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Cyclophosphamide for Injection USP 500mg, 1000mg, 2000mg Taj Pharma PILTajPharmaQC
Cyclophosphamide for Injection USP 500mg/1000mg/2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
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Clarithromycin for Infusion 500mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Clarithromycin Dosage & Rx Info | Clarithromycin Uses, Side Effects Clarithromycin: Indications, Side Effects, Warnings, Clarithromycin -Drug Information –Taj Pharma, Clarithromycin dose Taj pharmaceuticals Clarithromycin interactions, Taj Pharmaceutical Clarithromycin contraindications, Clarithromycin price, Clarithromycin Taj Pharma Clarithromycin SmPC-Taj Pharma Stay connected to all updated on Clarithromycin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
Fluorouracil 50mgml injection smpc taj pharmaceuticalsTaj Pharma
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Cyclophosphamide Tablets USP 25mg/50mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Cyclophosphamide Dosage & Rx Info | Cyclophosphamide Uses, Side Effects Cyclophosphamide: Indications, Side Effects, Warnings, Cyclophosphamide -Drug Information –Taj Pharma, Cyclophosphamide dose Taj pharmaceuticals Cyclophosphamide interactions, Taj Pharmaceutical Cyclophosphamide contraindications, Cyclophosphamide price, Cyclophosphamide Taj Pharma Cyclophosphamide SmPC-Taj Pharma Stay connected to all updated on Cyclophosphamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
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Fludarabine phosphate 25 mgml concentrate for solution for injection or infus...Taj Pharma
FLUDARABINE PHOSPHATE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, FLUDARABINE PHOSPHATE Dosage & Rx Info | FLUDARABINE PHOSPHATE Uses, Side Effects -: Indications, Side Effects, Warnings, FLUDARABINE PHOSPHATE - Drug Information - Taj Pharma, FLUDARABINE PHOSPHATE dose Taj pharmaceuticals FLUDARABINE PHOSPHATE interactions, Taj Pharmaceutical FLUDARABINE PHOSPHATE contraindications, FLUDARABINE PHOSPHATE price, FLUDARABINE PHOSPHATE Taj Pharma Cancer, oncologyFludarabine phosphate 25 mg/ml Concentrate for Solution for Injection or Infusion. SMPC- Taj Pharma
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Oxaliplatin for Injection 50mg, 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Oxaliplatin Dosage & Rx Info | Oxaliplatin Uses, Side Effects Oxaliplatin: Indications, Side Effects, Warnings, Oxaliplatin -Drug Information –Taj Pharma, Oxaliplatin dose Taj pharmaceuticals Oxaliplatin interactions, Taj Pharmaceutical Oxaliplatin contraindications, Oxaliplatin price, Oxaliplatin Taj Pharma Oxaliplatin SmPC-Taj Pharma Stay connected to all updated on Oxaliplatin Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
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Clozapine Tablets USP 25mg, 50mg and 100mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Clozapine Dosage & Rx Info | Clozapine Uses, Side Effects Clozapine: Indications, Side Effects, Warnings, Clozapine -Drug Information –Taj Pharma, Clozapine dose Taj pharmaceuticals Clozapine interactions, Taj Pharmaceutical Clozapine contraindications, Clozapine price, Clozapine Taj Pharma Clozapine SmPC-Taj Pharma Stay connected to all updated on Clozapine Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
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Doxorubin 10 mg, 50mg powder for solution for injection smpc taj pharmaceuti...Taj Pharma
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INTRODUCTION OF FUROSEMIDE
CLINICAL DATA
CHEMISTRY OF DRUG (INCLUDING DRUG PROPERTIES)
DRUG DATABASES (AVAILABILITY,STORAGE,DOSAGE,ROUTE PREFERENCE)
PHARMACOKINETICS (SITE OF ACTION,TIME/ACTION PROFILE)
MECHANISM OF ACTION
ACTIONS
DESIRED EFFECT
INDICATIONS
THERAPEUTIC USES
CONTRAINDICATIONS
PRECAUTIONS
ADVERSE EFFECTS/SIDE EFFECTS
WARNINGS INCLUDING DOSE ADJUSTMENT IN SPECIAL POPULATION
DRUG INTERACTIONS
TOXICOLOGY & IT’S MANAGEMENT
NURSING CONSIDERATIONS
;RESPONSIBILITIES;ASSESSMENT;POTENTIAL DIAGNOSIS; IMPLEMENTATIONS;EVALUATIONS DURING FUROSIDE ADMINISTRATION
PATIENT/FAMILY TEACHING
SPECIAL CALCULATIONS
CONCLUSION OF FUROSEMIDE
REFERENCES OF FUROSEMIDE
Cinnarizine 15 mg tablets smpc taj pharmaceuticalsTaj Pharma
Cinnarizine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Cinnarizine Dosage & Rx Info | Cinnarizine Uses, Side Effects -: Indications, Side Effects, Warnings, Cinnarizine - Drug Information - Taj Pharma, Cinnarizine dose Taj pharmaceuticals Cinnarizine interactions, Taj Pharmaceutical Cinnarizine contraindications, Cinnarizine price, Cinnarizine Taj Pharma Cinnarizine 15 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Cinnarizine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Paracetamol 10 mg per ml solution for infusion smpc taj pharmaceuticalsTaj Pharma
Paracetamol - Drug Information - Taj Pharma, Paracetamol dose Taj pharmaceuticals Paracetamol interactions, Taj Pharmaceutical Paracetamol contraindications, Paracetamol price, Paracetamol Taj Pharma Paracetamol 10 mg/ml Solution for Infusion SMPC- Taj Pharma . Stay connected to all updated on Paracetamol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Vasopressin 20 international units ml solution for injection smpc taj pharma...Taj Pharma
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Paracetamol Tablets BP 500mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Paracetamol Dosage & Rx Info | Paracetamol Uses, Side Effects Paracetamol: Indications, Side Effects, Warnings, Paracetamol-Drug Information –Taj Pharma, Paracetamol dose Taj pharmaceuticals Paracetamol interactions, Taj Pharmaceutical Paracetamol contraindications, Paracetamol price, Paracetamol Taj Pharma Paracetamol SmPC- Taj Pharma Stay connected to all updated on Paracetamol Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
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Amlodipine 5mg, 10mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Amlodipine Dosage & Rx Info | Amlodipine Uses, Side Effects - Amlodipine : Indications, Side Effects, Warnings, Amlodipine - Drug Information - Taj Pharma, Amlodipine dose Taj pharmaceuticals Amlodipine interactions, Taj Pharmaceutical Amlodipine contraindications, Amlodipine price, Amlodipine Taj Pharma Amlodipine 5mg, 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Amlodipine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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CYCLOPHOSPHAMIDE - Drug Information - Taj Pharma, CYCLOPHOSPHAMIDE dose Taj pharmaceuticals CYCLOPHOSPHAMIDE interactions, Taj Pharmaceutical CYCLOPHOSPHAMIDE contraindications, CYCLOPHOSPHAMIDE price, CYCLOPHOSPHAMIDE Taj Pharma Cancer, oncologyCyclophosphamide Tablets 50 mg. SMPC- Taj Pharma . Stay connected to all updated on CYCLOPHOSPHAMIDE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Zoledronic acid 4 mg/100 ml Solution for Infusion Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Zoledronic acid Dosage & Rx Info | Zoledronic acid Uses, Side Effects Zoledronic acid: Indications, Side Effects, Warnings, Zoledronic acid -Drug Information –Taj Pharma, Zoledronic acid dose Taj pharmaceuticals Zoledronic acid interactions, Taj Pharmaceutical Zoledronic acid contraindications, Zoledronic acid price, Zoledronic acid Taj Pharma Zoledronic acid SmPC-Taj Pharma Stay connected to all updated on Zoledronic acid Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SmPC.
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Warnings, DOXORUBIN Dosage & Rx Info | DOXORUBIN Uses, Side Effects -: Indications, Side Effects, Warnings, DOXORUBIN - Drug Information - Taj Pharma, DOXORUBIN dose Taj pharmaceuticals DOXORUBIN interactions, Taj Pharmaceutical DOXORUBIN contraindications, DOXORUBIN price, DOXORUBIN Taj Pharma Cancer, oncologyDoxorubin 10 mg, 50mg powder for solution for Injection. SMPC- Taj Pharma . Stay connected to all updated on DOXORUBIN Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
INTRODUCTION OF FUROSEMIDE
CLINICAL DATA
CHEMISTRY OF DRUG (INCLUDING DRUG PROPERTIES)
DRUG DATABASES (AVAILABILITY,STORAGE,DOSAGE,ROUTE PREFERENCE)
PHARMACOKINETICS (SITE OF ACTION,TIME/ACTION PROFILE)
MECHANISM OF ACTION
ACTIONS
DESIRED EFFECT
INDICATIONS
THERAPEUTIC USES
CONTRAINDICATIONS
PRECAUTIONS
ADVERSE EFFECTS/SIDE EFFECTS
WARNINGS INCLUDING DOSE ADJUSTMENT IN SPECIAL POPULATION
DRUG INTERACTIONS
TOXICOLOGY & IT’S MANAGEMENT
NURSING CONSIDERATIONS
;RESPONSIBILITIES;ASSESSMENT;POTENTIAL DIAGNOSIS; IMPLEMENTATIONS;EVALUATIONS DURING FUROSIDE ADMINISTRATION
PATIENT/FAMILY TEACHING
SPECIAL CALCULATIONS
CONCLUSION OF FUROSEMIDE
REFERENCES OF FUROSEMIDE
Cinnarizine 15 mg tablets smpc taj pharmaceuticalsTaj Pharma
Cinnarizine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Cinnarizine Dosage & Rx Info | Cinnarizine Uses, Side Effects -: Indications, Side Effects, Warnings, Cinnarizine - Drug Information - Taj Pharma, Cinnarizine dose Taj pharmaceuticals Cinnarizine interactions, Taj Pharmaceutical Cinnarizine contraindications, Cinnarizine price, Cinnarizine Taj Pharma Cinnarizine 15 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Cinnarizine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Paracetamol - Drug Information - Taj Pharma, Paracetamol dose Taj pharmaceuticals Paracetamol interactions, Taj Pharmaceutical Paracetamol contraindications, Paracetamol price, Paracetamol Taj Pharma Paracetamol 10 mg/ml Solution for Infusion SMPC- Taj Pharma . Stay connected to all updated on Paracetamol Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Vasopressin 20 international units ml solution for injection smpc taj pharma...Taj Pharma
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Paracetamol Tablets BP 500mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Paracetamol Dosage & Rx Info | Paracetamol Uses, Side Effects Paracetamol: Indications, Side Effects, Warnings, Paracetamol-Drug Information –Taj Pharma, Paracetamol dose Taj pharmaceuticals Paracetamol interactions, Taj Pharmaceutical Paracetamol contraindications, Paracetamol price, Paracetamol Taj Pharma Paracetamol SmPC- Taj Pharma Stay connected to all updated on Paracetamol Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Amlodipine 10mg tablets smpc taj pharmaceuticalsTaj Pharma
Amlodipine 5mg, 10mg Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Amlodipine Dosage & Rx Info | Amlodipine Uses, Side Effects - Amlodipine : Indications, Side Effects, Warnings, Amlodipine - Drug Information - Taj Pharma, Amlodipine dose Taj pharmaceuticals Amlodipine interactions, Taj Pharmaceutical Amlodipine contraindications, Amlodipine price, Amlodipine Taj Pharma Amlodipine 5mg, 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Amlodipine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Paracetamol and ibuprofen 500 mg and 150 mg film coated tablets smpc taj pha...Taj Pharma
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CYCLOPHOSPHAMIDE - Drug Information - Taj Pharma, CYCLOPHOSPHAMIDE dose Taj pharmaceuticals CYCLOPHOSPHAMIDE interactions, Taj Pharmaceutical CYCLOPHOSPHAMIDE contraindications, CYCLOPHOSPHAMIDE price, CYCLOPHOSPHAMIDE Taj Pharma Cancer, oncologyCyclophosphamide Tablets 50 mg. SMPC- Taj Pharma . Stay connected to all updated on CYCLOPHOSPHAMIDE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Linezolid Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Linezolid Dosage & Rx Info | Linezolid Uses, Side Effects -: Indications, Side Effects, Warnings, Linezolid - Drug Information - Taj Pharma, Linezolid dose Taj pharmaceuticals Linezolid interactions, Taj Pharmaceutical Linezolid contraindications, Linezolid price, Linezolid Taj Pharma Linezolid 600 mg Film-Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Linezolid Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Oxaliplatin 5mgml concentrate for solution for infusion smpc taj pharmaceuti...Taj Pharma
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Griseofulvin 500mg tablets smpc taj pharmaceuticalsTaj Pharma
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Ifosfamide for Injection USP Taj Pharma SmPCTajPharmaQC
Ifosfamide for Injection USP 100mg, 500mg, 1000mg, and 2000mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Ifosfamide Dosage & Rx Info | Ifosfamide Uses, Side Effects Ifosfamide: Indications, Side Effects, Warnings, Ifosfamide -Drug Information –Taj Pharma, Ifosfamide dose Taj pharmaceuticals Ifosfamide interactions, Taj Pharmaceutical Ifosfamide contraindications, Ifosfamide price, Ifosfamide Taj Pharma Ifosfamide SmPC-Taj Pharma Stay connected to all updated on Ifosfamide Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Chloroquine phosphate 250 mg tablets smpc taj pharmaceuticalsTaj Pharma
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Bleomycin 15000 iu powder for solution for injection infusion smpc taj pharm...Taj Pharma
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Somatropin human growth hormone (HGH) dosage & administrationJS Biology
Somatropin human growth hormone (HGH) dosage & administration schedule should be individualized for each patient. Therapy should not be continued if epiphyseal fusion has occurred. Response to growth hormone therapy tends to decrease with time. However, failure to increase growth rate, particularly during the first year of therapy, should prompt close assessment of compliance and evaluation of other causes of growth failure such as hypothyroidism, under-nutrition, and advanced bone age. Growth hormone-deficient pediatric patients --The recommended weekly dosage is 0.18 mg/kg (0.54 IU/kg) of body weight. The maximal replacement weekly dosage is 0.3 mg/kg (0.90 IU/kg) of body weight. It should be divided into equal doses given either on 3 alternate days, 6 times per week, or daily. The subcutaneous route of administration is preferable; intramuscular injection is also acceptable. The dosage and administration schedule for Somatropin should be individualized for each patient.
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Cyclophosphamide injection 500 mg inj smpc taj pharmaceuticals
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RX
CYCLOPHOSPHAMIDE
INJECTION
500MG
1.NAME OF THE MEDICINAL PRODUCT
Cyclophosphamide Injection 500 mg.
2. QUALITATIVE AND QUANTITATIVE
COMPOSITION
Each vial contains cyclophosphamide
monohydrate equivalent to 500 mg anhydrous
cyclophosphamide.
When reconstituted for intravenous use, the
solution for administration contains 20 mg
cyclophosphamide per ml.
3. PHARMACEUTICAL FORM
Powder for solution for injection.
A white crystalline powder contained in clear
glass injection vials.
4. CLINICAL PARTICULARS
4.1 Therapeutic indications
Cyclophosphamide is a cytotoxic drug for the
treatment of malignant disease in adults and
children. As a single agent, it has successfully
produced an objective remission in a wide range
of malignant conditions. Cyclophosphamide is
also frequently used in combination with other
cytotoxic drugs, radiotherapy or surgery.
4.2 Posology and method of administration
Cyclophosphamide Injection is for intravenous
or oral administration.
Cyclophosphamide should only be used by
clinicians experienced in the use of cancer
chemotherapy. Cyclophosphamide should only
be administered where there are facilities for
regular monitoring of clinical, biochemical and
haematological parameters before, during, and
after administration and under the direction of a
specialist oncology service.
Posology
Dosage must be individualized. Doses and
duration of treatment and/or treatment intervals
depend on the therapeutic indication, the scheme
of a combination therapy, the patient's general
state of health and organ function, and the
results of laboratory monitoring (in particular,
blood cell monitoring).
A guide to the dosage regimens used for most
indications is given below.
This treatment should be continued until a clear
remission or improvement is seen or be
interrupted when the extent of leucopenia
becomes unacceptable.
In combination with other cytostatics of similar
toxicity, a dose reduction or extension of the
therapy-free intervals may be necessary.
Activation of cyclophosphamide requires
hepatic metabolism; therefore, oral and
intravenous administrations are preferred.
Use of hematopoiesis stimulating agents
(colony-stimulating factors and erythropoiesis
stimulating agents) may be considered to reduce
the risk of myelosuppressive complications
and/or help facilitate the delivery of the intended
dosing.
During or immediately after the administration,
adequate amounts of fluid should be ingested or
infused to force diuresis in order to reduce the
risk of urinary tract toxicity. Therefore,
cyclophosphamide should be administered in the
morning. See Section 4.4.
To reduce the likelihood of adverse reactions
that appear to be administration rate-dependent
(e.g., facial swelling, headache, nasal
congestion, scalp burning), cyclophosphamide
should be injected or infused very slowly.
Patients with Hepatic Impairment
Conventional: 80-300 mg/m2
daily as a single i.v.
dose or daily divided oral doses.
300-600 mg/m2
as a single i.v. dose
weekly.
High dose: 600 - 1500 mg/m2
as a single i.v.
dose or short infusion given at 10-20
day intervals.
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Severe hepatic impairment may be associated
with decreased activation of cyclophosphamide.
This may alter the effectiveness of
cyclophosphamide treatment and should be
considered when selecting the dose and
interpreting response to the dose selected.
Patients with Renal Impairment
In patients with renal impairment, particularly in
patients with severe renal impairment, decreased
renal excretion may result in increased plasma
levels of cyclophosphamide and its metabolites.
This may result in increased toxicity and should
be considered when determining the dosage in
such patients.
Cyclophosphamide and its metabolites are
dialyzable, although there may be differences in
clearance depending upon the dialysis system
being used. In patients requiring dialysis, use of
a consistent interval between cyclophosphamide
administration and dialysis should be
considered. See Section 4.4.
Elderly
In elderly patients, monitoring for toxicities and
the need for dose adjustment should reflect the
higher frequency of decreased hepatic, renal,
cardiac, or other organ function, and
concomitant diseases or other drug therapy in
this population.
Children
No specific information. Children have received
Cyclophosphamide. No adverse reactions
specific to this group have been reported.
Method of Administration
Cyclophosphamide is inert until activated by
enzymes in the liver. However, as with all
cytotoxics, it is suggested that reconstitution
should be performed by trained personnel, in a
designated area.
Those handling the preparation should wear
protective gloves. Care should be taken to avoid
splashing material into the eyes. The material
should not be handled by women who are
pregnant or who are breast-feeding.
Intravenous administration
Intravenous administration preferably should be
conducted as an infusion, usually given directly
into the tubing of a fast running i.v. infusion
with the patient supine. Care should be taken
that extravasation does not take place, however,
should it occur, no specific measures need be
taken.
Duration of the infusion also should be
appropriate for the volume and type of carrier
fluid to be infused.
If injected directly, cyclophosphamide for
parenteral administration should be reconstituted
with physiological saline (0.9% sodium
chloride), see section 6.6. The pH of an aqueous
solution is between 4 and 6.
Cyclophosphamide, reconstituted in water, is
hypotonic and should not be injected directly.
For infusion, cyclophosphamide should be
reconstituted by adding sterile water and infused
in the recommended intravenous solutions.
Before parenteral administration, the substance
must be completely dissolved.
Parenteral drug products should be inspected
visually for particulate matter and discoloration
prior to administration, whenever solution and
container permit.
Oral administration
For oral use, an elixir may be prepared by
dissolving the dry powder in Aromatic Elixir
USP.
4.3 Contraindications
Cyclophosphamide is contra-indicated in
patients with:
• hypersensitivity to cyclophosphamide or to any
of its metabolites.
• acute infections,
• bone-marrow aplasia,
• urinary tract infection
• acute urothelial toxicity from cytotoxic
chemotherapy or radiation therapy
• Urinary outflow obstruction.
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Cyclophosphamide should not be used in the
management of non-malignant disease, except
for immunosuppression in life-threatening
situations.
Cyclophosphamide is contra-indicated during
pregnancy. See section 4.4 and 4.6.
4.4 Special Warnings and precautions for use
WARNINGS
Anaphylactic Reactions, Cross-sensitivity with
Other Alkylating Agents
Anaphylactic reactions including those with fatal
outcomes have been reported in association with
cyclophosphamide.
Possible cross-sensitivity with other alkylating
agents has been reported.
Myelosuppression, Immunosuppression,
Infections
Treatment with cyclophosphamide may cause
myelosuppression and significant suppression of
immune responses.
Cyclophosphamide-induced myelosuppression
can cause leukopenia, neutropenia,
thrombocytopenia (associated with a higher risk
of bleeding events), and anaemia.
Severe immunosuppression has lead to serious,
sometimes fatal, infections. Sepsis and septic
shock have also been reported. Infections
reported with cyclophosphamide include
pneumonias, as well as other bacterial, fungal,
viral, protozoal, and parasitic infections.
Latent infections can be reactivated.
Reactivation has been reported for various
bacterial, fungal, viral, protozoal, and parasitic
infections.
Infections must be treated appropriately.
Antimicrobial prophylaxis may be indicated in
certain cases of neutropenia at the discretion of
the managing physician.
In case of neutropenic fever, antibiotics and/or
antimycotics must be given.
Cyclophosphamide should be used with caution,
if at all, in patients with severe impairment of
bone marrow function and in patients with
severe immunosuppression.
Unless essential, cyclophosphamide should not
be administered to patients with a leukocyte
count below 2500 cells/microlitre (cells/ mm3
and/or a platelet count below 50,000
cells/microlitre (cells/mm3).
Cyclophosphamide treatment may not be
indicated, or should be interrupted, or the dose
reduced, in patients who have or who develop a
serious infection.
In principle, the fall in the peripheral blood cell
and thrombocyte count and the time taken to
recover may increase with increasing doses of
cyclophosphamide.
The nadirs of the reduction in leukocyte count
and thrombocyte count are usually reached in
weeks 1 and 2 of treatment. The bone marrow
recovers relatively quickly, and the levels of
peripheral blood cell counts normalize, as a rule,
after approximately 20 days.
Severe myelosuppression must be expected
particularly in patients pretreated with and/or
receiving concomitant chemotherapy and/or
radiation therapy.
Close haematological monitoring is required for
all patients during treatment.
Urinary Tract and Renal Toxicity
Hemorrhagic cystitis, pyelitis, ureteritis, and
haematuria have been reported with
cyclophosphamide therapy. Bladder
ulceration/necrosis, fibrosis/contracture and
secondary cancer may develop.
Urotoxicity may mandate interruption of
treatment.
Cystectomy may become necessary due to
fibrosis, bleeding, or secondary malignancy.
Cases of urotoxicity with fatal outcomes have
been reported.
Urotoxicity can occur with short-term and long-
term use of cyclophosphamide. Hemorrhagic
cystitis after single doses of cyclophosphamide
has been reported.
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Past or concomitant radiation or busulfan
treatment may increase the risk for
cyclophosphamide-induced hemorrhagic cystitis.
Cystitis is, in general, initially abacterial.
Secondary bacterial colonization may follow.
Before starting treatment, it is necessary to
exclude or correct any urinary tract obstructions.
See Section 4.3.
Urinary sediment should be checked regularly
for the presence of erythrocytes and other signs
of uro/nephrotoxicity.
Cyclophosphamide should be used with caution,
if at all, in patients with active urinary tract
infections.
Adequate treatment with mesna and/or strong
hydration to force dieresis can markedly reduce
the frequency and severity of bladder toxicity. It
is important to ensure that patients empty the
bladder at regular intervals.
Hematuria usually resolves in a few days after
cyclophosphamide treatment is stopped, but it
may persist.
It is usually necessary to discontinue
cyclophosphamide therapy in instances of severe
hemorrhagic cystitis.
Cyclophosphamide has also been associated
with nephrotoxicity, including renal tubular
necrosis.
Hyponatremia associated with increased total
body water, acute water intoxication, and a
syndrome resembling SIADH (syndrome of
inappropriate secretion of antidiuretic hormone)
have been reported in association with
cyclophosphamide administration. Fatal
outcomes have been reported.
Cardiotoxicity, Use in Patients with Cardiac
Disease
Myocarditis and myopericarditis, which may be
accompanied by significant pericardial effusion
and cardiac tamponade, have been reported with
cyclophosphamide therapy and have led to
severe, sometimes fatal congestive heart failure.
Histopathologic examination has primarily
shown hemorrhagic myocarditis.
Haemopericardium has occurred secondary to
hemorrhagic myocarditis and myocardial
necrosis.
Acute cardiac toxicity has been reported with a
single dose of less than 2mg/kg
cyclophosphamide.
Following exposure to treatment regimens that
included cyclophosphamide, supraventricular
arrhythmias (including atrial fibrillation and
flutter) as well as ventricular arrhythmias
(including severe QT prolongation associated
with ventricular tachyarrhythmia) have been
reported in patients with and without other signs
of cardiotoxicity.
The risk of cyclophosphamide cardiotoxicity
may be increased for example, following high
doses of cyclophosphamide, in patients with
advanced age, and in patients with previous
radiation treatment of the cardiac region and/or
previous or concomitant treatment with other
cardiotoxic agents. See Section 4.5.
Particular caution is necessary in patients with
risk factors for cardiotoxicity and in patients
with pre-existing cardiac disease.
Pulmonary Toxicity
Pneumonitis and pulmonary fibrosis have been
reported during and following treatment with
cyclophosphamide. Pulmonary veno-occlusive
disease and other forms of pulmonary toxicity
have also been reported.
Pulmonary toxicity leading to respiratory failure
has been reported.
While the incidence of cyclophosphamide-
associated pulmonary toxicity is low, prognosis
for affected patients is poor.
Late onset of pneumonitis (greater than 6
months after start of cyclophosphamide) appears
to be associated with a particularly high
mortality. Pneumonitis may develop even years
after treatment with cyclophosphamide.
Acute pulmonary toxicity has been reported
after a single cyclophosphamide dose.
Secondary Malignancies
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As with all cytotoxic therapy, treatment with
cyclophosphamide involves the risk of
secondary tumours and their precursors as late
sequelae.
The risk of urinary tract cancer as well as the
risk of myelodysplastic alterations, partly
progressing to acute leukemias, is increased.
Other malignancies reported after use of
cyclophosphamide or regimens with
cyclophosphamide include lymphoma, thyroid
cancer, and sarcomas.
In some cases, the second malignancy developed
several years after cyclophosphamide treatment
had been discontinued. Malignancy has also
been reported after in utero exposure.
Veno-occlusive Liver Disease
Veno-occlusive liver disease (VOLD) has been
reported in patients receiving
cyclophosphamide.
A cytoreductive regimen in preparation for bone
marrow transplantation that consists of
cyclophosphamide in combination with whole-
body irradiation, busulfan, or other agents has
been identified (see Section 4.5) as a major risk
factor for the development of VOLD. After
cytoreductive therapy, the clinical syndrome
typically develops 1 to 2 weeks after
transplantation and is characterized by sudden
weight gain, painful hepatomegaly, ascites, and
hyperbilirubinemia/jaundice.
However, VOLD has also been reported to
develop gradually in patients receiving long-
term low-dose immunosuppressive doses of
cyclophosphamide.
As a complication of VOLD, hepatorenal
syndrome and multiorgan failure may develop.
Fatal outcome of cyclophosphamide-associated
VOLD has been reported.
Risk factors predisposing a patient to the
development of VOLD with high-dose
cytoreductive therapy include:
– preexisting disturbances of hepatic function,
– previous radiation therapy of the abdomen,
and a
– low performance score.
Genotoxicity
Cyclophosphamide is genotoxic and mutagenic,
both in somatic and in male and female germ
cells. Therefore, women should not become
pregnant and men should not father a child
during therapy with cyclophosphamide.
Both women and men should wait at least 6 to
12 months after stopping Cyclophosphamide
before attempting to conceive or father a child.
Animal data indicate that exposure of oocytes
during follicular development may result in a
decreased rate of implantations and viable
pregnancies, and in an increased risk of
malformations. This effect should be considered
in case of intended fertilization or pregnancy
after discontinuation of cyclophosphamide
therapy. The exact duration of follicular
development in humans is not known, but may
be longer than 12 months.
Sexually active women and men should use
effective methods of contraception during these
periods of time.
Fertility, see section 4.6.
Impairment of Wound Healing
Cyclophosphamide may interfere with normal
wound healing.
PRECAUTIONS
Alopecia
Alopecia has been reported and may occur more
commonly with increasing doses.
Alopecia may progress to baldness.
The hair can be expected to grow back after
treatment with the drug or even during continued
drug treatment, though it may be different in
texture or colour.
Nausea and Vomiting
Administration of cyclophosphamide may cause
nausea and vomiting.
Current guidelines on the use of antiemetics for
prevention and amelioration of nausea and
vomiting should be considered.
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Alcohol consumption may increase
cyclophosphamide-induced vomiting and
nausea.
Stomatitis
Administration of cyclophosphamide may cause
stomatitis (oral mucositis).
Current guidelines on measures for prevention
and amelioration of stomatitis should be
considered.
Paravenous Administration
The cytostatic effect of cyclophosphamide
occurs after its activation, which takes place
mainly in the liver. Therefore, the risk of tissue
injury from accidental paravenous
administration is low.
In case of accidental paravenous administration
of cyclophosphamide, the infusion should be
stopped immediately, the extravascular
cyclophosphamide solution should be aspirated
with the cannula in place, and other measures
should be instituted as appropriate.
Use in Patients with Renal Impairment
In patients with renal impairment, particularly in
patients with severe renal impairment, decreased
renal excretion may result in increased plasma
levels of cyclophosphamide and its metabolites.
This may result in increased toxicity and should
be considered when determining the dosage in
such patients. See Section 4.2.
Use in Patients with Hepatic Impairment
Severe hepatic impairment may be associated
with decreased activation of cyclophosphamide.
This may alter the effectiveness of
cyclophosphamide treatment and should be
considered when selecting the dose and
interpreting response to the dose selected.
Use in Adrenalectomized Patients
Patients with adrenal insufficiency may require
an increase in corticoid substitution dose when
exposed to stress from toxicity due to
cytostatics, including cyclophosphamide.
4.5 Interaction with other medicinal
products and other forms of interaction
Planned coadministration or sequential
administration of other substances or treatments
that could increase the likelihood or severity of
toxic effects (by means of pharmacodynamic or
pharmacokinetic interactions) requires careful
individual assessment of the expected benefit
and the risks.
Patients receiving such combinations must be
monitored closely for signs of toxicity to permit
timely intervention. Patients being treated with
cyclophosphamide and agents that reduce its
activation should be monitored for a potential
reduction of therapeutic effectiveness and the
need for dose adjustment.
Interactions Affecting the Pharmacokinetics of
Cyclophosphamide and its Metabolites
• Reduced activation of cyclophosphamide may
alter the effectiveness of cyclophosphamide
treatment. Substances that delay activation of
cyclophosphamide include:
– Aprepitant
– Bupropion
– Busulfan: Cyclophosphamide clearance has
been reported to be reduced and half-life
prolonged in patients who receive high-dose
cyclophosphamide less than 24 hours after high-
dose busulfan.
– Ciprofloxacin: When given prior to the
treatment with cyclophosphamide (used for
conditioning prior to bone marrow
transplantation), ciprofloxacin has been reported
to result in a relapse of the underlying disease.
– Chloramphenicol
– Fluconazole
– Itraconazole
– Prasugrel
– Sulfonamides
– Thiotepa: A strong inhibition of
cyclophosphamide bioactivation by thiotepa in
high-dose chemotherapy regimens has been
reported when thiotepa was administered 1 hour
prior to cyclophosphamide.
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• An increase of the concentration of cytotoxic
metabolites may occur with:
– Allopurinol
– Chloral hydrate
– Cimetidine
– Disulfiram
– Glyceraldehyde
– Inducers of human hepatic and extrahepatic
microsomal enzymes (e.g., cytochrome P450
enzymes): The potential for hepatic and
extrahepatic microsomal enzyme induction must
be considered in case of prior or concomitant
treatment with substances known to induce an
increased activity of such enzymes such as
rifampin, phenobarbital, carbamazepine,
phenytoin, St. John's wort, and corticosteroids.
– Protease inhibitors: Concomitant use of
protease inhibitors may increase the
concentration of cytotoxic metabolites. Use of
protease inhibitor-based regimens was found to
be associated with a higher incidence of
infections and neutropenia in patients receiving
cyclophosphamide, doxorubicin, and etoposide
(CDE) than use of an NNRTI-based regimen.
• Ondansetron
There have been reports of a pharmacokinetic
interaction between ondansetron and high-dose
cyclophosphamide resulting in decreased
cyclophosphamide AUC.
Pharmacodynamic Interactions and Interactions
of Unknown Mechanism Affecting the Use of
Cyclophosphamide
Combined or sequential use of
cyclophosphamide and other agents with similar
toxicities can cause combined (increased) toxic
effects.
• Increased hematotoxicity and/or
immunosuppression may result from a combined
effect of cyclophosphamide and, for example
– ACE inhibitors: ACE inhibitors can cause
leukopenia.
– Natalizumab
– Paclitaxel: Increased hematotoxicity has been
reported when cyclophosphamide was
administered after paclitaxel infusion.
– Thiazide diuretics
– Zidovudine
– Clozapine
• Increased cardiotoxicity may result from a
combined effect of cyclophosphamide and, for
example
– Anthracyclines
– Cytarabine
– Pentostatin
– Radiation therapy of the cardiac region
– Trastuzumab
• Increased pulmonary toxicity may result from
a combined effect of cyclophosphamide and, for
example
– Amiodarone
– G-CSF, GM-CSF (granulocyte colony-
stimulating factor, granulocyte macrophage
colony-stimulating factor): Reports suggest an
increased risk of pulmonary toxicity in patients
treated with cytotoxic chemotherapy that
includes cyclophosphamide and G-CSF or
GMCSF.
• Increased nephrotoxicity may result from a
combined effect of cyclophosphamide and, for
example
– Amphotericin B
– Indomethacin: Acute water intoxication has
been reported with concomitant use of
indomethacin.
• Increase in other toxicities
– Azathioprine: Increased risk of hepatotoxicity
(liver necrosis)
– Busulfan: Increased incidence of hepatic veno-
occlusive disease and mucositis has been
reported.
– Protease inhibitors: Increased incidence of
mucositis.
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Other interactions
• Alcohol
A reduced antitumor activity was observed in
tumor-bearing animals during ethanol (alcohol)
consumption and concomitant oral low-dose
cyclophosphamide medication.
In some patients, alcohol may increase
cyclophosphamide-induced vomiting and
nausea.
• Etanercept
In patients with Wegener's granulomatosis, the
addition of etanercept to standard treatment,
including cyclophosphamide, was associated
with a higher incidence of non-cutaneous solid
malignancies.
• Metronidazole
Acute encephalopathy has been reported in a
patient receiving cyclophosphamide and
metronidazole. Causal association is unclear.
In an animal study, the combination of
cyclophosphamide with metronidazole was
associated with increased cyclophosphamide
toxicity.
• Tamoxifen
Concomitant use of tamoxifen and
chemotherapy may increase the risk of
thromboembolic complications.
Interactions Affecting the Pharmacokinetics
and/or Actions of Other Drugs
• Bupropion
Cyclophosphamide metabolism by CYP2B6
may inhibit bupropion metabolism.
• Coumarins
Both increased and decreased warfarin effect
have been reported in patients receiving warfarin
and cyclophosphamide.
• Cyclosporine
Lower serum concentrations of cyclosporine
have been observed in patients receiving a
combination of cyclophosphamide and
cyclosporine than in patients receiving only
cyclosporine. This interaction may result in an
increased incidence of graft-versus-host disease.
• Depolarizing muscle relaxants
Cyclophosphamide treatment causes a marked
and persistent inhibition of cholinesterase
activity. Prolonged apnea may occur with
concurrent depolarizing muscle relaxants (e.g.,
succinylcholine). If a patient has been treated
with cyclophosphamide within 10 days of
general anesthesia, the anesthesiologist should
be alerted.
• Digoxin, β-acetyldigoxin
Cytotoxic treatment has been reported to impair
intestinal absorption of digoxin and β-
acetyldigoxin tablets.
• Vaccines
The immunosuppressive effects of
cyclophosphamide can be expected to reduce the
response to vaccination. Use of live vaccines
may lead to vaccine-induced infection.
• Verapamil
Cytotoxic treatment has been reported to impair
intestinal absorption of orally administered
verapamil
4.6 Fertility, Pregnancy and lactation
Pregnancy
Cyclophosphamide is contraindicated in
pregnancy (see section 4.3). Cyclophosphamide
crosses the placental barrier. Treatment with
cyclophosphamide has a genotoxic effect and
may cause foetal damage when administered to
pregnant women. Both women and men should
wait at least 6 to 12 months after stopping
Cyclophosphamide before attempting to
conceive or father a child.
• Malformations have been reported in children
born to mothers treated with cyclophosphamide
during the first trimester of pregnancy.
However, there are also reports of children
without malformations born to women exposed
during the first trimester.
• Exposure to cyclophosphamide in utero may
cause miscarriage, foetal growth retardation, and
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foetotoxic effects manifesting in the newborn,
including leukopenia, anaemia, pancytopenia,
severe bone marrow hypoplasia, and
gastroenteritis.
• Animal data suggest that an increased risk of
failed pregnancy and malformations may persist
after discontinuation of cyclophosphamide as
long as oocytes/follicles exist that were exposed
to cyclophosphamide during any of their
maturation phases. See Section 4.4,
Genotoxicity.
• If cyclophosphamide is used during pregnancy,
or if the patient becomes pregnant while taking
this drug or after treatment (see Section 4.4,
Genotoxicity), the patient should be apprised of
the potential hazard to a foetus.
Breastfeeding
Cyclophosphamide is passed into the breast
milk. Neutropenia, thrombocytopenia, low
hemoglobin, and diarrhoea have been reported in
children breast fed by women treated with
cyclophosphamide. Women must not breastfeed
during treatment with cyclophosphamide.
Fertility
Cyclophosphamide interferes with oogenesis
and spermatogenesis. It may cause sterility in
both sexes.
Development of sterility appears to depend on
the dose of cyclophosphamide, duration of
therapy, and the state of gonadal function at the
time of treatment.
Cyclophosphamide-induced sterility may be
irreversible in some patients.
Sexually active women and men should use
effective methods of contraception during these
periods of time.
• Female patients
Amenorrhea, transient or permanent, associated
with decreased oestrogen and increased
gonadotrophin secretion develops in a
significant proportion of women treated with
cyclophosphamide.
For older women, in particular, amenorrhea may
be permanent.
Oligomenorrhea has also been reported in
association with cyclophosphamide treatment.
Girls treated with cyclophosphamide during
prepubescence generally develop secondary
sexual characteristics normally and have regular
menses.
Girls treated with cyclophosphamide during
prepubescence subsequently have conceived.
Girls treated with cyclophosphamide who have
retained ovarian function after completing
treatment are at increased risk of developing
premature menopause (cessation of menses
before age of 40 years).
• Male patients
Men treated with cyclophosphamide may
develop oligospermia or azoospermia, which are
normally associated with increased
gonadotrophin but normal testosterone secretion.
Sexual potency and libido generally are
unimpaired in these patients.
Boys treated with cyclophosphamide during
prepubescence may develop secondary sexual
characteristics normally, but may have
oligospermia or azoospermia.
Some degree of testicular atrophy may occur.
Cyclophosphamide-induced azoospermia is
reversible in some patients, though the
reversibility may not occur for several years
after cessation of therapy.
System Organ
Class
Preferred term Frequency
Infections and
infestations
Infections1
Pneumonia2
Sepsis1
Septic shock
Common
Uncommon
Uncommon
Not Known
Neoplasms
benign,
malignant and
unspecified
(incl cycts and
polyps)
Acute leukemia3
Myelodysplastic syndrome
Secondary tumours
Bladder cancer
Tumour lysis syndrome
Rare
Rare
Rare
Rare
Not known
Blood and
lymphatic
system
disorders
Myelosuppression 4
Haemolytic uraemic syndrome
Disseminated intravascular
coagulation (DIC )
Lymphopenia
Very common
Very common
Very rare
Not known
Immune system
disorders
Immunosuppression
Anaphylactic/Anaphylactoid
reaction
Very common
Very rare
Uncommon
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Hypersensitivity reaction
Endocrine
disorders
SIADH Rare
Metabolism and
nutrition
disorders
Anorexia
Dehydration
Hyponatraemia
Fluid retention
Blood glucose changes (increase
or decrease)
Uncommon
Rare
Very rare
Very rare
Not known
Psychic
disorders
Confusion Very rare
Nervous
system
disorders
Dizziness
Convulsion
Neurotoxicity5
Encephalopathy
Rare
Very rare
Unknown
Unknown
Eye disorders Conjunctivitis
Eye Oedema
Visual impairment
Lacrimation increased
Very Rare
Very Rare
Rare
Not known
Ear and
labyrinth
disorders
Deafness
Tinnitus
Not known
Not known
Cardiac
disorders
Ventricular fibrillation
Ventricular tachycardia
Cardiogenic shock
Pericardial effusion
Myocardial infarction
Cardiac failure
Cardiomyopathy
Myocarditis
Pericarditis
Electrocardiogram QT prolonged
Arrhythmias6
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Vascular
disorders
Flushing
Pulmonary embolism
Venous thrombosis
Vasculitis
Peripheral ischaemia
Uncommon
Not known
Not known
Not known
Not known
Respiratory,
thoracic and
mediastinal
disorders
Pulmonary veno-occlusive
disease
Acute respiratory distress
syndrome (ARDS)
Interstitial Lung Diseases7
Pulmonary hypertension
Pulmonary oedema
Bronchospasm
Dyspnea
Hypoxia
Cough
Nasal congestion
Rhinorrhea
Oropharyngeal pain
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Gastrointestinal
disorders
Enterocolitis haemorrhagic
Acute pancreatitis
Mucosal ulceration
Stomatitis
Diarrhoea
Vomiting
Constipation
Nausea
Gastrointestinal Haemorrhage
Colitis
Enteritis
Cecitis
Abdominal pain
Very rare
Very rare
Very rare
Very rare
Very rare
Very rare
Very rare
Very rare
Unknown
Unknown
Unknown
Unknown
Unknown
Parotid gland inflammation Unknown
Hepatobiliary
disorders
Hepatic function abnormal
Veno-occlusive disorder
Hepatitis
Cholestasis
Hepatotoxicity8
Common
Not known
Not known
Not known
Not known
Skin and
subcutaneous
tissue disorders
Alopecia
Rash
Dermatitis
Discoloration of the palms,
fingernails, soles
Toxic epidermal necrolysis
Stevens Johnson syndrome
Erythema multiforme
Palmar-plantar
erythrodysaesthesia
Radiation recall dermatitis
Erythema in irradiated area
Pruritus (including inflammatory
itching)
Erythema
Urticaria
Blisters
Facial swelling
Hyperhidrosis
Very common
Rare
Rare
Rare
Very rare
Very rare
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Not known
Musculoskeletal
and connective
tissue disorders
Rhabdomyolysis
Scleroderma
Muscle spasms
Myalgia
Arthralgia
Not known
Not known
Not known
Not known
Not known
Renal and
urinary
disorders
Cystitis
Microhematuria
Haemorrhagic cystitis
Macrohematuria
Suburethral bleeding
Oedema of the bladder wall
Interstitial inflammation, fibrosis,
and sclerosis of bladder
Renal failure
Blood creatinine increased
Renal tubular necrosis
Renal tubular disorder
Nephropathy toxic
Hemorrhagic ureteritis
Cystitis ulcerative
Bladder contracture
Nephrogenic diabetes insipidus
Atypical urinary bladder epithelial
cells
Blood urea nitrogen increased
Very common
Very common
Common
Common
Very rare
Very rare
Very rare
Very rare
Very rare
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Pregnancy,
puerperium and
perinatal
conditions
Premature labour Not known
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Reproductive
system and
breast
disorders
Impairment of spermatogenesis
Ovulation disorder
Amenorrhoea9
Azoospermia9
Oligospermia9
Infertility
Ovarian Failure
Oligomenorrhoea,
Testicular atrophy
Blood oestrogen decreased
Blood gonadotrophin increased
Common
Uncommon
Rare
Rare
Rare
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Congenital,
familial and
genetic
disorders
Intra-uterine death
Fetal malformation
Fetal growth retardation
Fetal toxicity (including
myelosuppression/gastroenteritis)
Not known
Not known
Not known
Not known
General
disorders and
administration
site conditions
Fever
Asthenia
Mucosal inflammation
Chest pain
Headache
Injection/infusion site reactions10
Multiorgan failure
Oedema
Influenza-like illness
General physical deterioration
Very common
Common
Common
Rare
Very Rare
Not known
Not known
Not known
Not known
Not known
Investigations Blood lactate hydrogenase
increased
C-reactive protein increased
Not known
Not known
1
including other bacterial, fungal, viral,
protozoal, parasitic, reactivation of latent
infections, including viral hepatitis, tuberculosis,
JC virus with progressive multifocal
leucoencephalopathy (including fatal outcomes),
Pneumocystis jiroveci, herpes zoster,
Strongyloides
2
including fatal outcomes
3
including acute myeloid leukemia, acute
promyelocytic leukemia
4
manifested as Bone marrow failure,
Pancytopenia, Neutropaenia, Agranulocytosis,
Granulocytopenia,Thrombocytopaenia
(complicated by bleeding), Leukopenia,
Anaemia
5
manifested as reversible posterior
leukoencephalopathy syndrome, myelopathy,
peripheral neuropathy,
polyneuropathy,neuralgia, dysesthesia,
hypoesthesia, paresthesia, tremor, dysgeusia,
hypogeusia,parosmia.
6
manifested as Atrial
fibrillation,Supraventricular arrhythmia
,Ventricular arrhythmia, Bradycardia,
Tachycardia,Palpitation
7
manifested by pulmonary fibrosis, obliterative
bronchiolitis, organizing pneumonia, alveolitis
allergic, pneumonitis
8
Hepatic failure, Hepatic encephalopathy,
Ascites, Hepatomegaly, Jaundice, Blood
bilirubin increased, Hepatic enzymes increased
(ASAT, ALAT, ALP, gamma-GT)
9
persistent
10
manifested by thrombosis, necrosis, phlebitis,
inflammation, pain, swelling, erythema.
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after
authorisation of the medicinal product is
important. It allows continued monitoring of the
benefit/risk balance of the medicinal product.
4.9 Overdose
Serious consequences of overdosage include
manifestations of dose dependent toxicities such
as myelosuppression, urotoxicity, cardiotoxicity
(including cardiac failure), veno-occlusive
hepatic disease, and stomatitis. See Section 4.4.
Patients who received an overdose should be
closely monitored for the development of
toxicities, and haematotoxicity in particular.
No specific antidote for cyclophosphamide is
known.
Cyclophophamide and its metabolites are
dialysable. Consider haemodialysis in cases of
severe overdose presenting early, particularly in
patients with renal impairment
Overdosage should be managed with supportive
measures, including appropriate, state-of-the-art
treatment for any concurrent infection,
myelosuppression, or other toxicity, should it
occur.
Cystitis prophylaxis with mesna may be helpful
in preventing or limiting urotoxic effects with
cyclophosphamide overdose.
5. PHARMACOLOGICAL PROPERTIES
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5.1 Pharmacodynamic properties
Cyclophosphamide has been demonstrated to
have a cytostatic effect in many tumour types.
The active metabolites of cyclophosphamide are
alkylating agents which transfer alkyl groups to
DNA during the process of cell division, thus
preventing normal synthesis of DNA.
5.2 Pharmacokinetic properties
Cyclophosphamide is well absorbed following
an oral dose with a mean half-life of 4-8 hours
for both oral and parenteral administration.
It is an inactive pro drug with alkylating
metabolites produced by hepatic metabolism,
reaching peak levels 4-6 hours after an i.v.
injection. Hepatic enzymes may be induced. The
parent compound binds poorly to plasma protein
but the active metabolites are significantly
protein-bound. The drug is widely distributed
and crosses the blood-brain barrier, the placental
barrier and is found in ascites. The metabolites
are excreted renally.
5.3 Preclinical safety data
There are no pre-clinical data of relevance to the
prescriber which are additional to the
information already stated in other sections of
the Summary of Product Characteristics.
6. PHARMACEUTICAL PARTICULARS
6.1 List of excipients
None.
6.2 Incompatibilities
Benzyl alcohol increases the degradation rate of
cyclophosphamide.
6.3 Shelf life
Unopened
36 months.
After reconstitution for intravenous
administration
Chemical and physical in-use stability has been
demonstrated (in aqueous, sodium chloride, and
glucose solutions) for 48 hours at 2 - 8°C.
From a microbiological point of view, the
product should be used immediately. If not used
immediately, in-use storage times and conditions
prior to use are the responsibility of the user and
would normally not be longer than 24 hours at 2
- 8°C, unless reconstitution has taken place in
controlled and validated aseptic conditions.
After reconstitution in Aromatic Elixir USP for
oral administration
At a concentration of 2 mg cyclophosphamide
per ml in Aromatic Elixir USP, chemical and
physical stability has been demonstrated for 14
days at 2 - 8°C.
6.4 Special precautions for storage
Do not store above 25°C.
Store in original container.
After reconstitution (for either intravenous or
oral administration), store at 2 - 8°C and protect
from light.
6.5 Nature and contents of container
50 ml type I or type III glass vials with butyl
rubber closures and plastic and aluminium caps.
Pack size : 1 vial.
Vials are packed with or without a protective
plastic overwrap. Protective plastic overwrap
does not come into contact with the medicinal
product and provides additional transport
protection, which increases the safety for the
medical and pharmaceutical personnel.
6.6 Special precautions for disposal and
other handling
For intravenous administration
Prior to administration the contents of a vial
should be dissolved in 25 ml physiological
saline (0.9% w/v sodium chloride) by
introducing the saline into the vial and shaking
vigorously until the powder is completely
dissolved. Reconstitution results in a clear
solution with a pH of between 4 and 6.
Cyclophosphamide Injection is compatible with
the following infusion solutions: sodium
chloride solution, glucose solution, sodium
chloride and glucose solution, sodium chloride
and potassium chloride solution, and potassium
chloride and glucose solution.
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For oral administration
Cyclophosphamide Injection may be dissolved
in Aromatic Elixir USP.
General instructions
If vials are stored above the recommended
temperature this can cause degradation of the
active ingredient, identifiable by a yellow melted
appearance to the vial contents. Vials containing
melted material should not be used.
Cyclophosphamide is a cytotoxic agent. The
handling and preparation of cyclophosphamide
should always be in accordance with current
guidelines on safe handling of cytotoxic agents.
The material should not be handled by women
who are pregnant or who are breast-feeding.
Adequate care and precautions should be taken
in the disposal of empty vials and items
(syringes, needles, etc) used in reconstitution
and administration.
7. MANUFACTURER:
Manufactured in India by:
TAJ PHARMACEUTICALS LTD.
Mumbai, India
At:388/34, Changodar Industrial Estate
Changodar- 382 210
Dist- Ahmedabad. Gujarat (India)
MFG. LIC NO: G/25A/4795-A