This document provides an overview of diabetes mellitus (DM), including its classification, pathophysiology, diagnosis, and types. It discusses:
1) DM is classified into type 1, type 2, and other types based on pathogenic processes leading to hyperglycemia. Type 1 is caused by autoimmune destruction of pancreatic beta cells leading to insulin deficiency. Type 2 is characterized by insulin resistance and impaired insulin secretion.
2) The pathogenesis of type 1 DM involves genetic susceptibility and environmental triggers activating an autoimmune response against beta cells. For type 2 DM, insulin resistance develops from genetic and lifestyle factors, impairing insulin secretion over time and resulting in hyperglycemia.
3) Diagnosis of DM is based on hem
Diabetes mellitus (DM) refers to a group of metabolic disorders characterized by hyperglycemia. The two main types are type 1 DM resulting from autoimmune destruction of pancreatic beta cells leading to insulin deficiency, and type 2 DM involving insulin resistance and impaired insulin secretion. DM prevalence has increased dramatically worldwide due to rising obesity and sedentary lifestyles. Precise classification, diagnosis, screening, pathogenesis, genetics, and treatment considerations vary depending on the specific type and cause of a patient's DM.
This document discusses diabetes mellitus (DM), including its classification, pathophysiology, and diagnosis. It describes the two main types of DM - type 1 resulting from autoimmune destruction of insulin-producing beta cells, and type 2 involving insulin resistance and impaired insulin secretion. Other types of DM exist that share features of type 1 and 2 or have distinct genetic causes. The classification of DM is based on the pathogenic processes leading to hyperglycemia. Precise diagnostic criteria exist involving hemoglobin A1c, fasting plasma glucose, and oral glucose tolerance tests.
This document discusses diabetes mellitus (DM). It defines DM and classifies it as type 1 or type 2. The pathogenesis of type 1 DM involves autoimmune destruction of pancreatic beta cells leading to insulin deficiency. Type 2 DM pathogenesis involves insulin resistance, abnormal insulin secretion, and various metabolic abnormalities such as lipid accumulation and inflammation in tissues. Both genetic and environmental factors contribute to the risk and development of both types of DM.
Diabetes Mellitus Types Diet Maintenance and Exerciseshama shabbir
The document discusses diabetes mellitus (DM), which is characterized by high blood glucose levels due to defects in insulin production or action. It describes the main types of DM - type 1, type 2, and gestational diabetes - and their causes and characteristics. The management of DM involves lifestyle modifications like diet and exercise as well as medication. Treatment may include oral anti-diabetic drugs or insulin, with the goal of maintaining normal blood glucose levels to prevent complications.
This document provides information on diabetes mellitus (DM), including its classification, differences between type 1 and type 2 DM, etiology, pathophysiology, and genetics. It discusses that DM is classified based on the pathogenic process causing hyperglycemia into type 1 and type 2. Type 1 DM results from beta cell destruction leading to insulin deficiency, while type 2 DM ranges from insulin resistance with relative deficiency to a secretory defect with resistance. The document outlines the etiology and pathophysiology of both types of DM in detail. It also addresses the genetic considerations for type 1 DM.
This document discusses the diagnosis and classification of diabetes mellitus. It defines diabetes as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion or action. The document then summarizes the main types of diabetes:
Type 1 diabetes results from autoimmune destruction of the beta cells of the pancreas leading to absolute insulin deficiency. Type 2 diabetes is much more prevalent and results from a combination of insulin resistance and inadequate insulin secretion in response. Other specific types of diabetes include genetic defects in beta cell function or insulin action, as well as diseases affecting the pancreas.
Diabetes mellitus is a clinical syndrome characterized by hyperglycemia due to insulin deficiency or resistance. It can be caused by genetic and environmental factors and leads to acute and chronic complications affecting metabolism and organ function if not properly managed. The main types are type 1 diabetes resulting from autoimmune destruction of pancreatic beta cells, and type 2 diabetes associated with obesity, genetic susceptibility, and aging. Diagnosis is based on symptoms and elevated blood glucose levels. Treatment involves lifestyle changes like diet and exercise as well as medication and insulin as needed.
Criterios de clasificacion de Diabetes ADAFiorella Lr
The document defines and classifies diabetes mellitus. It discusses that diabetes is characterized by hyperglycemia caused by defects in insulin secretion or action. There are two main types of diabetes - type 1 is caused by an absolute deficiency of insulin secretion, while type 2 is caused by a combination of insulin resistance and inadequate insulin secretion. The classification of diabetes depends on circumstances at diagnosis as some cases do not fit clearly into one type.
Diabetes mellitus (DM) refers to a group of metabolic disorders characterized by hyperglycemia. The two main types are type 1 DM resulting from autoimmune destruction of pancreatic beta cells leading to insulin deficiency, and type 2 DM involving insulin resistance and impaired insulin secretion. DM prevalence has increased dramatically worldwide due to rising obesity and sedentary lifestyles. Precise classification, diagnosis, screening, pathogenesis, genetics, and treatment considerations vary depending on the specific type and cause of a patient's DM.
This document discusses diabetes mellitus (DM), including its classification, pathophysiology, and diagnosis. It describes the two main types of DM - type 1 resulting from autoimmune destruction of insulin-producing beta cells, and type 2 involving insulin resistance and impaired insulin secretion. Other types of DM exist that share features of type 1 and 2 or have distinct genetic causes. The classification of DM is based on the pathogenic processes leading to hyperglycemia. Precise diagnostic criteria exist involving hemoglobin A1c, fasting plasma glucose, and oral glucose tolerance tests.
This document discusses diabetes mellitus (DM). It defines DM and classifies it as type 1 or type 2. The pathogenesis of type 1 DM involves autoimmune destruction of pancreatic beta cells leading to insulin deficiency. Type 2 DM pathogenesis involves insulin resistance, abnormal insulin secretion, and various metabolic abnormalities such as lipid accumulation and inflammation in tissues. Both genetic and environmental factors contribute to the risk and development of both types of DM.
Diabetes Mellitus Types Diet Maintenance and Exerciseshama shabbir
The document discusses diabetes mellitus (DM), which is characterized by high blood glucose levels due to defects in insulin production or action. It describes the main types of DM - type 1, type 2, and gestational diabetes - and their causes and characteristics. The management of DM involves lifestyle modifications like diet and exercise as well as medication. Treatment may include oral anti-diabetic drugs or insulin, with the goal of maintaining normal blood glucose levels to prevent complications.
This document provides information on diabetes mellitus (DM), including its classification, differences between type 1 and type 2 DM, etiology, pathophysiology, and genetics. It discusses that DM is classified based on the pathogenic process causing hyperglycemia into type 1 and type 2. Type 1 DM results from beta cell destruction leading to insulin deficiency, while type 2 DM ranges from insulin resistance with relative deficiency to a secretory defect with resistance. The document outlines the etiology and pathophysiology of both types of DM in detail. It also addresses the genetic considerations for type 1 DM.
This document discusses the diagnosis and classification of diabetes mellitus. It defines diabetes as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion or action. The document then summarizes the main types of diabetes:
Type 1 diabetes results from autoimmune destruction of the beta cells of the pancreas leading to absolute insulin deficiency. Type 2 diabetes is much more prevalent and results from a combination of insulin resistance and inadequate insulin secretion in response. Other specific types of diabetes include genetic defects in beta cell function or insulin action, as well as diseases affecting the pancreas.
Diabetes mellitus is a clinical syndrome characterized by hyperglycemia due to insulin deficiency or resistance. It can be caused by genetic and environmental factors and leads to acute and chronic complications affecting metabolism and organ function if not properly managed. The main types are type 1 diabetes resulting from autoimmune destruction of pancreatic beta cells, and type 2 diabetes associated with obesity, genetic susceptibility, and aging. Diagnosis is based on symptoms and elevated blood glucose levels. Treatment involves lifestyle changes like diet and exercise as well as medication and insulin as needed.
Criterios de clasificacion de Diabetes ADAFiorella Lr
The document defines and classifies diabetes mellitus. It discusses that diabetes is characterized by hyperglycemia caused by defects in insulin secretion or action. There are two main types of diabetes - type 1 is caused by an absolute deficiency of insulin secretion, while type 2 is caused by a combination of insulin resistance and inadequate insulin secretion. The classification of diabetes depends on circumstances at diagnosis as some cases do not fit clearly into one type.
This document summarizes diabetes mellitus (DM), including its main types, causes, classification, prevalence, and complications. DM refers to high blood glucose caused by issues with insulin secretion or insulin resistance. It is classified into type 1 DM (caused by lack of insulin) and type 2 DM (caused by insulin resistance and relative lack of insulin). DM is a leading cause of kidney failure, lower limb amputations, blindness and cardiovascular disease. Its prevalence has greatly increased worldwide in recent decades.
This document defines and classifies diabetes mellitus. It states that diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion or action. It then discusses the two main categories of diabetes: type 1 diabetes, caused by an absolute deficiency of insulin secretion, and type 2 diabetes, caused by a combination of insulin resistance and inadequate insulin secretion. Within these categories it further describes immune-mediated type 1 diabetes, idiopathic type 1 diabetes without autoimmunity, and the range of abnormalities seen in type 2 diabetes from predominant insulin resistance to predominant insulin secretory defect.
This document provides definitions and descriptions of diabetes mellitus and its classification. It states that diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion or action. The main types of diabetes are type 1, resulting from autoimmune destruction of beta cells leading to insulin deficiency, and type 2, caused by a combination of insulin resistance and inadequate compensatory insulin secretion. The classification of diabetes depends on circumstances at diagnosis as some cases do not fit clearly into one type or another.
This document discusses diabetes mellitus (DM), including defining DM, classifying its different types, explaining their pathogenesis and clinical presentation, listing common complications, and outlining management approaches. DM results from defects in insulin production/action leading to high blood glucose. The main types are type 1 (autoimmune beta cell destruction), type 2 (insulin resistance/deficiency), and gestational diabetes (during pregnancy). Complications can be acute or chronic, affecting eyes, kidneys, nerves, heart, etc. Treatment involves lifestyle changes, medications like insulin and oral drugs, glucose monitoring, and managing complications.
This document provides information about diabetes mellitus (DM). It defines DM as a group of diseases characterized by high blood glucose levels due to defects in insulin production or action. DM can cause long-term damage to organs and present with symptoms like excessive thirst and weight loss. There are different types of DM including type 1, type 2, and gestational diabetes. The treatment of DM involves lifestyle modifications like diet and exercise as well as medication like oral hypoglycemic agents or insulin. Diet and physical activity are essential for managing blood glucose levels and preventing complications of DM.
This document provides an overview of diabetes mellitus, including its definition, classification, clinical findings, diagnosis, prevalence, pathogenesis, treatment, and complications. It defines diabetes as a metabolic disorder resulting from either insufficient insulin production or ineffective insulin. There are several types of diabetes, including type 1, type 2, gestational diabetes, and other specific types. The diagnosis of diabetes is based on fasting plasma glucose levels, oral glucose tolerance tests, or symptoms and random plasma glucose. Diabetes prevalence is increasing worldwide and poses a major health burden.
This document provides an overview of childhood diabetes mellitus (DM). It discusses the classification, etiology, pathogenesis, clinical presentation, and natural history of the various types of childhood DM. The main types covered are type 1 DM (T1DM), which results from autoimmune destruction of beta cells, and maturity-onset diabetes of the young (MODY), which has a genetic cause. Risk factors for T1DM development include genetic susceptibility, particularly HLA alleles, as well as environmental triggers like certain viral infections. The disease progresses through stages from autoimmunity to near-complete beta cell loss and clinical presentation of hyperglycemia.
Diabetes mellitus is a group of metabolic diseases characterized by high blood glucose levels resulting from defects in insulin production or insulin action. The main types are type 1 diabetes, type 2 diabetes, and gestational diabetes. The long-term complications of diabetes include damage to various organs such as the eyes, kidneys, nerves, and heart. Management of diabetes focuses on lifestyle modifications like diet and exercise as well as medication including oral hypoglycemic drugs and insulin therapy to control blood glucose levels and minimize health risks.
Dr. Zeenat Hussain Foundation is working to create awareness against diseases like diabetes among the common people of Pakistan. This lecture is part of their campaign. The lecture discusses diabetes, including the different types of diabetes, symptoms, complications, diagnosis, management through lifestyle changes and medications, and prevention. Feedback from attendees is appreciated to help improve awareness efforts.
Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar levels resulting from defects in insulin production, insulin action, or both. The main types are type 1 diabetes, type 2 diabetes, gestational diabetes, and other specific types. The long-term complications of diabetes include damage to various organs including the eyes, kidneys, nerves, and blood vessels. Lifestyle changes and medications are used to manage diabetes and prevent associated health problems.
The document discusses diabetes mellitus (DM), which is characterized by high blood glucose levels due to defects in insulin production or action. There are two main types of DM: Type 1 is an autoimmune disease where the body destroys insulin-producing cells, while Type 2 is associated with obesity and aging and results from insulin resistance and relative insulin deficiency. Gestational diabetes occurs during pregnancy and increases risk of future Type 2 DM. Other types include genetic disorders. The prevalence of DM, especially Type 2, is increasing worldwide due to rising obesity and physical inactivity.
Diabetes mellitus (DM) is a group of diseases characterized by high levels of blood glucose resulting from defects in insulin production, insulin action, or both.
The term diabetes mellitus describes a metabolic disorder of multiple aetiology characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.
The effects of diabetes mellitus include long–term damage, dysfunction and failure of various organs.
The document discusses diabetes mellitus (DM), including its types and management. DM is characterized by high blood glucose levels due to defects in insulin production or action. The main types are type 1 DM resulting from autoimmune destruction of insulin-producing cells, type 2 DM associated with insulin resistance, and gestational DM occurring during pregnancy. Lifestyle changes including diet and exercise, as well as medication, are used to manage blood glucose levels and prevent complications of DM such as damage to organs and tissues.
Unit 2_Classif and Pathoge. of DM2.pptxImanuIliyas
This document provides an overview of the classification and pathogenesis of diabetes mellitus. It begins by outlining the learning objectives, which are to classify diabetes based on pathogenesis, describe the role of the endocrine pancreas in glucose homeostasis, and understand the pathogenesis of types 1 and 2 diabetes. It then discusses glucose regulation by hormones like insulin and the role of the pancreatic islets and beta cells in secreting insulin. The document classifies diabetes into four main types - type 1, type 2, gestational diabetes, and specific types - based on etiology. It provides details on the autoimmune pathogenesis of type 1 diabetes and the roles of genetic and environmental factors. For type 2 diabetes, it describes the pathogenesis as involving insulin resistance,
This document provides information on diabetes mellitus (DM), including the different types of DM, symptoms, complications, risk factors, management, and treatment options. It discusses the key types of DM: type 1 DM resulting from beta cell destruction leading to insulin deficiency; type 2 DM associated with insulin resistance and relative insulin deficiency; and gestational DM occurring during pregnancy. Lifestyle changes including diet and exercise are the first approach to managing all types of DM, along with medications such as oral hypoglycemics and insulin therapy. The goal of treatment is to maintain blood glucose as close to normal levels as possible to prevent complications and control symptoms.
Diabetes Mellitus type 1 major comorbidity now days.
Insulin injection being the major treatment Diabetes Mellitus.
Some other drugs used to treat the Diabetes Mellitus are Tablet Metformin 500 mg and other hypoglycemic drugs.
Diabetes Mellitus and Hypertension how they are interlinked.
This document discusses diabetes mellitus (DM), including its causes, types, management, and treatment. It defines DM as a group of metabolic diseases characterized by high blood glucose levels resulting from defects in insulin production or insulin action. The document outlines the main types of DM: type 1, type 2, gestational diabetes, and other rare forms. It then discusses the management of DM through diet, exercise, oral medications, and insulin therapy. Guidelines are provided for lifestyle modifications and treatment options based on the type and severity of a patient's DM.
This document discusses different types of diabetes mellitus. It describes the three main types: type 1 diabetes which results from failure to produce insulin; type 2 diabetes which results from insulin resistance; and gestational diabetes which occurs during pregnancy. It provides details on symptoms, causes, treatment and prevalence of each type. Other less common forms are also mentioned. The document emphasizes the importance of proper treatment and control of diabetes to prevent complications.
The document discusses diabetes mellitus and provides details about the endocrine pancreas. It defines diabetes as a metabolic disorder characterized by chronic hyperglycemia. The endocrine pancreas consists of islets of Langerhans containing beta cells that secrete insulin, alpha cells that secrete glucagon, and other minor cell types. The document classifies diabetes into type 1, type 2, and gestational diabetes and describes the pathogenesis of type 1 and type 2 diabetes.
This document discusses diabetes mellitus, including its diagnosis, types, complications, management, and treatment. It defines diabetes as a chronic disorder resulting from insulin deficiency or abnormal insulin function. There are three main types - type 1 caused by autoimmune destruction of beta cells, type 2 often associated with obesity and aging, and gestational diabetes during pregnancy. Complications arise from long-term hyperglycemia and include damage to various organs. Management involves dietary changes, physical activity, medication including insulin when needed, and treating complications.
This tutorial offers a step-by-step guide on how to effectively use Pinterest. It covers the basics such as account creation and navigation, as well as advanced techniques including creating eye-catching pins and optimizing your profile. The tutorial also explores collaboration and networking on the platform. With visual illustrations and clear instructions, this tutorial will equip you with the skills to navigate Pinterest confidently and achieve your goals.
This document summarizes diabetes mellitus (DM), including its main types, causes, classification, prevalence, and complications. DM refers to high blood glucose caused by issues with insulin secretion or insulin resistance. It is classified into type 1 DM (caused by lack of insulin) and type 2 DM (caused by insulin resistance and relative lack of insulin). DM is a leading cause of kidney failure, lower limb amputations, blindness and cardiovascular disease. Its prevalence has greatly increased worldwide in recent decades.
This document defines and classifies diabetes mellitus. It states that diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion or action. It then discusses the two main categories of diabetes: type 1 diabetes, caused by an absolute deficiency of insulin secretion, and type 2 diabetes, caused by a combination of insulin resistance and inadequate insulin secretion. Within these categories it further describes immune-mediated type 1 diabetes, idiopathic type 1 diabetes without autoimmunity, and the range of abnormalities seen in type 2 diabetes from predominant insulin resistance to predominant insulin secretory defect.
This document provides definitions and descriptions of diabetes mellitus and its classification. It states that diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion or action. The main types of diabetes are type 1, resulting from autoimmune destruction of beta cells leading to insulin deficiency, and type 2, caused by a combination of insulin resistance and inadequate compensatory insulin secretion. The classification of diabetes depends on circumstances at diagnosis as some cases do not fit clearly into one type or another.
This document discusses diabetes mellitus (DM), including defining DM, classifying its different types, explaining their pathogenesis and clinical presentation, listing common complications, and outlining management approaches. DM results from defects in insulin production/action leading to high blood glucose. The main types are type 1 (autoimmune beta cell destruction), type 2 (insulin resistance/deficiency), and gestational diabetes (during pregnancy). Complications can be acute or chronic, affecting eyes, kidneys, nerves, heart, etc. Treatment involves lifestyle changes, medications like insulin and oral drugs, glucose monitoring, and managing complications.
This document provides information about diabetes mellitus (DM). It defines DM as a group of diseases characterized by high blood glucose levels due to defects in insulin production or action. DM can cause long-term damage to organs and present with symptoms like excessive thirst and weight loss. There are different types of DM including type 1, type 2, and gestational diabetes. The treatment of DM involves lifestyle modifications like diet and exercise as well as medication like oral hypoglycemic agents or insulin. Diet and physical activity are essential for managing blood glucose levels and preventing complications of DM.
This document provides an overview of diabetes mellitus, including its definition, classification, clinical findings, diagnosis, prevalence, pathogenesis, treatment, and complications. It defines diabetes as a metabolic disorder resulting from either insufficient insulin production or ineffective insulin. There are several types of diabetes, including type 1, type 2, gestational diabetes, and other specific types. The diagnosis of diabetes is based on fasting plasma glucose levels, oral glucose tolerance tests, or symptoms and random plasma glucose. Diabetes prevalence is increasing worldwide and poses a major health burden.
This document provides an overview of childhood diabetes mellitus (DM). It discusses the classification, etiology, pathogenesis, clinical presentation, and natural history of the various types of childhood DM. The main types covered are type 1 DM (T1DM), which results from autoimmune destruction of beta cells, and maturity-onset diabetes of the young (MODY), which has a genetic cause. Risk factors for T1DM development include genetic susceptibility, particularly HLA alleles, as well as environmental triggers like certain viral infections. The disease progresses through stages from autoimmunity to near-complete beta cell loss and clinical presentation of hyperglycemia.
Diabetes mellitus is a group of metabolic diseases characterized by high blood glucose levels resulting from defects in insulin production or insulin action. The main types are type 1 diabetes, type 2 diabetes, and gestational diabetes. The long-term complications of diabetes include damage to various organs such as the eyes, kidneys, nerves, and heart. Management of diabetes focuses on lifestyle modifications like diet and exercise as well as medication including oral hypoglycemic drugs and insulin therapy to control blood glucose levels and minimize health risks.
Dr. Zeenat Hussain Foundation is working to create awareness against diseases like diabetes among the common people of Pakistan. This lecture is part of their campaign. The lecture discusses diabetes, including the different types of diabetes, symptoms, complications, diagnosis, management through lifestyle changes and medications, and prevention. Feedback from attendees is appreciated to help improve awareness efforts.
Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar levels resulting from defects in insulin production, insulin action, or both. The main types are type 1 diabetes, type 2 diabetes, gestational diabetes, and other specific types. The long-term complications of diabetes include damage to various organs including the eyes, kidneys, nerves, and blood vessels. Lifestyle changes and medications are used to manage diabetes and prevent associated health problems.
The document discusses diabetes mellitus (DM), which is characterized by high blood glucose levels due to defects in insulin production or action. There are two main types of DM: Type 1 is an autoimmune disease where the body destroys insulin-producing cells, while Type 2 is associated with obesity and aging and results from insulin resistance and relative insulin deficiency. Gestational diabetes occurs during pregnancy and increases risk of future Type 2 DM. Other types include genetic disorders. The prevalence of DM, especially Type 2, is increasing worldwide due to rising obesity and physical inactivity.
Diabetes mellitus (DM) is a group of diseases characterized by high levels of blood glucose resulting from defects in insulin production, insulin action, or both.
The term diabetes mellitus describes a metabolic disorder of multiple aetiology characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.
The effects of diabetes mellitus include long–term damage, dysfunction and failure of various organs.
The document discusses diabetes mellitus (DM), including its types and management. DM is characterized by high blood glucose levels due to defects in insulin production or action. The main types are type 1 DM resulting from autoimmune destruction of insulin-producing cells, type 2 DM associated with insulin resistance, and gestational DM occurring during pregnancy. Lifestyle changes including diet and exercise, as well as medication, are used to manage blood glucose levels and prevent complications of DM such as damage to organs and tissues.
Unit 2_Classif and Pathoge. of DM2.pptxImanuIliyas
This document provides an overview of the classification and pathogenesis of diabetes mellitus. It begins by outlining the learning objectives, which are to classify diabetes based on pathogenesis, describe the role of the endocrine pancreas in glucose homeostasis, and understand the pathogenesis of types 1 and 2 diabetes. It then discusses glucose regulation by hormones like insulin and the role of the pancreatic islets and beta cells in secreting insulin. The document classifies diabetes into four main types - type 1, type 2, gestational diabetes, and specific types - based on etiology. It provides details on the autoimmune pathogenesis of type 1 diabetes and the roles of genetic and environmental factors. For type 2 diabetes, it describes the pathogenesis as involving insulin resistance,
This document provides information on diabetes mellitus (DM), including the different types of DM, symptoms, complications, risk factors, management, and treatment options. It discusses the key types of DM: type 1 DM resulting from beta cell destruction leading to insulin deficiency; type 2 DM associated with insulin resistance and relative insulin deficiency; and gestational DM occurring during pregnancy. Lifestyle changes including diet and exercise are the first approach to managing all types of DM, along with medications such as oral hypoglycemics and insulin therapy. The goal of treatment is to maintain blood glucose as close to normal levels as possible to prevent complications and control symptoms.
Diabetes Mellitus type 1 major comorbidity now days.
Insulin injection being the major treatment Diabetes Mellitus.
Some other drugs used to treat the Diabetes Mellitus are Tablet Metformin 500 mg and other hypoglycemic drugs.
Diabetes Mellitus and Hypertension how they are interlinked.
This document discusses diabetes mellitus (DM), including its causes, types, management, and treatment. It defines DM as a group of metabolic diseases characterized by high blood glucose levels resulting from defects in insulin production or insulin action. The document outlines the main types of DM: type 1, type 2, gestational diabetes, and other rare forms. It then discusses the management of DM through diet, exercise, oral medications, and insulin therapy. Guidelines are provided for lifestyle modifications and treatment options based on the type and severity of a patient's DM.
This document discusses different types of diabetes mellitus. It describes the three main types: type 1 diabetes which results from failure to produce insulin; type 2 diabetes which results from insulin resistance; and gestational diabetes which occurs during pregnancy. It provides details on symptoms, causes, treatment and prevalence of each type. Other less common forms are also mentioned. The document emphasizes the importance of proper treatment and control of diabetes to prevent complications.
The document discusses diabetes mellitus and provides details about the endocrine pancreas. It defines diabetes as a metabolic disorder characterized by chronic hyperglycemia. The endocrine pancreas consists of islets of Langerhans containing beta cells that secrete insulin, alpha cells that secrete glucagon, and other minor cell types. The document classifies diabetes into type 1, type 2, and gestational diabetes and describes the pathogenesis of type 1 and type 2 diabetes.
This document discusses diabetes mellitus, including its diagnosis, types, complications, management, and treatment. It defines diabetes as a chronic disorder resulting from insulin deficiency or abnormal insulin function. There are three main types - type 1 caused by autoimmune destruction of beta cells, type 2 often associated with obesity and aging, and gestational diabetes during pregnancy. Complications arise from long-term hyperglycemia and include damage to various organs. Management involves dietary changes, physical activity, medication including insulin when needed, and treating complications.
This tutorial offers a step-by-step guide on how to effectively use Pinterest. It covers the basics such as account creation and navigation, as well as advanced techniques including creating eye-catching pins and optimizing your profile. The tutorial also explores collaboration and networking on the platform. With visual illustrations and clear instructions, this tutorial will equip you with the skills to navigate Pinterest confidently and achieve your goals.
The cherry: beauty, softness, its heart-shaped plastic has inspired artists since Antiquity. Cherries and strawberries were considered the fruits of paradise and thus represented the souls of men.
This document announces the winners of the 2024 Youth Poster Contest organized by MATFORCE. It lists the grand prize and age category winners for grades K-6, 7-12, and individual age groups from 5 years old to 18 years old.
Boudoir photography, a genre that captures intimate and sensual images of individuals, has experienced significant transformation over the years, particularly in New York City (NYC). Known for its diversity and vibrant arts scene, NYC has been a hub for the evolution of various art forms, including boudoir photography. This article delves into the historical background, cultural significance, technological advancements, and the contemporary landscape of boudoir photography in NYC.
Hadj Ounis's most notable work is his sculpture titled "Metamorphosis." This piece showcases Ounis's mastery of form and texture, as he seamlessly combines metal and wood to create a dynamic and visually striking composition. The juxtaposition of the two materials creates a sense of tension and harmony, inviting viewers to contemplate the relationship between nature and industry.
2. Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the
phenotype of hyperglycemia.
Several distinct types of DM are caused by a complex interaction of genetics and
environmental factors.
Depending on the etiology of the DM, factors contributing to hyperglycemia include
reduced insulin secretion, decreased glucose utilization, and increased glucose
production.
The metabolic dysregulation associated with DM causes secondary pathophysiologic
changes in multiple organ systems that impose a tremendous burden on the individual
with diabetes and on the health care system.
3.
4. In the United States, DM is the leading cause of end-stage renal disease (ESRD),
nontraumatic lower extremity amputations, and adult blindness. It also predisposes
to CVD.
With an increasing incidence worldwide, DM will be likely a leading cause of morbidity
and mortality in the future.
5. CLASSIFICATION
DM is classified on the basis of the pathogenic process that leads to hyperglycemia, as
opposed to earlier criteria such as age of onset or type of therapy (Fig. 417-1)
There are two broad categories of DM, designated type 1 and type 2 (Table 417-1).
However, there is increasing recognition of other forms of diabetes in which the
pathogenesis is better understood.
These other forms of diabetes may share features of type 1 and/or type 2 DM.
Both type 1 and type 2 DM are preceded by a phase of abnormal glucose homeostasis
as the pathogenic processes progress.
Type 1 DM is the result of complete or near-total insulin deficiency.
6.
7.
8. Type 2 DM is a heterogeneous group of disorders characterized by
variable degrees of insulin resistance, impaired insulin secretion, and
increased glucose production.
Distinct genetic and metabolic defects in insulin action and/or secretion
give rise to the common phenotype of hyperglycemia in type 2 DM and
have important potential therapeutic implications now that pharmacologic
agents are available to target specific metabolic derangements.
Type 2 DM is preceded by a period of abnormal glucose homeostasis
classified as impaired fasting glucose (IFG) or impaired glucose tolerance
tolerance (IGT).
9. OTHER TYPES OF DM
Other etiologies for DM include specific genetic defects in insulin secretion
or action, metabolic abnormalities that impair insulin secretion,
mitochondrial abnormalities, and a host of conditions that impair glucose
tolerance (Table 417-1).
Maturity-onset diabetes of the young (MODY) and monogenic diabetes
are subtypes of DM characterized by autosomal dominant inheritance, early
onset of hyperglycemia (usually <25 years; sometimes in neonatal period),
and impaired insulin secretion.
Mutations in the insulin receptor cause a group of rare disorders
characterized by severe insulin resistance.
10. DM can result from pancreatic exocrine disease when the majority of
pancreatic islets are destroyed.
Cystic fibrosis–related DM is an important consideration in that patient
population.
Hormones that antagonize insulin action can also lead to DM.
Thus, DM is often a feature of endocrinopathies such as acromegaly and
Cushing’s disease.
Viral infections have been implicated in pancreatic islet destruction but are
an extremely rare cause of DM.
A form of acute onset of type 1 diabetes, termed fulminant diabetes, has
been noted in Japan and may be related to viral infection of islets.
11. GESTATIONAL DIABETES MELLITUS
Glucose intolerance developing during pregnancy is classified as gestational
diabetes mellitus (GDM).
Insulin resistance is related to the metabolic changes of late pregnancy, and
the increased insulin requirements may lead to IGT or diabetes.
GDM occurs in ~7% (range 1–14%) of pregnancies in the United States; most
women revert to normal glucose tolerance postpartum but have a substantial
risk (35–60%) of developing DM in the next 10–20 years.
The International Association of the Diabetes and Pregnancy Study Groups and
the American Diabetes Association (ADA) recommend that diabetes diagnosed at
the initial prenatal visit should be classified as “overt” diabetes rather than GDM.
With the rising rates of obesity, the number of women being diagnosed with
GDM or overt diabetes is rising worldwide.
12. DIAGNOSIS
Glucose tolerance is classified into three broad categories:
1. normal glucose homeostasis
2. DM
3. impaired glucose homeostasis.
Glucose tolerance can be assessed using the fasting plasma glucose (FPG), the
response to oral glucose challenge, or the hemoglobin A1c (HbA1c).
A FPG <5.6 mmol/L (100 mg/dL), a plasma glucose <140 mg/dL (11.1
mmol/L) following an oral glucose challenge, and an HbA1c <5.7% are
considered to define normal glucose tolerance.
13. The International Expert Committee with members appointed by the ADA,
the European Association for the Study of Diabetes, and the International
Diabetes Federation have issued diagnostic criteria for DM (Table 417-2)
based on the following premises:
(1) the FPG, the response to an oral glucose challenge (oral glucose tolerance
test [OGTT]), and HbA1c differ among individuals
(2) DM is defined as the level of glycemia at which diabetes-specific
complications occur rather than on deviations from a population-based
mean.
A random plasma glucose concentration ≥11.1 mmol/L (200 mg/dL)
accompanied by classic symptoms of DM (polyuria, polydipsia, weight loss)
is also sufficient for the diagnosis of DM
14.
15. The current criteria for the diagnosis of DM emphasize the HbA1c or
the FPG as the most reliable and convenient tests for identifying DM in
asymptomatic individuals (however, some individuals may meet criteria
for one test but not the other).
OGTT, although still a valid means for diagnosing DM, is not often used
in routine clinical care.
These criteria also allow for the diagnosis of DM to be withdrawn in
situations when the glucose intolerance reverts to normal.
18. Type 1 DM is the result of interactions of genetic, environmental and immunologic
factors that ultimately lead to the destruction of the pancreatic beta cells and insulin
deficiency.
Type 1 DM, which can develop at any age, develops most commonly before 20 years of
age.
Worldwide, the incidence of type 1 DM is increasing at the rate of 3–4% per year for
uncertain reasons.
Type 1 DM results from autoimmune beta cell destruction, and most, but not all,
individuals have evidence of islet-directed autoimmunity.
19. Some individuals who have the clinical phenotype of type 1 DM lack
immunologic markers indicative of an autoimmune process involving the beta
cells and the genetic markers of type 1 DM.
These individuals are thought to develop insulin deficiency by unknown,
nonimmune mechanisms and may be ketosis prone; many are African
American or Asian in heritage.
The temporal development of type 1 DM is shown schematically as a function
of beta cell mass in Fig. 417-6.
20.
21. Individuals with a genetic susceptibility are thought to have normal beta cell
mass at birth but begin to lose beta cells secondary to autoimmune
that occurs over months to years.
This autoimmune process is thought to be triggered by an infectious or
environmental stimulus and to be sustained by a beta cell–specific molecule.
In the majority of patients, immunologic markers appear after the triggering
event but before diabetes becomes clinically overt.
Beta cell mass then begins to decrease, and insulin secretion progressively
declines, although normal glucose tolerance is maintained.
The rate of decline in beta cell mass varies widely among individuals, with some
patients progressing rapidly to clinical diabetes and others evolving more slowly.
Features of diabetes do not become evident until a majority of beta cells are
destroyed (70–80%).
22. At this point, residual functional beta cells exist but are insufficient in
number to maintain glucose tolerance.
The events that trigger the transition from glucose intolerance to diabetes
are often associated with increased insulin requirements, as might occur
during infections or puberty.
After the initial clinical presentation of type 1 DM, a “honeymoon” phase
may ensue during which time glycemic control is achieved with modest
doses of insulin or, rarely, insulin is not needed.
However, this fleeting phase of endogenous insulin production from residual
beta cells disappears and the individual becomes insulin deficient.
Many individuals with long-standing type 1 DM produce a small amount of
insulin (as reflected by C-peptide production), and some individuals with
more than 50 years of type 1 DM have insulin-positive cells in the pancreas
at autopsy.
23. GENETIC CONSIDERATIONS
Susceptibility to type 1 DM involves multiple genes.
The concordance of type 1 DM in identical twins ranges between 40 and 60%,
indicating that additional modifying factors are likely involved in determining
whether diabetes develops.
The major susceptibility gene for type 1 DM is located in the HLA region on
chromosome 6.
Polymorphisms in the HLA complex account for 40–50% of the genetic risk of
developing type 1 DM.
24. This region contains genes that encode the class II major histocompatibility
complex (MHC) molecules, which present antigen to helper T cells and thus are
involved in initiating the immune response.
The ability of class II MHC molecules to present antigen is dependent on the amino
acid composition of their antigen-binding sites.
Amino acid substitutions may influence the specificity of the immune response by
altering the binding affinity of different antigens for class II molecules.
25. Most individuals with type 1 DM have the HLA DR3 and/or DR4 haplotype.
Refinements in genotyping of HLA loci have shown that the haplotypes
DQA1*0301, DQB1*0302, and DQB1*0201 are most strongly associated with
type 1 DM.
These haplotypes are present in 40% of children with type 1 DM as compared to
2% of the normal U.S. population. However, most individuals with predisposing
haplotypes do not develop diabetes.
In addition to MHC class II associations, genome association studies have identified
at least 20 different genetic loci that contribute susceptibility to type 1 DM
(polymorphisms in the promoter region of the insulin gene, the CTLA-4 gene,
interleukin 2 receptor, CTLA4, and PTPN22, etc.)
26. Genes that confer protection against the development of the disease also
exist. The haplotype DQA1*0102, DQB1*0602 is extremely rare in
individuals with type 1 DM (<1%) and appears to provide protection from
from type 1 DM.
Although the risk of developing type 1 DM is increased tenfold in relatives
relatives of individuals with the disease, the risk is relatively low: 3–4% if
the parent has type 1 DM and 5–15% in a sibling (depending on which
HLA haplotypes are shared).
Hence, most individuals with type 1 DM do not have a first-degree
relative with this disorder.
27. Pathophysiology:
Although other islet cell types (alpha cells [glucagonproducing], delta cells
[somatostatin-producing], or PP cells [pancreatic polypeptide-producing]) are
functionally and embryologically similar to beta cells and express most of
same proteins as beta cells, they are spared from the autoimmune
destruction.
Pathologically, the pancreatic islets have a modest infiltration of lymphocytes
(a process termed insulitis). After beta cells are destroyed, it is thought that
the inflammatory process abates and the islets become atrophic.
28. Studies of the autoimmune process in humans and in animal models of
type 1 DM (NOD mouse and BB rat) have identified the following
abnormalities in the humoral and cellular arms of the immune system:
(1) islet cell autoantibodies;
(2) activated lymphocytes in the islets, peripancreatic lymph nodes, and
systemic circulation;
(3) T lymphocytes that proliferate when stimulated with islet proteins; and
(4) release of cytokines within the insulitis
29. Beta cells seem to be particularly susceptible to the toxic effect of some
cytokines (tumor necrosis factor α [TNF-α], interferon γ, and interleukin
1 [IL-1]).
The precise mechanisms of beta cell death are not known but may
involve formation of nitric oxide metabolites, apoptosis, and direct CD8+
CD8+ T cell cytotoxicity.
The islet destruction is mediated by T lymphocytes rather than islet
autoantibodies, as these antibodies do not generally react with the cell
surface of islet cells and are not capable of transferring DM to animals.
Efforts to suppress the autoimmune process at the time of diagnosis of
diabetes have largely been ineffective or only temporarily effective in
slowing beta cell destruction.
30. Pancreatic islet molecules targeted by the autoimmune process include
insulin, glutamic acid decarboxylase (GAD; the biosynthetic enzyme for the
neurotransmitter GABA), ICA-512/IA-2 (homology with tyrosine phosphatases),
and a beta cell–specific zinc transporter (ZnT-8).
Most of the autoantigens are not beta cell–specific, which raises the question
of how the beta cells are selectively destroyed.
Current theories favor initiation of an autoimmune process directed at one
beta cell molecule, which then spreads to other islet molecules as the
process destroys beta cells and creates a series of secondary autoantigens.
The beta cells of individuals who develop type 1 DM do not differ from
cells of normal individuals because islets transplanted from a genetically
identical twin are destroyed by a recurrence of the autoimmune process of type
1 DM.
31. Immunologic Markers Islet cell autoantibodies (ICAs) are a composite of several
different antibodies directed at pancreatic islet molecules such as GAD, insulin, IA-
2/ICA-512, and ZnT-8, and serve as a marker of the autoimmune process of type 1
DM.
Assays for autoantibodies to GAD-65 are commercially available.
Testing for ICAs can be useful in classifying the type of DM as type 1 and in
identifying nondiabetic individuals at risk for developing type 1 DM.
ICAs are present in the majority of individuals (>85%) diagnosed with new-onset
type 1 DM, in a significant minority of individuals with newly diagnosed type 2 DM
(5–10%), and occasionally in individuals with GDM (<5%).
32. ICAs are present in 3–4% of first-degree relatives of individuals with
type 1 DM.
In combination with impaired insulin secretion after IV glucose
tolerance testing, they predict a >50% risk of developing type 1 DM
within 5 years.
At present, the measurement of ICAs in nondiabetic individuals is a
research tool because no treatments have been demonstrated to
prevent the occurrence or progression to type 1 DM.
33. Environmental Factors: Numerous environmental events have been
proposed to trigger the autoimmune process in genetically susceptible
individuals; however, none have been conclusively linked to diabetes.
Identification of an environmental trigger has been difficult because the
event may precede the onset of DM by several years.
Putative environmental triggers include viruses (coxsackie, rubella,
enteroviruses most prominently), bovine milk proteins, and nitrosourea
compounds.
There is increasing interest in the microbiome and type 1 diabetes.
34. Prevention of Type 1 DM: A number of interventions have prevented diabetes
in animal models.
None of these interventions have been successful in preventing type 1 DM
humans.
For example, the Diabetes Prevention Trial–Type 1 concluded that
administering insulin (IV or PO) to individuals at high risk for developing type 1
DM did not prevent type 1 DM.
36. TYPE 2 DM
Insulin resistance and abnormal insulin secretion are central to the
development of type 2 DM.
Although the primary defect is controversial, most studies support the view that
insulin resistance precedes an insulin secretory defect but that diabetes
develops only when insulin secretion becomes inadequate.
Type 2 DM likely encompasses a range of disorders with common phenotype of
hyperglycemia.
37. It is becoming increasing apparent that DM in other ethnic groups (Asian,
African, and Latin American) has a somewhat different, but yet undefined,
pathophysiology.
In general, Latinos have greater insulin resistance and East Asians and South
Asians have more beta cell dysfunction, but both defects are present in both
populations.
East and South Asians appear to develop type 2 DM at a younger age and a
lower BMI.
In some groups, DM that is ketosis prone (often obese) or ketosis-resistant
(often lean) is seen.
38. GENETIC CONSIDERATIONS
Type 2 DM has a strong genetic component.
The concordance of type 2 DM in identical twins is between 70 and 90%.
Individuals with a parent with type 2 DM have an increased risk of diabetes; if both
parents have type 2 DM, the risk approaches 40%.
Insulin resistance, as demonstrated by reduced glucose utilization in skeletal
muscle, is present in many nondiabetic, first-degree relatives of individuals with
type 2 DM.
The disease is polygenic and multifactorial, because in addition to genetic
susceptibility, environmental factors (such as obesity, nutrition, and physical
activity) modulate the phenotype.
39. The in utero environment also contributes, and either increased
or reduced birth weight increases the risk of type 2 DM in adult
life.
The genes that predispose to type 2 DM are incompletely identified,
but recent genome-wide association studies have identified a
large number of genes that convey a relatively small risk for
DM (>70 genes, each with a relative risk of 1.06–1.5).
40. Most prominent is a variant of the transcription factor 7–like 2 gene that has
been associated with type 2 DM in several populations and with IGT in one
population at high risk for diabetes.
Genetic polymorphisms associated with type 2 DM have also been found in the
the genes encoding the peroxisome proliferator– activated receptor γ, inward
rectifying potassium channel, zinc transporter, IRS, and calpain 10.
The mechanisms by which these genetic loci increase the susceptibility to
type 2 DM are not clear, but most are predicted to alter islet function or
development or insulin secretion.
Although the genetic susceptibility to type 2 DM is under active investigation , it
is currently not possible to use a combination of known genetic loci to
type 2 DM.
41. Pathophysiology
Pathophysiology Type 2 DM is characterized by impaired insulin secretion,
insulin resistance, excessive hepatic glucose production, and abnormal
fat metabolism.
Obesity, particularly visceral or central (as evidenced by the hip-waist ratio), is
very common in type 2 DM (≥80% of patients are obese).
In the early stages of the disorder, glucose tolerance remains near-normal,
despite insulin resistance, because the pancreatic beta cells compensate by
increasing insulin output (Fig. 417-7).
As insulin resistance and compensatory hyperinsulinemia progress, the
pancreatic islets in certain individuals are unable to sustain the hyper
insulinemic state.
42.
43. IGT, characterized by elevations in postprandial glucose, then
develops.
A further decline in insulin secretion and an increase in hepatic
glucose production lead to overt diabetes with fasting
hyperglycemia.
Ultimately, beta cell failure ensues.
Although both insulin resistance and impaired insulin secretion
contribute to the pathogenesis of type 2 DM, the relative
contribution of each varies from individual to individual.
44. Metabolic Abnormalities
Abnormal muscle and fat metabolism
Insulin resistance, the decreased ability of insulin to act effectively on
target tissues (especially muscle, liver, and fat), is a prominent feature of
type 2 DM and results from a combination of genetic susceptibility and
obesity.
Insulin resistance is relative, however, because supra normal levels of
circulating insulin will normalize the plasma glucose.
Insulin dose-response curves exhibit a rightward shift, indicating
reduced sensitivity, and a reduced maximal response, indicating an
overall decrease in maximum glucose utilization (30–60% lower than in
normal individuals).
45. Insulin resistance impairs glucose utilization by insulin-sensitive tissues
and increases hepatic glucose output; both effects contribute to the
hyperglycemia.
Increased hepatic glucose output predominantly accounts for increased FPG
levels, whereas decreased peripheral glucose usage results in postprandial
hyperglycemia.
In skeletal muscle, there is a greater impairment in nonoxidative glucose
usage (glycogen formation) than in oxidative glucose metabolism through
glycolysis.
Glucose metabolism in insulin-independent tissues is not altered in type 2
DM.
46. The precise molecular mechanism leading to insulin resistance in type 2 DM has
not been elucidated.
Insulin receptor levels and tyrosine kinase activity in skeletal muscle are reduced,
these alterations are most likely secondary to hyperinsulinemia and are not a
primary defect.
Therefore, “post receptor” defects in insulin-regulate
phosphorylation/dephosphorylation appear to play the predominant role in insulin
resistance.
Abnormalities include the accumulation of lipid within skeletal myocytes, which may
impair mitochondrial oxidative phosphorylation and reduce insulin-stimulated
mitochondrial ATP production.
47. Impaired fatty acid oxidation and lipid accumulation within skeletal
myocytes also may generate reactive oxygen species such as lipid
peroxides.
Of note, not all insulin signal transduction pathways are resistant to the
the effects of insulin.
Consequently, hyperinsulinemia may increase the insulin action through
through these pathways, potentially accelerating diabetes related
conditions such as atherosclerosis.
48. The obesity accompanying type 2 DM, particularly in a central or visceral
location, is thought to be part of the pathogenic process
In addition to these white fat depots, humans now are recognized to have
brown fat, which has much greater thermogenic capacity.
Efforts are under way to increase the activity or quantity of brown fat (e.g., a
myokine, irisin, may convert white to brown fat).
The increased adipocyte mass leads to increased levels of circulating free fatty
acids and other fat cell products.
For example, adipocytes secrete a number of biologic products (nonesterified
free fatty acids, retinolbinding protein 4, leptin, TNF-α, resistin, IL-6, and
adiponectin).
49. In addition to regulating body weight, appetite, and energy expenditure,
adipokines also modulate insulin sensitivity.
The increased production of free fatty acids and some adipokines may cause
insulin resistance in skeletal muscle and liver.
For example, free fatty acids impair glucose utilization in skeletal muscle,
promote glucose production by the liver, and impair beta cell function.
In contrast, the production by adipocytes of adiponectin, an insulin-
sensitizing peptide, is reduced in obesity, and this may contribute to hepatic
insulin resistance.
Adipocyte products and adipokines also produce an inflammatory state and
may explain why markers of inflammation such as IL-6 and C-reactive protein
are often elevated in type 2 DM.
50. In addition, inflammatory cells have been found infiltrating adipose
tissue.
Inhibition of inflammatory signaling pathways such as the nuclear
κB (NF-κB) pathway appears to reduce insulin resistance and improve
hyperglycemia in animal models and is being tested in humans.
51. Impaired insulin secretion : Insulin secretion and sensitivity are interrelated.
In type 2 DM, insulin secretion initially increases in response to insulin
resistance to maintain normal glucose tolerance.
Initially, the insulin secretory defect is mild and selectively involves glucose-
stimulated insulin secretion, including a greatly reduced first secretory phase.
The response to other non glucose secretagogues, such as arginine, is
preserved, but overall beta function is reduced by as much as 50% at the
onset of type 2 DM.
Abnormalities in proinsulin processing are reflected by increased secretion of
proinsulin in type 2 DM.
Eventually, the insulin secretory defect is progressive.
52. The reason(s) for the decline in insulin secretory capacity in type 2 DM is
unclear.
The assumption is that a second genetic defect— superimposed upon
insulin resistance—leads to beta cell failure.
Beta cell mass is decreased by approximately 50% in individuals with
longstanding type 2 DM.
Islet amyloid polypeptide or amylin, co-secreted by the beta cell, forms the
amyloid fibrillar deposit found in the islets of individuals with long-standing
standing type 2 DM.
Whether such islet amyloid deposits are a primary or secondary event is
not known.
53. The metabolic environment of diabetes may also negatively impact islet
function.
For example, chronic hyperglycemia paradoxically impairs islet
function (“glucose toxicity”) and leads to a worsening of
hyperglycemia.
Improvement in glycemic control is often associated with improved
islet function.
In addition, elevation of free fatty acid levels (“lipotoxicity”) and
dietary fat may also worsen islet function.
Reduced GLP-1 action may contribute to the reduced insulin
secretion.
54. Increased hepatic glucose and lipid production: In type 2 DM, insulin
resistance in the liver reflects the failure of hyperinsulinemia to suppress
gluconeogenesis, which results in fasting hyperglycemia and decreased
glycogen storage by the liver in the postprandial state.
Increased hepatic glucose production occurs early in the course of
diabetes, although likely after the onset of insulin secretory abnormalities
and insulin resistance in skeletal muscle.
As a result of insulin resistance in adipose tissue, lipolysis and free fatty
acid flux from adipocytes are increased, leading to increased lipid (very-
low-density lipoprotein [VLDL] and triglyceride) synthesis in hepatocytes.
55. This lipid storage or steatosis in the liver may lead to
nonalcoholic fatty liver disease and abnormal liver function tests.
This is also responsible for the dyslipidemia found in type 2 DM
(elevated triglycerides, reduced high-density lipoprotein [HDL], and
increased small dense low-density lipoprotein [LDL] particles)
56. Insulin Resistance Syndromes: The insulin resistance condition comprises
a spectrum of disorders, with hyperglycemia representing one of the
most readily diagnosed features.
The metabolic syndrome, the insulin resistance syndrome, and
syndrome X are terms used to describe a constellation of metabolic
derangements that includes insulin resistance, hypertension,
dyslipidemia (decreased HDL and elevated triglycerides), central or
visceral obesity, type 2 DM or IGT/IFG, and accelerated
disease.
57. A number of relatively rare forms of severe insulin resistance include features
of type 2 DM or IGT.
Mutations in the insulin receptor that interfere with binding or signal
transduction are a rare cause of insulin resistance.
Acanthosis nigricans and signs of hyperandrogenism (hirsutism, acne, and
oligomenorrhea in women) are also common physical features.
Two distinct syndromes of severe insulin resistance have been described in
adults:
(1) type A, which affects young women and is characterized by severe
hyperinsulinemia, obesity, and features of hyperandrogenism.
(2) type B, which affects middle-aged women and is characterized by
hyperinsulinemia, features of hyperandrogenism, and autoimmune
disorders.
58. Individuals with the type A insulin resistance syndrome have an undefined defect
in the insulin-signaling pathway.
Individuals with the type B insulin resistance syndrome have autoantibodies
directed at the insulin receptor.
These receptor autoantibodies may block insulin binding or may stimulate the
insulin receptor, leading to intermittent hypoglycemia.
Polycystic ovary syndrome (PCOS) is a common disorder that affects
premenopausal women and is characterized by chronic anovulation and
hyperandrogenism.
Insulin resistance is seen in a significant subset of women with PCOS, and the
disorder substantially increases the risk for type 2 DM, independent of the effects
of obesity.
59. Prevention Type 2 DM is preceded by a period of IGT or IFG, and a number
of lifestyle modifications and pharmacologic agents prevent or delay the
onset of DM.
Individuals with prediabetes or increased risk of diabetes should be referred
referred to a structured program to reduce body weight and increase
physical activity as well as being screened for cardiovascular disease.
The Diabetes Prevention Program (DPP) demonstrated that intensive
changes in lifestyle (diet and exercise for 30 min/d five times/week) in
individuals with IGT prevented or delayed the development of type 2 DM
by 58% compared to placebo.
This effect was seen in individuals regardless of age, sex, or ethnic group.
In the same study, metformin prevented or delayed diabetes by 31%
compared to placebo.
The lifestyle intervention group lost 5–7% of their body weight during the 3
years of the study
60. Studies in Finnish and Chinese populations noted similar efficacy of diet
and exercise in preventing or delaying type 2 DM.
A number of agents, including α-glucosidase inhibitors, metformin,
thiazolidinediones, GLP-1 receptor pathway modifiers, and orlistat,
or delay type 2 DM but are not approved for this purpose.
Individuals with a strong family history of type 2 DM and individuals with
IFG or IGT should be strongly encouraged to maintain a normal BMI and
engage in regular physical activity.
Pharmacologic therapy for individuals with prediabetes is currently
controversial because its cost effectiveness and safety profile are not
known.
61. The ADA has suggested that metformin be considered in individuals with
both IFG and IGT who are at very high risk for progression to diabetes
(age <60 years, BMI ≥35 kg/m2, family history of diabetes in first-
relative, and women with a history of GDM).
Individuals with IFG, IGT, or an HbA1c of 5.7–6.4% should be monitored
annually to determine if diagnostic criteria for diabetes are present.
63. Clinical Features:
The symptoms and physical signs of DKA are listed in Table 418-7 and usually
develop over 24 h.
DKA may be the initial symptom complex that leads to a diagnosis of type 1
DM, but more frequently, it occurs in individuals with established diabetes.
Nausea and vomiting are often prominent, and their presence in an
with diabetes warrants laboratory evaluation for DKA.
Abdominal pain may be severe and can resemble acute pancreatitis or
ruptured viscus.
Hyperglycemia leads to glucosuria, volume depletion, and tachycardia.
Hypotension can occur because of volume depletion in combination with
peripheral vasodilatation.
64.
65. Kussmaul respirations and a fruity odor on the patient’s breath (secondary to
metabolic acidosis and increased acetone) are classic signs of the disorder.
Lethargy and central nervous system depression may evolve into coma with severe
DKA but should also prompt evaluation for other reasons for altered mental status
(e.g., infection, hypoxemia).
Cerebral edema, an extremely serious complication of DKA, is seen most frequently
in children.
Signs of infection, which may precipitate DKA, should be sought on physical
examination, even in the absence of fever.
Tissue ischemia (heart, brain) can also be a precipitating factor.
Omission of insulin because of an eating disorder, mental health disorders, or an
unstable psychosocial environment may sometimes be a factor precipitating DKA.
66. Pathophysiology
DKA results from relative or absolute insulin deficiency combined with
counterregulatory hormone excess (glucagon, catecholamines, cortisol, and
growth hormone).
Both insulin deficiency and glucagon excess, in particular, are necessary for
DKA to develop.
The decreased ratio of insulin to glucagon promotes gluconeogenesis,
glycogenolysis, and ketone body formation in the liver, as well as increases
in substrate delivery from fat and muscle (free fatty acids, amino acids) to the
liver.
Markers of inflammation (cytokines, C-reactive protein) are elevated in both
DKA and HHS (Hyperosmolar hyperglycemic state).
67. The combination of insulin deficiency and hyperglycemia reduces the
hepatic level of fructose-2,6-bisphosphate, which alters the activity of
phosphofructokinase and fructose-1,6-bisphosphatase.
Glucagon excess decreases the activity of pyruvate kinase, whereas insulin
deficiency increases the activity of phosphoenolpyruvate carboxykinase.
These changes shift the handling of pyruvate toward glucose synthesis and
away from glycolysis.
The increased levels of glucagon and catecholamines in the face of low
insulin levels promote glycogenolysis.
Insulin deficiency also reduces levels of the GLUT4 glucose transporter, which
impairs glucose uptake into skeletal muscle and fat and reduces
glucose metabolism.
68. Ketosis results from a marked increase in free fatty acid release from adipocytes, with
a resulting shift toward ketone body synthesis in the liver.
Reduced insulin levels, in combination with elevations in catecholamines and growth
hormone, increase lipolysis and the release of free fatty acids.
Normally, these free fatty acids are converted to triglycerides or very-low-density
lipoprotein (VLDL) in the liver.
However, in DKA, hyperglucagonemia alters hepatic metabolism to favor ketone
body formation, through activation of the enzyme carnitine palmitoyltransferase I.
This enzyme is crucial for regulating fatty acid transport into the mitochondria,
where beta oxidation and conversion to ketone bodies occur.
At physiologic pH, ketone bodies exist as ketoacids, which are neutralized by
bicarbonate. As bicarbonate stores are depleted, metabolic acidosis ensues.
Increased lactic acid production also contributes to the acidosis
69. The increased free fatty acids increase triglyceride and VLDL production. VLDL
clearance is also reduced because the activity of insulin-sensitive lipoprotein lipase
in muscle and fat is decreased.
Hypertriglyceridemia may be severe enough to cause pancreatitis.
DKA is often precipitated by increased insulin requirements, as occurs during a
concurrent illness (Table 418-7).
Failure to augment insulin therapy often compounds the problem.
Complete omission or inadequate administration of insulin by the patient or health
care team (in a hospitalized patient with type 1 DM) may precipitate DKA.
Patients using insulin-infusion devices with short-acting insulin may develop DKA,
because even a brief interruption in insulin delivery (e.g., mechanical malfunction)
quickly leads to insulin deficiency.
71. Clinical Features: The prototypical patient with HHS is an elderly individual with type 2
DM, with a several-week history of polyuria, weight loss, and diminished oral
that culminates in mental confusion, lethargy, or coma.
The physical examination reflects profound dehydration and hyperosmolality and
reveals hypotension, tachycardia, and altered mental status.
Notably absent are symptoms of nausea, vomiting, and abdominal pain and the
Kussmaul respirations characteristic of DKA.
HHS is often precipitated by a serious, concurrent illness such as myocardial infarction
or stroke.
Sepsis, pneumonia, and other serious infections are frequent precipitants and
be sought.
In addition, a debilitating condition (prior stroke or dementia) or social situation that
compromises water intake usually contributes to the development of the disorder.
72. Pathophysiology
Relative insulin deficiency and inadequate fluid intake are the underlying
causes of HHS.
Insulin deficiency increases hepatic glucose production (through glycogenolysis
and gluconeogenesis) and impairs glucose utilization in skeletal muscle.
Hyperglycemia induces an osmotic diuresis that leads to intravascular volume
depletion, which is exacerbated by inadequate fluid replacement.
The absence of ketosis in HHS is not understood.
Presumably, the insulin deficiency is only relative and less severe than in DKA.
Lower levels of counterregulatory hormones and free fatty acids have been
found in HHS than in DKA in some studies.
It is also possible that the liver is less capable of ketone body synthesis or that
the insulin/glucagon ratio does not favor ketogenesis.
74. Medical nutrition therapy
Nutrition Medical nutrition therapy (MNT) is a term used by the ADA to describe the
optimal coordination of caloric intake with other aspects of diabetes therapy (insulin,
exercise, weight loss).
Primary prevention measures of MNT are directed at preventing or delaying the
onset of type 2 DM in high-risk individuals (obese or with prediabetes) by promoting
weight reduction.
Medical treatment of obesity is a rapidly evolving area and is discussed in Chap. 416.
Secondary prevention measures of MNT are directed at preventing or delaying
diabetes-related complications in diabetic individuals by improving glycemic control.
75. Tertiary prevention measures of MNT are directed at managing diabetes-related
complications (cardiovascular disease, nephropathy) in diabetic individuals. MNT
in patients with diabetes and cardiovascular disease should incorporate dietary
principles used in nondiabetic patients with cardiovascular disease.
Although the recommendations for all three types of MNT overlap, this chapter
emphasizes secondary prevention measures of MNT.
Pharmacologic approaches that facilitate weight loss and bariatric surgery should
be considered in selected patients (Chaps. 415e and 416).
In general, the components of optimal MNT are similar for individuals with type 1
or type 2 DM and similar to those for the general population (fruits, vegetables,
fiber-containing foods, and low fat; Table 418-3).
MNT education is an important component of comprehensive diabetes care and
should be reinforced by regular patient education.
76.
77. Historically, nutrition education imposed restrictive, complicated regimens on the
patient.
Current practices have greatly changed, although many patients and health care
providers still view the diabetic diet as monolithic and static.
For example, MNT now includes foods with sucrose and seeks to modify other
risk factors such as hyperlipidemia and hypertension rather than focusing
exclusively on weight loss in individuals with type 2 DM.
The glycemic index is an estimate of the postprandial rise in the blood glucose
when a certain amount of that food is consumed.
Consumption of foods with a low glycemic index appears to reduce postprandial
glucose excursions and improve glycemic control. Reduced-calorie and
nonnutritive sweeteners are useful.
Currently, evidence does not support supplementation of the diet with vitamins,
antioxidants (vitamin C and E), or micronutrients (chromium) in patients with
diabetes.
78. The goal of MNT in the individual with type 1 DM is to coordinate and match
the caloric intake, both temporally and quantitatively, with the appropriate
amount of insulin.
MNT in type 1 DM and selfmonitoring of blood glucose must be integrated to
define the optimal insulin regimen.
The ADA encourages patients and providers to use carbohydrate counting or
exchange systems to estimate the nutrient content of a meal or snack. Based on
the patient’s estimate of the carbohydrate content of a meal, an insulin-to-
carbohydrate ratio determines the bolus insulin dose for a meal or snack.
MNT must be flexible enough to allow for exercise, and the insulin regimen must
allow for deviations in caloric intake. An important component of MNT in type 1
DM is to minimize the weight gain often associated with intensive diabetes
management.
79. The goals of MNT in type 2 DM should focus on weight loss and address the
greatly increased prevalence of cardiovascular risk factors (hypertension,
dyslipidemia, obesity) and disease in this population.
The majority of these individuals are obese, and weight loss is strongly
encouraged and should remain an important goal.
Hypocaloric diets and modest weight loss (5–7%) often result in rapid and
dramatic glucose lowering in individuals with new-onset type 2 DM.
Nevertheless, numerous studies document that long-term weight loss is
uncommon.
MNT for type 2 DM should emphasize modest caloric reduction (low-
carbohydrate) and increased physical activity.
Increased consumption of soluble, dietary fiber may improve glycemic control
in individuals with type 2 DM. Weight loss and exercise improve insulin
resistance.