Polynomial and rational expressions can be added, subtracted, multiplied, divided, and factored using specific steps and properties. A polynomial is an expression involving variables and coefficients that can be written in standard form. Polynomials can be added and subtracted by combining like terms. Multiplication uses the distributive property or FOIL method for binomials. Rational expressions are quotients of polynomials that can be simplified by cancelling common factors. Specific factoring techniques like GCF, difference of squares, and grouping are used to factor polynomial expressions into their prime factors.