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Figure 16.1 The human digestive system
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 Functions of saliva
1. Ptyalin or salivary amylase at pH 7 hydrolyses starch and glycogen into maltose,
isomaltose and limit dextrins
2. Some maltose is hydrolysed into glucose by maltase
3. Mucus in saliva mixes with food and makes it soft and viscous to be easily masticated
by pm and m
4. With saliva the churned food forms a bolus to be swallowed easily. Bolus is the well-
chewed food that is made into a ball-like structure for swallowing in the buccal
cavity.
5. Saliva keeps the tongue and buccal cavity moist and helps in speaking
6. Enzyme polysaccharidase destroys bacteria
7. Bicarbonates, phosphates and mucin act as buffers and neutralise acids in food
8. Saliva helps in tasting of food
9. Lysozyme present in saliva acts as an antibacterial agent that prevents infections
10.Thiocyanate ions- [SCN]− act as an antimicrobial agent and prevent bacterial infection
22
23
duct of Wirsung
Dilated to form Vater’s
ampulla.
sphincter muscle of
Boyden
sphincter of
Oddi
24
25
26
27
28
All these secretions collectively form the gastric juice. Its daily
secretion is 2-3l per day. The pH of gastric juice is 1.2 to 1.8. HCl
forms 0.05-0.3% of gastric juice. Gastric juice secretion is stimulated
by the thought of food, smell of food, chewing of food and the contact
of food with the stomach wall.
Functions of HCl:
1. It softens the food and disinfects it by killing bacteria
2. It stops the action of salivary enzymes
3. It activates pepsinogen to pepsin and prorennin to rennin
4. It maintains the appropriate pH value of about 1.8 for protein digestion
5. It controls the function of Castle’s Intrinsic Factor
6. It controls the opening and closing of the pyloric sphincter
29
 INTESTINAL GLANDS
 Numerous, microscopic glands present in the mucosa of small intestine between the villi and these are of the
following types:
30
Secretion of intestinal glands is called
intestinal juice or succus entericus which is
alkaline with pH 7.8-8.3. About 2-3l of
intestinal juice is secretes per day
31
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34
35
36
37
38
39
40
41
42
43
44
45
46
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symbiotic bacteria like Escherichia coli and
residing in the human colon feed on protein contents of the chyle breaking them into
amino acids which are absorbed into the blood
colon bacteria also synthesise vitamins B and K. They convert bile into brown
pigments like stercobilin that give characteristic colour to the faeces.
48
49
50
51
Na+ is transported by simple diffusion and active transport. The absorption of Na+
is coupled with glucose molecule as a symport. Ca++, Mg++, Iron, K+ and PO43- are
taken in by active transport. Absorption of Ca++ is enhanced by vitamin D and
parathormone. Cl- may enter the mucosa by diffusion or active transport
All water soluble vitamins are absorbed by simple diffusion. B12 requires the
presence of Castle’s Intrinsic Factor for absorption.
Absorption of substances takes place in different parts of the alimentary canal,
like mouth, stomach, small intestine and large intestine
However, maximum absorption occurs in the small intestine
A summary of absorption (sites of absorption and substances absorbed) is given
in the table below:
52
53
The incorporation of absorbed food material into the tissue cells so
that it becomes an integral part of their cytoplasm and is used for
energy, growth and repair process is called assimilation
1. In the body cells fatty acids and glycerol in the form of chylomicrons are
again converted into fat which is stored in adipose tissue to be used again
when there is a metabolic need
2. The glucose formed after digestion is metabolised in every cell to release
energy for life processes. Extra glucose is converted to glycogen which is
stored in the liver and muscle cells. The stored glycogen is used under
conditions of stress
3. Amino acids are utilised by cells to synthesise various types of structural
proteins and enzymes. The excess amino acids are deaminated. Ammonia
released during deamination combines with CO2 to form urea and
eliminated through urine. The deaminated organic molecules of amino
acids are converted into glucose and then into fats for storage
54
55
56
57
SUBSTRATE CALORIC VALUE PHYSIOLOGICAL VALUE
1kcal=4.2kJ
4kcal=17kJ
9.5kcal=38kJ
CARBOHYDRATES 4.1kcal/g 4kcal/g
FATS 9.4kcal/g 9kcal/g
PROTEINS 5.6kcal/g 4kcal/g
58
59
60
61
PROTEIN DEFICIENCY DISEASE OR PROTEIN
ENERGY MALNUTRITION OR PROTEIN HYDRATE
MALNUTRITION(PEM)
KWASHIORKOR MARASMUS
62
63
64
65
66
67
68
69
70
71
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DIGESTION AND ABSORPTION 2022

  • 1. 1
  • 2. 2
  • 3. 3
  • 4. 4 Figure 16.1 The human digestive system
  • 5. 5
  • 6. 6
  • 7. 7
  • 8. 8
  • 9. 9
  • 10. 10
  • 11. 11
  • 12. 12
  • 13. 13
  • 14. 14
  • 15. 15
  • 16. 16
  • 17. 17
  • 18. 18
  • 19. 19
  • 20. 20
  • 21. 21  Functions of saliva 1. Ptyalin or salivary amylase at pH 7 hydrolyses starch and glycogen into maltose, isomaltose and limit dextrins 2. Some maltose is hydrolysed into glucose by maltase 3. Mucus in saliva mixes with food and makes it soft and viscous to be easily masticated by pm and m 4. With saliva the churned food forms a bolus to be swallowed easily. Bolus is the well- chewed food that is made into a ball-like structure for swallowing in the buccal cavity. 5. Saliva keeps the tongue and buccal cavity moist and helps in speaking 6. Enzyme polysaccharidase destroys bacteria 7. Bicarbonates, phosphates and mucin act as buffers and neutralise acids in food 8. Saliva helps in tasting of food 9. Lysozyme present in saliva acts as an antibacterial agent that prevents infections 10.Thiocyanate ions- [SCN]− act as an antimicrobial agent and prevent bacterial infection
  • 22. 22
  • 23. 23 duct of Wirsung Dilated to form Vater’s ampulla. sphincter muscle of Boyden sphincter of Oddi
  • 24. 24
  • 25. 25
  • 26. 26
  • 27. 27
  • 28. 28 All these secretions collectively form the gastric juice. Its daily secretion is 2-3l per day. The pH of gastric juice is 1.2 to 1.8. HCl forms 0.05-0.3% of gastric juice. Gastric juice secretion is stimulated by the thought of food, smell of food, chewing of food and the contact of food with the stomach wall. Functions of HCl: 1. It softens the food and disinfects it by killing bacteria 2. It stops the action of salivary enzymes 3. It activates pepsinogen to pepsin and prorennin to rennin 4. It maintains the appropriate pH value of about 1.8 for protein digestion 5. It controls the function of Castle’s Intrinsic Factor 6. It controls the opening and closing of the pyloric sphincter
  • 29. 29  INTESTINAL GLANDS  Numerous, microscopic glands present in the mucosa of small intestine between the villi and these are of the following types:
  • 30. 30 Secretion of intestinal glands is called intestinal juice or succus entericus which is alkaline with pH 7.8-8.3. About 2-3l of intestinal juice is secretes per day
  • 31. 31
  • 32. 32
  • 33. 33
  • 34. 34
  • 35. 35
  • 36. 36
  • 37. 37
  • 38. 38
  • 39. 39
  • 40. 40
  • 41. 41
  • 42. 42
  • 43. 43
  • 44. 44
  • 45. 45
  • 46. 46
  • 47. 47 symbiotic bacteria like Escherichia coli and residing in the human colon feed on protein contents of the chyle breaking them into amino acids which are absorbed into the blood colon bacteria also synthesise vitamins B and K. They convert bile into brown pigments like stercobilin that give characteristic colour to the faeces.
  • 48. 48
  • 49. 49
  • 50. 50
  • 51. 51 Na+ is transported by simple diffusion and active transport. The absorption of Na+ is coupled with glucose molecule as a symport. Ca++, Mg++, Iron, K+ and PO43- are taken in by active transport. Absorption of Ca++ is enhanced by vitamin D and parathormone. Cl- may enter the mucosa by diffusion or active transport All water soluble vitamins are absorbed by simple diffusion. B12 requires the presence of Castle’s Intrinsic Factor for absorption. Absorption of substances takes place in different parts of the alimentary canal, like mouth, stomach, small intestine and large intestine However, maximum absorption occurs in the small intestine A summary of absorption (sites of absorption and substances absorbed) is given in the table below:
  • 52. 52
  • 53. 53 The incorporation of absorbed food material into the tissue cells so that it becomes an integral part of their cytoplasm and is used for energy, growth and repair process is called assimilation 1. In the body cells fatty acids and glycerol in the form of chylomicrons are again converted into fat which is stored in adipose tissue to be used again when there is a metabolic need 2. The glucose formed after digestion is metabolised in every cell to release energy for life processes. Extra glucose is converted to glycogen which is stored in the liver and muscle cells. The stored glycogen is used under conditions of stress 3. Amino acids are utilised by cells to synthesise various types of structural proteins and enzymes. The excess amino acids are deaminated. Ammonia released during deamination combines with CO2 to form urea and eliminated through urine. The deaminated organic molecules of amino acids are converted into glucose and then into fats for storage
  • 54. 54
  • 55. 55
  • 56. 56
  • 57. 57
  • 58. SUBSTRATE CALORIC VALUE PHYSIOLOGICAL VALUE 1kcal=4.2kJ 4kcal=17kJ 9.5kcal=38kJ CARBOHYDRATES 4.1kcal/g 4kcal/g FATS 9.4kcal/g 9kcal/g PROTEINS 5.6kcal/g 4kcal/g 58
  • 59. 59
  • 60. 60
  • 61. 61
  • 62. PROTEIN DEFICIENCY DISEASE OR PROTEIN ENERGY MALNUTRITION OR PROTEIN HYDRATE MALNUTRITION(PEM) KWASHIORKOR MARASMUS 62
  • 63. 63
  • 64. 64
  • 65. 65
  • 66. 66
  • 67. 67
  • 68. 68
  • 69. 69
  • 70. 70
  • 71. 71
  • 72. 72
  • 73. 73