Maxillofacial and Cleft Surgery Group's CoE at Anand Hospital, Gurgaon
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This document summarizes the Maxillofacial and Cleft Surgery Group's new Centre of Excellence at Anand Hospital in Gurgaon. The center brings together surgeons experienced in cleft and craniofacial surgery, oral and maxillofacial surgery, and oral cancer screening. It is led by Dr. Himanshi Singla, who has over 2000 surgical experiences and training in Zurich and Delhi. The center aims to develop expertise in these four specialties and currently has other centers across India, with this new center providing access to all of their specialties and experience of over 10,000 surgical corrections by the group.
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Dental clinics were ranked according to their GCR Score, against other clinics in the same country on the level of apparent expertise, services, facilities and patient feedback available by the clinic. The GCR feedback score for the clinics includes patient rating scores from Google & Facebook and other independent rating providers.
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Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
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Gastrointestinal Infections
GASTROINTESTINAL INFECTIONS result from the ingestion of pathogens that cause infections at the level of this tract, generally being transmitted by food, water and hands contaminated by microorganisms such as E. coli, Salmonella, Shigella, Vibrio cholerae, Campylobacter, Staphylococcus, Rotavirus among others that are generally contained in feces, thus configuring a FECAL-ORAL type of transmission.
Among the factors that lead to the occurrence of gastrointestinal infections are the hygienic and sanitary deficiencies that characterize our markets and other places where raw or cooked food is sold, poor environmental sanitation in communities, deficiencies in water treatment (or in the process of its plumbing), risky hygienic-sanitary habits (not washing hands after major and/or minor needs), among others.
These are generally consequences (signs and symptoms) resulting from gastrointestinal infections: diarrhea, vomiting, fever and malaise, among others.
The treatment consists of replacing lost liquids and electrolytes (drinking drinking water and other recommended liquids, including consumption of juicy fruits such as papayas, apples, pears, among others that contain water in their composition).
To prevent this, it is necessary to promote health education, improve the hygienic-sanitary conditions of markets and communities in general as a way of promoting, preserving and prolonging PUBLIC HEALTH.
Gastritis and Gastric Health
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Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
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Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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Maxillofacial and Cleft Surgery Group's CoE at Anand Hospital, Gurgaon
- 1. MCSG’s Centre of Excellence at Anand Hospital, Gurgaon Maxillofacial and Cleft Surgery Group in collaboration with Anand Hospital, Gurgaon brings a rich experience of surgeons, in the field of Cleft & Craniofacial Surgery, Oral & Maxillofacial Surgery, Oral Cancer Screening and Tobacco Intervention. This group was founded and is being led by Dr. Himanshi Singla, who has OA&P experience of 2000+ surgical corrections across India. She has completed her Fellowship from CCI, Zurich, after completing her Masters in Dental Surgery in Oral & Maxillofacial Surgery and Observer-ship in Head & Neck Surgical Oncology Unit located at Rajiv Gandhi Cancer Institute & Research Centre, New Delhi. MCSG is currently being funded by Private Investors and is in process of developing workable model and prototype in all four areas of expertise. At Present MCSG has following* Centre’s of Excellence across India: OMFS Unit at Sudha Multispecialty Dental & Facial Surgery Clinic, Durg Oral Cancer Screening and Tobacco Intervention at Cancer Hospital, Bathinda. CCS Unit at DJ Institute of Medical Sciences & Research, Modinagar OMFS Unit at Deep Dental Care, Indirapuram CCS cum OMFS Unit at Noida Dental Care, Noida Online Consultation is provided through various web links in India & Abroad. *All the above will be operational by 1st June, 2013. This Centre of Excellence will have privilege to in-house, all MCSG’s units namely OMFS, CCS, OCS & TI, thereby bringing together the quality and rich experience, of 10,000+ surgical corrections performed by Team MCSG in various parts of India.