The proliferation of new sources of data opens up the possibility for designers to develop new approaches towards the creation of interactive artifacts. While design practice has been driven by a user-centered paradigm, which aims at providing people with solutions to their everyday issues, it now examines data as a new material that can be extracted, manipulated and visualized to better inform users about the world. In this presentation, Pierrick Thébault will draw upon his past research and projects to highlight the differences between data-centric, application-centric and artifact-centric approaches and to discuss the challenges and opportunities of designing with data.