencillin resistence staphylococcus
  Surgical drainage of affected gland
Acute bacterial sialadenitis
Mycotic Infections
 Actinomycosis
 Cause
   A.Israliae
 Types
   Primary ascending canalicular
  inflammation. Infection penetrates
  from mouth into gland and affects it
  entirely.
  Secondary when transferred to
  gland from tissue surrounding, non
  tender, non fluctuant indurated lesion
  with formation of multiple fistulae with
  discharge of sulphur granules.
Autoimmune Disorders
   Sjorgen’s syndrome
Chronic inflammatory disease that
predominantly affects salivary, lacrimal &
other exocrine glands
It was first described by HENNIK SJOGREN
in 1933.
 Types
 primary – dry eyes, dry mouth.
 secondary – dry eyes , dry mouth ,
               collagen disorders
               usually rheumatoid
               arthritis & SLE.
Dry & Fissured Tongue



                        Benign Lymphoepithelial Lesion
Clinical Features
    Middle aged and female are commonly infected
    Xerostomia
    Soreness and difficulty in controlling dentures
    Pus from duct
    Difficulty in eating and unpleasant taste
    Unilateral and bilateral enlargement of parotid gland
    Frothy saliva
    Severe dental caries
    Depapillation of tongue
    Dry eyes
    Vaginal dryness
    Connective tissue disorder
    Enlargement of lymph nodes
Radiographic Findings
    Snow storm appearance
    In some cases cherry blossom appearance
MANAGEMENT
   SYMTOMATIC TREATMENT
    Occular lubricant- artificial tears coating methyl cellulose
    Saliva substitute
    Oral hygiene
    Surgery for enlargement of glands
MIKULICZ’S DISEASE
   Symmetric or bilateral chronic painless enlargement
   of lacrimal or salivary gland has inflammatory
   characteristics.
Clinical Features
    Women in middle and later life
   Site- unilateral or bilateral enlargement of parotid or
   submandibular gland
   Fever
   Upper respiratory tract infection
   Occasional pain
   Xerostomia
   Diffuse poorly outline and enlargement of gland

Management
  Surgical excision
Investigations
Non-invasive investigations
  Radiographs
  Computerized Tomography
  Ultrasound scanning
  Magnetic resonance imaging
  Single Photon emission Computed Tomography

Invasive Investigations
   Biopsy
   Fine needle Aspiration cytology

Sialography
SIALOGRAPHY
  “It is a specialized radiographic view of
  salivary gland taken by introduction of
  soluble contrast material into the ductal
  system.” The radiographs are called
  Sialographs.
Indications
  Detection of sialoliths, calculus, foreign
  bodies.
  Evaluation of extend of irreversible ductal
  damage.
  Detection/diagnosis of recurrent swelling &
  inflammatory process.
Evaluation of diverticula's, strictures and
 fistulae.
 Tumor location & size.
 Selection of a site for biopsy.
 Outline the plane of facial nerve.
 Residual stone/tumor, fistulae &
 stenosis.
Contraindications
 Acute infection of salivary gland.
 Allergic reaction to any radio opaque
 material to be used.
 Thyroid disorders.
Phases
  Filling phase
  Emptying phase
  Parenchyma phase

Agents used
Contrast media
X-ray film
Contrast media (Ideal requisites)
    Physiologic properties similar to saliva.
    Miscibility with saliva.
    Absence of systemic/local toxicity.
    Low surface tension & low viscosity.
    Easy elimination.
Types of contrast media
 Water soluble - Hyopaque
 Fat soluble - Lipidol

Sialographic appearance
  Normal
  Calculus
  Inflammation/blockage (Sialadenitis)
  Strictures
  Sjogren’s syndrome
  Tumors
Sialadenitis




Large calcified stone       Sjogren’s syndrome
T
H
A
N
K

Y
O
U

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Disorders of salivary glands

  • 1. God A fte o o rnon
  • 2. GUIDED BY: PRESENTED BY: Dr S.R.PANAT SWATI SHARDA Dr S.TALUKDAR ROLL NO. 51 Dr PRASHANT GUPTA 4th batch Dr PARAG AGARWAL Dr SONAL
  • 3. SEMINAR ON DISORDERS OF SALIVARY GLANDS.
  • 4. CLASSIFICATION OF SALIVARY GLAND DISORDERS A) Developmental disorders Aberrancy Aplasia & Hypoplasia Hyperplasia Atresia Accessory ducts Diverticuli Congenital fistula
  • 5. B) Functional disorders Sialorrhoea Xerostomia C) Obstructive disorders Sialolithiasis Mucus plug Stricture & stenosis Foreign bodies Extra ductal causes
  • 6. D) Cyst Mucocele Ranula E) Asymptomatic enlargement Sialosis Allergic Associated with malnutrition and alcoholism
  • 7. F) Infection Viral Bacterial Mycotic G) Autoimmune disorders Sjogren’s syndrome Mikulicz’s disease Uveoparotid fever Recurrent non specific parotitis
  • 8. Developmental anomalies Aberrant salivary glands An aberrant or ectopic is salivary gland tissue that develops at a site where it is not normally found. Clinical features Site – cervical region near the parotid gland or body of mandible. Posterior to first molar Clinical signifance Site for development of retention cyst or neoplasm
  • 9. Aplasia & hypoplasia It is congenitally absence of salivary gland. Aplasia occurs in combination with congenital anomalies. Hypoplasia in patient with Melkersen Rosenthal syndrome. Clinical features One or group of glands missing unilaterally or bilaterally. Xerostomia Dental caries Early loss of teeth Dry & smooth oral mucosa Cracking & Fissuring at corner of mouth. Management Good oral hygiene.
  • 10. Hyperplasia Cause- Hormonal Metabolic Clinical features Site minor salivary glands of palate. Asymptomatic when surface firm,sessile & normal in color. Management Excision for microscopic examination.
  • 11. Accesory ducts Most common developmental anomoli. Site- superior and anterior to normal stenson’s duct orifice. Atresia Congenital occlusion or absence of one or two major salivary gland ducts. Site- submandibular duct in floor of mouth. Causes severe xerostomia.
  • 12. Diverticuli Small pouches or outpocketing of ductal system of one of the major salivary glands. Congenital fistula Sinus tract form either in crease behind the pinna or in front of tragus. Management Complete surgical excision of sinus tract.
  • 13. Functional disorders Sialorrhoea or ptyalism It is increase salivary secretion. Stimulation of parasympathetic causes profuse secretion of watery saliva. Etiology Drugs like sialogogues Local factors ANUG,erythema multiforme Systemic like paralysis Misc. like metal poisoning
  • 14. Clinical features Drooling from mouth Lip chapping Infection from constant exposure to saliva Cheek scarring. Management Oral motor draining Biofeed Removal of local factors Anti cholinergic drugs (atropine sulphate 0.4 mg in adults .01 mg / kg in children upto 0.4 Surgery
  • 15. Xerostomia Dryness of mouth. Etiology Radiation induced Drug induced Nutritional Clinical features Increase thirst Dry leathery tongue Difficulty in speech, swallowing & eating dry food Burning sensation Blurred vision Fissuring of tongue. Management Preventive therapy Symptomatic treatment Topical salivary stimulation Systemic salivary stimulation Bromhexiene 8mg T.D.S. adult 4mg B.D. children
  • 16. Obstructive disorders Sialolithiasis Salivary gland stone or salivary gland calculus within major & minor salivary gland. Clinical features Site Submandibular 83% Parotid 10% Sublingual 7% Severe pain Swelling during meals Pus from duct orifice Inflammatory reaction to surrounding soft tissue Overlying mucosa may ulcerate along calculus to extend into oral floor Radiographically almost radio opaque, oval shape & with multiple layers of calcification, smooth borders.
  • 17. Management Manual manipulation of stone within duct. If in submandibular duct then incision is made directly over it. If in gland then excision is done Antibiotics if acute infection is present. Mucus plug Incompletely mineralized sialolithes.
  • 18. Hard mass Minor salivary gland sialolith
  • 19. Strictures & stenosis Etiology Irritation Acute trauma Tumour Types Papillary obstruction Duct obstruction Management Saline rinses Salivary gland massage Ductoplasty
  • 20. Foreign Bodies Tooth brush bristles Tooth picks Spikes of wheat Finger nails Extraductal causes Muscle pressure Tumors Enlarged lymph nodes Denture flanges associated with the primary salivary duct.
  • 21. Cysts of salivary gland Mucocele Swelling caused by pooling of saliva at site of injured minor salivary gland. Types Mucous extravasation cyst Mucous retention cyst Clinical features Site inner aspect of lower lip, palate, cheek,tongue,floor of mouth. Painless swelling which is frequently recurrent develops at meal time and drains simultaneously at intervals. Shape round or oval & smooth. Consistency soft or hard depend upon tension of fluid.
  • 22. Blue pigmented nodule Exophytic lesion Superficial vesicle like Nodule
  • 23. Management Complete excision of cyst under L.A. Injection steroid & cryosurgery.
  • 24. Ranula It is used for the mucoceles occurring in the floor of the mouth in association with ducts of sub mandibular or sub lingual glands Types Superficial Plunging Clinical features Site – floor of mouth on side of frenum Unilateral bluish swelling Shape – spherical or dome shaped only top visible
  • 25. Fluctuation & Transillumination – positive brilliantly translucent On aspiration – sticky clear fluid Slowly enlarging swelling on side of floor of big ranula may cause difficulty in speech or eating. Plunging ranula when intra buccal ranula has cervical prolongation it is called deep or plunging ranula. It is located along post border of mylohyoid muscles in submandibular region.
  • 26. Management Surgical excision including portion of surrounding tissue. Partial excision & marsupilization.
  • 27. Blue pigmented swelling Ranula Plunging Ranula
  • 28. Viral Infections Mumps Contagious viral infection caused by para myxo virus Clinical features Unilateral & bilateral swelling of salivary gland Fever, malaise, anorexia. Tender & pain on eating sore food Involved gland continues to enlarge for 2-3 days & comes back to normal. Complication oophritis, orchitis, meningitis, encephalitis. Management Self limiting MMR vaccine Systemic corticosteroids
  • 29. Unilateral Bilateral Parotid enlargement
  • 30. Bacterial Infection Acute bacterial sialadenitis (acute supprative parotitis) Causes Staph aureus Staph viridans Clinical features Site- unilateral involvement of parotid Fever Pain at angle of jaw Elevation of ear lobule Cervical lymphadenopathy Management Oral hygiene Soft diet I.V. fluids Parentral antibodies active against pencillin resistence staphylococcus Surgical drainage of affected gland
  • 32. Mycotic Infections Actinomycosis Cause A.Israliae Types Primary ascending canalicular inflammation. Infection penetrates from mouth into gland and affects it entirely. Secondary when transferred to gland from tissue surrounding, non tender, non fluctuant indurated lesion with formation of multiple fistulae with discharge of sulphur granules.
  • 33. Autoimmune Disorders Sjorgen’s syndrome Chronic inflammatory disease that predominantly affects salivary, lacrimal & other exocrine glands It was first described by HENNIK SJOGREN in 1933. Types primary – dry eyes, dry mouth. secondary – dry eyes , dry mouth , collagen disorders usually rheumatoid arthritis & SLE.
  • 34. Dry & Fissured Tongue Benign Lymphoepithelial Lesion
  • 35. Clinical Features Middle aged and female are commonly infected Xerostomia Soreness and difficulty in controlling dentures Pus from duct Difficulty in eating and unpleasant taste Unilateral and bilateral enlargement of parotid gland Frothy saliva Severe dental caries Depapillation of tongue Dry eyes Vaginal dryness Connective tissue disorder Enlargement of lymph nodes Radiographic Findings Snow storm appearance In some cases cherry blossom appearance MANAGEMENT SYMTOMATIC TREATMENT Occular lubricant- artificial tears coating methyl cellulose Saliva substitute Oral hygiene Surgery for enlargement of glands
  • 36. MIKULICZ’S DISEASE Symmetric or bilateral chronic painless enlargement of lacrimal or salivary gland has inflammatory characteristics. Clinical Features Women in middle and later life Site- unilateral or bilateral enlargement of parotid or submandibular gland Fever Upper respiratory tract infection Occasional pain Xerostomia Diffuse poorly outline and enlargement of gland Management Surgical excision
  • 37. Investigations Non-invasive investigations Radiographs Computerized Tomography Ultrasound scanning Magnetic resonance imaging Single Photon emission Computed Tomography Invasive Investigations Biopsy Fine needle Aspiration cytology Sialography
  • 38. SIALOGRAPHY “It is a specialized radiographic view of salivary gland taken by introduction of soluble contrast material into the ductal system.” The radiographs are called Sialographs. Indications Detection of sialoliths, calculus, foreign bodies. Evaluation of extend of irreversible ductal damage. Detection/diagnosis of recurrent swelling & inflammatory process.
  • 39. Evaluation of diverticula's, strictures and fistulae. Tumor location & size. Selection of a site for biopsy. Outline the plane of facial nerve. Residual stone/tumor, fistulae & stenosis. Contraindications Acute infection of salivary gland. Allergic reaction to any radio opaque material to be used. Thyroid disorders.
  • 40. Phases Filling phase Emptying phase Parenchyma phase Agents used Contrast media X-ray film Contrast media (Ideal requisites) Physiologic properties similar to saliva. Miscibility with saliva. Absence of systemic/local toxicity. Low surface tension & low viscosity. Easy elimination.
  • 41. Types of contrast media Water soluble - Hyopaque Fat soluble - Lipidol Sialographic appearance Normal Calculus Inflammation/blockage (Sialadenitis) Strictures Sjogren’s syndrome Tumors
  • 42. Sialadenitis Large calcified stone Sjogren’s syndrome