This document summarizes a pilot study that evaluated the safety and effectiveness of an alternative therapy for polycystic ovary syndrome (PCOS) using natural minerals. 20 women with PCOS received weekly treatments involving wrapping the body in bandages soaked in a mineral solution for 1 hour. Hormone levels were measured before and after treatment. Results found that treatment significantly improved levels of luteinizing hormone, prolactin, anti-Mullerian hormone, fasting insulin, and liver enzymes. No adverse events occurred. The study suggests this natural mineral treatment may be a safe and effective approach for managing symptoms of PCOS.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is an open access international journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is an open access international journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
The profile of infants born to mothers with subclinical hypothyroidism in a t...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Prevalence and Correlates of Polycystic Ovarian Syndrome among Women Attendin...AJHSSR Journal
Polycystic ovarian syndrome (PCOS) is a complex endocrine disorder which affects 5% to10%
of women worldwide. The disease is caused by insulin resistant that results in hyperinsulinaemia, and further
stimulates the excessive production of androgen and luteinizing hormone. Hyperandrogenism which is referred
to the excessive production of androgen leads to the clinical conditions like acne, obesity, alopecia and irregular
menstruation. Previous studies have shown the risk factors of PCOS include age, ethnicity, obesity, smoking,
alcohol consumption and menstrual problem. A cross sectional study was conducted at infertility clinic in
Hospital Serdang. Simple random sampling was adopted to recruit 138 women who attended the infertile clinic.
Data including sociodemographic data, lifestyle factors, medical disorders, gynaecology disorders, family
medical history, menstrual problem, diagnostic criteria of PCOS, metabolic parameters, and causes of infertility,
were retrieved from medical record. Chi square test and SPSS version 21 was used for data analysis. Among
138 participants, 37.7% are diagnosed with PCOS and 62.3% are not diagnosed with PCOS. Among PCOS
patients, 92.3% are found to age less than 35 years old, 90.4% Malay, 75% with menstrual problem and 80.8%
obese. Age, menstrual problem, and obesity were significantly associated with PCOS diagnosis. Measures like
medical education and healthy lifestyle should be implemented to prevent the complications of PCOS.
Introduction: Preeclampsia is a medical emergency implicated in maternal and foetal morbidity and mortality. Research directed at finding the aetiologies of pre-eclampsia is inconclusive because most studies are either cross-sectional or semi -longitudinal in design with very limited potentials to determine precisely the age of pregnancy to suspect the development of preeclampsia with an absolute biomarker.
IDD situation in our country has improved
A good number of thyroid disorder patients are either undiagnosed and or untreated
Thyroid disorder in pregnancy- Rate high
As a sound thyroid functioning status is crucial for growth, development in children; reproduction, psychological and general wellbeing in adults, we must be proactive in screening, diagnosing and treating our patients.
Prevalence of Anamiea and Its Predictors in Pregnant Women Attending Antenata...iosrjce
Background: Anemia impairs cognitive development, reduces physical work capacity and in severe cases
increases risk of mortality particularly during prenatal period. In India, 16% of maternal deaths are attributed
to anemia. However, high prevalence of anemia among pregnant women persists in India despite the
availability of effective, low-cost interventions for prevention and treatment. Aknowledge of them
sociodemographic factors associated with anemia will help to formulate multipronged strategies to attack this
important public health problem in pregnancy.
Objective: To assess the prevalence of anaemia and its predicting factors among pregnant women attending
antenatal clinic at Tertiary care center.
Study Design: Descriptive cross-sectional study
Methods: A hospital based cross-sectional study design was conducted from January 2014 – September 2014
among 5788 pregnant womens who had been attending antenatal clinic. Red blood cell morphology and Hgb
level determination were assessed following the standard procedures. Socio-demographic data was collected by
using a structured questionnaire. The data entered and analyzed by using the SPSS version 16.0 statistical
software. P<0.05 was considered as statistically significant.
Result: Overall prevalence of anemia among the pregnant women was found to be 86.37%. Factors such as
diet, level of education of women and their husbands and socioeconomic status were found to be significantly
associated with the prevalence of anemia in pregnancy.
Conclusion: The present study showed high prevalence of anemia and the majority of them were of the
moderate type (hemoglobin: 10-10.9 g/dl). Low socioeconomic class, illiteracy, Multiparous were significantly
associated with high prevalence of anemia during pregnancy in Indian women.
Introduction: Though there are many studies on the effects of anesthesia methods used for cesarean section on the newborn,
research on this topic still continues. In our prospective observational study, we investigated the effects of different anesthesia techniques used in routine cesarean deliveries on early neonatal outcomes in our hospital. This prospective, observational, randomized study included a total of 222 ASA II risk group pregnant women undergoing elective cesarean section at term (38-41 weeks’ gestation) without fetal distress. The women were randomized into three groups. In the general anesthesia with propofol group (Group P, n = 74), anesthesia was induced with 2 mg∙kg-1 propofol and 0.6-0.9 mg∙kg-1
rocuronium. In the general anesthesia with thiopental sodium group (Group T, n = 74), anesthesia was induced with 5 mg∙kg-1 thiopental sodium and 0.6-0.9 mg∙kg-1 rocuronium. Women in the spinal anesthesia group (Group SA, n = 74) were administered 0.5% (10 mg) hypertonic bupivacaine and 10 mcg fentanyl.
The effect of Metformin on endometrial tumor-regulatory genes and systemic metabolic parameters in polycystic ovarian syndrome – a proof-of-concept study
Explore the intricacies of ovulation induction in intrauterine insemination (IUI) with Dr Laxmi Shrikhande's informative slide share presentation. From understanding the hormonal mechanisms to the latest techniques, this presentation offers insights into optimizing fertility through IUI. Whether you're a clinician seeking to enhance patient outcomes or an individual navigating fertility treatments, this resource provides valuable knowledge for your journey towards conception.
The profile of infants born to mothers with subclinical hypothyroidism in a t...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Prevalence and Correlates of Polycystic Ovarian Syndrome among Women Attendin...AJHSSR Journal
Polycystic ovarian syndrome (PCOS) is a complex endocrine disorder which affects 5% to10%
of women worldwide. The disease is caused by insulin resistant that results in hyperinsulinaemia, and further
stimulates the excessive production of androgen and luteinizing hormone. Hyperandrogenism which is referred
to the excessive production of androgen leads to the clinical conditions like acne, obesity, alopecia and irregular
menstruation. Previous studies have shown the risk factors of PCOS include age, ethnicity, obesity, smoking,
alcohol consumption and menstrual problem. A cross sectional study was conducted at infertility clinic in
Hospital Serdang. Simple random sampling was adopted to recruit 138 women who attended the infertile clinic.
Data including sociodemographic data, lifestyle factors, medical disorders, gynaecology disorders, family
medical history, menstrual problem, diagnostic criteria of PCOS, metabolic parameters, and causes of infertility,
were retrieved from medical record. Chi square test and SPSS version 21 was used for data analysis. Among
138 participants, 37.7% are diagnosed with PCOS and 62.3% are not diagnosed with PCOS. Among PCOS
patients, 92.3% are found to age less than 35 years old, 90.4% Malay, 75% with menstrual problem and 80.8%
obese. Age, menstrual problem, and obesity were significantly associated with PCOS diagnosis. Measures like
medical education and healthy lifestyle should be implemented to prevent the complications of PCOS.
Introduction: Preeclampsia is a medical emergency implicated in maternal and foetal morbidity and mortality. Research directed at finding the aetiologies of pre-eclampsia is inconclusive because most studies are either cross-sectional or semi -longitudinal in design with very limited potentials to determine precisely the age of pregnancy to suspect the development of preeclampsia with an absolute biomarker.
IDD situation in our country has improved
A good number of thyroid disorder patients are either undiagnosed and or untreated
Thyroid disorder in pregnancy- Rate high
As a sound thyroid functioning status is crucial for growth, development in children; reproduction, psychological and general wellbeing in adults, we must be proactive in screening, diagnosing and treating our patients.
Prevalence of Anamiea and Its Predictors in Pregnant Women Attending Antenata...iosrjce
Background: Anemia impairs cognitive development, reduces physical work capacity and in severe cases
increases risk of mortality particularly during prenatal period. In India, 16% of maternal deaths are attributed
to anemia. However, high prevalence of anemia among pregnant women persists in India despite the
availability of effective, low-cost interventions for prevention and treatment. Aknowledge of them
sociodemographic factors associated with anemia will help to formulate multipronged strategies to attack this
important public health problem in pregnancy.
Objective: To assess the prevalence of anaemia and its predicting factors among pregnant women attending
antenatal clinic at Tertiary care center.
Study Design: Descriptive cross-sectional study
Methods: A hospital based cross-sectional study design was conducted from January 2014 – September 2014
among 5788 pregnant womens who had been attending antenatal clinic. Red blood cell morphology and Hgb
level determination were assessed following the standard procedures. Socio-demographic data was collected by
using a structured questionnaire. The data entered and analyzed by using the SPSS version 16.0 statistical
software. P<0.05 was considered as statistically significant.
Result: Overall prevalence of anemia among the pregnant women was found to be 86.37%. Factors such as
diet, level of education of women and their husbands and socioeconomic status were found to be significantly
associated with the prevalence of anemia in pregnancy.
Conclusion: The present study showed high prevalence of anemia and the majority of them were of the
moderate type (hemoglobin: 10-10.9 g/dl). Low socioeconomic class, illiteracy, Multiparous were significantly
associated with high prevalence of anemia during pregnancy in Indian women.
Introduction: Though there are many studies on the effects of anesthesia methods used for cesarean section on the newborn,
research on this topic still continues. In our prospective observational study, we investigated the effects of different anesthesia techniques used in routine cesarean deliveries on early neonatal outcomes in our hospital. This prospective, observational, randomized study included a total of 222 ASA II risk group pregnant women undergoing elective cesarean section at term (38-41 weeks’ gestation) without fetal distress. The women were randomized into three groups. In the general anesthesia with propofol group (Group P, n = 74), anesthesia was induced with 2 mg∙kg-1 propofol and 0.6-0.9 mg∙kg-1
rocuronium. In the general anesthesia with thiopental sodium group (Group T, n = 74), anesthesia was induced with 5 mg∙kg-1 thiopental sodium and 0.6-0.9 mg∙kg-1 rocuronium. Women in the spinal anesthesia group (Group SA, n = 74) were administered 0.5% (10 mg) hypertonic bupivacaine and 10 mcg fentanyl.
The effect of Metformin on endometrial tumor-regulatory genes and systemic metabolic parameters in polycystic ovarian syndrome – a proof-of-concept study
Explore the intricacies of ovulation induction in intrauterine insemination (IUI) with Dr Laxmi Shrikhande's informative slide share presentation. From understanding the hormonal mechanisms to the latest techniques, this presentation offers insights into optimizing fertility through IUI. Whether you're a clinician seeking to enhance patient outcomes or an individual navigating fertility treatments, this resource provides valuable knowledge for your journey towards conception.
Polycystic ovary syndrome PCOS is a common endocrine and metabolic disorder in premenopausal women. Heterogeneous by its nature, PCOS is defined as combination of signs and symptoms of androgen excess and ovarian dysfunction in the absence of other specific diagnoses. The etiology of the syndrome remains unknown, but evidence suggests that PCOS might be a complex multigenic disorder with strong epigenetic and environmental influences, including diet and lifestyle factors. It affects 8 to 13 of reproductive aged women. Polycystic ovary syndrome PCOS is associated with hormonal, biochemical disturbance and adverse cosmetic, reproductive, metabolic, and psychological consequences, resulting in reduced health related quality of life HRQoL . The most recent international guidelines set lifestyle management as the cornerstone of the PCOS treatment. Hridyanshi | R. K. Patil | Lovish Kansal "Polycystic Ovary Syndrome: A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd41134.pdf Paper URL: https://www.ijtsrd.commedicine/gynecology/41134/polycystic-ovary-syndrome-a-review/hridyanshi
Do Women With Polycystic Morphology Without Any Other Features of PCOS Benefi...Alex Swanton
Women with ovaries of polycystic morphology (PCO), without any other features of polycystic ovary syndrome(PCOS), respond similarly to women with PCOS when stimulated with exogenous gonadotrophins, and both groups share various endocrinological disturbances underlying their pathology.
Detection of Polycystic Ovary Syndrome and Its Treatment with Pergularia Daem...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Diabetes is a rapidly and serious health problem in Pakistan. This chronic condition is associated with serious long-term complications, including higher risk of heart disease and stroke. Aggressive treatment of hypertension and hyperlipideamia can result in a substantial reduction in cardiovascular events in patients with diabetes 1. Consequently pharmacist-led diabetes cardiovascular risk (DCVR) clinics have been established in both primary and secondary care sites in NHS Lothian during the past five years. An audit of the pharmaceutical care delivery at the clinics was conducted in order to evaluate practice and to standardize the pharmacists’ documentation of outcomes. Pharmaceutical care issues (PCI) and patient details were collected both prospectively and retrospectively from three DCVR clinics. The PCI`s were categorized according to a triangularised system consisting of multiple categories. These were ‘checks’, ‘changes’ (‘change in drug therapy process’ and ‘change in drug therapy’), ‘drug therapy problems’ and ‘quality assurance descriptors’ (‘timer perspective’ and ‘degree of change’). A verified medication assessment tool (MAT) for patients with chronic cardiovascular disease was applied to the patients from one of the clinics. The tool was used to quantify PCI`s and pharmacist actions that were centered on implementing or enforcing clinical guideline standards. A database was developed to be used as an assessment tool and to standardize the documentation of achievement of outcomes. Feedback on the audit of the pharmaceutical care delivery and the database was received from the DCVR clinic pharmacist at a focus group meeting.
efficacy and safety of Sulfad tablets in the management of NASH
patients: A randomized ,prospective, open label, multi-center,
controlled, phase III clinical trial.
Journal of Schizophrenia Research is a peer-reviewed, open access journal published by Austin Publishers. It provides easy access to high quality Manuscripts in all related aspects of a mental disorder often characterized by abnormal social behavior and failure to recognize what is real with common symptoms including false beliefs, auditory hallucinations, confused or unclear thinking, inactivity, and reduced social engagement and emotional expression. The journal focuses upon the latest research in finding causes, understanding mechanisms, diagnosis, prevention, management, prognosis, epidemiology, ancestral history and treatment of schizophrenia.
Austin Publishing Group is a successful host of more than hundred peer reviewed, open access journals in various fields of science and medicine with intent to bridge the gap between academia and research access.
Journal of Schizophrenia Research accepts original research articles, review articles, case reports, mini reviews, rapid communication, opinions and editorials on all related aspects of schizophrenia including, finding causes, understanding mechanisms, diagnosis, prevention, management, prognosis, epidemiology, ancestral history and its treatment.
Because of such a high consumption level, any risky impact of these pills on public health would be important. The present study aimed to determine the relationship between consumption of OCPs and hypertension. Method: In this retrospective, cross-sectional study, 165women below 40 years of age who used OCPs were selected by convenience sampling. Necessary information was obtained by a checklist containing demographic information, obstetric history, and OCPs use history based on the subjects’ medical records. Besides, blood pressure and weight were measured at the beginning of OCPs consumption as well as 6 months and one year after that. Results: The results showed a significant difference between the subjects’ mean systolic blood pressure one year after OCPs consumption compared to the beginning (P=0.03). Moreover, this difference was related to the type of pills, such a way that it was significant in the patients who took Low Dose (LD) OCPs compared to those who used Triphasic pills (P=0.01). Conclusion: Consuming the currently available OCPs that contain lower estrogen content had an insignificant effect on blood pressure. However, it is recommended to take care of blood pressure in order to identify the unique occasional responses.
Managing DM and thyroid disease in shift workersNemencio Jr
This slide deck discusses the effects of shift work on physiology and behavior of thyroid axis and beta cell function and risk of diabetes, including glucose control among those with diabetes. Management strategies are also discussed
2. 2 This Article is Available in: http://www.jusurgery.com/archive.php
2016
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ISSN 2254-6758
concentrations and the arrest of antral follicle growth in the final
stages of maturation [4].
The exact cause of polycystic ovary syndrome is unknown. Early
diagnosis and treatment along with weight loss may reduce
the risk of long-term complications, such as type 2 diabetes
and heart disease [5]. A main underlying problem with PCOS is
a hormonal imbalance. In women with PCOS, the ovaries make
more androgens than normal. Androgens are male hormones
that females also make. High levels of these hormones affect the
development and release of eggs during ovulation [5].
PCOS is caused by an imbalance in the hormones [3,4]. PCOS
usually happens when a hormone called LH (from the pituitary
gland) or levels of insulin (from the pancreas) are too high, which
results in extra testosterone production by the ovary.
Medical treatment of PCOS with medications such as
clomiphene citrate, tamoxifen, aromatase inhibitors, metformin,
glucocorticoids, or gonadotropins or surgically by laparoscopic
ovarian drilling is under practise. In vitro fertilization will remain
the last option to achieve pregnancy when others fail. Chronic
anovulation over a long period of time is also associated with
an increased risk of endometrial hyperplasia and carcinoma, which
should be seriously investigated and treated. There are androgenic
symptoms that will vary from patient to patient, such as hirsutism,
acne, and/or alopecia. These are troublesome presentations to the
patients and require adequate treatment [4].
Alternative medicine has been emerging as one of the commonly
practiced medicines for different health problems. Alternative
medicines include many modalities, such as kinesiology,
herbalism, homeopathy, reflexology, acupressure, acupuncture,
and massage therapy. Acupuncture is the most common
modality. Low-frequency EA and physical exercise improved
hyperandrogenism and menstrual frequency more effectively
than no intervention in women with PCOS. Low-frequency EA
was superior to physical exercise and may be useful for treating
hyperandrogenism and oligo/amenorrhea [4]. The benefit
acupuncture seems to have for PCOS sufferers is in helping them
regulate and manage their periods. However, it has also been
shown to aid in weight loss and reducing headaches as well as
improving patients’ moods and outlooks. Women with PCOS will
have needles placed along the acupuncture meridians related
to the reproductive system. This will help stimulate the organs,
improve blood flow to the area, and contribute to normalizing
hormone levels, and promote the proper functioning of the
reproductive system [5].
Neutraceutical is “a food (or part of a food) that provides medical
or health benefits, including the prevention and/or treatment
of a disease”. Scicchitano P et al. [6] reviewed that these foods
can protect human body from adverse events because of the
beneficial effects of some photochemical. Several studies have
reported the validity of this idea in clinical practice and could be
considered for patients of PCOS in addition to other treatment
strategy [6,7].
One more approach for natural treatment is utilization of the
natural mineral base containing practically every known element
of the earth and taking advantage of current technology and
research, there is strong possibility to improve hormonal balance
in particularly PCOS patients. The wrapping process ‘contours’
the body which results in better balances hormones.
In present single centric, non-randomized, open label pilot study,
exclusive natural mineral solution and reserve wellness wrapping
technique is combined to study in PCOS patients. Objective of
present study is to evaluate the efficacy and safety of Natural
mineral solution in treatment of polycystic ovary syndrome.
Before planning study, all types of wrap solutions known to
use in women were studied. Additional evaluation for known
information with the techniques and processes for the purpose
of balancing hormones were carried out.
Methods
Both married and unmarried female patients with Polycystic
Ovary Syndrome (PCOS) who are willing to sign a copy of the
written Informed Consent form and agree to attend all follow-up
appointments were included in present study. Pregnant females
and females with Phlebitis and/or Emphysema were excluded
from study. Patients with allergies to metal mined from earth or
any study Ingredient and who had undergone any major surgery
in last 3 months were also excluded from this study. Post-natal
and lactating women, patients with cancer, lupus and heart
problems, epilepsy, hypertension, hypotension, skin diseases
or disorders, diabetes and asthma were wrapped in study with
special precautions.
Present study was conducted in accordance with the ethical
principles that have their origins in the Declaration of Helsinki
along with the local regulatory requirements of GCP for Clinical
Research in India, Schedule Y, ICMR guidelines for Biomedical
Research on Human Patients and all relevant SOPs of Study
centre. Ethical approval of study documents was obtained from
ethics committee in written before conduct of study, as per
regulatory requirement. Details of the study such as objectives,
procedures, risks, benefits, restrictions and requirements of the
study was presented to all the patients in a language that the
patient best comprehended. The patients were given ample time
to read the ICF followed by explanation by the study personnel.
All the queries of the patient were resolved before obtaining the
consent. All patients were encouraged to ask questions and all the
questions were fully answered. Study specific written informed
consent was obtained from each patient before enrolling into the
study.
A total of 20 females (10 married and 10 unmarried) who fulfilled
predefined inclusion/exclusion criteria were enrolled in present
study. Baseline demography of Patient age, height and weight
was recorded for individual patients.
Patients were undergone study procedure and efficacy data were
collected at pre study and post study treatment. Natural mineral
powder used for study consist of mixture of Bentonite Clay,
Magnesium Chloride, Magnesium Sulphate, Sodium Chloride and
Zinc Oxide 2%.
Study was single arm pen label study with only one treatment
arm so method of assigning patients to treatment groups is
not applicable. Individual patient was given prescheduled
4. 4 This Article is Available in: http://www.jusurgery.com/archive.php
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Vol. 4 No. 2: 53
Journal of Universal Surgery
ISSN 2254-6758
of the earth and taking advantage of current technology and
research, there is strong possibility to improve hormonal balance
in particularly PCOS patients.
Hormones play vital role in female reproduction system.
Improvement in hormonal balance may beneficial in many
gynaecological diseases including Polycystic ovary syndrome
(PCOS). There was statistically significant improvement in
Luteinizing Hormone (LH), Prolactin, AMH, Fasting Insulin, SGPT
and LH/FSH ratio, post-treatment from the preoperative values
(P<0.05).
We have not placed any patients on diet change or any life
style modifications. So, weight and BMI was not studied at end
of treatment. LH/FSH Ratio at pre-treatment was 2.76:1 which
was high compared to healthy female with usual hormonal level,
which was reduced positively to 1.21:1 at post-treatment. This
reduction is significant statistically (<0.001). In healthy females,
generally this ratio may be near to 1:1, so study results are
approaching towards positive clinical aspects.
Any complications or adverse events were not reported in present
report denoted the safety of this procedure.
Both married and unmarried females were included in present
study equally. Sample size of 10 married and 10 unmarried
females were quite less and insufficient to establish proof of
concept for efficacy and safety.
Parameter Range Unit
Pre treatment Values Post treatment Values
P-Value
Mean S.D. Min Max Mean S.D Min Max
FSH 4.00 to 13.0 mlU/ml 4.18 0.76 2.91 5.6 4.27 0.65 3.15 5.6 0.131
LH 1.90 to 12.5 mlU/ml 11.52 2.16 8.18 16.75 5.2 0.94 3.75 7.1 <.0001
Prolactin 2.8 to 29.2 ng/ml 36.36 1.94 31.17 39.1 29.35 1.32 27.61 31.25 <0.001
TSH 0.35 to 5.5 microIU/l 3.63 0.65 2.75 4.85 3.62 0.64 2.75 4.75 0.207
AMH 4.00 to 6.79 ng/ml 10.84 1.25 8.95 12.81 6.79 0.18 6.26 7.02 <0.001
Fasting Insulin 2.6 to 37.6 mU/l 15.77 1.94 11.6 18.2 15.32 1.53 12.1 17.8 0.018
S.G.P.T. 0 to 31 U/L 35.83 1.41 33.2 38.1 29.4 1.68 26.7 32.2 <0.001
LH/FSH Ratio 01:01 2.76 0.18 2.47 3.1 1.21 0.09 1.1 1.49 <0.001
Table 2: Comparison of pre-treatment and post treatment hormonal level.
Pre treatment Values Mean
FSH LH
Prolactin TSH
AM
H
Fasting
Insulin
S.G
.P.TLH
/FSH
R
atio
40.00
35.00
30.00
25.00
20.00
15.00
10.00
5.00
0.00
36.36 35.83
2.76
1.21
15.77
15.32
10.8411.52
4.18 4.27 5.20
29.35
3.63 3.62
29.4029.35
6.79
Figure 1 Comparison of pre-treatment and post treatment hormonal level.
Study results favoured effectiveness of mineral therapy in
treatment of patients with PCOS.
Safety Results
All 20 patients were exposed to study treatment and were
included in safety analysis. No adverse event was reported during
conduct of present study. Present study procedure for PCOS
treatment is found safe and well tolerable without any incidence
of adverse events.
Discussion
The present study was performed to evaluate safety and
efficacy of alternative therapy with minerals in patients of PCOS.
Exclusive natural mineral solution and reserve wellness wrapping
technique is combined to study in PCOS patients. Before planning
study, all types of wrap solutions known to use in women were
studied. Additional evaluation for known information with the
techniques and processes for the purpose of balancing hormones
were carried out.
Mineral solution base used in present study is natural minerals.
Individual minerals have shown advantageous role in PCOS
patient as a natural therapy but specific combination of minerals
with well-designed specific technique was not studied till date
[2,7]. Present study was carried out on hypothesis of utilizing the
natural mineral base containing practically every known element
6. 6 This Article is Available in: http://www.jusurgery.com/archive.php
2016
Vol. 4 No. 2: 53
Journal of Universal Surgery
ISSN 2254-6758
References
1 Mayo Clinic (2016) Diseases and Conditions Polycystic ovary
syndrome (PCOS).
2 Bargiota A, Diamanti-Kandarakis E (2012) The effects of old, new
and emerging medicines on metabolic aberrations in PCOS. Ther Adv
Endocrinol Metab 3: 27-47.
3 Turan V, Sezer ED, Zeybek B, Sendag F (2015) Infertility and the
presence of insulin resistance are associated with increased
oxidative stress in young, non-obese Turkish women with polycystic
ovary syndrome. J Pediatr Adolesc Gynecol 28: 119-123.
4 Jedel E, Labrie F, Odén A, Holm G, Nilsson L, et al. (2011) Impact
of electro-acupuncture and physical exercise on hyperandrogenism
and oligo/amenorrhea in women with polycystic ovary syndrome:
a randomized controlled trial. Am J Physiol Endocrinol Metab 300:
E37-E45.
5 Badawy A, Abubaker E (2011) Treatment options for polycystic ovary
syndrome. Int J Womens Health 3: 25-35.
6 Scicchitano P, Cameli M, Maiello M, Modesti PA, Muiesan ML, et
al. (2014) Nutraceuticals and dyslipidaemia: beyond the common
therapeutics. J Funct Foods 6: 11-32.
7 http://womenshealth.gov/publications/our-publications/fact-
sheet/polycystic-ovary-syndrome.html