Kung fu is a Chinese martial art that uses force to cause harm to opponents or for health purposes. It has existed in China for millennia and incorporates thousands of styles. Practitioners learn to harness and expand their innate energy known as chi or qi. In kung fu, force is understood as the transfer of energy from one body to another through fast, powerful strikes. Later, the concept of force expanded to include detaching and molding it into different forms for combat in kung fu comics. Some depictions show practitioners using telekinetic powers to issue explosive forces from their bodies without contact.
What is the view that you wake up to in the morning? Is it the garden? Is it a sunrise view? Or is it just the sight of the people you love? Most of us wake up to the same view every morning – a view that heralds the start of our day and helps us greet the day with a smile. A good start to the day, after all, is about waking up in familiar surroundings. Shiv Prabhakar wakes up to one such view every morning – the view of his carefully cultivated garden.
Slide 10 WestCal Political Science 5 Western Political Thought 2016WestCal Academy
Political Science 5 - Western Political Thought provides an overall perspective of major political movements of history from the rising of Egyptian, Greek and Roman Empires to Fascism and Communism as seen by great political thinkers from Plato, Aristotle, and St. Augustine, Machiavelli, Marx, and Lenin. Students will analyze the most important ideas and theories that have been developed from the time of the ancient Greeks to the present day. Students will learn that the American Founding Fathers designed a viable representative government by first dedicating themselves to careful study of the political philosophy of Europeans, with particular attention given to British political thinkers from the 16th and 17th century. The founding fathers focused primarily on the natural rights of man, which in turn varied according to the individual philosopher studied. Over the course of their study, the founding fathers openly discussed their opinions with one another so as to properly bring forth differing views in order to prudently construct a government that would protect individual liberty, as well as determine what was required of government to protect civil liberties. The class is taught from the perspective of industry professionals with knowledge of how classical and modern political continues to influence American government. Students will learn of multiple career options relating to the field of political science.
Cosmic Adventure Episode 2.04 Where did these equations come from?Stephen Kwong
Maxwell made a clever suggestion to detect the presence of the aether which formed the model basis of the Michelson and Morley experiment. The excalibur was inserted into the stone.
What is the view that you wake up to in the morning? Is it the garden? Is it a sunrise view? Or is it just the sight of the people you love? Most of us wake up to the same view every morning – a view that heralds the start of our day and helps us greet the day with a smile. A good start to the day, after all, is about waking up in familiar surroundings. Shiv Prabhakar wakes up to one such view every morning – the view of his carefully cultivated garden.
Slide 10 WestCal Political Science 5 Western Political Thought 2016WestCal Academy
Political Science 5 - Western Political Thought provides an overall perspective of major political movements of history from the rising of Egyptian, Greek and Roman Empires to Fascism and Communism as seen by great political thinkers from Plato, Aristotle, and St. Augustine, Machiavelli, Marx, and Lenin. Students will analyze the most important ideas and theories that have been developed from the time of the ancient Greeks to the present day. Students will learn that the American Founding Fathers designed a viable representative government by first dedicating themselves to careful study of the political philosophy of Europeans, with particular attention given to British political thinkers from the 16th and 17th century. The founding fathers focused primarily on the natural rights of man, which in turn varied according to the individual philosopher studied. Over the course of their study, the founding fathers openly discussed their opinions with one another so as to properly bring forth differing views in order to prudently construct a government that would protect individual liberty, as well as determine what was required of government to protect civil liberties. The class is taught from the perspective of industry professionals with knowledge of how classical and modern political continues to influence American government. Students will learn of multiple career options relating to the field of political science.
Cosmic Adventure Episode 2.04 Where did these equations come from?Stephen Kwong
Maxwell made a clever suggestion to detect the presence of the aether which formed the model basis of the Michelson and Morley experiment. The excalibur was inserted into the stone.
Modern networking for php developers - Dutch PHP conference 2015SynchroM
Many developers are stuck in the world of old-school IPv4 - it's an easy and comfortable place to be! But beneath the cosy world of PHP, your network layer has been undergoing major changes that might be outside your comfort zone. IPv6, SPDY (aka HTTP/2.0) and SSL are all important technologies that you need to get to grips with, both inside and outside PHP. This talk covers the key features of these technologies and how you can use them to improve your app's availability, performance and security.
This talk was presented at the Dutch PHP conference 2015
Prepare yourself for the tough world with our tips on app for the time management section that may assist you in developing good work habits to perform better.
Design of an Effective Method for Image RetrievalAM Publications
Image retrieval has been highly concussed in major sectors and systems. The relevance feedback technique is
commonly used for analyzing the images for maintaining secure systems. It covers the wide range of techniques in
supporting user information and improving the facilities for image retrieval. In this paper, relevance feedback with respect
to Self-Organizing Maps (SOM) has been discussed .Comparative results show the high impact of relevance feedback in image retrieval.
A series of satellite projects to secure more and better images of the Cosmic Microwave Background (CMB) since 1980. Age of universe estimated to be 13.73 billion years.
CA 10.01 Discovery of CMB (Cosmic Microwave Background)Stephen Kwong
Discovery of Cosmic Microwave Background by Arno Penzias and Robert Wilson in the 1960s. Found to be the relic radiation from the beginning of the Universe. One of the greatest discovery in science history so far.
Relativity, Visonics, Classical physics on acceleration. Different results in different views. Relativity results in lengthy and complicated equations, almost unworkable. But in visonics, apparent acceleration = actual acceleration.
CA 5.11 Velocity Transform in Relativity & VisonicsStephen Kwong
The kinematic entity of velocity is transformed in the Theory of Relativity by the Lorentz transformation of frames; in visionics, by delayed images. Simpler results in visonics.
Cosmic Adventure 5.8 Time Dilation of Clocks in Motion in VisonicsStephen Kwong
Time dilation phenomenon for clocks on the move in visonics. The result is the same as clocks at rest since the speed of light is not affected by the motion of the source.
Modern networking for php developers - Dutch PHP conference 2015SynchroM
Many developers are stuck in the world of old-school IPv4 - it's an easy and comfortable place to be! But beneath the cosy world of PHP, your network layer has been undergoing major changes that might be outside your comfort zone. IPv6, SPDY (aka HTTP/2.0) and SSL are all important technologies that you need to get to grips with, both inside and outside PHP. This talk covers the key features of these technologies and how you can use them to improve your app's availability, performance and security.
This talk was presented at the Dutch PHP conference 2015
Prepare yourself for the tough world with our tips on app for the time management section that may assist you in developing good work habits to perform better.
Design of an Effective Method for Image RetrievalAM Publications
Image retrieval has been highly concussed in major sectors and systems. The relevance feedback technique is
commonly used for analyzing the images for maintaining secure systems. It covers the wide range of techniques in
supporting user information and improving the facilities for image retrieval. In this paper, relevance feedback with respect
to Self-Organizing Maps (SOM) has been discussed .Comparative results show the high impact of relevance feedback in image retrieval.
A series of satellite projects to secure more and better images of the Cosmic Microwave Background (CMB) since 1980. Age of universe estimated to be 13.73 billion years.
CA 10.01 Discovery of CMB (Cosmic Microwave Background)Stephen Kwong
Discovery of Cosmic Microwave Background by Arno Penzias and Robert Wilson in the 1960s. Found to be the relic radiation from the beginning of the Universe. One of the greatest discovery in science history so far.
Relativity, Visonics, Classical physics on acceleration. Different results in different views. Relativity results in lengthy and complicated equations, almost unworkable. But in visonics, apparent acceleration = actual acceleration.
CA 5.11 Velocity Transform in Relativity & VisonicsStephen Kwong
The kinematic entity of velocity is transformed in the Theory of Relativity by the Lorentz transformation of frames; in visionics, by delayed images. Simpler results in visonics.
Cosmic Adventure 5.8 Time Dilation of Clocks in Motion in VisonicsStephen Kwong
Time dilation phenomenon for clocks on the move in visonics. The result is the same as clocks at rest since the speed of light is not affected by the motion of the source.
The concept of length contraction in traditional theory of Special Relativity. Although seemingly verified by many experiment, its reality still remains controversial and pending amendment.
Cosmic adventure 5.4 Moving Objects in VisonicsStephen Kwong
The visonic version of objects in motion. The approach is different from relativity and the results are also different. But they are all realistic and classical.
Cosmic Adventure 5.3 Frames in Motion in RelativityStephen Kwong
The Einstein way of transforming time and location by the Lorentz factor, marking the departure from Newtonian physics. But why is it so is not explained.
Cosmic Adventure 5.2 Visonic Transform Without MotionStephen Kwong
The case when v=0 not covered by Relativity. Delay timing happens normally in static cases. The static case leads to the universe in spatial and temporal layers.It is just the world we live in.
Cosmic Adventure 5.1 Relative Motion in Special RelativityStephen Kwong
The classical equations of relative motion are translated by the theory of Special Relativity into relativistic equations. The origin of the Lorentz factor recapitulated.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.