ClojureScript allows developers to use Clojure to build rich client applications that run in browsers. It offers powerful functional programming concepts like immutability, pure functions, and core.async for asynchronous programming. The presentation introduces ClojureScript fundamentals like Lisp syntax, REPL, and how it is a hosted language that runs on the browser. It also discusses recommended tools for getting started and explores Om and React for building UIs and core.async for managing asynchronous code. In the end, ClojureScript is concluded to be overkill for simple enhancements but mature for tackling complex UIs while being demanding to learn initially.