Practice quiz on the clotting cascade with correct answer highlighted on following slide. Questions in multiple choice, true/false, and matching formats.

2. MOST CLOTTING FACTORS ARE
SYNTHESIZED IN THE:
• KIDNEYS
• LIVER
• BONE MARROW
• SPLEEN

3. MOST CLOTTING FACTORS ARE
SYNTHESIZED IN THE:
• KIDNEYS
• LIVER
• BONE MARROW
• SPLEEN

4. WHICH VITAMIN IS REQUIRED BY THE LIVER
FOR SYNTHESIS OF CLOTTING FACTORS?
• VITAMIN D
• VITAMIN A
• VITAMIN B
• VITAMIN C
• VITAMIN K

5. WHICH VITAMIN IS REQUIRED BY THE LIVER
FOR SYNTHESIS OF CLOTTING FACTORS?
• VITAMIN D
• VITAMIN A
• VITAMIN B
• VITAMIN C
• VITAMIN K

6. BLOOD CLOTTING REINFORCES THE
PLATELET PLUG WITH:
• PROCOAGULENTS
• CLOTTING FACTOR PROTEINS
• FIBRIN
• COLLAGEN
• CONNECTIN

7. BLOOD CLOTTING REINFORCES THE
PLATELET PLUG WITH:
• PROCOAGULENTS
• CLOTTING FACTOR PROTEINS
• FIBRIN
• COLLAGEN
• CONNECTIN

8. BLOOD FACTORS CIRCULATE IN THE BLOOD
STREAM IN THEIR INACTIVE FORM:
• TRUE
• FALSE

9. BLOOD FACTORS CIRCULATE IN THE BLOOD
STREAM IN THEIR INACTIVE FORM:
• TRUE
• FALSE

10. A CLOTTING FACTOR IS ACTIVATED WHEN A PIECE OF
PROTEIN IS CUT OFF, CAUSING A SHAPE CHANGE THAT
TURNS THE FACTOR FROM A PROTEIN TO AN ENZYME:
• ALWAYS TRUE
• TRUE WITH EXCEPTIONS
• ALWAYS FALSE
• FALSE WITH EXCEPTIONS

11. A CLOTTING FACTOR IS ACTIVATED WHEN A PIECE OF
PROTEIN IS CUT OFF, CAUSING A SHAPE CHANGE THAT
TURNS THE FACTOR FROM A PROTEIN TO AN ENZYME:
• ALWAYS TRUE
• TRUE WITH EXCEPTIONS
• ALWAYS FALSE
• FALSE WITH EXCEPTIONS

12. WHY IS CLOTTING CALLED A “CASCADE”?
• BECAUSE ALL THE PROTEINS INVOLVED IN CLOTTING ARE ACTIVATED AT ONCE
• BECAUSE ONE FACTOR ACTIVATES THE NEXT FACTOR, AND SO ON
• BECAUSE CLOTTING FACTORS MUST BE “SWEPT TOGETHER” IN THE BLOOD STREAM FOR ACTIVATION TO
OCCUR
• BECAUSE THE SEQUENCE OF EVENTS IN PLATELET AGGREGATION INDUCES CLOTTING

13. WHY IS CLOTTING CALLED A “CASCADE”?
• BECAUSE ALL THE PROTEINS INVOLVED IN CLOTTING ARE ACTIVATED AT ONCE
• BECAUSE ONE FACTOR ACTIVATES THE NEXT FACTOR, AND SO ON
• BECAUSE CLOTTING FACTORS MUST BE “SWEPT TOGETHER” IN THE BLOOD STREAM FOR ACTIVATION TO
OCCUR
• BECAUSE THE SEQUENCE OF EVENTS IN PLATELET AGGREGATION INDUCES CLOTTING

14. WHAT IS THE DIFFERENCE BETWEEN THE
INTRINSIC AND EXTRINSIC PATHWAYS?
• IN THE INTRINSIC PATHWAY, THE NECESSARY FACTORS ARE FOUND WITHIN THE BLOOD, AND IN THE
EXTRINSIC PATHWAYS, THE FACTORS THAT INDUCE CLOTTING ARE FOUND OUTSIDE THE BLOOD
• THE EXTRINSIC PATHWAY OCCURS OUTSIDE THE BODY, AND THE INTRINSIC PATHWAY OCCURS INSIDE
THE BODY
• THE INTRINSIC PATHWAY LEADS TO A LOT INSIDE THE BLOOD VESSEL, AND THE EXTRINSIC PATHWAY
LEADS TO A CLOT ON THE SURFACE OF THE BODY

15. WHAT IS THE DIFFERENCE BETWEEN THE
INTRINSIC AND EXTRINSIC PATHWAYS?
• IN THE INTRINSIC PATHWAY, THE NECESSARY FACTORS ARE FOUND WITHIN THE BLOOD, AND IN THE
EXTRINSIC PATHWAYS, THE FACTORS THAT INDUCE CLOTTING ARE FOUND OUTSIDE THE BLOOD
• THE EXTRINSIC PATHWAY OCCURS OUTSIDE THE BODY, AND THE INTRINSIC PATHWAY OCCURS INSIDE
THE BODY
• THE INTRINSIC PATHWAY LEADS TO A LOT INSIDE THE BLOOD VESSEL, AND THE EXTRINSIC PATHWAY
LEADS TO A CLOT ON THE SURFACE OF THE BODY

16. WHICH OF THE FOLLOWING CLOTTING FACTORS IS
THE “COMMON FACTOR” OF THE INTRINSIC AND
EXTRINSIC PATHWAYS?
• CA2+
• THROMBIN
• PROTHROMBIN
• X

17. WHICH OF THE FOLLOWING CLOTTING FACTORS IS
THE “COMMON FACTOR” OF THE INTRINSIC AND
EXTRINSIC PATHWAYS?
• CA2+
• THROMBIN
• PROTHROMBIN
• X

18. WHAT TRIGGERS THE INTRINSIC
PATHWAY?
• TISSUE FACTOR (TF)
• PROTHROMBIN ACTIVATOR
• NEGATIVELY CHARGED SURFACES (PLATELETS, COLLAGEN, GLASS)
• PLATELETS

19. WHAT TRIGGERS THE INTRINSIC
PATHWAY?
• TISSUE FACTOR (TF)
• PROTHROMBIN ACTIVATOR
• NEGATIVELY CHARGED SURFACES (PLATELETS, COLLAGEN, GLASS)
• PLATELETS ACTIVATED PLATELETS DISPLAY PHOSPHATIDYLSERINE, A NEGATIVELY CHARGED PARTICLE
THAT DOES ACTIVATE THE INTRINSIC PATHWAY, BUT INACTIVE PLATELETS DO NOT

20. WHAT INITIATES THE EXTRINSIC
PATHWAY?
• NEGATIVELY CHARGED MEMBRANES
• PROTHROMBIN ACTIVATOR
• CALCIUM IONS
• TISSUE FACTOR (TF)

21. WHAT INITIATES THE EXTRINSIC
PATHWAY?
• NEGATIVELY CHARGED MEMBRANES
• PROTHROMBIN ACTIVATOR
• CALCIUM IONS
• TISSUE FACTOR (TF)

22. WHAT IS THE CORRECT ORDER OF
CLOTTING FACTORS FOR THE INTRINSIC
PATHWAY?
• CA2+, VII, VIIA, TF/VIIA
• XII, XIIA, XI, XIA, IX, IXA, VIII, VIIIA, IXA/VIIIA
• X, XA + V, VA + CA2+, PROTHROMBIN (II), THROMBIN (IIA), FIBRINOGEN (I), FIBRIN

23. WHAT IS THE CORRECT ORDER OF
CLOTTING FACTORS FOR THE INTRINSIC
PATHWAY?
• CA2+, VII, VIIA, TF/VIIA
• XII, XIIA, XI, XIA, IX, IXA, VIII, VIIIA, IXA/VIIIA
• X, XA + V, VA + CA2+, PROTHROMBIN (II), THROMBIN (IIA), FIBRINOGEN (I), FIBRIN

24. WHAT IS THE CORRECT ORDER OF
CLOTTING FACTORS FOR THE EXTRINSIC
PATHWAY?
• CA2+, VII, VIIA, TF/VIIA
• XII, XIIA, XI, XIA, IX, IXA, VIII, VIIIA, IXA/VIIIA
• X, XA + V, VA + CA2+, PROTHROMBIN (II), THROMBIN (IIA), FIBRINOGEN (I), FIBRIN

25. WHAT IS THE CORRECT ORDER OF
CLOTTING FACTORS FOR THE EXTRINSIC
PATHWAY?
• CA2+, VII, VIIA, TF/VIIA
• XII, XIIA, XI, XIA, IX, IXA, VIII, VIIIA, IXA/VIIIA
• X, XA + V, VA + CA2+, PROTHROMBIN (II), THROMBIN (IIA), FIBRINOGEN (I), FIBRIN

26. WHICH FACTOR SEQUENCE IS THE
COMMON PATHWAY?
• CA2+, VII, VIIA, TF/VIIA
• XII, XIIA, XI, XIA, IX, IXA, VIII, VIIIA, IXA/VIIIA
• X, XA + V, VA + CA2+, PROTHROMBIN (II), THROMBIN (IIA), FIBRINOGEN (I), FIBRIN

27. WHICH FACTOR SEQUENCE IS THE
COMMON PATHWAY?
• CA2+, VII, VIIA, TF/VIIA
• XII, XIIA, XI, XIA, IX, IXA, VIII, VIIIA, IXA/VIIIA
• X, XA + V, VA + CA2+, PROTHROMBIN (II), THROMBIN (IIA), FIBRINOGEN (I), FIBRIN

28. WHAT IS THE FUNCTION OF FIBRIN?
• FIBRIN CATALYZES THE PROTEIN PROTHROMBIN INTO THE ENZYME THROMBIN
• FIBRIN USES ACTIN-MYOSIN CONTRACTION TO DRAW THE EDGES OF THE WOUND TOGETHER
• FIBRIN ACTIVATES ANTICOAGULANTS TO END LOCAL CLOTTING ACTIVITY
• FIBRIN FORMS A MESH THAT FORMS THE STRUCTURE OF A CLOT, CEMENTING AGGREGATED PLATELETS IN
PLACE

29. WHAT IS THE FUNCTION OF FIBRIN?
• FIBRIN CATALYZES THE PROTEIN PROTHROMBIN INTO THE ENZYME THROMBIN
• FIBRIN USES ACTIN-MYOSIN CONTRACTION TO DRAW THE EDGES OF THE WOUND TOGETHER
• FIBRIN ACTIVATES ANTICOAGULANTS TO END LOCAL CLOTTING ACTIVITY
• FIBRIN FORMS A MESH THAT FORMS THE STRUCTURE OF A CLOT, CEMENTING AGGREGATED PLATELETS IN
PLACE

30. HOW DOES THE PRESENCE OF CA2+ AFFECT
CLOT FORMATION?
• CALCIUM BINDS TO NEGATIVELY CHARGED MEMBRANES TO ACTIVATE THE INTRINSIC PATHWAY
• IN THE PRESENCE OF CALCIUM, THROMBIN ACTIVATES FACTOR XIII, FIBRIN STABILIZING FACTOR
• IN THE PRESENCE OF CALCIUM, THE EXTRINSIC PATHWAY IS ACTIVATED
• CALCIUM IONS BIND TO FIBRIN AND LINK THE FIBERS TOGETHER TO FORM A MESH

31. HOW DOES THE PRESENCE OF CA2+ AFFECT
CLOT FORMATION?
• CALCIUM BINDS TO NEGATIVELY CHARGED MEMBRANES TO ACTIVATE THE INTRINSIC PATHWAY
• IN THE PRESENCE OF CALCIUM, THROMBIN ACTIVATES FACTOR XIII, FIBRIN STABILIZING FACTOR
• IN THE PRESENCE OF CALCIUM, THE EXTRINSIC PATHWAY IS ACTIVATED
• CALCIUM IONS BIND TO FIBRIN AND LINK THE FIBERS TOGETHER TO FORM A MESH

32. MATCH THE FACTORS TO THE PATHWAY:• FIBRINOGEN – I
• PROTHROMBIN - II
• TISSUE FACTOR – III
• CALCIUM IONS – IV
• PROACCELERIN – V
• PROCONVERTIN - VII
• ANTIHEMOPHILIC FACTOR – VIII
• PLASMA THROMBOPLASTIN COMPONENT – IX
• STUART FACTOR - X
• PLASMA THROMBOPLASTIN ANTECEDENT – XI
• HAGEMAN FACTOR – XII
• FIBRIN STABILIZING FACTOR - XIII
• INTRINSIC PATHWAY
• COMMON PATHWAY
• EXTRINSIC PATHWAY
• BOTH PATHWAYS

33. MATCH THE FACTORS TO THE PATHWAY:• FIBRINOGEN – I
• PROTHROMBIN - II
• TISSUE FACTOR – III
• CALCIUM IONS – IV
• PROACCELERIN – V
• PROCONVERTIN - VII
• ANTIHEMOPHILIC FACTOR – VIII
• PLASMA THROMBOPLASTIN COMPONENT – IX
• STUART FACTOR - X
• PLASMA THROMBOPLASTIN ANTECEDENT – XI
• HAGEMAN FACTOR – XII
• FIBRIN STABILIZING FACTOR - XIII
• INTRINSIC PATHWAY
• COMMON PATHWAY
• EXTRINSIC PATHWAY
• BOTH PATHWAYS

34. MATCH THE FACTORS TO THE PATHWAY:• FIBRINOGEN – I
• PROTHROMBIN - II
• TISSUE FACTOR – III
• CALCIUM IONS – IV
• PROACCELERIN – V
• PROCONVERTIN - VII
• ANTIHEMOPHILIC FACTOR – VIII
• PLASMA THROMBOPLASTIN COMPONENT – IX
• STUART FACTOR - X
• PLASMA THROMBOPLASTIN ANTECEDENT – XI
• HAGEMAN FACTOR – XII
• FIBRIN STABILIZING FACTOR - XIII
• INTRINSIC PATHWAY
• COMMON PATHWAY
• EXTRINSIC PATHWAY
• BOTH PATHWAYS

35. MATCH THE FACTORS TO THE PATHWAY:• FIBRINOGEN – I
• PROTHROMBIN - II
• TISSUE FACTOR – III
• CALCIUM IONS – IV
• PROACCELERIN – V
• PROCONVERTIN - VII
• ANTIHEMOPHILIC FACTOR – VIII
• PLASMA THROMBOPLASTIN COMPONENT – IX
• STUART FACTOR - X
• PLASMA THROMBOPLASTIN ANTECEDENT – XI
• HAGEMAN FACTOR – XII
• FIBRIN STABILIZING FACTOR - XIII
• INTRINSIC PATHWAY
• COMMON PATHWAY
• EXTRINSIC PATHWAY
• BOTH PATHWAYS

36. MATCH THE FACTORS TO THE PATHWAY:• FIBRINOGEN – I
• PROTHROMBIN - II
• TISSUE FACTOR – III
• CALCIUM IONS – IV
• PROACCELERIN – V
• PROCONVERTIN - VII
• ANTIHEMOPHILIC FACTOR – VIII
• PLASMA THROMBOPLASTIN COMPONENT – IX
• STUART FACTOR - X
• PLASMA THROMBOPLASTIN ANTECEDENT – XI
• HAGEMAN FACTOR – XII
• FIBRIN STABILIZING FACTOR - XIII
• INTRINSIC PATHWAY
• COMMON PATHWAY
• EXTRINSIC PATHWAY
• BOTH PATHWAYS

37. A DEFICIENCY OF WHICH FACTORS RESULTS
IN HEMOPHILIA?
• VIII (ANTIHEMOPHILIC), IX (PLASMA THROMBOPLASTIN COMPONENT), AND XI (PLASMA
THROMBOPLASTIN ANTECEDENT)
• IX (PLASMA THROMBOPLASTIN COMPONENT), X (STUART), AND XI (PLASMA THROMBOPLASTIN
ANTECEDENT)
• I (FIBRINOGEN), II (PROTHROMBIN), AND VIII (ANTIHEMOPHILIC),
• V (PROACCELERIN), VII (PROCONVERTIN), AND VIII (ANTIHEMOPHILIC),

38. A DEFICIENCY OF WHICH FACTORS RESULTS
IN HEMOPHILIA?
• VIII (ANTIHEMOPHILIC), IX (PLASMA THROMBOPLASTIN COMPONENT), AND XI (PLASMA
THROMBOPLASTIN ANTECEDENT)
• IX (PLASMA THROMBOPLASTIN COMPONENT), X (STUART), AND XI (PLASMA THROMBOPLASTIN
ANTECEDENT)
• I (FIBRINOGEN), II (PROTHROMBIN), AND VIII (ANTIHEMOPHILIC),
• V (PROACCELERIN), VII (PROCONVERTIN), AND VIII (ANTIHEMOPHILIC),

39. WHICH FACTOR IS NEEDED FOR ALL STAGES
OF THE CLOTTING CASCADE?
• FIBRINOGEN
• FIBRIN STABILIZING FACTOR
• VITAMIN K
• CA2+

40. WHICH FACTOR IS NEEDED FOR ALL STAGES
OF THE CLOTTING CASCADE?
• FIBRINOGEN
• FIBRIN STABILIZING FACTOR
• VITAMIN K
• CA2+

41. WHICH FACTOR CONVERTS FIBRINOGEN TO
FIBRIN?
• TISSUE FACTOR
• PROCONVERTIN
• PROACCELERIN
• PROTHROMBIN

42. WHICH FACTOR CONVERTS FIBRINOGEN TO
FIBRIN?
• TISSUE FACTOR
• PROCONVERTIN
• PROACCELERIN
• PROTHROMBIN

43. WHICH FACTOR IS CONVERTED TO FIBRIN?
• FIBRIN STABILIZING FACTOR
• THROMBIN
• HAGEMAN FACTOR
• FIBRINOGEN

44. WHICH FACTOR IS CONVERTED TO FIBRIN?
• FIBRIN STABILIZING FACTOR
• THROMBIN
• HAGEMAN FACTOR
• FIBRINOGEN