The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is an open access international journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Detection of Polycystic Ovary Syndrome and Its Treatment with Pergularia Daem...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is an open access international journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Detection of Polycystic Ovary Syndrome and Its Treatment with Pergularia Daem...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Pcos & Infertility by dr alka mukherjee nagpur m.s. Indiaalka mukherjee
Polycystic ovary syndrome represents 80% of anovulatory infertility cases. Treatment initially includes preconception guidelines, such as lifestyle changes (weight loss), folic acid therapy to prevent the risk of fetal neural tube defects and halting the consumption of tobacco and alcohol. The first-line pharmacological treatment for inducing ovulation consists of a clomiphene citrate treatment for timed intercourse. The second-line pharmacological treatment includes the administration of exogenous gonadotropins or laparoscopic ovarian surgery (ovarian drilling). Ovulation induction using clomiphene citrate or gonadotropins is effective with cumulative live birth rates of approximately 70%. Ovarian drilling should be performed when laparoscopy is indicated; this procedure is typically effective in approximately 50% of cases. Finally, a high-complexity reproduction treatment (in vitro fertilization or intracytoplasmic sperm injection) is the third-line treatment and is recommended when the previous interventions fail. This option is also the first choice in cases of bilateral tubal occlusion or semen alterations that impair the occurrence of natural pregnancy. Evidence for the routine use of metformin in infertility treatment of anovulatory women with polycystic ovary syndrome is not available. Aromatase inhibitors are promising and longer term studies are necessary to prove their safety.
PCOD,How are they different ??Difficulties & Solutions made Easy , Dr. Sharda...Lifecare Centre
Tremendous advances and extensive human studies have uncovered the complexity and management of PCOD
Global prevalence -2.2% to 26% Roughly 1 in 15 women worldwide, (Lancet, 2007)
Polycystic ovarian Syndrome ( PCOS) is a common endocrine disorder (i.e Endocrinopathy) in women of Reproductive age. In which the Harmones secretion rate and the metabolism of the androgens and estrogens are disturbed and disrupted, resulting in the chronic anovulation and hyperandrogenism it also occurs from the insulin resistance and the compensatory Hyperinsulinemia. Adverse effect on multiple organ can cause the abnormal Uterus bleeding and Infertility. Symptoms of POCS can be Irregular menstrual cycle, Hirsutism and Dyslipidemia etc. The prevalence of POCS is generally thought to be between 3% and 12% based on the geographical locations and race.According to Ayurveda point of view POCS can be correlated with Aarthava Kshaya related to the subfertility patients presented Osuki Ayurvedila Centre.The Pharmaceutical treatment significs single symptoms and may be contra- indicated in some cases. According to the ayurvedic theories of Shodhana, Shamana and Tarpana, the treatment held in 3 stages for around 6-7 months. around 40 patients was taken for the test. The response to the treatment was recorded and therapeutic effects were evaluated by symptomatic rest and the LH and FSH hormone levels. The results showed that subfertility due to POCS can be Cured by Ayurveda treatment.
Contents:
1. PCOS: etiopathogenesis
2. DOGMA theory – Dysbiosis of Gut Microbiota
3. Evidence for microbiological dysbiosis and a “leaky” gut in PCOS
4. Chronic low-grade inflammation as a cornerstone of PCOS pathology
5. Chronic inflammation as a cause of insulin resistance
6. Probiotics and Prebiotics – potential new treatment for PCOS
Explore the intricacies of ovulation induction in intrauterine insemination (IUI) with Dr Laxmi Shrikhande's informative slide share presentation. From understanding the hormonal mechanisms to the latest techniques, this presentation offers insights into optimizing fertility through IUI. Whether you're a clinician seeking to enhance patient outcomes or an individual navigating fertility treatments, this resource provides valuable knowledge for your journey towards conception.
Pcos & Infertility by dr alka mukherjee nagpur m.s. Indiaalka mukherjee
Polycystic ovary syndrome represents 80% of anovulatory infertility cases. Treatment initially includes preconception guidelines, such as lifestyle changes (weight loss), folic acid therapy to prevent the risk of fetal neural tube defects and halting the consumption of tobacco and alcohol. The first-line pharmacological treatment for inducing ovulation consists of a clomiphene citrate treatment for timed intercourse. The second-line pharmacological treatment includes the administration of exogenous gonadotropins or laparoscopic ovarian surgery (ovarian drilling). Ovulation induction using clomiphene citrate or gonadotropins is effective with cumulative live birth rates of approximately 70%. Ovarian drilling should be performed when laparoscopy is indicated; this procedure is typically effective in approximately 50% of cases. Finally, a high-complexity reproduction treatment (in vitro fertilization or intracytoplasmic sperm injection) is the third-line treatment and is recommended when the previous interventions fail. This option is also the first choice in cases of bilateral tubal occlusion or semen alterations that impair the occurrence of natural pregnancy. Evidence for the routine use of metformin in infertility treatment of anovulatory women with polycystic ovary syndrome is not available. Aromatase inhibitors are promising and longer term studies are necessary to prove their safety.
PCOD,How are they different ??Difficulties & Solutions made Easy , Dr. Sharda...Lifecare Centre
Tremendous advances and extensive human studies have uncovered the complexity and management of PCOD
Global prevalence -2.2% to 26% Roughly 1 in 15 women worldwide, (Lancet, 2007)
Polycystic ovarian Syndrome ( PCOS) is a common endocrine disorder (i.e Endocrinopathy) in women of Reproductive age. In which the Harmones secretion rate and the metabolism of the androgens and estrogens are disturbed and disrupted, resulting in the chronic anovulation and hyperandrogenism it also occurs from the insulin resistance and the compensatory Hyperinsulinemia. Adverse effect on multiple organ can cause the abnormal Uterus bleeding and Infertility. Symptoms of POCS can be Irregular menstrual cycle, Hirsutism and Dyslipidemia etc. The prevalence of POCS is generally thought to be between 3% and 12% based on the geographical locations and race.According to Ayurveda point of view POCS can be correlated with Aarthava Kshaya related to the subfertility patients presented Osuki Ayurvedila Centre.The Pharmaceutical treatment significs single symptoms and may be contra- indicated in some cases. According to the ayurvedic theories of Shodhana, Shamana and Tarpana, the treatment held in 3 stages for around 6-7 months. around 40 patients was taken for the test. The response to the treatment was recorded and therapeutic effects were evaluated by symptomatic rest and the LH and FSH hormone levels. The results showed that subfertility due to POCS can be Cured by Ayurveda treatment.
Contents:
1. PCOS: etiopathogenesis
2. DOGMA theory – Dysbiosis of Gut Microbiota
3. Evidence for microbiological dysbiosis and a “leaky” gut in PCOS
4. Chronic low-grade inflammation as a cornerstone of PCOS pathology
5. Chronic inflammation as a cause of insulin resistance
6. Probiotics and Prebiotics – potential new treatment for PCOS
Explore the intricacies of ovulation induction in intrauterine insemination (IUI) with Dr Laxmi Shrikhande's informative slide share presentation. From understanding the hormonal mechanisms to the latest techniques, this presentation offers insights into optimizing fertility through IUI. Whether you're a clinician seeking to enhance patient outcomes or an individual navigating fertility treatments, this resource provides valuable knowledge for your journey towards conception.
A Clinical Study to Evaluate the Efficacy of Rajpravartini Vati & Hingvashtak...iosrphr_editor
The women face a lot of physical & psychological problem both at the time of menarche as well as menopause. Kashtartava is a disease where in a female during her reproductive age experiences difficult & painful menstruation. Pathologically its tridoshas having vata predominance .A total 60 patients were randomly divided in these group. An assessment was done on the basis of subjective as well as objective parameters with the help of vas.The study revealed the good report.
A Clinical Study to Evaluate the Efficacy of Rajpravartini Vati & Hingvashtak...iosrphr_editor
The women face a lot of physical & psychological problem both at the time of menarche as well as menopause. Kashtartava is a disease where in a female during her reproductive age experiences difficult & painful menstruation. Pathologically its tridoshas having vata predominance .A total 60 patients were randomly divided in these group. An assessment was done on the basis of subjective as well as objective parameters with the help of vas.The study revealed the good report.
Do Women With Polycystic Morphology Without Any Other Features of PCOS Benefi...Alex Swanton
Women with ovaries of polycystic morphology (PCO), without any other features of polycystic ovary syndrome(PCOS), respond similarly to women with PCOS when stimulated with exogenous gonadotrophins, and both groups share various endocrinological disturbances underlying their pathology.
Congenital Agenesis Of The Corpus Callosum With Intracerebral Lipoma And Fron...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
“Hemodynamic and recovery profile with Dexmedetomidine and Fentanyl in intrac...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Correlation of Estrogen and Progesterone Receptor expression in Breast Canceriosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Analytical Study of Urine Samples for Epidemiology of Urinary Tract Infection...iosrphr_editor
The current study was carried out in District Abbottabad aimed to determine the common urinary
tract infections in local community to determine the epidemiology of significant diseases in asymptomatic patients
of renal disorder. In this study a total of 1000 urine samples were examined during 3rd February to 1st April 2015
from patients attending Ayub Teaching Hospital Abbottabad by using dipstick and microscopic analysis of urine.
There were 638 females and 362 males patients examined during this period. The range of age groups is between
1.5 years to 80 years. Results of this study was reported as Pyuria 11%, Proteinuria 21.1%, Hematuria 10.4%,
Epithelial Cells 8.2%, pH 7.8 %, Granular casts 7.3%, Triple phosphate 6.6%, Calcium oxalate 6.4%, Glycosuria
6.3%, Bacteria 6.2% and mucous 4.1%. This study concludes that routing urinalysis should be performed for all
individuals to diagnose the asymptomatic diseases that will help in simple therapeutic measurements as urinalysis
is a simple step to determine the root of Urinary tract disorders.
Chest sonography images in neonatal r.d.s. And proposed gradingiosrphr_editor
BACKGROUND : Lung sonography has been used to monitor the patients of R.D.S. in
N.I.C.U. in recent times.
AIMS : To Describe and Grade the changes of R.D.S. by lung sonography.
SETTING & DESIGN : Tertiary care institutional set up in a rural medical college.
STUDY DURATION : September 2014 to May 2015. Follow-up variable, upto 2 weeks.
PROSPECTIVE, ANALYTICAL STUDY.
MATERIALS AND METHODS -This was a single institute study approved by the institutional ethics
committee. Prior informed consent was obtained from the parents. 100 consecutive patients admitted in
N.I.C.U. WITH gestational age < 36 weeks with respiratory complaints were enrolled. Chest x-ray was
obtained within few hours of admission and lung sonography was performed within 24 hours. Follow – up
sonography was performed as and when necessary. Sonography image was graded and correlated with chest
xray and clinical picture
The Comprehensive Review on Fat Soluble Vitaminsiosrphr_editor
This review article deals with brief description of fat soluble vitamins with figures and tables
showing statistical analytical data duly quoting the references wherever necessary. The word “soluble” actually
means “able to be dissolved.” Whether a vitamin is classified as 'fat-soluble' or 'water-soluble' has to do with
how the vitamin is absorbed, stored and removed from the body. Vitamins are tiny organic compounds with a
huge impact on the health and well-being of the body. The body needs a small amount of fat soluble vitamins in
order to stay in optimal health. Fat soluble vitamins play an important role in keeping the body healthy and
functioning from immune system and muscle and heart function, easy flow and clotting of blood as well as eye
health. They are critical to health and wellness–particularly reproductive health and wellness. Low-fat, no-fat
and vegan diets are woefully lacking in fat soluble vitamins. However a diet based on traditional foods can
naturally provide these vitamins. Science is still learning about many of the functions of vitamins. "Too much
vitamin A, D, or K can lead to increased levels that are unhealthy and can cause serious health consequences.
Diseased conditions leading to decreased fat absorption leads to decreased absorption of vitamins. The fatsoluble
vitamins work most safely and effectively when obtained them from natural foods within the context of a
diet rich in all their synergistic partners. If fat soluble vitamins are stored for lengthy time they generate threat
for toxicity than water soluble vitamins and such situation even aggravated, provided they are consumed in
excess. Vitamin products, above the legal limits are not considered food supplements and must be registered as
prescription or non-prescription (over-the-counter drugs) due to their potential side effects. Vitamin A and E
supplements do not provide health benefits for healthy individuals, instead they may enhance mortality, and it is
held proved that beta-carotene supplements can be harmful to smokers
Sulphasalazine Induced Toxic Epidermal Necrolysis A Case Reportiosrphr_editor
Toxic Epidermal Necrolysis (TEN) is a rare and life threatening mucocutaneous reaction
characterized by extensive necrosis and detachment of epidermis. The Worldwide incidence of TEN is 0.9 to 1.4
per million populations per year [1]. Here we have discussed a case of Toxic Epidermal Necrolysis secondary
to Sulfasalazine managed with fluid replacement, analgesics, anti-infective therapy aggressive nutritional
support and intravenous high dose steroid therapy.
Keywords- Toxic Epidermal Necrolysis, Sulfasalazine
Evaluation the efficacy of IVIgG in treatment of Hemolytic Disease of Newborniosrphr_editor
Hemolytic disease of newborn (HDN) is an important cause of hyperbilirubinemia in the
neonatal period,and delayed diagnosis and treatment may lead to permanent brain damage. Traditional
neonatal treatment of HDN is intensive phototherapy and exchange transfusion.Intravenous
immunoglobulin(IVIgG) has been introduced as an alternative therapy to exchange transfusion. This study was
conducted to assess the effect of IVIG in HDN .
FIBROLIPOMATOUS HAMARTOMA OF ULNAR NERVE: A RARE CASE REPORT.iosrphr_editor
Nervous fibrolipomatous hamartoma is said to be a rare tumor-like condition involving the peripheral
nerves,in which the epineurium and perineurium are enlarged and distorted by excess of fatty and fibrous tissue
s that infiltrate between and around nerve boundaries. The median nerve is more likely to develop a hamartoma
than other nerves with a predilection for the carpal tunnel.
A fibrolipomatous hamartoma – is a rare, benign, congenital lesion most commonly found in the median nerve,
usually at the level of the wrist or hand.
We report a case of this rare condition in ulnar nerve.
SELF MEDICATION PRACTICES FOR ORAL HEALTH PROBLEMS AMONG DENTAL PATIENTS IN B...iosrphr_editor
Introduction: Self‑ medication is commonly practiced all over the world. Self-medication is defined as the use
of medication by a patient on his own initiative or on the advice of a pharmacist or a lay person instead of
consulting a medical practitioner. The present study was aimed to estimate the prevalence of self-medication for
oral health problems among dental patients in Bengaluru city; to identify triggering factors that could influence
self-medication practices; to identify sources of medications used; to identify sources of information about
medications used; and to identify reasons for self-medication.Study Design: A Cross sectional Study.Methods:A
survey was conducted among 175 subjects among dental patients in Bengaluru city. Data were collected
through a specially designed proforma using a closed‑ ended, self‑ administered questionnaire containing 15
questions, in five sections.
Results: The prevalence of
Clinico-haematological Profile of Falciparum Malaria in a Rural Hospital of T...iosrphr_editor
Aim: To study the clinico-haematological profile malaria in a rural hospital of Tripura.
Material and methods: A cross-sectional hospital-based study was done from at Kulai District
Hospital,Tripura. This hospital based cross sectional study was done on 60 confirmed cases of falciparum
malaria (either by peripheral smear or rapid diagnostic test) admitted in Kulai District Hospital. A case sheet
proforma was prepared and data (demographic profile,clinical feature, investigation, treatment, and
complication) from all indoor patients was collected and analyzed.
Result: Out of 60 patients, 40(66.6%) were males and 20 (33.4%) were females. Most of the patients were
between the age group 21-40 years with the highest prevalence between the age group of 21-30. Fever was the
most common symptom. Anemia was present in 42(70%) patients, out of which 6(10%) patients had severe
anemia. Thrombocytopenia was present in 36(60%) patients.Abnormal liver function tests were observed in
26(43.3%) subjects while abnormal kidney function tests were observed in16(26.6%) patients. All the 60
patients received Artemisinin based antimalarial drugs.
Conclusion: Early detection, prompt management, and adequate supportive therapy may reduce mortality due
to falciparum cerebral malaria.
Indonesian Wild Ginger (Zingiber sp) Extract: Antibacterial Activity against ...iosrphr_editor
Lempuyang gajah (Zingiber zerumbet (L.) Smith), lempuyang pahit (Zingiber amaricans BL.), and
lempuyang wangi (Zingiber aromaticum Vahl.) are used as traditional medicine (jamu) in Indonesia. It is also
used for treatment of microbial infections, helps to increase appetite and stimulate digestion in chickens.
Information on their uses are available, but only limited in the scientific data on their bioactivity. The study was
conducted on the antibacterial effect of organic extracts of these plants with Mycoplasma gallisepticum as the
agent of chronic respiratory disease in chickens. Juice and extracts of fresh and dried rhizome are evaluated
through the disc diffusion assay and minimum inhibitory concentration. Oxytetracyclin (30 µg) are used as
standards. All extracts are individually exhibited as antibacterial activity against Mycoplasma gallisepticum (7
± 0.11 mm to 21 ± 0.86 mm). The minimum inhibitory concentration (MIC) determination of plants extracts are
ranged from 7.8 mg/ml to 31.2 mg/ml. The preliminary results suggested promising antibacterial properties of
wild ginger from Indonesia, and probably could be used in management of chronic respiratory disease in
chickens.
A case of allergy and food sensitivity: the nasunin, natural color of eggplantiosrphr_editor
Abstract: Allergies and food sensitivities can both be considered as "adverse reactions individualistic" to food.
Are pathological and individual forms because they affect a few individuals in way rather serious; immediate
or delayed reactions occur instead with simple effects histamine, or, in severe cases with respiratory and
anaphylactic shock
The eggplant (Solanum melongena L.) is known to cause food allergies in some Asian countries, but detailed
studies on allergies caused by eggplant are lacking, however, it was highlighted the presence of allergens in
edible parts of eggplant with preponderance in the peel .
The purpose of this study was to propose an extraction method rapid, efficient and cost of natural dye from
waste products from the food industry, such as the peels of eggplant, from which it was extracted, isolated and
purified the nasunin,a colored molecule in red-fuchsia.
Nasusin was tested on 58 patients to evaluate the potential sensitizing effect on the skin. The results demonstrate
that allergenic effects are negligible and therefore the nasunin can be used as a colorant in various industrial
sectors with a certain safety margin
Complete NMR Assignment of MogrosidesII A2, II E andIII A1Isolated from Luo H...iosrphr_editor
NMR analysis allowed complete assignments of three known mogrol glycosides, Mogroside IIA2 (1),
II E (2)and IIIA1 (3), isolated from the extracts of Luo Han Guo. Herein, complete 1H and 13C NMR
assignmentsof all threemogrosidesare described based on NMR experiments (1H NMR, 13C NMR, COSY,
HSQC-DEPT, HMBC, NOESY and 1DTOCSY) and mass spectral data.
Nanoemulsion and Nanoemulgel as a Topical Formulationiosrphr_editor
: Nanoemulsion is referred type of emulsion with uniform and extremely small droplet size in the range
of 20-200 nm. Nanoemulsion provides numerous advantages over other carrier such as polymeric nanoparticle
and liposomes, including low cost preparation procedure, high hydrophilic and lipophilic drug loading system
to enhance the longer shelf live upon preserving the therapeutic agents. Incorporating the preparation of
nanoemulsion with hydrogel matrix to produce nanoemulgel exhibited by the two separate systems that forming
it. Nanoemulgel possesses the properties of thixotropic, non-greasy, effortlessly spreadable, easily be removed,
emollient, not staining, soluble in water, longer shelf life, bio-friendly, translucent and agreeable appearance.
Pharmacokinetics of High-Dose Methotrexate in Egyptian Children with Acute Ly...iosrphr_editor
Aim:Since several factors have been shown to influence the clearance of methotrexate, the purpose of this study
was to identify potential relationships between patient covariates and the methotrexate clearance estimates and
deduce a pharmacokinetic model for the estimation of methotrexate clearance in Egyptian pediatric ALL
patients that may help dosage adjustment and achieve target steady-state plasma concentrations in a similar
sittings.
Patients and methods: A total of 94 pediatric patients with B-cell ALL, of whom 70 were the studied population
and 24 were the test population, were treated with four courses of HDMTX doses 2.5 gm/m2
(low-risk arm) or 5
gm/m2
(standard-/high-risk arm) given every other week by intermittent intravenous infusions over 24 hours as
a part of their treatment protocol. Patients were monitored for the 24 hour MTX concentration and the systemic
methotrexate clearance was calculated for each methotrexate dose
Epidemiology of Tuberculosis (TB) in Albania 1998-2009iosrphr_editor
Abstract : In Albania, many people erroneously think that tuberculosis (TB) is a disease of the past-an illness
that no longer constitutes a public health threat. Surveillance is an integral part of tuberculosis (TB) control.
Albania has a highTB notification rate and there are doubts about underreporting. The evolution of the
incidence of tuberculosis is presented, together with more detailed figures over the period 1998-2009. These
figures were obtained by the monthly forms (called 14/Sh) compared with the individual notification data.
Objective: To examine the distribution and sources of increased tuberculosis (TB) morbidity and reporting
system deficiencies in the Albania from 1998 through 2009. Metodology: The study is descriptive one conductet
during the period 1998-2009. The statistical analysis is based on data reported from regional level (regional
epidemiological departments) to the central level (Public Health Institute). Results: The main findings were:
discordance between the collected data (individual form) and reported data (monthly form); tuberculosis
incidence rate shows little oscillations which ranges from 6.67 to 9.2 cases/100.000 population; 50% of the
regions show a lack of information on the confirmation of diagnosis and laboratory examination type used for
confirmation. Conclusion: TB disease in high-risk populations where it is difficult to detect, diagnose, and treat;
limitations of current control measures and the need for new tests and treatments, including an effective
vaccine; improving information system, regulation of individual form and personnel training.
Total Phenol and Antioxidant from Seed and Peel of Ripe and Unripe of Indones...iosrphr_editor
Study on total phenol and antioxidantactivity ofsugar apple fruits of various solvent, part of fruits, and level of ripening. Solvent extraction used were 80% (v/v) methanol, 50% (v/v) acetone, boiling water, and 50% (v/v) ethanol. Part of fruits thatbeen used for samples were seed and peel which are normally by products of sugar apple processing, level of ripening were unripe, and ripe sugar apple fruits. Total phenol was determined by Folin-ciocalteau method. Total antioxidant was quantified by 1,1-diphenyl-2-picrylhydrazyl(DPPH) method.Therewas a difference in type of solvent, part of fruits, and level of ripeningon total phenol and antioxidant concentration of sugar apple fruits. Seeds have higher total phenol concentration than peels of this fruits. Unripe sugar apple fruits have higher total phenol and antioxidant than ripe fruit. The best solvent for phenol extraction was ethanol 50%butthe best solvent for antioxidant extraction was acetone 50%.
A Review on Step-by-Step Analytical Method Validationiosrphr_editor
When analytical method is utilized to generate results about the characteristics of drug related samples it is essential that the results are trustworthy. They may be utilized as the basis for decisions relating to administering the drug to patients. Analytical method validation required during drug development and manufacturing and these analytical methods are fit for their intended purpose. To comply with the requirements of GMP pharmaceutical industries should have an overall validation policy which documents how validation will be performed. The purpose of this validation is to show that processes involved in the development and manufacture of drug, production and analytical testing can be performed in an effective and reproducible manner. This review article provides guidance on how to perform validation characteristics for the analytical method which are utilized in pharmaceutical analysis.
A Cross Sectional Study of Ethnic Differences in Occurrence and Severity of A...iosrphr_editor
Non-steroidal anti-inflammatory drugs are the most widely used "over the counter" medication all over the world despite their complications in different major organs. Present studies envisaged for knowing the occurrence and severity of adverse drug reactions from NSAIDs in different ethnic communities of Sikkim. A cross sectional study was undertaken in the medicine outpatients department of a secondary and tertiary care hospital. The patients belonging to Nepalese, Bhutias, Lepchas ethnic communities and others community (settlers from other parts of India) were included to analyzed the data based on the age and gender, ethnicity and ADRs, drugs and ADRs. Severity assessment was done using Hartwing and Siegel scale and causality assessment by Naranjo scale. Total 109 cases of ADRs, predominating in female were detected. Nepalese were the most affected and Gastrointestinal tract (GIT) being the most affected organ in them. Diclofenac showed maximum number of ADRs in all the communities. Maximum number of cases occurred on single day use (40.36%) of drugs. All the cases were belonging to the "possible category" and the maximum being the mild (72.48%) in nature. It is advisable to consider the ethnic/racial differences equally with other factors, to improve the safety and efficacy of a drug.
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
1. IOSR Journal Of Pharmacy
(e)-ISSN: 2250-3013, (p)-ISSN: 2319-4219
Www.Iosrphr.Org Volume 3, Issue 4 (May 2013), Pp 21-25
21
“Clinical Efficacy Of Ayurveda Treatment On Polycystic Ovarian
Syndrome”
1,
Dr.Bhagyashri Mahavir Khot. 2,
Dr.Meenal Dipak Lad. 3,
Dr.Arun Jagannath
Patil. 4,
Dr.Anil Chindhu Kakad
(Asso.Professor-Streerog-Prasutitantra Dept.R.A.Podar Medical CollegeWorli Mumbai.) .
(Prof.&Head Dravyaguna Dept.College Of Ayurved AndResearch Center Nigadi.)1 .
(Asso. Professor-Streerog-Prasutitantra Dept.R.A.Podar Medical College Worli Mumbai)2
(P.G.Scholar Streerog-Prasutitantra Dept.R.A.Podar Medical College Worli Mumbai.)3.
ABSTRACT: Polycystic ovarian syndrome (PCOS) also known by the name of stein-leventhal syndrome.
Incidence of this condition is growing amongst young women in reproductive age.It is almost ranging between
5.10% of young women coming for infertility, it is now increasingly perceived as disorder of changed life styles
and is a rainbow metabolic syndrome Research shows that history of gestational diabetes 40% are cases at
PCOS. Death rates amongst PCOS due to diabetes mellitus and metabolic syndrome s 5:1.4 to normal
population, excessive exposure to estrogen unopposed by progesterone could cause greater incidence of
malignancies endometrium and breast. Infertility is by far the most common feature due to anovulation,
therefore the present study was carried out for clinical evaluation of the efficacy of ayurveda treatment on
PCOS. The treatment was conducted for duration of 3 months the response to the treatment was recorded by
parameters, the result revealed that PCOS can be cured by successfully by using this ayurvedic regimen
KEY WORDS: Polycystic Ovarian Syndrome,Endocrine Disturbance, Herbal Compound,Dashmool
Decoction, Til Tail,Sahchar Tail, Shatavari Tail.
I. INTRODUCTION
Polycystic ovarian syndrome is a most prevalent endocrinopathy. Incidence of this disease is increasing
now a days because of sedentary lifestyles, pollution, excessive intake of junk food.It is obviously observed in
women seeking medical advice for infertility as well as irregular menstrual bleeding, majority of these cases
could be treated either by hormonal therapy or surgical intervention ,this study will emphasize on careful
management of polycystic ovarian syndromePolycystic ovarian syndrome is a condition where a hormonal
imbalance affects follicular growth during the ovarian cycle causing the affected follicles to remain in the ovary.
The retained follicle forms into a cyst & with each ovarian cycle a new cyst is formed leading to multiple
ovarian cyst ultrasonic morphologic evidence of >_ 12 follicles measuring 2.9mm diameter in single plane
during quiescent phase of ovary i.e. 2.7 days of cycle associated with obesity, oligomenorrohea, anovulation &
hyperandrogenism,.hyperinsulinemia- increased level of insulin in the blood is due to densitivity of cells to
insulin, a factor present in the blood stimulates androgen secretion by the ovarian stroma, the connective tissue
of ovarian tissue of ovary & reduces serum sex hormone binding globin(SHBG) causing increased levels of free
testesterone. Due to the presence of increased androgen in the ovary , the follicle undergoing maturation in the
ovarian cycle is affected causing anovualtion of particular follicle.
The ovarian cycle is governed by a hormonal feedback system moderated by the hypothalamus thus it
requires constant feedback of hormonal for it to properly regulate the release of follicle stimulating hormone
(FSH), lutenizing hormone (LH) from the anterior pituitary gland. The hormonal feedback that the
hypothalamus is receiving is due to high levels of oestrogen that has been formed from free androgens in the
peripheral tissue. Ayurveda suggests that this is vata type disorder (Apan vayu) though the involvement of other
dosha can be there but in some measure because the gynaecological disorder are mainly supposed to be due to
vitiation of vata.Pcos Is A Disorder Involving Pitta, Kapha, Medas,Ambhuvahasrotas & Artava Dhatu .The
causes of PCOS as per ayurveda can be taken as eating excessive sweet and kaphagenic foods, mandagni
because of this is kapha getting aggrevated in PCOS, we find kapha disorder. As well as pitta and vata dosha
disorder. Because of all three doshas play important & distinctive role in the production, development,
maturation & release of ovum & therefore the ovarian cycle & menstrual cycle is under control of three doshas .
The selected trial drug was decided according to dosha dushya dushti & hypothesized samprapti.
2. Clinical Efficacy Of Ayurveda…..
22
1.1.Aims & Objective
To verify the efficacy of ayurvedic treatment regimen on polycystic ovarian syndrome(PCOD).
To observe the rate of conception or fertilization and rule out other causes of inferlity.
To provide safe, cost effective, non surgical, non HRT treatment.
1.2.Materials & Methods
Total 40 patients were registered from OPD of the streerog & prasutitantra dept , of R.A. Podar
medical college, worli Mumbai, fulfilling the criteria of selection were included into study. Approval of the
institutional ethics committee was taken.
1.3.Inclusion Criteria
Married patients(Age group 20-40yrs)
Infertility patient
P.C.O.D.
Irregular menses / scanty menses due to anovulatory cycle
Anovulatory cycle
Elevated LH
LH:FSH ratio>3.
Clinical or biochemical evidence of Hyperandogenism.
1.4.Exclusion Criteria
Unmarried patients
Cervical tumour, polyp, Ca cervix
Uterine fibroid
Congenital anomalies in female genital tract
Tubercular endometritis
Congenital adrenal hyperplasia.
HIV/VDRL/HbsAg positive
Malignant diseased patients and cytotoxic patients.
Other gynaecological disorder.
1.4.Discontinuous Criteria
An acute or severe illness.
Patient left against medical advice.
1.5.Subjective and objective parameters
A) Subjective parameters
1 Duration of bleeding-(Table 1)
Duration Grade Score
3-5 days Nil 0
1-2/6-7days Mild 1
1/8-9days Moderate 2
Spotting >9 days. Severe 3
Bleeding 1 or above days are considered as bleeding throughout the day.spotting is considered as bleeding just 2
or 3 drops.
2 Irregular menstruation-(Table 2)
IMP days Grade Score
28 days Nil 0
28-45 days Mild 1
45-60days Moderate 2
Above 60 days. Severe 3
3. Clinical Efficacy Of Ayurveda…..
23
3 Amount of bleeding and quantity of menstrual blood-(table 3)
No of pad per cycle Grade Score
<15 Nil 0
15-19 Mild 1
20-25 Moderate 2
>25 Severe 3
4 Pain during menstrual period-(Table 4)
Pain Grade Score
No pain Nil 0
Menstruation is painful but daily
activities are not affected,no need of
analgesic.
Mild 1
Daily activities are affected,need to
take analgesics.
Moderate 2
Daily activities are inhibited
affected,pain continous after taking
analgesic.
Severe 3
B) Objective Parameter
1 Haematological investigations -
o CBC,ESR.
o Blood group
o HIV/ VDRL/ HbsAg
o BSL(F/PP)
o Urine (R/ M)
o LH, FSH ratio.
2. USG ( Pelvis & Abdomen):
3. Follicular study- A serial vaginal or abdominal sonography was done from 10th day of menstrual cycle, till
after ovulation.
II. TREATMENT PROTOCOL
Standardization & authentication of drug will be done. The treatment was conducted in following way
for duration of 3 months Patient were treated with 5 gm of powder of Ashoka( Saraka Indica) , Manjistha,
(Rubia Cordifolia), Shalmali(Bombax Malbaricum), Lodhra( Symplocos Racemosus), Rasanjan(Barberis
Chitra),Sariva(Hemidesmus Indicus), Gokshur(Tribulus Teristris), Punarnava (Boerrhavia Diffusa) ,
Nagkeshar(Mesua Ferea), Chandan (Santalum Albam), Amalaki(Embelica Officinalis), Haridra(Curcuma Longa),
Gudmar(Gymnema Sylvestre), Guduchi(Tinospora Cordifolia) Methi(Trigonella Foenum Gaecum),
Vijaysar(Pterocarpus Marsupium), twice a day in the morning & evening at 6 pm.These herbs are also quite
beneficial in crubing three aggrevated doshas.
Before menses patient were treated with yog basti(dashmool kwatha & til tail) for three consecutive
cycles.After cessation of menstruation uttarbasti(shatavari oil & sahachar oil) is used for 3 days, in one cycle was
given for three consecutive cycles. A patient is admitted for uttarbasti after cessation of menstruation. Snehana
(oleation) of til oil on lower abdomen, back & lower limbs followed by nadisweda (fomentation) with steam on
lower abdomen & back was given to patients before each uttarbasti. Yoniprakshalana with Triphala kwatha
was performed to sterilise perivaginal part, the procedure was carried out in minor OT the oils & instruments
were autoclaved.Patients advised for consumption of vegetables preferred karela & drumsticks , avoid oily &
spicy food , sweets & honey because food is integral part of the overall health. PCOS may eliminated or
aggrevated by the foods which are consumed, basically garlic , onion are beneficial for PCOS patients Regular
exercise , suryanamaskara, sarvangasana, paschimottanasana, ardhamatsyendrasana, matsyasana, ushtrasana all
backward bending asanas are recommended for PCOS patients Follow up study was done for 3 months at
interval of every month & for pregnancy follow up study was carried out for 3 months after completion of the
treatment.Any new complaint that raised during the follow up period releated to the study was also noted.
2.1.End Point
If some complication developed during treatment it was decided to stop treatment
III. OBSERVATIONS
In the patient study 74.50% patients were housewives & 25.50% were professionals.90% patients were
4. Clinical Efficacy Of Ayurveda…..
24
not using any contraceptive method while 10% used condom & natural methods. In the treatment period all the
patients had not taken any kind of medicine Patients complained mostly irregular ,few or absent menstruation ,
scanty or less menstrual blood, dysmenorrhoea, acne, obesity, hirsutism. Assessnent criteria was based on the
gradation of symptoms,the cardinal symptom which are irregular menstruation duration of bleeding,
dysmenorrhoea ,quantity of menstrual blood ,hirsutism ,acne , & obesity before & after treatment. Data was
analized by using paired ‘t’ test . LH/FSH hormone report revealed that the ratio came to the normal level.
Report revealed that reduce of polycystic appearance of ovaries and improvement of follicular maturity.
Result-(Table 6)-
Symptom N
o
(n
)
Mean score
B.T. A.T
Mea
n d
Rel
ief
%
SD SE t
1).Irregular
menstruation
4
0
2.475 0.250 2.27
5
76 0.733 0.116 19.19
2)Duration
of bleeding.
4
0
2.350 0.425 1.92
5
57.
5
0.5723 0.0905 21.27
3)Dymenorr
ea.
4
0
1.000 0.050 0.90 92 0.579 0.0944 10.06
4)Quantity
of menstrual
blood.
4
0
1.900 0.150 1.75
0
70 1.104 0.174 10.03
5)Hirsutism 4
0
1.950 1.875 0.07
5
- 0.2667 0.0422 1.78
6)Obesity. 4
0
1.700 0.200 1.50
0
85 0.5991 0.0947 15.83
From the observation made before & after the treatment following inference are drawn The symptoms like
irregular menstruation improved by 76% , At the end of treatment 57.5% patients had normal duration of
menstrual bleeding ,92% of patient was relieved from dysmenorrhoea 70% patients had average quantity of
menstrual blood. In obese patient 85% had normal BMI level . But in hirsutism there was no statistically
significant result seen.
IV. DISCUSSION
According to ayurveda PCOS is a disorder involving pitta, kapha &vata doshas. Rasa & meda dhatu,
rasa, rakta & artava vaha strotasa. The given treatment works to improve hormone utilization & regulates overall
hormone balance. The powder of herbal drugs are also quite beneficial in curbing the three aggravated doshas &
brings balance & strength to the menstrual system & it helps to regulate artava dhatu. The properties of deepana &
pachana of above drugs they elevate the jatharagni, dhatwagni as well as artavagni. Powder of guduchi inhances
the overall immunity & atibala has properties of prajasthapana, garbhashayyadaurbalyahara, balya bruhana &
ojovardhana. Therefore at the end of 6 months 62% patients get conceived and avoid miscarriage.There is also
kapha reducing, insulin enhancing & harmone rebalancing , drugs helps to relieve the symptoms PCOS.Due to
basti the treatment principle is to clear obstruction in pelvis, normalize metabolism & regulate menstrual
system(artava dhatu) uttarbasti is most effective treatment in gynecological disorders. Shatavari oil & sahachar oil
contains til oil & its very good for menstrual problems.Its polysaturated fatty acid which ultimately intensify the
penetration of oil based substances through cell membrane which is composed of lipid bilayer which has inherent
capability of movement & this movement is directly proportional to temperature,.this may be the reason to heat
the oil in mild temperature before administration of uttarbasti.
General basti regulates the nervous control & uttarbasti regulates CNS controlling the pelvic organs.
Hence by governing HPO axis through hypothalamus it helps in maintenance of follicular growth (oil of
sahachara were helped to destroy cysts in ovaries & stimulates the follicular maturity. Oil of shatavari were helped
to bring balance & strength to the menstrual system because it contains phytooestrogens)
V. CONCLUSION
In case of PCOS 87% patients were successfully get cured. 62% patients had conceived within the
follow up period of 3 months No significant complication is evident in study . it is non surgical & non hormonal
treatment In conclusion PCOS can be cured by using ayurvedic treatment regimen.
5. Clinical Efficacy Of Ayurveda…..
25
BIBLIOGRAPHY
Ayurvedic Texts:
[1.] Agnivesha & Dridhabala, Charak Samhita – Khand 1 &Chaukhamba Sanskrit Prakashan. 2. Sushrut Samhita - Ayurved
Tatwa sandeepika, Chaukhamba Sanskrit prakashan, 3rd
edition (1974) commentary
[2.] Anant Damodar Athawale Ayurvediya, Astang Sangraha by Vruddha vagbhatta edited muudranalaya 1980.
[3.] Pandit Paraswankum Shastri, Sharangdhar Samhita – edited Chaukhamba orientatia 3rd
edition.
[4.] Nadkarni A.K., Indian meteria media, popular Book Depot, Bombay 1954.
[5.] Bhrahmashankar Shastri, Bhavprakash, Part 1st& 2nd, Chaukhambha sanskrita series, Banaras, 2ndedi. 1949.
[6.] Hemraja Sharma and Y.T. Acharya, Kashyap – Samhita - by Kasyapa edited Publication Nirnaga sagar press, Bombay.
[7.] Vaishya Shaligramji, Bangsen Samhita, Bangasen, 1st
[8.] Ed., Shri venkateshwara Steem Press, Bombay, 1946.
[9.] Jharkhande Ojha, Dhanvantari nighantu – edited and commentrated by publistrer ,Adarsha vidya Niketan B1/96 B.H.U. Assi,
Varanasi 221005 1st
edition.
[10.] Madanpal Pandit Shaktidhar Shukla, Madanpal nighantu published Navalkishor press, Lucknow 1st
edition. 1930.
[11.] Sharma P.V. Kraiyadev nighantu, Pub. Chaukhamba Orientatia varanasi 1st
edition 1979.
[12.] Apte V.G, Raj Nighantu Samhita, Dhanvantari Nigantu, Ed. Anandashram Mudranalaya, Pune, 1925.
[13.] Vaisha Shaligramji, Shaligram nighantu – by shaligram vaishya publisher shri venkateshwar steem press Bombay 1st
[14.] edition 1981.
[15.] Nadkarni K.M., Indian Materia medica – Vol I & II, Popular Book Depot, Bombay.
[16.] R.N. Chopra, Nayar, S.L. & Chopra I.c. Glossary of Indian medicinal plants, reprinted edition, Publications and Information
Directorate, CSIR, New Delhi.
[17.] Ramanath Ramanath Dwivedi, Stri - rog vigyan, Chaukhamba Sanskrit Series.
[18.] Jahansinha Chauhan, Stri - rog chikitsa, Chaukhamba Sanskrit Series.
[19.] Jahansing chavan, Stri – rog chikitsa, Chaukhamba Sanskrit Series.
[20.] Premvati Tiwari, Prasutitantra Part I & II, Chaukhamba Sanskrit Series.
[21.] Nirmala Joshi, Ayurvedic concepts in Gynaecology, Varanasi, 1965
[22.] Rajendra Prakash Bhatnagar, Abhinav stri - rog vigyan - suryaprakashan vdaypan
[23.] Shivakhanna Khanna, Sachitra stri - rog chikitsa, Chaukhamba Sanskrit series.
[24.] Arundatta and Hemadri, ‘Sarvangasundari and Ayurvedic Rasayana’ Comm. On
[25.] Ashtanga Hidaya, Chokhamba Orientalia, Varanasi, 1982.
[26.] Lifestyle Induced Diseases in Women . Dr.H.S. Palep, Ayurmedline 2002.
MODERNTEXTS-
[1.] Shaw's textbook of Gynaecology - Shaw Wilfred, B.I. Churchil 6th edition.
[2.] Jeffcott's principle of gynaecology - Jeffcott Norman 2001
[3.] Textbook of Gynaecology - D.C.Dutta 3rd editon.
[4.] Goodman and Gillman's The pharmacological basis of therapeutics, edited by Alfred Goodman
Gilmann, T. W. Rall, A.S.Neis and P.Taylor, volume I and II 8th edition , Maxwell Macmillan
International Edition Pergaman Press pg. no. 9 of vol I and 1051 of vol II
[5.] A.K. Nadkarni, Indian Materia and Medica, 3rd edition, Popular press building, Tardeo Road, Bombay
400034, 1976
[6.] Anonymous, Database on medicinal plants used in Ayurved, Published by Central Council for
Research in Ayurveda and Siddha.Dept of ISM & H, Ministry of Family health and welfare, Govt of
India. Vol 8,pg 419
JOURNALS-
Jounal Inst che India, 1973,45, 205.
Indian J. Chem, 1979, 1713, 180.
J Indian chem. soc, 1980, 57, 417.
Indian J. Exp. Biol, 1969, 7, 250.
WEBSITES-
[1.] www.wikipedia.com
[2.] www.emedicine.com
[3.] .www.herbalinformation.com
[4.] www.chakrapaniayurveda.com