This presentation gives a brief information about cinchona and it's constituents it's uses and the marketed formulations of cinchona constituents

1. CINCHONA
BIOLOGICAL SOURCE: Cinchona officinalis
Cinchona glandulifera
Cinchona calisaya
Cinchona pubescens
FAMILY: Rubiaceae

2. Cinchona officinalis
• SYNONYM: Jesuit’s bark, Jesuit’s powder
• DESCRIPTION: large shrubs or small trees
with evergreen foliage, 5-15m (16-49
feet) in height.
• LEAVES: Opposite, rounded to lanceolate.
• FLOWERS : White, pink or red.
• FRUIT: Small capsule containing numerous
seeds.

3. CONSTITUENTS
CINCHONA ALKALOIDS – 25 types:
• Cinchonine and cinchonidine - isomers
• Quinine and quinidine - stereoisomers
• Dihydroquinine and dihydroquinidine
• Cinchotannic acid, bitter essential oil.
• Quinovin hydrolysis to quinovic acid &
quinovose.
The alkaloids contains at least 15% of
quinine with not more than 20%.
GENERAL STRUCTURE OF
CINCHONA ALKALOID

4. HISTORY

5. USES
• QUININE : antimalarial, skeletal muscle relaxant,
night muscles spasm and abortifacient.
• QUINIDINE : indicated for treatment of
arrhythmia and cardiac depressant, atrial
fibrillation.
• CINCHONINE : has mild antimalarial activity.
• CINCHONA EXTRACT AND TINCTURE : bitter
stomachic and anti-pyretic. CINCHONA BARK WITH MOSES

6. FORMULATIONS

7. TONIC WATER
• EDIBLE USE : Quinine as a bitter
flavouring agent in tonic water and
carbonated drinks.
• INGREDIENTS : Cinchona, ginger, clove
and carbonated water.

8. CINCHONA CAPSULES
• INGREDIENTS: Cinchona officinalis dried
bark – 1000mg. 100% Pure Gelatin
capsules.
• DIRECTION: 2capsules 2-3 times a day with
meal.
• CONTAINS: Quinine, Quina.
• USE: Cold and cough treatment,
hypothermia and antimalarial drug.

9. QUININE TABLETS
• INGREDIENTS: Each tablet consists of
quinine sulphate 300mg and other
excipients.
• DIRECTION: 600mg for every 8hours for
7days.
• CONTAINS: Quinine
• USE: Antimalarial drug, treatment of
nocturnal leg cramps, produce slight sleep.

10. QUINIDINE SULPHATE INJECTION
• INGREDIENTS: Each ampoule
contains quinidine sulphate
190mg.
• DIRECTION: Not more than
4grams daily.
• CONTAINS: Quinidine
• USES: Ventricular arrhythmias,
atrial fibrillation, antimalarial
drug.

11. COSMETICS - SHAMPOOS
• INGREDIANTS: Quinine(Supports
microcirculation) and vitamins
B5(hydrates & fortifies the hair shaft),
B6(strengthens keratin & reduces
sebum) and B8(health to hair strands).
• DIRECTION: Apply to wet hair. Work
into lather & then rinse. Use as often as
required.
• CONTAINS: Quinine.
• USES: Revitalize & Strengthen thinning
hair.

12. OTHER USES
• EYE LOTION: numb pain, kill germs, astringent.
• SKIN: Hemorrhoids.
• Ulcers
• Managing varicose veins
• Influenza
• Fever
• Cancer
• Mouth & throat diseases.
• Enlarged spleen
• Muscle cramps
• Loss of appetite.
• Stomach discomforts like bloating & fullness.
• Gargles to treat sore throats.
• Hair oil & sun tan oil
• Insecticides.
• Vulcanising agent in rubber industry.