This is a presentation for the International Congress of Young Medical Scientists in Poznań.

1. Differential Diagnosis
of
Erythemato-Exfoliative
Skin Disorders
Wojciech Francuzik, Aleksandra Skłodowska
Tutor: Prof. Zygmunt Adamski
Student Scientific Working Group of Skin Diseases

2. The difficulties of diagnosing skin
disorders
?

4. What is it? Definetly not this!

5. Materials
Database form the UCI repository was used in
this study, with retrospective diagnosis of six
diseases:
Database consisted of 366 Patients
PR
Pityriasis rosea
P
Psoriasis
LP
Lichen planus
CD
Chronic dermatitis
SD
Seborrhoeic dermatitis
PRP
Pityriasis rubra pilaris
Source: http://archive.ics.uci.edu/ml/datasets/Dermatology

6. METHOD
Clinical Attributes:
1: erythema
2: scaling
3: definite borders
4: itching
5: koebner phenomenon
6: polygonal papules
7: follicular papules
8: oral mucosal involvement
9: knee and elbow involvement
10: scalp involvement
11: family history, (0 or 1)
34: Age (linear)

7. Histopathological Attributes:
12: melanin incontinence
13: eosinophils in the infiltrate
14: PNL infiltrate
15: fibrosis of the papillary dermis
16: exocytosis
17: acanthosis
18: hyperkeratosis
19: parakeratosis
20: clubbing of the rete ridges
21: elongation of the rete ridges
22: thinning of the suprapapillary epidermis
23: spongiform pustule
24: munro microabcess
25: focal hypergranulosis
26: disappearance of the granular layer
27: vacuolisation and damage of basal layer
28: spongiosis
29: saw-tooth appearance of retes
30: follicular horn plug
31: perifollicular parakeratosis
32: inflammatory monoluclear inflitrate
33: band-like infiltrate
METHOD

8. 0, 1, 2, 3
0 & 1

9. Statistical analysis
PR
P
LP
CD
SD
PRP
All othervs & Odds
Ratio

10. Algorithm preparation
PR
P
LP
CD
SD
PRP
Distinctive features
Algorithm design
Over 95% of correct diagnosis

11. Results
P
CD
PRP
Definite borders OR= ∞ (6,856 - ∞)
Thinning of the
suprapappilary epidermis OR= 3402 (527.161-30722.447)
Elongation of the rete ridges OR= ∞ (79,848 - ∞)
follicular papules OR= ∞ (90- ∞)
follicular horn plug OR= 2172,33 (185,951- 62594.677)
follicular parakeratosis OR= ∞ (513.304- ∞)
fibrosis of the papillary dermis OR= ∞ (908.579 - ∞)

12. Results
LP
SD
PR
Polygonal papules OR= ∞ (900,336- ∞)
Melanin incontinency OR= ∞ (∞ -1158,445)
Oral mucosa involvement OR= ∞ (614,1 - ∞)
Polygonal papules OR= 0
Knee and elbow involvement OR= 0 (0- 0,1)
Follicular papules OR= 0
Polygonal papules OR= 0
Clubbing of the rete ridges OR= 0
Saw tooth apparence OR= 0

15. Imperfections
• Unability to differentiate
properly between
Pityriasis rosea and
Seborrhoeic dermatitis

16. Results
LP
SD
PR
Polygonal papules OR= ∞ (900,336- ∞)
Melanin incontinency OR= ∞ (∞ -1158,445)
Oral mucosa involvement OR= ∞ (614,1 - ∞)
Polygonal papules OR= 0
Knee and elbow involvement OR= 0 (0- 0,1)
Follicular papules OR= 0
Polygonal papules OR= 0
Clubbing of the rete ridges OR= 0
Saw tooth apparence OR= 0

17. Results
LP
SD
PR
Polygonal papules OR= ∞ (900,336- ∞)
Melanin incontinency OR= ∞ (∞ -1158,445)
Oral mucosa involvement OR= ∞ (614,1 - ∞)
Polygonal papules OR= 0
Knee and elbow involvement OR= 0 (0- 0,1)
Follicular papules OR= 0
Polygonal papules OR= 0
Clubbing of the rete ridges OR= 0
Saw tooth apparence OR= 0
+ Herald Patch !!!

18. SPECIAL THANKS TO
DATA PROVIDERS:
Professor Nilsel Ilter, M.D, PhD.
Grazi University
Professor Altalay Guvenir PhD.
Bilkent University

19. Collaboration and Open Data Sharing