The document summarizes the evolution of knowledge transfer between the University of Guelph and the Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA) from an extension model to knowledge translation and transfer (KTT). It describes the unique partnership that attracts research expertise and provides $1.15 billion in annual economic impact. Through several calls for proposals, the partnership has funded around 60 KTT projects across 7 research themes using $5 million in one-time funding. The goal is to facilitate collaboration, networking, and innovation between researchers and agri-food sector partners.