This Presentation shows the effect of Cytoreg(R) in various Brian Tumor Cell lines. Performed at the Medical College of Georgia. Presented in April of 2008
This Presentation shows the effect of Cytoreg(R) in various Brian Tumor Cell lines. Performed at the Medical College of Georgia. Presented in April of 2008
Brief introduction of android telephony framework, detailed analyze of RIL (radio interface layer), and some examples for doing telephony thing in a low layer
Pharmaceutical industry – change in discovery and developmentBhaswat Chakraborty
Drug discovery and development of yester years
Drug discovery and development now
Preclinical
Drug
Organization
Clinical
IT & Data management
Approval
Postapproval
Targeted nanoparticle tumor ablation. Multi-walled Carbon Nanotubes (MWCNT) are designed with internal antennae tuned to a specific Near Infrared (NIR) laser frequency, which when activated, oscillate at high speeds, generating thermal energy (heat) sufficient to cause cell apoptosis. Using targeting probes, the MWCNT only seek out, attach to, and within, specific cancer cells. The NIR laser is non-invasive, and does not injure the skin. The MWCNT can also be conjugated with probes for very specific imaging for diagnostics purposes using existing MRI technology.
Targeted nanoparticle tumor ablation. Multi-walled Carbon Nanotubes (MWCNT) are designed with internal antennae tuned to a specific Near Infrared (NIR) laser frequency, which when activated, oscillate at high speeds, generating thermal energy (heat) sufficient to cause cell apoptosis. Using targeting probes, the MWCNT only seek out, attach to, and within, specific cancer cells. The NIR laser is non-invasive, and does not injure the skin. The MWCNT can also be conjugated with probes for very specific imaging for diagnostics purposes using existing MRI technology.
MDNA Life Sciences is a pioneer in the science of mitochondrial DNA. It’s our mission to create an extensive portfolio of proprietary tests that dramatically improve diagnosis, treatment, prognosis and monitoring. Putting an end to the unnecessary surgical procedures, pain and uncertainty that affect patients across the world.
Perpective Management- Pharmaceutical Industry Overviewsdusane1
Perception" is defined as the "process by which individuals select, organize, and interpret the input from their senses to give meaning and order to the world around them".[3] Components of perception include the perceiver, target of perception, and the situation. The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications.[1] Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy and marketing of drugs.
We can aid decision making from the pre-clinical to the clinical setting, supporting line of sight to the clinic, by identifying and translating crucial biomarker approaches into the real world.
Brief introduction of android telephony framework, detailed analyze of RIL (radio interface layer), and some examples for doing telephony thing in a low layer
Pharmaceutical industry – change in discovery and developmentBhaswat Chakraborty
Drug discovery and development of yester years
Drug discovery and development now
Preclinical
Drug
Organization
Clinical
IT & Data management
Approval
Postapproval
Targeted nanoparticle tumor ablation. Multi-walled Carbon Nanotubes (MWCNT) are designed with internal antennae tuned to a specific Near Infrared (NIR) laser frequency, which when activated, oscillate at high speeds, generating thermal energy (heat) sufficient to cause cell apoptosis. Using targeting probes, the MWCNT only seek out, attach to, and within, specific cancer cells. The NIR laser is non-invasive, and does not injure the skin. The MWCNT can also be conjugated with probes for very specific imaging for diagnostics purposes using existing MRI technology.
Targeted nanoparticle tumor ablation. Multi-walled Carbon Nanotubes (MWCNT) are designed with internal antennae tuned to a specific Near Infrared (NIR) laser frequency, which when activated, oscillate at high speeds, generating thermal energy (heat) sufficient to cause cell apoptosis. Using targeting probes, the MWCNT only seek out, attach to, and within, specific cancer cells. The NIR laser is non-invasive, and does not injure the skin. The MWCNT can also be conjugated with probes for very specific imaging for diagnostics purposes using existing MRI technology.
MDNA Life Sciences is a pioneer in the science of mitochondrial DNA. It’s our mission to create an extensive portfolio of proprietary tests that dramatically improve diagnosis, treatment, prognosis and monitoring. Putting an end to the unnecessary surgical procedures, pain and uncertainty that affect patients across the world.
Perpective Management- Pharmaceutical Industry Overviewsdusane1
Perception" is defined as the "process by which individuals select, organize, and interpret the input from their senses to give meaning and order to the world around them".[3] Components of perception include the perceiver, target of perception, and the situation. The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications.[1] Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy and marketing of drugs.
We can aid decision making from the pre-clinical to the clinical setting, supporting line of sight to the clinic, by identifying and translating crucial biomarker approaches into the real world.
Crystal Research Associates has initiated coverage on immune-oncology company Biosceptre International Ltd. (closely held) with the release of a 52-page Executive Informational Overview.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
2. Introduction
This presentation describes Cytorex
Bioscience, Inc.; a Florida based preclinical
stage Biopharmaceutical Company
developing new therapies based on its
expertise in pharmacologically active low
pH acidic formulations.
Cytoreg®, the Company’s lead drug
candidate, is currently in preclinical
development for various cancers.
3. Market Overview
• In 2007, worldwide sales of cancer therapies
totaled USD $42.2 billion.
• Within the 7 major markets (US, Japan, France,
Germany, Italy, Spain, and the United Kingdom),
sales amounted to USD $34.3 billion.
• These sales are expected to grow at a
compound annual growth rate (CAGR) of 12%
between 2006 and 2013, almost 3 times faster
than the pharmaceutical industry as a whole,
reaching USD $55 billion by 2012.
4. Focus
• Cytorex intends to initially focus development
efforts of Cytoreg® on cancer types with high
levels of unmet need: Glioblastoma Multiforme
(grade IV brain tumor); pancreatic cancer; and
metastatic melanoma.
• Cytoreg® may also be developed for brain
metastases. These four cancer types have low
survival rates, are currently underserved with
existing marketed therapies and have few
pipeline products.
5. Technology Overview
• Cytorex has developed a number of therapeutic
candidates based on its US patented
pharmacologically active low pH acidic technology
for a wide range of disorders, including cancer and
diseases of immunological origin.
• Cytoreg® is Cytorex lead drug candidate and is the
primary focus of this presentation.
• Cytoreg®, a novel cancer therapeutic candidate, is a
formulation of balanced acids, where hydrofluoric
acid (HF) is the key active ingredient.
• Cytoreg® may be used to treat several types of
cancers, including solid tumors and hematological
malignancies.
6. Portfolio
PRODUCT STAGE APPLICATION
1
Cytoreg™: Development Currently in preclinical development stage
for these indications: 1) Brain Tumors
(Glioblastoma Multiforme); 2) Pancreatic
Cancer and 3) Metastatic Melanoma (skin
cancer). Also being investigated in brain
metastases.
2
CytoregUNO™ Development skin cancer such as basal cell cancer,
squamous cell cancer, sarcoma,
melanoma, and disorders caused by fungi,
viruses and bacteria on the skin.
3
CytoCardio™ Discovery Product for treatment of hypertension
4
CytoKStones ™: Discovery Product for treatment of Kidney Stones
5
CytoNeuroSys™ Discovery Product for treatment of MS, Alzheimer’s,
Parkinson’s, and chronic diseases like
epilepsy.
6
CytoOS™ Discovery Product for treatment of Otosclerosis
7
CytoDiabet™ Discovery Product for treatment/regulation of
Diabetes
8
CytoAntioxidant™ Discovery Antioxidant
9
CytoHormone™ Discovery Product for treatment of hormonal disorders
7. Selectivity and MOA
• Preclinical studies in Glioblastoma Multiforme and other
cancer cell types have demonstrated that Cytoreg® has
high specificity and selectivity in targeting and inhibiting
cancer growth, as well as inducing selective apoptosis.
• Mechanisms of action studies have also been performed
to understand how Cytoreg® kills cancer cells. These
studies have demonstrated that Cytoreg®: disrupts the
cell membrane in brain cancer cell lines; acts
independently of the tumor suppressor gene p53 and
caspase cascade pathways; inhibits cancer cell growth
factor; and induces selective apoptosis.
8. Key product advantages
• A targeted therapy with multiple
mechanisms of action.
• Demonstrated potential to reduce
tumor mass and/or stops tumor
growth or even destroys the tumor.
• Favorable side effect profile, as
demonstrated in human
compassionate use program and in
preclinical studies performed to date.
• Very low manufacturing costs.
9. Clinical Development Plan &
Regulatory Strategy
• The Company expects that Cytoreg® will be brought to market
at a much faster pace than typical oncology products by
targeting indications with high levels of unmet need, including
Glioblastoma Multiforme; pancreatic cancer; and metastatic
melanoma.
• By focusing on these indications, Cytoreg® will be a candidate
for Fast Track and Orphan Drug designations, and potentially
accelerated approval by US Food & Drug Administration
(USFDA).
• Our initial plan is to perform some preliminary clinical trials in
Latin America, get approval for at least two indications, and
then start the FDA/EMA approval process.
• If Funding is sufficient we may choose to initiate Clinical Trials
directly in the USA.
10. Intellectual Property
• Cytorex believes the Company’s intellectual property
(IP) position is secure. The Company has one issued
patent (US patent 7,141,251, “Pharmacologically
Active Strong Acid Solutions”) containing over 70
claims related to composition and therapeutic use.
• Cytorex has developed a detailed patent prosecution
strategy to further enhance its IP position in the US
and worldwide. Cytorex’ IP estate has been reviewed
by Mr. Michael Keller, Esq. Mr. Keller has over 20
years’ experience prosecuting biomedical drug,
diagnostic and device patents.
11. Management Team
• Prof. David Martucci, Chairman, President, Chief
Executive Officer and Chief Scientific Officer
• Mr. William Jimenez, Director, Vice-President,
Treasurer and Chief Financial Officer
• Mr. Carlos M. Garcia, Director, Secretary & Chief
Operations Officer
• Mr. Ramon Alvarez, Business Development
Director
12. Key Advisors
• Dr. Kris Dhandapani, Scientific Consultant
• Mr. Michael J. Keller, Intellectual Property
Attorney
13. Scientific Committee
• Dr. Kris Dhandapani, PhD, Assistant Professor, Neurology Department,
Institute of Molecular Medicine and Genetics, Medical College of
Georgia. Research Interest: Brain Cancer Tumors & Brain Injuries.
• Dr. James Kumi-Diaka, DVM, PhD, Prof. of Cancer Biology (Florida
Atlantic University, Davie FL). Research Interest: Molecular Biology &
Apoptosis.
• Dr. Manzur Hassanhi, MD, Professor of Immunology (University of
Zulia, Venezuela). Research Interest: Clinical Oncology.
• Dr. Nelson Vicuña, MD, Professor of Toxicology (University of los
Andes, Merida, Venezuela), Research Interest: Toxicology &
Pharmacology
• Dr. Paula Durante, PhD, Biological Research (Private Consulting)
Research Interest: Physiology and Cellular Biochemical Mechanisms
• Dr. Rosa de Jesús, PhD (University of Los Andes, Merida, Venezuela)
Research Interest: Animal Models
14. Cytorex Biosciences, Inc.
Carlos M. Garcia, Managing Director & COO
4474 Weston Road No. 108
Weston, FL 33331
Direct: 954-573-4006
cmgarcia@cytorex.com
Contact Information: