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Detoxification, brain chemistry and addictions
- 2. Living in Utah sets us up! (see blog post—at least 3 Hit categories during Winter inversions) Pesticide exposure (even via foods), tainted well water, some drinking water (pg. 197 LAoT) Occupational or accidental exposure to toxic substances (pg. 210 and 396-401 LAoT for charts) Burning candles with metal wicks Cleaning products & other unhealthy things: new carpet, new paint, make-up, smoking, etc. Food- the obvious & sometimes food intolerances
- 4. Hard stool or difficult to pass BMs. Constipation (should have daily BMs.) Infrequent urination that is dark and a strong odor. Almost never break into a sweat. Have one or more of the following symptoms: Fatigue, muscle aches, headaches, concentration and memory problems. * Have fibromyalgia or chronic fatigue syndrome.
- 5. I drink unfiltered water or from plastic bottles. The clothes I wear are dry cleaned. I work/live in a building w/poor ventilation or windows that won’t open. I live(d) in/near a large urban/industrial area. I use household or lawn and garden chemicals to treat for bugs or use an exterminator. I have mercury fillings in my teeth. I eat (or ate) large fish or tainted fish.
- 6. I am bothered by 1 or more of the following: the smell of gas or diesel fumes, perfumes, new cars, fabric stores, dry cleaning, hair spray, soaps, detergents, tobacco smoke, chlorinated water, other strong smells. I have a negative reaction when I consume foods with MSG, sulfites, sodium benzoate, red wine, cheese, bananas, chocolate, alcohol, garlic, onions, caffeine (wired up or feel anxious, palpitations, sweating, dizziness.)
- 7. I regularly have any of the following: Tylenol (acetaminophen), acid-blocking drugs (Tagamet, Zantac, Pepcid, Prilosec, Prevacid), hormone-modulating medications of any kind (birth-control, hormones, prostate medication), ibuprofen or naproxen, medications for colitis, Chrone’s disease, recurrent headaches, allergy symptoms, nausea, diarrhea, or indigestions I have had jaundice for any reason or have Gilbert’s syndrome (Elevation of billirubin.)
- 8. I live on the Wasatch Front. I have a family history of Parkinson’s Alzheimer’s ALS, or other motor neuron diseases or multiple sclerosis. SCORE: 0-6 You may have low levels of toxicity, follow Nedley/UltraMind program. 7-9: You may have moderate toxicity (do program and self-care steps in UltraMind.) 10+ May have severe toxicity: Do all and see things to discuss w/functional medicine doctor
- 10. “Almost every mental disorder and neurodegenerative disease from depression to Alzheimers, from ADHD to autism, from Parkinson’s to bipolar disease can be improved by fixing problems with methylation and sulfation trains.” Dr. Hyman, The UltraMind Solution
- 11. Hyman’s methylation quiz: ___I eat any kind of animal protein more than 5 times a week (i.e. any meat, eggs, milk products. Etc.) ___ I eat more than 1-2 foods a week with hydrogenated fats. (“0 grams” is misleading!) ___ I have servings of animal protein greater than 4-6 ounces (the size of the palm of your hand.) ___ I eat less than 1 cup of dark leafy green vegetables a day. ___ I eat fewer than 5-9 servings of veggies and fruit a day. (1/2 c= srvng) ___ I have more than 3 alcoholic servings a week. ___ I have depression, depressed mood or other mood or behavior disorders. ___ I have a history of heart attack or other heart disease. ___ I have a history of stroke. ___ I have a history of cancer (especially colon, cervix, breast.)
- 12. ___ I have a history of abnormal PAP tests (cervical dysplasia.) ___ I have a history of birth defects in offspring (spina bifida, neural tube defects, or Down syndrome.) ___ I have a history of dementia. ___ I have a loss of balance of sensation in the feet. ___ I have a history of multiple sclerosis or other diseases with nerve damage. ___ I have a history of carpal tunnel syndrome. ___ I do not take a multi-vitamin. ___ I am over 65 years old. Key: 0-8: Low level problem, follow UltraMind/Nedley program 9 and above: You may have a severe problem and may need medical care from a doctor well-versed in functional medicine &/or nutrition.
- 14. Sulphur soaks up toxins Production of Glutathione is critical to good health!
- 16. Hyman on Genes and depression What it does How to improve its function MTHFR Controls methylation High doses of folic acid or methyl-folate Apolipoprotein E4 Carries cholesterol & heavy metals Whole foods, low-glycemic-load diet; exercise GSTM, GTSP Helps body detoxify & produce glutathione Adequate intake of B12,B6, folate, & amino acids w/sulfur like NAC; eat 2 cups of cruciferous veggies a day CETP Transports cholesterol away from arteries Whole foods, low-glycemic-load diet; exercise COMT Metabolizes neurotransmitters & hormones via methylation Adequate intake of B6, B12, and folate SOD-2 Powerful intracellular antioxidant Take zinc, manganese & copper (multi-vitamin) & plenty of phytonutrient antioxidants Multi-gene disorders Interaction between many genes UMS pg. 223-4. Turn off bad genes through diet, nutrition, 2 cups kale or cabbage
- 17. Toxic exposure + poor methylation + poor sulfation + genetic pre-dispositon (+ hormones (ie. strong sugar addict- hormone connection) + ACEs, etc.) = Low functioning neurotransmitters Predisposed to ADDICTIONS
- 19. Brain Chemistry at a Glance (from Ten Ways to Balance Your Brain Chemistry by Cristine Price, M.S.) Neuro-Chemical Function/ Experience Mimicked by/Counterfeits Facilitated/ Supported by Norepinephrine Stimulant/ Energy/ Wakefulness/ Focus (concentration) Caffeine/ Amphetamines High pH diet/SAM-e /Exercise/ Passion for Life [Endorsing] GABA (see Hyman quiz, pg. 106-7 & nutrition) Depressant/ Sleep/ Relaxation Sleeping pills/ Alcohol/ Benzodiazepines Benadryl/ GABA/ Meditation/ Yoga, Deep Breathing [Endorsing], Q- 96 Serotonin (see Hyman quiz, pg. 103 & nutrition) Well Being/ Mood Stabilizer/ Contentment [Calmness]/ Inclinations/ [Patience]/ [Sleep]/ Comfort foods/ SSRIs/ Marijuana 5-HTP/ Mindful Eating/ Cal-Mag Fizz/ Positive Affirmations/ [Endorsing], Q-96
- 20. Beta-Endorphins Pain relief/ Euphoria/ Comfort/ Numbness Sugar/ Pain pills/ Narcotics/ Morphine High Protein Diet (?)/ EFT/ Theta Waves/ Massage/ Spiritual Highs Dopamine (see Hyman quiz, pg. 101 & nutrition) Stimulant + Euphoria/ Fantasy/ Pleasure Rush/ [Balance & Controlled Movement/ Motivation Drive]/ Regulation of brain’s information flow] Chocolate/ Cocaine/ Sex/ Thrill Seeking DL Phenylalanine/ Intense Exercise/ Sensory Enhancement, Q-96 [Norepinephrine and Dopamine] Attention Information from The Lost Art of Thinking, Dr. Nedley [High Tyrosine diet, low animal protein diet, pg. 149 LAoT] [Serotonin and Dopamine] Appetite “ “
- 22. The entire Nedley program! Water intake, deep breathing, contrasting showers, plant-based diet, exercise, sunlight, melatonin-friendly sleep, etc. etc. etc. (see blog posts) What Dr. Hyman did: Detoxifying foods, supplements (like green drinks, herbs (tumeric, curry, milk thistle), intraveneous glutathione and vitamin C, metal chelators, and saunas (or can use steam rooms.) Dr. Nedley’s book: The Lost Art of Thinking Hyman book: The Blood Sugar 10-Day Detox Diet Dr. Elson Haas book: The False Fat Diet Clear Body, Clear Mind book: needs supervision
- 24. Eat organic and clean meats if you eat meat True Hope, Equilib, Q-96 supplement Oil pulling (see my blog post) Remember that negative emotions can literally be very toxic---use CBT, EFT, Emotional release Forgiveness work and prayer. Eden Energy medicine has various routines that help the body detoxify. Acupuncture, moxibustion, homeopathics, etc.
- 26. RDA approx. 48-60 g/day avocado = 10 g protein 1 c. broccoli = 5 g 1 c. spinach = 5 g 2 c. cooked kale = 5 g 1 c. boiled peas = 9 g 1 c. sweet potato = 9 g 1 c. soybeans = 28 g 1 c. lentils = 18 g 1 c. refried beans = 16 g 1 c. hummus = 14.5 g 1 c. pinto, kidney, black beans = 13-15 g 1 oz. peanuts = 6.5 g 1 oz. cashews = 4.4 g 1 oz. sesame seed = 7g ¼ c. walnuts = 5 g 1 oz. pistachios = 4 g 2 tbsp. almonds = 4 g Nut butters abt. 8 g per 2 tblspn.
- 27. quinoa 1 c. = 9 g seitan (flavored wheat gluten) 1 c. = 52 g Oatmeal 1 c. = 6 g Hemp powder 30 gm = 11 g Other high protein grains: amaranth, bulgur, brown rice, wheat germ and oat bran
Editor's Notes
- Blog Post: http://depressionhealinginsights.blogspot.com/2011/04/geographical-features-and-depression.html
- These are symptoms of toxicity. Have individuals mark for each symptom or condition, etc. they have. Slide 8 has the key.
- These are conditions that contribute to toxicity.
- These are conditions that indicate toxicity.
- These medications strongly contribute to toxicity. Jaundice indicates toxicity.
- What is methylation? In simple terms it is a process in which certain chemicals called ‘methyl groups’ are added to various constituents of proteins, DNA and other molecules. These are needed to keep them in good ‘working’ condition. For example, if the antidepressant, ‘feel-good’ brain chemical serotonin is not methylated it will become inactive which in turns leads to depression! This is just one of the many ‘chemicals’ in the body that need to be methylated and if they are not can lead to serious health consequences. Sulfation: Sulfation: Is a phase-II detoxification pathway that occurs in the liver and in which compounds that contain sulfur combine with components to remove them from the body. The sulphur acts like “fly paper” to help the body remove the toxins. Ask participants to put a tally down for each answer that applies to them. The key is on the next slide.
- This is very simplified, but it shows how B12, B6 and folate help keep the process of methylation running! The yellow “flowers” mark key nutrients Dr. Nedley has talked about. You see other critical neurotransmitters in this slide as well.
- Very complicated, but if you study it a bit it helps one begin to understand why the food intake is so much more important than just taking vitamins. These cycles interlace and the end outcome is very related to beginning food intake. Healthy food intake will help with the yellow highlighted nutrients: Glutathione and Sulphur. (Note: Dr. Hyman did intravenous glutathione to help his body detox due to all the toxic exposure to formaldehyde, etc. in medical school.
- From The UltraMind Solution. This chart shows genes found to contribute to depression. Notice that most of them are related to the body’s detoxification process. In the “How to improve its function” column, I have highlighted things we have talked about in the Nedley program.
- ACE= Adverse Childhood Experiences (a gamut of possibilities, Nedley would call them “developmental hits”.) ACEs are a hot topic of late.
- Add in the “flavor enhancers”, etc. (See the movie “Fed Up” to get a true picture of what many big food industry giants do.)
- These next two slides are self-explanatory. I just highlighted those neurotransmitters we’ve talked about at least some in class. Spend some time pointing out counterfeits people may turn to in an effort to self-medicate since their neurotransmitters are low or off-balance. Really point out the “Supported by” column. Note that a high pH diet is reached by eating lots of healthy low glycemic vegetables and very little (or no) meat. Note that I would NOT use Benadryl as a way to calm down! This causes more toxicity! I would only use it as a last resort! Again, note how many in the “Supported by” column are in the Nedley program. Note: Q-96 is a supplement under the True Hope umbrella—most have heard about it. I don’t go into that.
- Note: I would only do a high protein diet with PLANT PROTEINS. There is too much evidence that a high animal protein diet slow neurotransmitter production, etc.
- Some may be feeling pretty overwhelmed by now, especially if they scored high on the quizzes. If it’s bad enough they should try to get some medical help. If that’s not possible, they need to follow the Nedley program religiously, read Hyman’s book and maybe look into food intolerances, and be patient and prayerful. Miracles do happen!
- Foods that help the methylation/sulfation process: garlic, onions, cruciferous vegetables, plant-based proteins, broccli family: collards, kale, cabbage, kohlrabi, mustard green, rutabaga,turnips, bok choy, Chinese cabbage, arugula, horseradish, radish, wasabi, and watercress. Also fish, eggs, sunflower seeds, some herbs like milk thistle, etc.
- True Hope products and other excellent vitamins are herbs can help the body detoxify if taken at the right time and in the right way. Some people have to do yeast detox, or metal detox (i.e. like flouride detox, etc.), fix their “leaky guts”, etc. before the vitamins will do anything. Hyman’s book, The UltraMind Solution gets into details about some of that.
- Be determined, consistent, and be patient. It is so worth it in the end!
- Notice how easy it is to get plant-based protein!
- Summary: Our bodies can have toxic build-up due to exposures, foods, and genetic pre-disposition. This can make it more difficult for our bodies to produce the nutrition that creates the neurotransmitters and hormones we need to feel well, leading to depression, anxiety, etc. (Most with anxiety have a high need for detoxification!) In an effort to feel better, we may turn to addictive substances. This creates a vicious cycle—and Dr. Nedley shows us the way out of that vicious cycle. Hopefully this PowerPoint helps you understand why it is so important to do EVERY part of the Nedley program.