DENGUE VACCINE(1).pptx
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Dengue is a viral infection spread by mosquitoes that infects over 390 million people annually and causes 21,000 deaths, mainly in tropical and subtropical regions. Dengvaxia is the first approved dengue vaccine, produced by Sanofi Pasteur for individuals ages 6-16 who have had a previous dengue infection. It requires three doses over one year and provides protection against the four dengue virus serotypes. Common side effects include headache, injection site pain, malaise, and myalgia.
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Dengue.pptx
Dengue is a viral infection transmitted by mosquitoes that infects around 100-400 million people annually worldwide. It is caused by the dengue virus of which there are 4 serotypes. Infection with one type provides lifelong immunity to that type but subsequent infections with other types increase the risk of severe dengue. The disease ranges from mild fever to life-threatening dengue hemorrhagic fever/dengue shock syndrome. There is no vaccine for dengue prevention currently.
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Dengue is a mosquito-borne viral disease caused by the dengue virus. There are four serotypes of the dengue virus. Diagnosis can be made through laboratory tests such as virus isolation, nucleic acid detection through RT-PCR, immunological response tests like ELISA and RDTs, and analysis of hematological parameters. Clinical diagnosis is based on signs and symptoms that present in three phases - febrile, critical, and recovery phase. Common symptoms include high fever, headache, muscle and joint pains, rashes, and bleeding manifestations in severe cases. Laboratory tests aid in diagnosis, screening, monitoring disease severity through platelet count and hematocrit levels.
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Dengue is a mosquito-borne viral infection transmitted by Aedes mosquitoes, causing flu-like symptoms. It occasionally develops into a potentially lethal complication known as severe dengue or "break-bone fever". Epidemics occurred as early as the 18th century in Asia, Africa, and North America. There are four types of the dengue virus. While most age groups and both sexes can be affected, children are at higher risk than adults. The disease occurs more frequently during and after the rainy season in India. There is no specific treatment, but fluid intake, rest, and antipyretics are used. A licensed dengue vaccine was approved in 2015 but further analysis found it may increase risk
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Dengue is a viral infection transmitted by mosquitoes that infects around 100-400 million people annually worldwide. It is caused by the dengue virus of which there are 4 serotypes. Infection with one type provides lifelong immunity to that type but subsequent infections with other types increase the risk of severe dengue. The disease ranges from mild fever to life-threatening dengue hemorrhagic fever/dengue shock syndrome. There is no vaccine for dengue prevention currently.
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Dengue virus is spread through the bites of infected Aedes mosquitoes and causes dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. It infects up to 400 million people annually, with 22,000 deaths from severe dengue. The virus has a positive-sense RNA genome that encodes structural and nonstructural proteins, including the essential NS2B-NS3 protease which contains a catalytic triad and is highly conserved among the four dengue serotypes.
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DENGUE VACCINE(1).pptx
- 2. What is dengue? • Dengue (break-bone fever) is a viral infection that spreads from mosquitoes to people. • 4 serotypes involved (DENV) 1, 2, 3, and 4. • It is more common in tropical and subtropical climates. • dengue is now endemic in over 100 countries (40% world population) • 390 million dengue virus infections per year of which 96 million manifest clinically and 21,000 deaths.
- 3. Dengvaxia • First vaccine to be licensed • DENGVAXIA® (Tetravalent recombinant) • Introduced by Sanofi Pasteur, A French multinational pharmaceutical and healthcare company • Indication: for the prevention of dengue disease caused by dengue virus serotypes 1, 2, 3 and 4,approved for use in individuals 6-16 years of age with laboratory-confirmed previous dengue infection and living in endemic areas.
- 5. • Dosage and administration : Subcutaneous vaccine, given in three doses (0.5 mL each) 6 months apart (at month 0, 6, and 12). • Preparation: The package contains a vial of lyophilized vaccine antigen and a vial of saline diluent (0.4% NaCl). after reconstitution vaccine should be administered within 30mins or stored at 2C to 8C . Contraindicated for immunocompromised individuals • Adverse reactions: Headache, injection site pain, malaise ,myalgia
- 7. REFERANCES Dengvaxia- Full prescription information given by Sanofi Pasteur Inc,2023 Guideline on management of Dengue Fever and dengue hemorrhagic fever in children and adolescents-May 2023 WHO- Official website Wong JM, Adams LE, Durbin AP, et al. Dengue: A Growing Problem With New Interventions. Pediatrics. 2022;149(6):e2021055522