Quantitative Image Analysis for Cancer Diagnosis and Radiation TherapyWookjin Choi
1.Lung Cancer Screening
1.1.Deep learning (feasible but not interpretable)
1.2.Radiomics (concise model)
1.3.Spiculation quantification (interpretable feature)
2.PET/CT Tumor Response
2.1.Aggressive Lung ADC subtype prediction (helpful for surgeons)
2.2.Pathologic response prediction (accurate but not concise)
2.3.Local tumor morphological changes (accurate and interpretable)
What would you recommend as first line therapy for a 68 y/o woman with local pancreatic cancer and no metastatic disease with ECOG-1?
Chemoradiation: Rachna Shroff, MD
Surgical Resection: Yongyut Sirivatanauksorn, MD
Preoperative radiotherapy and surgery rectal cancers: optimal intervalGaurav Kumar
Preoperative radiotherapy and surgery rectal cancers: optimal interval between neoadjuvant radiotherapy/chemotherapy and surgery, evidence based approach
MRgFUS in Locally Non-Advanced Prostate CancerINSIGHTEC Ltd
MR guided Focused Ultrasound in Locally Non-Advanced Prostate Cancer
MRgFUS
Sapienza University of Rome
Dpt of Radiological Sciences
MR guided Focused Ultrasound Therapy 2011
September 22-23 2011
Rome
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Quantitative Image Analysis for Cancer Diagnosis and Radiation TherapyWookjin Choi
1.Lung Cancer Screening
1.1.Deep learning (feasible but not interpretable)
1.2.Radiomics (concise model)
1.3.Spiculation quantification (interpretable feature)
2.PET/CT Tumor Response
2.1.Aggressive Lung ADC subtype prediction (helpful for surgeons)
2.2.Pathologic response prediction (accurate but not concise)
2.3.Local tumor morphological changes (accurate and interpretable)
What would you recommend as first line therapy for a 68 y/o woman with local pancreatic cancer and no metastatic disease with ECOG-1?
Chemoradiation: Rachna Shroff, MD
Surgical Resection: Yongyut Sirivatanauksorn, MD
Preoperative radiotherapy and surgery rectal cancers: optimal intervalGaurav Kumar
Preoperative radiotherapy and surgery rectal cancers: optimal interval between neoadjuvant radiotherapy/chemotherapy and surgery, evidence based approach
MRgFUS in Locally Non-Advanced Prostate CancerINSIGHTEC Ltd
MR guided Focused Ultrasound in Locally Non-Advanced Prostate Cancer
MRgFUS
Sapienza University of Rome
Dpt of Radiological Sciences
MR guided Focused Ultrasound Therapy 2011
September 22-23 2011
Rome
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Pharynx and Clinical Correlations BY Dr.Rabia Inam Gandapore.pptx
CRP and inflammatory response (1)
1. Insufficient decrease of C-reactive
protein after elective colorectal
surgery predicts major septic post-
operative complications
Montserrat Juvany, Xavier Guirao, Sara Amador, Ruben
Hernando, Guzmán Franch, Josep Maria Badía
Hospital General de Granollers, Barcelona. Spain
TSIS 2010, March 12, Munich
2. Complications in colorectal surgery
• Surgical site infection (SSI):
– Wound
– Organ-space
o Anastomotic leakage is the main cause (2-24%)
o It is associated with a postoperative mortality (7-25%)
o Delayed diagnosis and treatment might be associated
with a worse prognosis
o Previous observations have demonstrated that clinical
parameters of SIRS are scarcely present on the
postoperative period
TSIS 2010, March 12, Munich
3. C- reactive protein (CRP)
• IL-6 dependent protein produced in the liver
• Appears in blood at 4 hour after the inflammatory stimulus
• Peaks at 48 hours
400
CRP 300
(mg/L)
200
100
0
Preop 24h 48h 120h 240h
TSIS 2010, March 12, Munich
4. OBJECTIVE
• To evaluate the value of C-reactive
protein (CRP) as an early predictor
marker of major septic complications
after elective colorectal surgery
TSIS 2010, March 12, Munich
5. MATERIALS AND METHODS
• Prospective study during 30 months (from August
2006 to March 2009)
• Inclusion criteria
– Elective colorectal surgery
– Intestinal anastomosis
• Exlusion criteria
– Emergency colorectal surgery
– No intestinal anastomosis
– Intrabdominal infection at surgery
• Major septic complications
– Deep wound SSI EARLY (<5th PO day)
– Organ-space SSI
– Pneumonia
LATE (≥ 5th PO day)
TSIS 2010, March 12, Munich
6. MATERIALS AND METHODS
• Analysis:
– CRP
• 2nd PO
• 5th PO SIRS (Systemic inflammatory response
syndrome) parameters:
– SIRS parameters
• Temperature (T) >38ºC or < 36ºC
• During the first 5 • Heart rate (HR) > 90 bpm
days of PO
• Breath rate (BR) > 20 bpm
• Data: mean SD. • White count cell (WCC) >12000 /cc or <
• Statistics 4000 / cc.
SIRS criteria (2 or more SIRS parameters).
– Student-t test
– Receiver operative
curve (ROC) test
TSIS 2010, March 12, Munich
7. RESULTS
Age (y) 68 11
n=151 Sex (%) M (67)
F (33)
ASA (%) I (1)
36 major septic complications II (60)
III (35)
IV (4)
Diagnosis (%) Benign (12)
Malign (88)
Type of surgery Sigmoidectomy (30)
(%) Right colectomy (29)
5 early 31 late Rectum anterior res (24)
Left colectomy (8)
Organ-space 3 19 Hartmann 2nd time (7)
SSI Subtotal colectomy (2)
Deep wound 0 4 Access route Open (51)
SSI (%) Laparoscopic (49)
Pneumonia 2 8
TSIS 2010, March 12, Munich
8. RESULTS
Complicated vs. non complicated patients (late complications:≥ 5 PO day)
CRP Complicated Non complicated
(mg/L) (n=31) (n=115)
2nd PO 200 67* 163 77 p<0.05
5th PO 213 100* 65 59 p<0.05
TSIS 2010, March 12, Munich
9. Complicated vs. non complicated patients (late complications:≥ 5 PO day)
SIRS Complicated Non complicated
parameters (n=31) (n=115)
HR 2nd PO 90 14* 82 14 p<0.05
(bpm)
5th PO 96 24* 82 14 p<0.05
WCC 2nd PO 9448 3029 8791 2683
(leu/cc)
5th PO 7476 3641* 6304 2103 p<0.05
RR 2nd PO 20 2 21 2
(bpm)
5th PO 22 5 21 3
T (ºC) 2nd PO 36.8 0.6 36.7 0.5
5th PO 36.7 0.7 36.6 0.3
TSIS 2010, March 12, Munich
10. RESULTS
Early vs late complicated on the 2nd PO day
Early Late
complicated complicated
(n=5) (n=31)
CRP (mg/L) 348 70.8 * 200 67 p<0.05
RR (bpm) 28 11* 20 2 p<0.05
HR (bpm) 106 23* 90 14 p<0.05
WCC (L/cc) 10223 4083 9448 3029
T (ºC) 36.5 0.8 36.8 0.5
TSIS 2010, March 12, Munich
11. RESULTS
Changes in CRP values as a percentage between 2nd-5th postoperative day
Complicated
Non complicated
CRP (5nd) - CRP (2th)
D CRP % = X 100
CRP (2nd)
TSIS 2010, March 12, Munich
12. RESULTS
ROC curve. Cut off point of D% CRP (2-5): decrease of 36%
• AUC=0.929
•IC=0,87-0,97
•Se= 28/31 (0.9)
• Sp= 99/115 (0.86)
TSIS 2010, March 12, Munich
13. RESULTS
Comparison complicated vs non complicated (late)
Complicated Non complicated
Non ￬ > 36% 28 16 44
￬ > 36% 3 99 102
31 115 146
• Se= 28/31 (0.9)
• Sp= 99/115 (0.86) Out of 31 patients with complications, 28 did not
• PPV= 28/44 (0.64)
have the decrease of > 36% (sens of 90%)
• NPV = 99/102 (0.97) Out of 102 patients who had the decrease >
36%, 99 did not have complications (NPV of 97%)
16 patients (out of 44) with insufficient
decrease, did not have major complications
TSIS 2010, March 12, Munich
14. CONCLUSIONS
• An insufficient decrease (less than 36%) of CRP values between the
2nd-5th PO days is likely to be a good tool for predicting major septic
complications
• A decrease of more than 36 % can help surgeons to safely
discharge patients by the 5th PO day
• Levels of CRP more than 300 mg/L on the 2nd PO day might indicate
early major septic complications
TSIS 2010, March 12, Munich
