This document discusses consumer genomics and provides an agenda and overview of the topic. It defines consumer genomics, discusses the current status including companies offering direct-to-consumer genetic testing, and how consumer genomics companies could enable more efficient translational research through infrastructure like biobanks and genotyping. It also summarizes 10 predictions about consumer genomics from Bob Green at Harvard.

1. Consumer Genomics
June 2009 Updates
Simon Lin

2. Agenda
s What is Consumer Genomics?
s The Current Status of Consumer Genomics
s Consumer Genomics and Translational Research
s Ten Predictions by Bob Green at Harvard
“Consumer Genomics” Simon Lin June 2009

3. What is “consumer genomics”?
“Consumer Genomics” Simon Lin June 2009

4. Current Status
s More than 4,500 physicians have been trained by
Navigenics Inc. through CME
s About 500 attendees at the Consumer Genomics
Conference, Boston, June 2009
s Venture Capital firms are still investing
s Consumer product companies, such as P&G, is
using genomics in R&D, and maybe future product
offerings
“Consumer Genomics” Simon Lin June 2009

5. Consumer Branding
Navigenics 23andme Sorenson TruGeentics
Ancestry NO ✔ ✔
Health ✔ ✔ ✔
Paternity NO ✔
Price $2,499 $399 $149 $0
“Consumer Genomics” Simon Lin June 2009

6. Effect Size too Small?
Environment
Risk Factor Condition Effect Size
Ex-smoker T2D 1.15
HDL<35mg/dl CHD 2.08
BMI>35 T2D 42
Gene
Risk Factor Condition Effect Size
PPARG T2D 1.53
MHC RA 5
APOE AD 18
“Consumer Genomics” Simon Lin June 2009

7. Annotation of Evidences
s Study Design:
– Sample size
– Population: ethnicity, gender, age
– QC of the genotyping
s Significance of the findings
– Statistically significant: multiple testing; population
stratification
– Biologically sound
“Consumer Genomics” Simon Lin June 2009

8. Consumer Genomics Companies (CGCs) and
Translational Research
“Consumer Genomics” Simon Lin June 2009

9. CGCs have the Infrastructure
Biobank Genotyping Bioinformaitcs
(CLIA-certified)
“Consumer Genomics” Simon Lin June 2009

10. CGCs need the Revenue
s IPO is unlikely for CGCs in the near future
s If focusing on consumers
– Assuming 10% profit margin of a $400 test
– Needs 250,000 tests per year for $10M profit
“Consumer Genomics” Simon Lin June 2009

11. CGCs can make it more efficient
s Grass-root organizations
– patients like me. Com
– Self-reported data
– Prospective validation
“Consumer Genomics” Simon Lin June 2009

12. Ten Predictions from Bob Green
s # of human genomes s Hospital will be sued by
s Biomarker-driven not testing genes
consumer products in s Microsoft will buy more
the supermarket genomics
s Larger GWAS studies s Facebook will be used
s Market Channeling in marketing healthcare
products
s Point-of-Care
s WG price: drop 2/3
s Multiple payer system
“Consumer Genomics” Simon Lin June 2009