The document discusses options for designing an e-infrastructure architecture to share laboratory data across multiple institutions for the TCS project. It notes that current states vary, with some institutions having good infrastructures and metadata schemes while others only have data stored locally. Three generic architecture options are presented: fully distributed, metadata centralized, and metadata and data centralized. A hybrid option is recommended to accommodate different institutional setups. Key points are that some effort is needed for metadata harmonization and digital infrastructure, and the chosen architecture should balance technical and resource factors with willingness to share.