COVID-19 has implications for the scholarly communication system by affecting dissemination, accessibility, quality control, and findability of research. The pandemic led to a large increase in preprint submissions as researchers sought rapid dissemination of COVID-19 findings. Preprint servers helped make research widely accessible. While traditional peer review was bypassed, some preprints received rapid or post-publication peer review. Open access publishing also increased accessibility. The value of preprint servers and next-generation search technologies was demonstrated, but literature databases not covering preprints may lose value. COVID-19 provides a strong argument for open access and shows preprints can play an important role in biomedical research dissemination.